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Clonal Hematopoiesis drivers

This resource contains genes with signals of positive selection across blood samples of ~ 12,000 donors with no hematopoietic disease. These constitute, thus drivers of clonal hematopoiesis identified de novo in an unbiased manner. While the most frequently mutated among them constitute long known drivers of clonal hematopoiesis, others are identified here for the first time.


Release develop
  • Cohorts 3
  • Blood samples 19,212
  • Blood somatic mutations 2,338,218
  • Clonal hematopoiesis drivers 64
Cohort Age Type Drivers Samples Mutations
Clonal hematopoiesis genes
This driver cloud represents the most recurrently mutated clonal hematopoiesis driver genes . The size of the gene symbol is relative to the count of samples with mutation in that gene.
This plot shows the most recurrently mutated clonal hematopoiesis driver genes . Each bar of the histogram indicates the amount of samples with the gene mutated.
Symbol Mutations Samples Samples (%) Cohorts