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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
BCLAF1 AML ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
6:136268310:A R750L missense_variant 1.00 11
6:136268287:T P758T missense_variant 0.97 6
6:136269502:C S718R missense_variant 0.80 3
6:136269560:T R699H missense_variant 0.99 2
6:136273139:A S634L missense_variant 0.75 2
6:136279811:A S19F missense_variant 0.52 2
6:136276311:C T405R missense_variant 0.92 1
6:136261411:A R871C missense_variant 0.89 1
6:136268310:T R750Q missense_variant 1.00 0
6:136268310:G R750P missense_variant 1.00 0
6:136269572:C H695R missense_variant 1.00 0
6:136269572:G H695P missense_variant 1.00 0
6:136269572:A H695L missense_variant 1.00 0
6:136269565:C I697M missense_variant 0.99 0
6:136269560:A R699L missense_variant 0.99 0
6:136269560:G R699P missense_variant 0.99 0
6:136273084:C H652Q missense_variant 0.97 0
6:136268287:A P758S missense_variant 0.97 0
6:136278006:C I292S missense_variant 0.97 0
6:136268287:C P758A missense_variant 0.97 0
6:136278006:T I292N missense_variant 0.97 0
6:136277997:G I295T missense_variant 0.97 0
6:136277997:C I295S missense_variant 0.97 0
6:136277997:T I295N missense_variant 0.97 0
6:136278006:G I292T missense_variant 0.97 0
6:136273084:T H652Q missense_variant 0.97 0
6:136275658:A V576F missense_variant 0.97 0
6:136275658:T V576I missense_variant 0.97 0
6:136275658:G V576L missense_variant 0.97 0
6:136269512:G R715T missense_variant 0.97 0
6:136269512:A R715M missense_variant 0.97 0
6:136269512:T R715K missense_variant 0.97 0
6:136269452:T S735Y missense_variant 0.97 0
6:136275865:T V554I missense_variant 0.97 0
6:136275865:G V554L missense_variant 0.97 0
6:136275865:A V554F missense_variant 0.97 0
6:136278363:T P173H missense_variant 0.97 0
6:136278363:C P173R missense_variant 0.97 0
6:136278363:A P173L missense_variant 0.97 0
6:136269452:C S735C missense_variant 0.97 0
6:136269452:A S735F missense_variant 0.97 0
6:136275589:C K599E missense_variant 0.97 0
6:136275589:G K599Q missense_variant 0.97 0
6:136276384:T L381I missense_variant 0.97 0
6:136276384:C L381V missense_variant 0.97 0
6:136269467:C Y730C missense_variant 0.97 0
6:136269467:G Y730S missense_variant 0.97 0
6:136269467:A Y730F missense_variant 0.97 0
6:136269573:T H695N missense_variant 0.96 0
6:136269573:C H695D missense_variant 0.96 0
6:136269573:A H695Y missense_variant 0.96 0
6:136278252:A G210V missense_variant 0.96 0
6:136278252:G G210A missense_variant 0.96 0
6:136278252:T G210D missense_variant 0.96 0
6:136277918:T F321L missense_variant 0.96 0
6:136277918:C F321L missense_variant 0.96 0
6:136278277:T F202I missense_variant 0.96 0
6:136278277:G F202L missense_variant 0.96 0
6:136278277:C F202V missense_variant 0.96 0
6:136278102:A Q260L missense_variant 0.96 0
6:136276119:G E469A missense_variant 0.96 0
6:136276119:C E469G missense_variant 0.96 0
6:136276119:A E469V missense_variant 0.96 0
6:136278102:G Q260P missense_variant 0.96 0
6:136278102:C Q260R missense_variant 0.96 0
6:136278541:G S114R missense_variant 0.96 0
6:136278541:C S114G missense_variant 0.96 0
6:136278541:A S114C missense_variant 0.96 0
6:136269602:A K685I missense_variant 0.96 0
6:136269602:C K685R missense_variant 0.96 0
6:136273103:A Q646L missense_variant 0.96 0
6:136269602:G K685T missense_variant 0.96 0
6:136273103:C Q646R missense_variant 0.96 0
6:136273103:G Q646P missense_variant 0.96 0
6:136278084:A Q266L missense_variant 0.96 0
6:136278084:G Q266P missense_variant 0.96 0
6:136278084:C Q266R missense_variant 0.96 0
6:136278033:T R283Q missense_variant 0.96 0
6:136278033:G R283P missense_variant 0.96 0
6:136278033:A R283L missense_variant 0.96 0
6:136277977:A A302S missense_variant 0.96 0
6:136268281:C S760A missense_variant 0.96 0
6:136268281:G S760P missense_variant 0.96 0
6:136268281:T S760T missense_variant 0.96 0
6:136277977:G A302P missense_variant 0.96 0
6:136277977:T A302T missense_variant 0.96 0
6:136278316:A D189Y missense_variant 0.96 0
6:136277901:A D327V missense_variant 0.96 0
6:136278316:T D189N missense_variant 0.96 0
6:136277901:C D327G missense_variant 0.96 0
6:136278223:A D220Y missense_variant 0.96 0
6:136278223:G D220H missense_variant 0.96 0
6:136278253:T G210S missense_variant 0.96 0
6:136278253:A G210C missense_variant 0.96 0
6:136277901:G D327A missense_variant 0.96 0
6:136278316:G D189H missense_variant 0.96 0
6:136278253:G G210R missense_variant 0.96 0
6:136278223:T D220N missense_variant 0.96 0
6:136277982:A S300I missense_variant 0.96 0
6:136277944:A D313Y missense_variant 0.96 0
6:136277944:G D313H missense_variant 0.96 0
6:136277944:T D313N missense_variant 0.96 0
6:136277946:A R312I missense_variant 0.96 0
6:136277946:G R312T missense_variant 0.96 0
6:136277946:T R312K missense_variant 0.96 0
6:136278156:A C242F missense_variant 0.96 0
6:136278156:G C242S missense_variant 0.96 0
6:136278510:T R124K missense_variant 0.96 0
6:136278510:G R124T missense_variant 0.96 0
6:136278510:A R124I missense_variant 0.96 0
6:136278229:T A218T missense_variant 0.96 0
6:136278156:T C242Y missense_variant 0.96 0
6:136278229:G A218P missense_variant 0.96 0
6:136278480:T R134K missense_variant 0.96 0
6:136278480:G R134T missense_variant 0.96 0
6:136278480:A R134I missense_variant 0.96 0
6:136278447:T R145H missense_variant 0.96 0
6:136278447:G R145P missense_variant 0.96 0
6:136278447:A R145L missense_variant 0.96 0
6:136277982:G S300T missense_variant 0.96 0
6:136277982:T S300N missense_variant 0.96 0
6:136278328:G E185Q missense_variant 0.96 0
6:136277988:A R298L missense_variant 0.96 0
6:136277988:G R298P missense_variant 0.96 0
6:136277988:T R298Q missense_variant 0.96 0
6:136278229:A A218S missense_variant 0.96 0
6:136278405:T R159Q missense_variant 0.96 0
6:136278405:G R159P missense_variant 0.96 0
6:136278405:A R159L missense_variant 0.96 0
6:136278328:T E185K missense_variant 0.96 0
6:136278078:T S268N missense_variant 0.96 0
6:136278078:A S268I missense_variant 0.96 0
6:136278078:G S268T missense_variant 0.96 0
6:136276117:C R470G missense_variant 0.95 0
6:136276117:A R470W missense_variant 0.95 0
6:136275906:T S540N missense_variant 0.95 0
6:136275906:G S540T missense_variant 0.95 0
6:136275906:A S540I missense_variant 0.95 0
6:136278210:T R224K missense_variant 0.95 0
6:136278210:G R224T missense_variant 0.95 0
6:136275856:A D557Y missense_variant 0.95 0
6:136275856:G D557H missense_variant 0.95 0
6:136275856:T D557N missense_variant 0.95 0
6:136278210:A R224I missense_variant 0.95 0
6:136278117:G K255T missense_variant 0.95 0
6:136278117:C K255R missense_variant 0.95 0
6:136278117:A K255I missense_variant 0.95 0
6:136278280:G E201Q missense_variant 0.95 0
6:136278238:G G215R missense_variant 0.95 0
6:136278238:T G215S missense_variant 0.95 0
6:136276150:T Y459N missense_variant 0.95 0
6:136276150:G Y459H missense_variant 0.95 0
6:136276150:C Y459D missense_variant 0.95 0
6:136276374:C F384C missense_variant 0.95 0
6:136276374:G F384S missense_variant 0.95 0
6:136277943:A D313V missense_variant 0.95 0
6:136276374:T F384Y missense_variant 0.95 0
6:136277943:C D313G missense_variant 0.95 0
6:136277943:G D313A missense_variant 0.95 0
6:136278511:C R124G missense_variant 0.95 0
6:136278483:G Y133S missense_variant 0.95 0
6:136278483:C Y133C missense_variant 0.95 0
6:136278483:A Y133F missense_variant 0.95 0
6:136278481:C R134G missense_variant 0.95 0
6:136278357:G E175A missense_variant 0.95 0
6:136278357:C E175G missense_variant 0.95 0
6:136278357:A E175V missense_variant 0.95 0
6:136278337:G K182Q missense_variant 0.95 0
6:136278337:C K182E missense_variant 0.95 0
6:136278088:A I265F missense_variant 0.95 0
6:136278325:T E186K missense_variant 0.95 0
6:136278325:G E186Q missense_variant 0.95 0
6:136278088:C I265V missense_variant 0.95 0
6:136278088:G I265L missense_variant 0.95 0
6:136278300:G D194A missense_variant 0.95 0
6:136278300:C D194G missense_variant 0.95 0
6:136278300:A D194V missense_variant 0.95 0
6:136278280:T E201K missense_variant 0.95 0
6:136278238:A G215C missense_variant 0.95 0
6:136278150:A D244V missense_variant 0.95 0
6:136278150:C D244G missense_variant 0.95 0
6:136278150:G D244A missense_variant 0.95 0
6:136276256:C F423L missense_variant 0.95 0
6:136277937:T S315Y missense_variant 0.95 0
6:136276256:T F423L missense_variant 0.95 0
6:136277937:A S315F missense_variant 0.95 0
6:136277937:C S315C missense_variant 0.95 0
6:136278262:T A207T missense_variant 0.95 0
6:136276287:C K413R missense_variant 0.95 0
6:136278262:A A207S missense_variant 0.95 0
6:136269591:A D689Y missense_variant 0.95 0
6:136269591:G D689H missense_variant 0.95 0
6:136269591:T D689N missense_variant 0.95 0
6:136278000:G H294P missense_variant 0.95 0
6:136278000:C H294R missense_variant 0.95 0
6:136278000:A H294L missense_variant 0.95 0
6:136269557:A R700L missense_variant 0.95 0
6:136278262:G A207P missense_variant 0.95 0
6:136276287:A K413M missense_variant 0.95 0
6:136276287:G K413T missense_variant 0.95 0
6:136269557:T R700H missense_variant 0.95 0
6:136269557:G R700P missense_variant 0.95 0
6:136275984:C P514R missense_variant 0.94 0
6:136275984:A P514L missense_variant 0.94 0
6:136275984:T P514H missense_variant 0.94 0
6:136275946:T F527I missense_variant 0.94 0
6:136275946:G F527L missense_variant 0.94 0
6:136275946:C F527V missense_variant 0.94 0
6:136275974:A K517N missense_variant 0.94 0
6:136275967:G D520H missense_variant 0.94 0
6:136275967:A D520Y missense_variant 0.94 0
6:136275967:T D520N missense_variant 0.94 0
6:136275974:G K517N missense_variant 0.94 0
6:136275942:T R528K missense_variant 0.94 0
6:136275942:G R528T missense_variant 0.94 0
6:136275942:A R528I missense_variant 0.94 0
6:136277865:A R339M missense_variant 0.94 0
6:136277865:G R339T missense_variant 0.94 0
6:136277865:T R339K missense_variant 0.94 0
6:136277881:A G334W missense_variant 0.94 0
6:136277881:G G334R missense_variant 0.94 0
6:136277881:T G334R missense_variant 0.94 0
6:136276052:A K491N missense_variant 0.94 0
6:136276052:G K491N missense_variant 0.94 0
6:136276311:A T405I missense_variant 0.92 0
6:136276311:T T405K missense_variant 0.92 0
6:136271995:A K681N missense_variant 0.92 0
6:136271995:G K681N missense_variant 0.92 0
6:136267125:C N816K missense_variant 0.92 0
6:136267125:T N816K missense_variant 0.92 0
6:136276104:T T474K missense_variant 0.91 0
6:136276104:A T474I missense_variant 0.91 0
6:136276104:C T474R missense_variant 0.91 0
6:136277898:A Q328L missense_variant 0.90 0
6:136278112:A T257S missense_variant 0.90 0
6:136278099:A H261L missense_variant 0.90 0
6:136278336:G K182T missense_variant 0.90 0
6:136278099:C H261R missense_variant 0.90 0
6:136278112:G T257P missense_variant 0.90 0
6:136278336:C K182R missense_variant 0.90 0
6:136278112:C T257A missense_variant 0.90 0
6:136277898:G Q328P missense_variant 0.90 0
6:136277898:C Q328R missense_variant 0.90 0
6:136278099:G H261P missense_variant 0.90 0
6:136278081:C H267R missense_variant 0.90 0
6:136278081:G H267P missense_variant 0.90 0
6:136278336:A K182I missense_variant 0.90 0
6:136278081:A H267L missense_variant 0.90 0
6:136261399:C R875G missense_variant 0.90 0
6:136261399:A R875C missense_variant 0.90 0
6:136261399:T R875S missense_variant 0.90 0
6:136276398:C E376G missense_variant 0.90 0
6:136276398:G E376A missense_variant 0.90 0
6:136276027:T V500I missense_variant 0.90 0
6:136276027:G V500L missense_variant 0.90 0
6:136276027:A V500L missense_variant 0.90 0
6:136276398:A E376V missense_variant 0.90 0
6:136276014:G K504T missense_variant 0.90 0
6:136276014:C K504R missense_variant 0.90 0
6:136276014:A K504M missense_variant 0.90 0
6:136275922:G I535L missense_variant 0.90 0
6:136275922:C I535V missense_variant 0.90 0
6:136275922:A I535F missense_variant 0.90 0
6:136269563:G D698A missense_variant 0.89 0
6:136269563:A D698V missense_variant 0.89 0
6:136269563:C D698G missense_variant 0.89 0
6:136278625:A G86C missense_variant 0.89 0
6:136278625:G G86R missense_variant 0.89 0
6:136278625:T G86S missense_variant 0.89 0
6:136267112:C N821D missense_variant 0.89 0
6:136267112:A N821Y missense_variant 0.89 0
6:136267112:G N821H missense_variant 0.89 0
6:136278770:G R37S missense_variant 0.89 0
6:136261411:T R871S missense_variant 0.89 0
6:136278636:C Q82R missense_variant 0.89 0
6:136261411:C R871G missense_variant 0.89 0
6:136278636:G Q82P missense_variant 0.89 0
6:136278636:A Q82L missense_variant 0.89 0
6:136278770:A R37S missense_variant 0.89 0
6:136278603:A Y93F missense_variant 0.88 0
6:136278693:G N63T missense_variant 0.88 0
6:136278693:C N63S missense_variant 0.88 0
6:136278693:A N63I missense_variant 0.88 0
6:136278651:T G77D missense_variant 0.88 0
6:136278651:G G77A missense_variant 0.88 0
6:136278651:A G77V missense_variant 0.88 0
6:136278642:G Y80S missense_variant 0.88 0
6:136278642:C Y80C missense_variant 0.88 0
6:136278642:A Y80F missense_variant 0.88 0
6:136278603:G Y93S missense_variant 0.88 0
6:136278603:C Y93C missense_variant 0.88 0
6:136273084:A H652H splice_region_variant 0.88 0
6:136269457:C Y733* stop_gained 0.88 0
6:136269457:T Y733* stop_gained 0.88 0
6:136276101:G K475T missense_variant 0.88 0
6:136276101:C K475R missense_variant 0.88 0
6:136276101:A K475I missense_variant 0.88 0
6:136276013:G K504N missense_variant 0.88 0
6:136276013:A K504N missense_variant 0.88 0
6:136276456:G D357H missense_variant 0.88 0
6:136273116:C H642D missense_variant 0.88 0
6:136276225:G E434Q missense_variant 0.88 0
6:136276225:T E434K missense_variant 0.88 0
6:136276018:T E503K missense_variant 0.88 0
6:136276018:G E503Q missense_variant 0.88 0
6:136276268:A Q419H missense_variant 0.88 0
6:136276268:G Q419H missense_variant 0.88 0
6:136273116:A H642Y missense_variant 0.88 0
6:136273116:T H642N missense_variant 0.88 0
6:136276456:T D357N missense_variant 0.88 0
6:136276456:A D357Y missense_variant 0.88 0
6:136276162:T E455K missense_variant 0.88 0
6:136276162:G E455Q missense_variant 0.88 0
6:136267111:G N821T missense_variant 0.88 0
6:136267111:A N821I missense_variant 0.88 0
6:136267111:C N821S missense_variant 0.88 0
6:136278680:G M67I missense_variant 0.88 0
6:136278652:T G77S missense_variant 0.88 0
6:136278680:A M67I missense_variant 0.88 0
6:136278680:T M67I missense_variant 0.88 0
6:136278652:A G77C missense_variant 0.88 0
6:136278652:G G77R missense_variant 0.88 0
6:136278711:G Y57S missense_variant 0.88 0
6:136278711:A Y57F missense_variant 0.88 0
6:136278711:C Y57C missense_variant 0.88 0
6:136278648:G R78T missense_variant 0.87 0
6:136278648:T R78K missense_variant 0.87 0
6:136278648:A R78I missense_variant 0.87 0
6:136276423:C K368E missense_variant 0.87 0
6:136273130:C K637R missense_variant 0.87 0
6:136273130:A K637I missense_variant 0.87 0
6:136272042:C T666A missense_variant 0.87 0
6:136276009:G K506Q missense_variant 0.87 0
6:136276009:C K506E missense_variant 0.87 0
6:136272042:G T666P missense_variant 0.87 0
6:136276423:G K368Q missense_variant 0.87 0
6:136273130:G K637T missense_variant 0.87 0
6:136276505:T F340L missense_variant 0.87 0
6:136272042:A T666S missense_variant 0.87 0
6:136276505:C F340L missense_variant 0.87 0
6:136275557:C I609M missense_variant 0.87 0
6:136276463:C N354K missense_variant 0.87 0
6:136276463:T N354K missense_variant 0.87 0
6:136276020:T S502Y missense_variant 0.87 0
6:136276020:A S502F missense_variant 0.87 0
6:136276020:C S502C missense_variant 0.87 0
6:136267136:G A813P missense_variant 0.87 0
6:136267136:T A813T missense_variant 0.87 0
6:136267136:A A813S missense_variant 0.87 0
6:136272069:C I657V missense_variant 0.87 0
6:136276194:C L444R missense_variant 0.87 0
6:136276194:G L444P missense_variant 0.87 0
6:136276194:T L444Q missense_variant 0.87 0
6:136276426:T E367K missense_variant 0.87 0
6:136276426:G E367Q missense_variant 0.87 0
6:136272069:G I657L missense_variant 0.87 0
6:136272069:A I657F missense_variant 0.87 0
6:136277973:G K303T missense_variant 0.87 0
6:136277973:C K303R missense_variant 0.87 0
6:136278354:C E176G missense_variant 0.87 0
6:136278354:A E176V missense_variant 0.87 0
6:136277973:A K303M missense_variant 0.87 0
6:136278354:G E176A missense_variant 0.87 0
6:136277899:C Q328E missense_variant 0.87 0
6:136278279:A E201V missense_variant 0.87 0
6:136278279:C E201G missense_variant 0.87 0
6:136278279:G E201A missense_variant 0.87 0
6:136278168:A Q238L missense_variant 0.87 0
6:136278168:C Q238R missense_variant 0.87 0
6:136278168:G Q238P missense_variant 0.87 0
6:136277899:T Q328K missense_variant 0.87 0
6:136278583:A R100W missense_variant 0.87 0
6:136278583:C R100G missense_variant 0.87 0
6:136278679:C R68G missense_variant 0.87 0
6:136278426:A K152I missense_variant 0.87 0
6:136278220:A N221Y missense_variant 0.87 0
6:136278220:C N221D missense_variant 0.87 0
6:136278426:C K152R missense_variant 0.87 0
6:136278426:G K152T missense_variant 0.87 0
6:136277984:G R299S missense_variant 0.87 0
6:136278318:A K188I missense_variant 0.87 0
6:136277984:A R299S missense_variant 0.87 0
6:136278318:C K188R missense_variant 0.87 0
6:136278318:G K188T missense_variant 0.87 0
6:136278319:C K188E missense_variant 0.87 0
6:136278319:G K188Q missense_variant 0.87 0
6:136269526:T D710E missense_variant 0.87 0
6:136269526:C D710E missense_variant 0.87 0
6:136278352:G S177R missense_variant 0.87 0
6:136278220:G N221H missense_variant 0.87 0
6:136278352:C S177G missense_variant 0.87 0
6:136278352:A S177C missense_variant 0.87 0
6:136278330:G Q184P missense_variant 0.87 0
6:136278274:A N203Y missense_variant 0.87 0
6:136278315:G D189A missense_variant 0.87 0
6:136278330:A Q184L missense_variant 0.87 0
6:136278330:C Q184R missense_variant 0.87 0
6:136278274:G N203H missense_variant 0.87 0
6:136278315:C D189G missense_variant 0.87 0
6:136278315:A D189V missense_variant 0.87 0
6:136278274:C N203D missense_variant 0.87 0
6:136272000:C Q680E missense_variant 0.86 0
6:136272000:T Q680K missense_variant 0.86 0
6:136278013:C S290G missense_variant 0.86 0
6:136278013:A S290C missense_variant 0.86 0
6:136278079:G S268R missense_variant 0.86 0
6:136278079:C S268G missense_variant 0.86 0
6:136278079:A S268C missense_variant 0.86 0
6:136278264:A S206L missense_variant 0.86 0
6:136278013:G S290R missense_variant 0.86 0
6:136278378:C K168R missense_variant 0.86 0
6:136278378:G K168T missense_variant 0.86 0
6:136278378:A K168I missense_variant 0.86 0
6:136276036:C P497A missense_variant 0.86 0
6:136276036:T P497T missense_variant 0.86 0
6:136276036:A P497S missense_variant 0.86 0
6:136275954:C K524R missense_variant 0.86 0
6:136276417:A R370W missense_variant 0.86 0
6:136276417:C R370G missense_variant 0.86 0
6:136276452:A K358I missense_variant 0.86 0
6:136276452:C K358R missense_variant 0.86 0
6:136276452:G K358T missense_variant 0.86 0
6:136276494:A E344V missense_variant 0.86 0
6:136276494:C E344G missense_variant 0.86 0
6:136276494:G E344A missense_variant 0.86 0
6:136276096:G K477Q missense_variant 0.86 0
6:136276096:C K477E missense_variant 0.86 0
6:136276500:A D342V missense_variant 0.86 0
6:136276500:C D342G missense_variant 0.86 0
6:136276500:G D342A missense_variant 0.86 0
6:136275880:A L549F missense_variant 0.86 0
6:136275880:C L549V missense_variant 0.86 0
6:136275880:T L549I missense_variant 0.86 0
6:136275883:C K548E missense_variant 0.86 0
6:136275883:G K548Q missense_variant 0.86 0
6:136276030:T Q499K missense_variant 0.86 0
6:136276030:C Q499E missense_variant 0.86 0
6:136275954:G K524T missense_variant 0.86 0
6:136275954:A K524M missense_variant 0.86 0
6:136268229:T F777Y missense_variant 0.86 0
6:136268229:G F777S missense_variant 0.86 0
6:136268229:C F777C missense_variant 0.86 0
6:136267150:T A808D missense_variant 0.86 0
6:136267150:C A808G missense_variant 0.86 0
6:136267150:A A808V missense_variant 0.86 0
6:136275589:A K599* stop_gained 0.86 0
6:136276357:T G390R missense_variant 0.86 0
6:136276357:G G390R missense_variant 0.86 0
6:136269439:T D739E missense_variant 0.86 0
6:136269439:C D739E missense_variant 0.86 0
6:136276446:T A360D missense_variant 0.86 0
6:136276446:C A360G missense_variant 0.86 0
6:136276446:A A360V missense_variant 0.86 0
6:136276049:G K492N missense_variant 0.86 0
6:136275911:C I538M missense_variant 0.86 0
6:136275907:G S540R missense_variant 0.86 0
6:136275907:C S540G missense_variant 0.86 0
6:136275907:A S540C missense_variant 0.86 0
6:136277998:G I295L missense_variant 0.86 0
6:136277998:C I295V missense_variant 0.86 0
6:136277998:A I295F missense_variant 0.86 0
6:136276049:A K492N missense_variant 0.86 0
6:136275667:A S573C missense_variant 0.85 0
6:136275667:G S573R missense_variant 0.85 0
6:136275667:C S573G missense_variant 0.85 0
6:136277869:C K338E missense_variant 0.85 0
6:136272067:C I657M missense_variant 0.85 0
6:136277869:G K338Q missense_variant 0.85 0
6:136275976:C K517E missense_variant 0.85 0
6:136275976:G K517Q missense_variant 0.85 0
6:136276432:T G365R missense_variant 0.85 0
6:136276432:G G365R missense_variant 0.85 0
6:136269594:G C688R missense_variant 0.85 0
6:136269594:C C688G missense_variant 0.85 0
6:136269594:T C688S missense_variant 0.85 0
6:136276279:T L416I missense_variant 0.85 0
6:136276279:C L416V missense_variant 0.85 0
6:136276279:A L416F missense_variant 0.85 0
6:136278157:G C242R missense_variant 0.85 0
6:136278157:C C242G missense_variant 0.85 0
6:136278157:T C242S missense_variant 0.85 0
6:136261281:T R914K missense_variant 0.84 0
6:136261281:G R914T missense_variant 0.84 0
6:136261281:A R914I missense_variant 0.84 0
6:136269570:A D696Y missense_variant 0.84 0
6:136269570:T D696N missense_variant 0.84 0
6:136269570:G D696H missense_variant 0.84 0
6:136269531:T G709R missense_variant 0.84 0
6:136269531:G G709R missense_variant 0.84 0
6:136269569:G D696A missense_variant 0.84 0
6:136269569:C D696G missense_variant 0.84 0
6:136269569:A D696V missense_variant 0.84 0
6:136276486:A V347L missense_variant 0.83 0
6:136273143:A T633S missense_variant 0.83 0
6:136273143:C T633A missense_variant 0.83 0
6:136273143:G T633P missense_variant 0.83 0
6:136278285:C I199S missense_variant 0.83 0
6:136278285:G I199T missense_variant 0.83 0
6:136276486:T V347I missense_variant 0.83 0
6:136278285:T I199N missense_variant 0.83 0
6:136276486:G V347L missense_variant 0.83 0
6:136275927:T L533H missense_variant 0.83 0
6:136278055:C S276A missense_variant 0.83 0
6:136278055:G S276P missense_variant 0.83 0
6:136275927:G L533P missense_variant 0.83 0
6:136275927:C L533R missense_variant 0.83 0
6:136278055:T S276T missense_variant 0.83 0
6:136269476:C P727R missense_variant 0.83 0
6:136269476:A P727L missense_variant 0.83 0
6:136272054:T L662M missense_variant 0.83 0
6:136269476:T P727Q missense_variant 0.83 0
6:136272054:C L662V missense_variant 0.83 0
6:136272012:C K676E missense_variant 0.83 0
6:136272012:G K676Q missense_variant 0.83 0
6:136278328:A E185* stop_gained 0.83 0
6:136278067:C S272A missense_variant 0.82 0
6:136278067:G S272P missense_variant 0.82 0
6:136278067:T S272T missense_variant 0.82 0
6:136278280:A E201* stop_gained 0.82 0
6:136278511:A R124* stop_gained 0.82 0
6:136278337:A K182* stop_gained 0.82 0
6:136278481:A R134* stop_gained 0.82 0
6:136278325:A E186* stop_gained 0.82 0
6:136269502:T S718R missense_variant 0.80 0
6:136275982:C L515V missense_variant 0.80 0
6:136276499:C D342E missense_variant 0.80 0
6:136276499:T D342E missense_variant 0.80 0
6:136275982:T L515I missense_variant 0.80 0
6:136278436:A P149S missense_variant 0.80 0
6:136278436:T P149T missense_variant 0.80 0
6:136278267:A S205L missense_variant 0.80 0
6:136278436:C P149A missense_variant 0.80 0
6:136276459:C R356G missense_variant 0.80 0
6:136269542:T S705N missense_variant 0.80 0
6:136269542:G S705T missense_variant 0.80 0
6:136269542:A S705I missense_variant 0.80 0
6:136276459:A R356W missense_variant 0.80 0
6:136278147:C A245G missense_variant 0.79 0
6:136276368:C D386G missense_variant 0.79 0
6:136278147:A A245V missense_variant 0.79 0
6:136276368:A D386V missense_variant 0.79 0
6:136276368:G D386A missense_variant 0.79 0
6:136278147:T A245D missense_variant 0.79 0
6:136275995:T D510E missense_variant 0.79 0
6:136275995:C D510E missense_variant 0.79 0
6:136275998:C F509L missense_variant 0.79 0
6:136275998:T F509L missense_variant 0.79 0
6:136276140:C K462R missense_variant 0.78 0
6:136273163:T M626K missense_variant 0.78 0
6:136273163:G M626T missense_variant 0.78 0
6:136273163:C M626R missense_variant 0.78 0
6:136276140:G K462T missense_variant 0.78 0
6:136276140:A K462I missense_variant 0.78 0
6:136275617:C F589L missense_variant 0.76 0
6:136275617:T F589L missense_variant 0.76 0
6:136276450:G E359Q missense_variant 0.76 0
6:136275928:T L533I missense_variant 0.76 0
6:136276450:T E359K missense_variant 0.76 0
6:136275928:C L533V missense_variant 0.76 0
6:136275928:A L533F missense_variant 0.76 0
6:136261387:C K879E missense_variant 0.75 0
6:136261413:C Q870R missense_variant 0.75 0
6:136261413:A Q870L missense_variant 0.75 0
6:136261413:G Q870P missense_variant 0.75 0
6:136261387:G K879Q missense_variant 0.75 0
6:136261355:T H889Q missense_variant 0.75 0
6:136261342:G G894R missense_variant 0.75 0
6:136261342:A G894W missense_variant 0.75 0
6:136261355:C H889Q missense_variant 0.75 0
6:136261342:T G894R missense_variant 0.75 0
6:136269509:A E716V missense_variant 0.75 0
6:136269509:C E716G missense_variant 0.75 0
6:136269509:G E716A missense_variant 0.75 0
6:136275610:A I592F missense_variant 0.75 0
6:136275610:C I592V missense_variant 0.75 0
6:136275610:G I592L missense_variant 0.75 0
6:136275696:T A563D missense_variant 0.75 0
6:136269527:A D710V missense_variant 0.75 0
6:136273139:C S634W missense_variant 0.75 0
6:136275696:C A563G missense_variant 0.75 0
6:136275696:A A563V missense_variant 0.75 0
6:136269527:C D710G missense_variant 0.75 0
6:136269527:G D710A missense_variant 0.75 0
6:136276243:C H428D missense_variant 0.74 0
6:136276243:A H428Y missense_variant 0.74 0
6:136276243:T H428N missense_variant 0.74 0
6:136275585:A S600I missense_variant 0.74 0
6:136275585:T S600N missense_variant 0.74 0
6:136275585:G S600T missense_variant 0.74 0
6:136271995:T K681K splice_region_variant 0.74 0
6:136269446:G K737T missense_variant 0.73 0
6:136275653:T H577Q missense_variant 0.73 0
6:136275653:C H577Q missense_variant 0.73 0
6:136275948:A T526I missense_variant 0.73 0
6:136275948:T T526N missense_variant 0.73 0
6:136275948:C T526S missense_variant 0.73 0
6:136268265:A E765V missense_variant 0.73 0
6:136268265:C E765G missense_variant 0.73 0
6:136278258:C T208R missense_variant 0.73 0
6:136278258:A T208I missense_variant 0.73 0
6:136268265:G E765A missense_variant 0.73 0
6:136269446:A K737I missense_variant 0.73 0
6:136269446:C K737R missense_variant 0.73 0
6:136273149:C R631G missense_variant 0.73 0
6:136273149:A R631W missense_variant 0.73 0
6:136278258:T T208K missense_variant 0.73 0
6:136276275:A A417V missense_variant 0.73 0
6:136276275:C A417G missense_variant 0.73 0
6:136276275:T A417E missense_variant 0.73 0
6:136268249:G K770N missense_variant 0.73 0
6:136268245:T E772K missense_variant 0.73 0
6:136268249:A K770N missense_variant 0.73 0
6:136268172:T R796Q missense_variant 0.73 0
6:136268172:G R796P missense_variant 0.73 0
6:136268172:A R796L missense_variant 0.73 0
6:136268241:A R773I missense_variant 0.73 0
6:136268241:G R773T missense_variant 0.73 0
6:136268241:T R773K missense_variant 0.73 0
6:136268245:G E772Q missense_variant 0.73 0
6:136278096:A S262L missense_variant 0.72 0
6:136276305:G D407A missense_variant 0.72 0
6:136276305:C D407G missense_variant 0.72 0
6:136276305:A D407V missense_variant 0.72 0
6:136276303:G Y408H missense_variant 0.72 0
6:136275999:C F509C missense_variant 0.72 0
6:136276153:A N458Y missense_variant 0.72 0
6:136276303:C Y408D missense_variant 0.72 0
6:136275873:T M551K missense_variant 0.72 0
6:136275913:A I538L missense_variant 0.72 0
6:136275913:C I538V missense_variant 0.72 0
6:136275913:G I538L missense_variant 0.72 0
6:136275873:G M551T missense_variant 0.72 0
6:136275873:C M551R missense_variant 0.72 0
6:136275936:A E530V missense_variant 0.72 0
6:136275936:C E530G missense_variant 0.72 0
6:136275936:G E530A missense_variant 0.72 0
6:136275999:T F509Y missense_variant 0.72 0
6:136275999:G F509S missense_variant 0.72 0
6:136276303:T Y408N missense_variant 0.72 0
6:136276153:C N458D missense_variant 0.72 0
6:136276153:G N458H missense_variant 0.72 0
6:136275879:T L549H missense_variant 0.72 0
6:136275879:C L549R missense_variant 0.72 0
6:136276032:G E498A missense_variant 0.72 0
6:136276489:C R346G missense_variant 0.72 0
6:136276032:C E498G missense_variant 0.72 0
6:136276032:A E498V missense_variant 0.72 0
6:136275879:G L549P missense_variant 0.72 0
6:136276444:C S361A missense_variant 0.70 0
6:136276444:G S361P missense_variant 0.70 0
6:136276444:T S361T missense_variant 0.70 0
6:136276251:A T425I missense_variant 0.70 0
6:136276251:T T425N missense_variant 0.70 0
6:136272038:A R667L missense_variant 0.70 0
6:136276251:C T425S missense_variant 0.70 0
6:136272038:G R667P missense_variant 0.70 0
6:136272038:T R667H missense_variant 0.70 0
6:136278036:G S282T missense_variant 0.70 0
6:136269445:A K737N missense_variant 0.70 0
6:136269445:G K737N missense_variant 0.70 0
6:136269513:A R715W missense_variant 0.70 0
6:136269513:C R715G missense_variant 0.70 0
6:136275648:C V579G missense_variant 0.70 0
6:136275648:G V579A missense_variant 0.70 0
6:136275648:T V579D missense_variant 0.70 0
6:136275649:A V579F missense_variant 0.70 0
6:136275649:G V579L missense_variant 0.70 0
6:136275649:T V579I missense_variant 0.70 0
6:136276300:C R409G missense_variant 0.70 0
6:136278036:A S282I missense_variant 0.70 0
6:136278036:T S282N missense_variant 0.70 0
6:136278057:A G275V missense_variant 0.70 0
6:136278057:G G275A missense_variant 0.70 0
6:136278057:T G275D missense_variant 0.70 0
6:136275886:G V547L missense_variant 0.70 0
6:136275886:T V547I missense_variant 0.70 0
6:136275886:A V547F missense_variant 0.70 0
6:136276383:C L381R missense_variant 0.70 0
6:136272005:G E678A missense_variant 0.70 0
6:136276383:T L381Q missense_variant 0.70 0
6:136276383:G L381P missense_variant 0.70 0
6:136272005:A E678V missense_variant 0.70 0
6:136272005:C E678G missense_variant 0.70 0
6:136275584:T S600R missense_variant 0.70 0
6:136275584:C S600R missense_variant 0.70 0
6:136269567:C I697V missense_variant 0.70 0
6:136269561:A R699C missense_variant 0.70 0
6:136269561:C R699G missense_variant 0.70 0
6:136269561:T R699S missense_variant 0.70 0
6:136269567:G I697L missense_variant 0.70 0
6:136269567:A I697F missense_variant 0.70 0
6:136276495:G E344Q missense_variant 0.69 0
6:136276180:G E449Q missense_variant 0.69 0
6:136276239:A R429L missense_variant 0.69 0
6:136276239:G R429P missense_variant 0.69 0
6:136276180:T E449K missense_variant 0.69 0
6:136276028:G Q499H missense_variant 0.69 0
6:136276239:T R429Q missense_variant 0.69 0
6:136276028:A Q499H missense_variant 0.69 0
6:136268326:T E745K missense_variant 0.69 0
6:136276396:A D377Y missense_variant 0.69 0
6:136276396:G D377H missense_variant 0.69 0
6:136276396:T D377N missense_variant 0.69 0
6:136276399:G E376Q missense_variant 0.69 0
6:136276399:T E376K missense_variant 0.69 0
6:136276495:T E344K missense_variant 0.69 0
6:136268326:G E745Q missense_variant 0.69 0
6:136269564:T D698N missense_variant 0.69 0
6:136269566:C I697S missense_variant 0.69 0
6:136269564:G D698H missense_variant 0.69 0
6:136269566:T I697N missense_variant 0.69 0
6:136269566:G I697T missense_variant 0.69 0
6:136269564:A D698Y missense_variant 0.69 0
6:136276044:T T494N missense_variant 0.69 0
6:136276044:A T494I missense_variant 0.69 0
6:136276044:C T494S missense_variant 0.69 0
6:136268244:A E772V missense_variant 0.69 0
6:136268244:C E772G missense_variant 0.69 0
6:136268244:G E772A missense_variant 0.69 0
6:136269568:T D696E missense_variant 0.69 0
6:136269568:C D696E missense_variant 0.69 0
6:136267123:C T817S missense_variant 0.69 0
6:136267123:T T817N missense_variant 0.69 0
6:136267123:A T817I missense_variant 0.69 0
6:136277956:A N309Y missense_variant 0.68 0
6:136273154:A N629I missense_variant 0.68 0
6:136273154:C N629S missense_variant 0.68 0
6:136277956:C N309D missense_variant 0.68 0
6:136277956:G N309H missense_variant 0.68 0
6:136273154:G N629T missense_variant 0.68 0
6:136278584:G R99S missense_variant 0.68 0
6:136278686:A R65S missense_variant 0.68 0
6:136278686:G R65S missense_variant 0.68 0
6:136278716:A R55S missense_variant 0.68 0
6:136278716:G R55S missense_variant 0.68 0
6:136278584:A R99S missense_variant 0.68 0
6:136278682:C M67V missense_variant 0.68 0
6:136278682:A M67L missense_variant 0.68 0
6:136278682:G M67L missense_variant 0.68 0
6:136275687:C T566S missense_variant 0.68 0
6:136277964:T A306E missense_variant 0.68 0
6:136275687:T T566N missense_variant 0.68 0
6:136277964:C A306G missense_variant 0.68 0
6:136275687:A T566I missense_variant 0.68 0
6:136277964:A A306V missense_variant 0.68 0
6:136278718:C R55G missense_variant 0.67 0
6:136275940:T E529K missense_variant 0.67 0
6:136275940:G E529Q missense_variant 0.67 0
6:136276419:T G369E missense_variant 0.67 0
6:136276419:G G369A missense_variant 0.67 0
6:136276419:A G369V missense_variant 0.67 0
6:136273127:A A638V missense_variant 0.67 0
6:136273127:T A638D missense_variant 0.67 0
6:136273127:C A638G missense_variant 0.67 0
6:136269470:C D729G missense_variant 0.67 0
6:136276333:G E398Q missense_variant 0.67 0
6:136276333:T E398K missense_variant 0.67 0
6:136276339:A D396Y missense_variant 0.67 0
6:136276339:G D396H missense_variant 0.67 0
6:136276339:T D396N missense_variant 0.67 0
6:136269470:A D729V missense_variant 0.67 0
6:136276330:T G399R missense_variant 0.67 0
6:136269470:G D729A missense_variant 0.67 0
6:136276330:A G399W missense_variant 0.67 0
6:136272077:T R654K missense_variant 0.67 0
6:136272077:G R654T missense_variant 0.67 0
6:136272077:A R654I missense_variant 0.67 0
6:136276330:G G399R missense_variant 0.67 0
6:136276065:T R487K missense_variant 0.67 0
6:136273122:T E640K missense_variant 0.67 0
6:136273122:G E640Q missense_variant 0.67 0
6:136276065:A R487I missense_variant 0.67 0
6:136276065:G R487T missense_variant 0.67 0
6:136276138:T E463K missense_variant 0.67 0
6:136276138:G E463Q missense_variant 0.67 0
6:136276098:G D476A missense_variant 0.67 0
6:136276380:A D382V missense_variant 0.67 0
6:136276380:C D382G missense_variant 0.67 0
6:136276098:A D476V missense_variant 0.67 0
6:136276092:G H478P missense_variant 0.67 0
6:136276092:C H478R missense_variant 0.67 0
6:136276092:A H478L missense_variant 0.67 0
6:136276380:G D382A missense_variant 0.67 0
6:136276098:C D476G missense_variant 0.67 0
6:136278124:G S253P missense_variant 0.67 0
6:136278124:C S253A missense_variant 0.67 0
6:136278124:T S253T missense_variant 0.67 0
6:136278647:G R78S missense_variant 0.66 0
6:136278647:A R78S missense_variant 0.66 0
6:136278720:T S54Y missense_variant 0.66 0
6:136278720:C S54C missense_variant 0.66 0
6:136278720:A S54F missense_variant 0.66 0
6:136277992:T S297T missense_variant 0.66 0
6:136277992:C S297A missense_variant 0.66 0
6:136277992:G S297P missense_variant 0.66 0
6:136278690:G N64T missense_variant 0.66 0
6:136278690:C N64S missense_variant 0.66 0
6:136278690:A N64I missense_variant 0.66 0
6:136278126:C H252R missense_variant 0.66 0
6:136278126:A H252L missense_variant 0.66 0
6:136278126:G H252P missense_variant 0.66 0
6:136272059:G S660T missense_variant 0.66 0
6:136272059:T S660N missense_variant 0.66 0
6:136269500:G G719A missense_variant 0.66 0
6:136269500:T G719E missense_variant 0.66 0
6:136275670:A A572S missense_variant 0.66 0
6:136275670:G A572P missense_variant 0.66 0
6:136269500:A G719V missense_variant 0.66 0
6:136275670:T A572T missense_variant 0.66 0
6:136272059:A S660I missense_variant 0.66 0
6:136269528:G D710H missense_variant 0.66 0
6:136276002:C L508R missense_variant 0.66 0
6:136276002:G L508P missense_variant 0.66 0
6:136269597:C R687G missense_variant 0.66 0
6:136269597:A R687W missense_variant 0.66 0
6:136269528:T D710N missense_variant 0.66 0
6:136269528:A D710Y missense_variant 0.66 0
6:136276002:T L508H missense_variant 0.66 0
6:136278282:A D200V missense_variant 0.66 0
6:136275679:A R569W missense_variant 0.66 0
6:136275679:C R569G missense_variant 0.66 0
6:136278282:G D200A missense_variant 0.66 0
6:136278282:C D200G missense_variant 0.66 0
6:136275580:C S602A missense_variant 0.66 0
6:136275580:G S602P missense_variant 0.66 0
6:136275580:T S602T missense_variant 0.66 0
6:136275664:C T574A missense_variant 0.66 0
6:136275664:G T574P missense_variant 0.66 0
6:136275664:A T574S missense_variant 0.66 0
6:136278100:C H261D missense_variant 0.65 0
6:136278261:T A207D missense_variant 0.65 0
6:136278261:C A207G missense_variant 0.65 0
6:136278100:A H261Y missense_variant 0.65 0
6:136278100:T H261N missense_variant 0.65 0
6:136278261:A A207V missense_variant 0.65 0
6:136278388:T Q165K missense_variant 0.65 0
6:136278388:C Q165E missense_variant 0.65 0
6:136272021:C R673G missense_variant 0.65 0
6:136269598:G L686F missense_variant 0.65 0
6:136269598:A L686F missense_variant 0.65 0
6:136276042:T Q495K missense_variant 0.65 0
6:136276042:C Q495E missense_variant 0.65 0
6:136275673:T L571I missense_variant 0.64 0
6:136276031:A E498D missense_variant 0.64 0
6:136276031:G E498D missense_variant 0.64 0
6:136275673:C L571V missense_variant 0.64 0
6:136276336:C S397A missense_variant 0.64 0
6:136276336:G S397P missense_variant 0.64 0
6:136276336:T S397T missense_variant 0.64 0
6:136275673:A L571F missense_variant 0.64 0
6:136276086:C E480G missense_variant 0.64 0
6:136276086:A E480V missense_variant 0.64 0
6:136276086:G E480A missense_variant 0.64 0
6:136276326:A D400V missense_variant 0.64 0
6:136276326:G D400A missense_variant 0.64 0
6:136276237:G N430H missense_variant 0.64 0
6:136276237:C N430D missense_variant 0.64 0
6:136276237:A N430Y missense_variant 0.64 0
6:136276224:G E434A missense_variant 0.64 0
6:136276422:A K368I missense_variant 0.64 0
6:136276422:C K368R missense_variant 0.64 0
6:136276422:G K368T missense_variant 0.64 0
6:136276224:C E434G missense_variant 0.64 0
6:136276224:A E434V missense_variant 0.64 0
6:136276204:G K441Q missense_variant 0.64 0
6:136276204:C K441E missense_variant 0.64 0
6:136276203:G K441T missense_variant 0.64 0
6:136276203:C K441R missense_variant 0.64 0
6:136276203:A K441I missense_variant 0.64 0
6:136276455:A D357V missense_variant 0.64 0
6:136276455:C D357G missense_variant 0.64 0
6:136276455:G D357A missense_variant 0.64 0
6:136276090:G K479Q missense_variant 0.64 0
6:136276090:C K479E missense_variant 0.64 0
6:136277923:C S320A missense_variant 0.64 0
6:136277923:G S320P missense_variant 0.64 0
6:136277923:T S320T missense_variant 0.64 0
6:136276024:G K501Q missense_variant 0.64 0
6:136276024:C K501E missense_variant 0.64 0
6:136275919:G K536Q missense_variant 0.64 0
6:136275919:C K536E missense_variant 0.64 0
6:136275916:G M537L missense_variant 0.64 0
6:136275916:C M537V missense_variant 0.64 0
6:136275916:A M537L missense_variant 0.64 0
6:136275874:G M551L missense_variant 0.64 0
6:136275874:C M551V missense_variant 0.64 0
6:136275874:A M551L missense_variant 0.64 0
6:136276326:C D400G missense_variant 0.64 0
6:136276162:A E455* stop_gained 0.64 0
6:136276018:A E503* stop_gained 0.64 0
6:136276225:A E434* stop_gained 0.64 0
6:136277949:A P311L missense_variant 0.64 0
6:136277949:T P311Q missense_variant 0.64 0
6:136277949:C P311R missense_variant 0.64 0
6:136278144:A P246L missense_variant 0.64 0
6:136278144:C P246R missense_variant 0.64 0
6:136278144:T P246H missense_variant 0.64 0
6:136278493:A R130C missense_variant 0.64 0
6:136278493:C R130G missense_variant 0.64 0
6:136278493:T R130S missense_variant 0.64 0
6:136278345:G L179S missense_variant 0.63 0
6:136278345:C L179W missense_variant 0.63 0
6:136277889:T A331E missense_variant 0.63 0
6:136277889:A A331V missense_variant 0.63 0
6:136277889:C A331G missense_variant 0.63 0
6:136276491:A S345F missense_variant 0.62 0
6:136269611:A G682V missense_variant 0.62 0
6:136269611:G G682A missense_variant 0.62 0
6:136269611:T G682E missense_variant 0.62 0
6:136276491:T S345Y missense_variant 0.62 0
6:136276491:C S345C missense_variant 0.62 0
6:136276009:A K506* stop_gained 0.62 0
6:136276423:A K368* stop_gained 0.62 0
6:136261447:C W859G missense_variant 0.62 0
6:136261447:T W859R missense_variant 0.62 0
6:136261447:G W859R missense_variant 0.62 0
6:136278726:C M52R missense_variant 0.62 0
6:136278726:G M52T missense_variant 0.62 0
6:136278726:T M52K missense_variant 0.62 0
6:136276426:A E367* stop_gained 0.62 0
6:136278190:C P231A missense_variant 0.62 0
6:136278190:A P231S missense_variant 0.62 0
6:136278190:T P231T missense_variant 0.62 0
6:136273133:A Q636L missense_variant 0.61 0
6:136273133:G Q636P missense_variant 0.61 0
6:136275566:C I606M missense_variant 0.61 0
6:136273133:C Q636R missense_variant 0.61 0
6:136272000:A Q680* stop_gained 0.61 0
6:136275883:A K548* stop_gained 0.61 0
6:136276096:A K477* stop_gained 0.61 0
6:136276030:A Q499* stop_gained 0.61 0
6:136277976:T A302E missense_variant 0.61 0
6:136277976:A A302V missense_variant 0.61 0
6:136277976:C A302G missense_variant 0.61 0
6:136277899:A Q328* stop_gained 0.60 0
6:136278319:A K188* stop_gained 0.60 0
6:136276120:G E469Q missense_variant 0.60 0
6:136276120:T E469K missense_variant 0.60 0
6:136278331:C Q184E missense_variant 0.60 0
6:136278331:T Q184K missense_variant 0.60 0
6:136278679:A R68* stop_gained 0.60 0
6:136276029:A Q499L missense_variant 0.60 0
6:136276183:C R448G missense_variant 0.60 0
6:136276029:C Q499R missense_variant 0.60 0
6:136276029:G Q499P missense_variant 0.60 0
6:136276467:A G353V missense_variant 0.60 0
6:136276467:T G353D missense_variant 0.60 0
6:136276467:G G353A missense_variant 0.60 0
6:136269450:G Y736H missense_variant 0.60 0
6:136269450:T Y736N missense_variant 0.60 0
6:136269454:A K734N missense_variant 0.60 0
6:136269450:C Y736D missense_variant 0.60 0
6:136269454:G K734N missense_variant 0.60 0
6:136269439:A D739D splice_region_variant 0.60 0
6:136276357:A G390* stop_gained 0.60 0
6:136272029:T G670E missense_variant 0.60 0
6:136272029:G G670A missense_variant 0.60 0
6:136268302:C S753A missense_variant 0.60 0
6:136278484:T Y133N missense_variant 0.60 0
6:136268302:G S753P missense_variant 0.60 0
6:136268302:T S753T missense_variant 0.60 0
6:136272029:A G670V missense_variant 0.60 0
6:136278484:G Y133H missense_variant 0.60 0
6:136278484:C Y133D missense_variant 0.60 0
6:136276291:A R412W missense_variant 0.59 0
6:136276291:C R412G missense_variant 0.59 0
6:136276453:C K358E missense_variant 0.59 0
6:136276017:A E503V missense_variant 0.59 0
6:136276192:G K445Q missense_variant 0.59 0
6:136276425:G E367A missense_variant 0.59 0
6:136276425:C E367G missense_variant 0.59 0
6:136276425:A E367V missense_variant 0.59 0
6:136275934:A S531C missense_variant 0.59 0
6:136275934:C S531G missense_variant 0.59 0
6:136276192:C K445E missense_variant 0.59 0
6:136276017:C E503G missense_variant 0.59 0
6:136276453:G K358Q missense_variant 0.59 0
6:136276227:A E433V missense_variant 0.59 0
6:136276227:C E433G missense_variant 0.59 0
6:136276227:G E433A missense_variant 0.59 0
6:136275955:G K524Q missense_variant 0.59 0
6:136275955:C K524E missense_variant 0.59 0
6:136276230:A E432V missense_variant 0.59 0
6:136276230:C E432G missense_variant 0.59 0
6:136276230:G E432A missense_variant 0.59 0
6:136275934:G S531R missense_variant 0.59 0
6:136276017:G E503A missense_variant 0.59 0
6:136268320:G D747H missense_variant 0.59 0
6:136268320:A D747Y missense_variant 0.59 0
6:136268320:T D747N missense_variant 0.59 0
6:136275888:A E546V missense_variant 0.59 0
6:136275888:C E546G missense_variant 0.59 0
6:136275888:G E546A missense_variant 0.59 0
6:136276432:A G365* stop_gained 0.59 0
6:136278676:C R69G missense_variant 0.59 0
6:136278288:T S198Y missense_variant 0.59 0
6:136278288:C S198C missense_variant 0.59 0
6:136278288:A S198F missense_variant 0.59 0
6:136276408:T G373R missense_variant 0.59 0
6:136276408:G G373R missense_variant 0.59 0
6:136278406:C R159G missense_variant 0.59 0
6:136273187:G E618A missense_variant 0.59 0
6:136273187:C E618G missense_variant 0.59 0
6:136273187:A E618V missense_variant 0.59 0
6:136276137:A E463V missense_variant 0.59 0
6:136272008:A E677V missense_variant 0.59 0
6:136276137:C E463G missense_variant 0.59 0
6:136272008:C E677G missense_variant 0.59 0
6:136272008:G E677A missense_variant 0.59 0
6:136276137:G E463A missense_variant 0.59 0
6:136275969:T L519Q missense_variant 0.59 0
6:136278044:C N279K missense_variant 0.59 0
6:136275969:G L519P missense_variant 0.59 0
6:136275969:C L519R missense_variant 0.59 0
6:136278044:T N279K missense_variant 0.59 0
6:136272007:A E677D missense_variant 0.59 0
6:136268280:T S760Y missense_variant 0.59 0
6:136268280:C S760C missense_variant 0.59 0
6:136268280:A S760F missense_variant 0.59 0
6:136272007:G E677D missense_variant 0.59 0
6:136273119:G E641Q missense_variant 0.59 0
6:136273119:T E641K missense_variant 0.59 0
6:136275985:C P514A missense_variant 0.59 0
6:136276111:C S472G missense_variant 0.59 0
6:136276111:G S472R missense_variant 0.59 0
6:136272032:C A669G missense_variant 0.59 0
6:136275985:T P514T missense_variant 0.59 0
6:136275881:G K548N missense_variant 0.59 0
6:136275881:A K548N missense_variant 0.59 0
6:136268325:C E745G missense_variant 0.59 0
6:136272032:A A669V missense_variant 0.59 0
6:136268325:A E745V missense_variant 0.59 0
6:136268325:G E745A missense_variant 0.59 0
6:136268332:C K743E missense_variant 0.59 0
6:136268332:G K743Q missense_variant 0.59 0
6:136272032:T A669E missense_variant 0.59 0
6:136276091:C H478Q missense_variant 0.59 0
6:136276091:T H478Q missense_variant 0.59 0
6:136276111:A S472C missense_variant 0.59 0
6:136275985:A P514S missense_variant 0.59 0
6:136276068:A E486V missense_variant 0.59 0
6:136276302:C Y408C missense_variant 0.59 0
6:136276068:G E486A missense_variant 0.59 0
6:136276302:G Y408S missense_variant 0.59 0
6:136276302:A Y408F missense_variant 0.59 0
6:136276068:C E486G missense_variant 0.59 0
6:136278138:C L248R missense_variant 0.59 0
6:136278138:G L248P missense_variant 0.59 0
6:136278138:T L248H missense_variant 0.59 0
6:136276080:G D482A missense_variant 0.59 0
6:136278180:A T234I missense_variant 0.59 0
6:136276404:A E374V missense_variant 0.59 0
6:136276404:C E374G missense_variant 0.59 0
6:136276404:G E374A missense_variant 0.59 0
6:136278180:C T234R missense_variant 0.59 0
6:136276080:C D482G missense_variant 0.59 0
6:136276080:A D482V missense_variant 0.59 0
6:136276213:T Y438N missense_variant 0.59 0
6:136276213:G Y438H missense_variant 0.59 0
6:136276213:C Y438D missense_variant 0.59 0
6:136278180:T T234K missense_variant 0.59 0
6:136268331:A K743I missense_variant 0.59 0
6:136268331:C K743R missense_variant 0.59 0
6:136268331:G K743T missense_variant 0.59 0
6:136278264:C S206* stop_gained 0.59 0
6:136278264:T S206* stop_gained 0.59 0
6:136275853:G D558H missense_variant 0.59 0
6:136275853:A D558Y missense_variant 0.59 0
6:136276206:T S440Y missense_variant 0.59 0
6:136275853:T D558N missense_variant 0.59 0
6:136276206:C S440C missense_variant 0.59 0
6:136276206:A S440F missense_variant 0.59 0
6:136275991:G S512R missense_variant 0.58 0
6:136275699:C P562R missense_variant 0.58 0
6:136275991:C S512G missense_variant 0.58 0
6:136275991:A S512C missense_variant 0.58 0
6:136275699:T P562H missense_variant 0.58 0
6:136276504:C T341A missense_variant 0.58 0
6:136276504:G T341P missense_variant 0.58 0
6:136275699:A P562L missense_variant 0.58 0
6:136276504:A T341S missense_variant 0.58 0
6:136277874:C F336C missense_variant 0.58 0
6:136276081:A D482Y missense_variant 0.58 0
6:136276081:G D482H missense_variant 0.58 0
6:136276081:T D482N missense_variant 0.58 0
6:136277874:T F336Y missense_variant 0.58 0
6:136277874:G F336S missense_variant 0.58 0
6:136276006:T D507N missense_variant 0.58 0
6:136276006:G D507H missense_variant 0.58 0
6:136276006:A D507Y missense_variant 0.58 0
6:136275937:T E530K missense_variant 0.58 0
6:136275937:G E530Q missense_variant 0.58 0
6:136267151:G A808P missense_variant 0.58 0
6:136267142:G V811L missense_variant 0.58 0
6:136267121:G G818R missense_variant 0.58 0
6:136268192:C F789L missense_variant 0.58 0
6:136268192:T F789L missense_variant 0.58 0
6:136267121:T G818S missense_variant 0.58 0
6:136267121:A G818C missense_variant 0.58 0
6:136267151:T A808T missense_variant 0.58 0
6:136267142:A V811F missense_variant 0.58 0
6:136267151:A A808S missense_variant 0.58 0
6:136267142:T V811I missense_variant 0.58 0
6:136261350:A K891I missense_variant 0.58 0
6:136261350:G K891T missense_variant 0.58 0
6:136261350:C K891R missense_variant 0.58 0
6:136277869:A K338* stop_gained 0.57 0
6:136275976:A K517* stop_gained 0.57 0
6:136278397:C Q162E missense_variant 0.57 0
6:136278397:T Q162K missense_variant 0.57 0
6:136267169:G I802L missense_variant 0.57 0
6:136267169:A I802F missense_variant 0.57 0
6:136261374:G S883T missense_variant 0.57 0
6:136261374:A S883I missense_variant 0.57 0
6:136261374:T S883N missense_variant 0.57 0
6:136267169:C I802V missense_variant 0.57 0
6:136269531:A G709* stop_gained 0.57 0
6:136276473:G D351A missense_variant 0.56 0
6:136276473:A D351V missense_variant 0.56 0
6:136278145:A P246S missense_variant 0.56 0
6:136278145:C P246A missense_variant 0.56 0
6:136276473:C D351G missense_variant 0.56 0
6:136278145:T P246T missense_variant 0.56 0
6:136279839:G S10P missense_variant 0.56 0
6:136279839:T S10T missense_variant 0.56 0
6:136279839:C S10A missense_variant 0.56 0
6:136269571:T H695Q missense_variant 0.56 0
6:136269571:C H695Q missense_variant 0.56 0
6:136269562:C D698E missense_variant 0.56 0
6:136269562:T D698E missense_variant 0.56 0
6:136272012:A K676* stop_gained 0.55 0
6:136277922:A S320L missense_variant 0.55 0
6:136277922:C S320W missense_variant 0.55 0
6:136272047:C K664R missense_variant 0.54 0
6:136272047:A K664M missense_variant 0.54 0
6:136272047:G K664T missense_variant 0.54 0
6:136272003:A N679Y missense_variant 0.53 0
6:136272003:G N679H missense_variant 0.53 0
6:136272003:C N679D missense_variant 0.53 0
6:136273118:G E641A missense_variant 0.53 0
6:136273118:C E641G missense_variant 0.53 0
6:136273118:A E641V missense_variant 0.53 0
6:136273140:G S634P missense_variant 0.53 0
6:136273140:T S634T missense_variant 0.53 0
6:136273140:C S634A missense_variant 0.53 0
6:136279811:T S19Y missense_variant 0.52 0
6:136279811:C S19C missense_variant 0.52 0
6:136278064:G G273R missense_variant 0.51 0
6:136277911:G D324H missense_variant 0.51 0
6:136277911:A D324Y missense_variant 0.51 0
6:136268305:T S752T missense_variant 0.51 0
6:136268305:G S752P missense_variant 0.51 0
6:136268305:C S752A missense_variant 0.51 0
6:136278064:T G273R missense_variant 0.51 0
6:136277911:T D324N missense_variant 0.51 0
6:136278064:A G273W missense_variant 0.51 0
6:136275588:G K599T missense_variant 0.51 0
6:136275588:C K599R missense_variant 0.51 0
6:136275588:A K599I missense_variant 0.51 0
6:136278283:A D200Y missense_variant 0.51 0
6:136273099:A K647N missense_variant 0.51 0
6:136273099:G K647N missense_variant 0.51 0
6:136278283:T D200N missense_variant 0.51 0
6:136278283:G D200H missense_variant 0.51 0
6:136269612:T G682R missense_variant 0.51 0
6:136276072:G S485P missense_variant 0.51 0
6:136276072:T S485T missense_variant 0.51 0
6:136269612:G G682R missense_variant 0.51 0
6:136276072:C S485A missense_variant 0.51 0
6:136269554:T R701K missense_variant 0.51 0
6:136269554:G R701T missense_variant 0.51 0
6:136269554:A R701I missense_variant 0.51 0
6:136267130:C T815A missense_variant 0.50 0
6:136267130:A T815S missense_variant 0.50 0
6:136267130:G T815P missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(AML) Acute myeloid leukemia AML 0.90 0.11