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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
CDKN2A BLCA ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
9:21971121:A R80* stop_gained 1.00 3
9:21971030:T W110* stop_gained 1.00 2
9:21971037:A D108Y missense_variant 1.00 2
9:21971037:T D108N missense_variant 1.00 2
9:21971112:A H83Y missense_variant 1.00 2
9:21971037:G D108H missense_variant 1.00 1
9:21971019:T P114T missense_variant 1.00 1
9:21974793:T S12* stop_gained 0.99 1
9:21974696:T Y44* stop_gained 0.98 1
9:21971109:T D84N missense_variant 0.94 1
9:21971200:T M53I missense_variant 0.92 1
9:21971024:G R112P missense_variant 0.83 1
9:21974761:G G23R missense_variant 0.79 1
9:21971028:A G111C missense_variant 0.74 1
9:21971187:A R58* stop_gained 1.00 0
9:21971029:T W110* stop_gained 1.00 0
9:21971097:A E88* stop_gained 1.00 0
9:21971112:T H83N missense_variant 1.00 0
9:21971112:C H83D missense_variant 1.00 0
9:21971019:A P114S missense_variant 1.00 0
9:21971019:C P114A missense_variant 1.00 0
9:21971018:T P114H missense_variant 1.00 0
9:21971018:A P114L missense_variant 1.00 0
9:21971018:C P114R missense_variant 1.00 0
9:21971036:G D108A missense_variant 1.00 0
9:21971036:A D108V missense_variant 1.00 0
9:21971036:C D108G missense_variant 1.00 0
9:21974678:T Q50Q splice_region_variant 1.00 0
9:21971001:A E120* stop_gained 1.00 0
9:21971004:A E119* stop_gained 1.00 0
9:21971111:A H83L missense_variant 1.00 0
9:21971111:G H83P missense_variant 1.00 0
9:21971111:C H83R missense_variant 1.00 0
9:21968763:A G156* stop_gained 1.00 0
9:21974731:A E33* stop_gained 1.00 0
9:21970902:A E153* stop_gained 1.00 0
9:21971154:A E69* stop_gained 1.00 0
9:21974749:A E27* stop_gained 0.99 0
9:21974680:A Q50* stop_gained 0.99 0
9:21974800:A E10* stop_gained 0.99 0
9:21971108:G D84A missense_variant 0.99 0
9:21971108:A D84V missense_variant 0.99 0
9:21971108:C D84G missense_variant 0.99 0
9:21971138:G D74A missense_variant 0.99 0
9:21971138:C D74G missense_variant 0.99 0
9:21971138:A D74V missense_variant 0.99 0
9:21968742:A R163* stop_gained 0.99 0
9:21970972:T Y129* stop_gained 0.99 0
9:21970972:C Y129* stop_gained 0.99 0
9:21970947:A R138* stop_gained 0.99 0
9:21970904:T S152* stop_gained 0.99 0
9:21970904:C S152* stop_gained 0.99 0
9:21971178:A E61* stop_gained 0.99 0
9:21974752:A E26* stop_gained 0.98 0
9:21974783:T W15* stop_gained 0.98 0
9:21970914:A E149* stop_gained 0.98 0
9:21968749:T W160* stop_gained 0.98 0
9:21971139:A D74Y missense_variant 0.98 0
9:21971139:T D74N missense_variant 0.98 0
9:21971139:G D74H missense_variant 0.98 0
9:21974696:C Y44* stop_gained 0.98 0
9:21974824:A E2* stop_gained 0.97 0
9:21974784:T W15* stop_gained 0.97 0
9:21968753:T L159* stop_gained 0.97 0
9:21968750:T W160* stop_gained 0.97 0
9:21974685:T P48Q missense_variant 0.97 0
9:21974685:C P48R missense_variant 0.97 0
9:21974685:A P48L missense_variant 0.97 0
9:21971054:T A102E missense_variant 0.95 0
9:21971054:C A102G missense_variant 0.95 0
9:21971054:A A102V missense_variant 0.95 0
9:21971118:A P81S missense_variant 0.94 0
9:21971118:T P81T missense_variant 0.94 0
9:21971118:C P81A missense_variant 0.94 0
9:21971106:G A85P missense_variant 0.94 0
9:21971109:A D84Y missense_variant 0.94 0
9:21971099:G R87P missense_variant 0.94 0
9:21971099:T R87Q missense_variant 0.94 0
9:21971109:G D84H missense_variant 0.94 0
9:21971106:T A85T missense_variant 0.94 0
9:21971106:A A85S missense_variant 0.94 0
9:21971099:A R87L missense_variant 0.94 0
9:21974770:T A20T missense_variant 0.93 0
9:21974770:G A20P missense_variant 0.93 0
9:21974770:A A20S missense_variant 0.93 0
9:21974678:G Q50H missense_variant 0.93 0
9:21974678:A Q50H missense_variant 0.93 0
9:21971012:A D116V missense_variant 0.93 0
9:21971012:C D116G missense_variant 0.93 0
9:21971012:G D116A missense_variant 0.93 0
9:21971172:C L63V missense_variant 0.93 0
9:21971172:T L63M missense_variant 0.93 0
9:21971102:A A86V missense_variant 0.93 0
9:21971102:T A86D missense_variant 0.93 0
9:21971102:C A86G missense_variant 0.93 0
9:21968743:T C162* stop_gained 0.93 0
9:21971143:T C72* stop_gained 0.93 0
9:21971200:G M53I missense_variant 0.92 0
9:21971200:A M53I missense_variant 0.92 0
9:21971117:T P81H missense_variant 0.91 0
9:21971117:C P81R missense_variant 0.91 0
9:21971117:A P81L missense_variant 0.91 0
9:21974679:A Q50L missense_variant 0.91 0
9:21974679:C Q50R missense_variant 0.91 0
9:21974679:G Q50P missense_variant 0.91 0
9:21971006:C A118G missense_variant 0.88 0
9:21971006:A A118V missense_variant 0.88 0
9:21971006:T A118D missense_variant 0.88 0
9:21970970:T L130Q missense_variant 0.87 0
9:21970970:C L130R missense_variant 0.87 0
9:21970970:G L130P missense_variant 0.87 0
9:21971081:A T93M missense_variant 0.86 0
9:21971081:T T93K missense_variant 0.86 0
9:21971081:C T93R missense_variant 0.86 0
9:21971024:A R112L missense_variant 0.83 0
9:21971024:T R112H missense_variant 0.83 0
9:21974725:A G35W missense_variant 0.82 0
9:21974725:G G35R missense_variant 0.82 0
9:21974725:T G35R missense_variant 0.82 0
9:21974773:A A19S missense_variant 0.82 0
9:21974773:G A19P missense_variant 0.82 0
9:21974773:T A19T missense_variant 0.82 0
9:21971171:T L63Q missense_variant 0.82 0
9:21971198:T M54K missense_variant 0.82 0
9:21971171:C L63R missense_variant 0.82 0
9:21971198:G M54T missense_variant 0.82 0
9:21971198:C M54R missense_variant 0.82 0
9:21971171:G L63P missense_variant 0.82 0
9:21974761:A G23C missense_variant 0.79 0
9:21974761:T G23S missense_variant 0.79 0
9:21974680:T Q50K missense_variant 0.78 0
9:21974680:C Q50E missense_variant 0.78 0
9:21971067:T H98N missense_variant 0.77 0
9:21971067:A H98Y missense_variant 0.77 0
9:21971067:C H98D missense_variant 0.77 0
9:21971007:G A118P missense_variant 0.75 0
9:21971007:T A118T missense_variant 0.75 0
9:21971007:A A118S missense_variant 0.75 0
9:21971120:A R80L missense_variant 0.75 0
9:21971120:G R80P missense_variant 0.75 0
9:21971120:T R80Q missense_variant 0.75 0
9:21971156:T A68E missense_variant 0.74 0
9:21971156:C A68G missense_variant 0.74 0
9:21971156:A A68V missense_variant 0.74 0
9:21971150:T P70H missense_variant 0.74 0
9:21971150:C P70R missense_variant 0.74 0
9:21971150:A P70L missense_variant 0.74 0
9:21971028:G G111R missense_variant 0.74 0
9:21971028:T G111S missense_variant 0.74 0
9:21971055:G A102P missense_variant 0.73 0
9:21971055:T A102T missense_variant 0.73 0
9:21971055:A A102S missense_variant 0.73 0
9:21971011:T D116E missense_variant 0.73 0
9:21971011:C D116E missense_variant 0.73 0
9:21970902:G E153Q missense_variant 0.73 0
9:21970902:T E153K missense_variant 0.73 0
9:21971129:A T77I missense_variant 0.72 0
9:21971129:T T77N missense_variant 0.72 0
9:21971129:C T77S missense_variant 0.72 0
9:21974769:T A20E missense_variant 0.71 0
9:21974769:C A20G missense_variant 0.71 0
9:21974769:A A20V missense_variant 0.71 0
9:21974781:T L16Q missense_variant 0.69 0
9:21974781:C L16R missense_variant 0.69 0
9:21974781:G L16P missense_variant 0.69 0
9:21971082:A T93S missense_variant 0.67 0
9:21971082:G T93P missense_variant 0.67 0
9:21971082:C T93A missense_variant 0.67 0
9:21971048:T L104Q missense_variant 0.66 0
9:21971048:C L104R missense_variant 0.66 0
9:21971048:G L104P missense_variant 0.66 0
9:21971110:C H83Q missense_variant 0.65 0
9:21971110:T H83Q missense_variant 0.65 0
9:21971029:A W110C missense_variant 0.64 0
9:21971029:G W110C missense_variant 0.64 0
9:21971100:C R87G missense_variant 0.64 0
9:21971100:A R87W missense_variant 0.64 0
9:21971035:T D108E missense_variant 0.62 0
9:21971035:C D108E missense_variant 0.62 0
9:21971066:G H98P missense_variant 0.61 0
9:21971066:A H98L missense_variant 0.61 0
9:21971066:C H98R missense_variant 0.61 0
9:21971157:G A68P missense_variant 0.61 0
9:21971157:A A68S missense_variant 0.61 0
9:21971157:T A68T missense_variant 0.61 0
9:21974715:A P38L missense_variant 0.57 0
9:21974715:C P38R missense_variant 0.57 0
9:21974715:T P38H missense_variant 0.57 0
9:21974682:C I49S missense_variant 0.55 0
9:21974682:G I49T missense_variant 0.55 0
9:21974682:T I49N missense_variant 0.55 0
9:21971159:A G67V missense_variant 0.55 0
9:21971159:G G67A missense_variant 0.55 0
9:21971159:T G67D missense_variant 0.55 0
9:21974760:T G23D missense_variant 0.54 0
9:21974760:A G23V missense_variant 0.54 0
9:21974760:G G23A missense_variant 0.54 0
9:21971207:G V51A missense_variant 0.53 0
9:21971207:C V51G missense_variant 0.53 0
9:21971207:T V51D missense_variant 0.53 0
9:21971069:T L97Q missense_variant 0.52 0
9:21971069:C L97R missense_variant 0.52 0
9:21971069:G L97P missense_variant 0.52 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(BLCA) Bladder cancer SOLID 0.33 0.28