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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
CTNNB1 HC ×
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Mutation AA change Consequence type BoostDM score IntOGen frequency
3:41224633:G T41A missense_variant 1.00 50
3:41224645:C S45P missense_variant 1.00 29
3:41224610:G S33C missense_variant 1.00 24
3:41224619:C H36P missense_variant 1.00 24
3:41224609:C S33P missense_variant 1.00 20
3:41224646:T S45F missense_variant 1.00 15
3:41224607:T D32V missense_variant 1.00 15
3:41224607:G D32G missense_variant 1.00 15
3:41224616:G I35S missense_variant 1.00 15
3:41224622:G S37C missense_variant 1.00 14
3:41227275:T K335I missense_variant 0.97 14
3:41224622:T S37F missense_variant 1.00 12
3:41224613:A G34E missense_variant 1.00 12
3:41224606:T D32Y missense_variant 1.00 11
3:41224634:T T41I missense_variant 1.00 10
3:41224646:A S45Y missense_variant 1.00 10
3:41224613:T G34V missense_variant 1.00 10
3:41224606:A D32N missense_variant 1.00 9
3:41224621:C S37P missense_variant 1.00 8
3:41224610:A S33Y missense_variant 1.00 8
3:41224609:G S33A missense_variant 1.00 7
3:41224610:T S33F missense_variant 1.00 7
3:41224612:C G34R missense_variant 1.00 6
3:41224612:A G34R missense_variant 1.00 6
3:41224621:G S37A missense_variant 1.00 5
3:41224622:A S37Y missense_variant 1.00 5
3:41224606:C D32H missense_variant 1.00 5
3:41224645:G S45A missense_variant 1.00 4
3:41224646:G S45C missense_variant 1.00 4
3:41233420:A N387K missense_variant 0.88 4
3:41227275:C K335T missense_variant 0.97 3
3:41233420:G N387K missense_variant 0.88 3
3:41224598:T S29F missense_variant 1.00 2
3:41224604:C L31P missense_variant 1.00 2
3:41224612:T G34* stop_gained 1.00 2
3:41224609:A S33T missense_variant 1.00 1
3:41224645:A S45T missense_variant 1.00 1
3:41224634:A T41N missense_variant 1.00 1
3:41224619:G H36R missense_variant 1.00 1
3:41224607:C D32A missense_variant 1.00 1
3:41224664:C N51T missense_variant 1.00 1
3:41224663:C N51H missense_variant 1.00 1
3:41224613:C G34A missense_variant 1.00 1
3:41224637:A T42K missense_variant 1.00 1
3:41224674:C E54D missense_variant 0.80 1
3:41224621:A S37T missense_variant 1.00 0
3:41224633:T T41S missense_variant 1.00 0
3:41224633:C T41P missense_variant 1.00 0
3:41224598:A S29Y missense_variant 1.00 0
3:41224634:G T41S missense_variant 1.00 0
3:41224598:G S29C missense_variant 1.00 0
3:41224657:G K49E missense_variant 1.00 0
3:41224657:C K49Q missense_variant 1.00 0
3:41224658:T K49I missense_variant 1.00 0
3:41224658:G K49R missense_variant 1.00 0
3:41224658:C K49T missense_variant 1.00 0
3:41224664:G N51S missense_variant 1.00 0
3:41224615:C I35L missense_variant 1.00 0
3:41224615:G I35V missense_variant 1.00 0
3:41224615:T I35F missense_variant 1.00 0
3:41224619:T H36L missense_variant 1.00 0
3:41224630:C T40P missense_variant 1.00 0
3:41224630:G T40A missense_variant 1.00 0
3:41224630:T T40S missense_variant 1.00 0
3:41224636:C T42P missense_variant 1.00 0
3:41224636:G T42A missense_variant 1.00 0
3:41224636:T T42S missense_variant 1.00 0
3:41224663:G N51D missense_variant 1.00 0
3:41224663:T N51Y missense_variant 1.00 0
3:41224664:T N51I missense_variant 1.00 0
3:41224651:C S47R missense_variant 1.00 0
3:41224651:G S47G missense_variant 1.00 0
3:41224601:C Y30S missense_variant 1.00 0
3:41224601:G Y30C missense_variant 1.00 0
3:41224651:T S47C missense_variant 1.00 0
3:41224601:T Y30F missense_variant 1.00 0
3:41224652:T S47I missense_variant 1.00 0
3:41224652:A S47N missense_variant 1.00 0
3:41224652:C S47T missense_variant 1.00 0
3:41224627:T A39S missense_variant 1.00 0
3:41224660:C G50R missense_variant 1.00 0
3:41224660:A G50S missense_variant 1.00 0
3:41224625:A G38D missense_variant 1.00 0
3:41224624:A G38S missense_variant 1.00 0
3:41224624:C G38R missense_variant 1.00 0
3:41224624:T G38C missense_variant 1.00 0
3:41224660:T G50C missense_variant 1.00 0
3:41224639:A A43T missense_variant 1.00 0
3:41224639:C A43P missense_variant 1.00 0
3:41224639:T A43S missense_variant 1.00 0
3:41224661:T G50V missense_variant 1.00 0
3:41224661:C G50A missense_variant 1.00 0
3:41224661:A G50D missense_variant 1.00 0
3:41224625:T G38V missense_variant 1.00 0
3:41224625:C G38A missense_variant 1.00 0
3:41224627:C A39P missense_variant 1.00 0
3:41224627:A A39T missense_variant 1.00 0
3:41224600:A Y30N missense_variant 1.00 0
3:41224600:G Y30D missense_variant 1.00 0
3:41224600:C Y30H missense_variant 1.00 0
3:41224649:C L46P missense_variant 1.00 0
3:41224616:A I35N missense_variant 1.00 0
3:41224604:G L31R missense_variant 1.00 0
3:41224604:A L31Q missense_variant 1.00 0
3:41224649:A L46Q missense_variant 1.00 0
3:41224649:G L46R missense_variant 1.00 0
3:41224616:C I35T missense_variant 1.00 0
3:41224655:T G48V missense_variant 1.00 0
3:41224655:C G48A missense_variant 1.00 0
3:41224654:A G48S missense_variant 1.00 0
3:41224654:C G48R missense_variant 1.00 0
3:41224654:T G48C missense_variant 1.00 0
3:41224655:A G48D missense_variant 1.00 0
3:41224640:A A43D missense_variant 1.00 0
3:41224640:G A43G missense_variant 1.00 0
3:41224640:T A43V missense_variant 1.00 0
3:41224642:A P44T missense_variant 1.00 0
3:41224642:G P44A missense_variant 1.00 0
3:41224642:T P44S missense_variant 1.00 0
3:41224643:A P44H missense_variant 1.00 0
3:41224643:G P44R missense_variant 1.00 0
3:41224643:T P44L missense_variant 1.00 0
3:41224618:A H36N missense_variant 1.00 0
3:41224618:G H36D missense_variant 1.00 0
3:41224618:T H36Y missense_variant 1.00 0
3:41224637:G T42R missense_variant 1.00 0
3:41224637:T T42I missense_variant 1.00 0
3:41224620:G H36Q missense_variant 1.00 0
3:41224620:A H36Q missense_variant 1.00 0
3:41224657:T K49* stop_gained 1.00 0
3:41224628:A A39D missense_variant 1.00 0
3:41224628:G A39G missense_variant 1.00 0
3:41224628:T A39V missense_variant 1.00 0
3:41224631:A T40N missense_variant 1.00 0
3:41224631:G T40S missense_variant 1.00 0
3:41224631:T T40I missense_variant 1.00 0
3:41224653:A S47R missense_variant 1.00 0
3:41224653:G S47R missense_variant 1.00 0
3:41233731:G P463R missense_variant 1.00 0
3:41233731:A P463H missense_variant 1.00 0
3:41233731:T P463L missense_variant 1.00 0
3:41224608:G D32E missense_variant 1.00 0
3:41224608:A D32E missense_variant 1.00 0
3:41224617:G I35M missense_variant 1.00 0
3:41224603:A L31M missense_variant 1.00 0
3:41224603:G L31V missense_variant 1.00 0
3:41224648:A L46M missense_variant 1.00 0
3:41224648:G L46V missense_variant 1.00 0
3:41224659:C K49N missense_variant 0.99 0
3:41224659:T K49N missense_variant 0.99 0
3:41227274:C K335Q missense_variant 0.97 0
3:41227274:G K335E missense_variant 0.97 0
3:41227275:G K335R missense_variant 0.97 0
3:41224602:A Y30* stop_gained 0.96 0
3:41224602:G Y30* stop_gained 0.96 0
3:41224674:T E54D missense_variant 0.80 0
3:41233867:T K508N missense_variant 0.79 0
3:41233867:C K508N missense_variant 0.79 0
3:41233439:C K394Q missense_variant 0.76 0
3:41236418:G K625E missense_variant 0.76 0
3:41236419:C K625T missense_variant 0.76 0
3:41236419:G K625R missense_variant 0.76 0
3:41236419:T K625M missense_variant 0.76 0
3:41236644:C K671Q missense_variant 0.76 0
3:41236644:G K671E missense_variant 0.76 0
3:41236645:C K671T missense_variant 0.76 0
3:41236645:G K671R missense_variant 0.76 0
3:41224567:C K19Q missense_variant 0.76 0
3:41236645:T K671M missense_variant 0.76 0
3:41225109:C K133Q missense_variant 0.76 0
3:41225109:G K133E missense_variant 0.76 0
3:41225110:C K133T missense_variant 0.76 0
3:41225110:G K133R missense_variant 0.76 0
3:41225110:T K133I missense_variant 0.76 0
3:41225184:C K158Q missense_variant 0.76 0
3:41225184:G K158E missense_variant 0.76 0
3:41225185:C K158T missense_variant 0.76 0
3:41225185:G K158R missense_variant 0.76 0
3:41225185:T K158I missense_variant 0.76 0
3:41225347:C K170T missense_variant 0.76 0
3:41225347:G K170R missense_variant 0.76 0
3:41225347:T K170M missense_variant 0.76 0
3:41225376:C K180Q missense_variant 0.76 0
3:41225376:G K180E missense_variant 0.76 0
3:41225377:C K180T missense_variant 0.76 0
3:41225377:G K180R missense_variant 0.76 0
3:41225377:T K180I missense_variant 0.76 0
3:41225787:C K288Q missense_variant 0.76 0
3:41225787:G K288E missense_variant 0.76 0
3:41225788:C K288T missense_variant 0.76 0
3:41225788:G K288R missense_variant 0.76 0
3:41225788:T K288I missense_variant 0.76 0
3:41224568:T K19I missense_variant 0.76 0
3:41224568:G K19R missense_variant 0.76 0
3:41227304:C K345Q missense_variant 0.76 0
3:41227304:G K345E missense_variant 0.76 0
3:41227305:C K345T missense_variant 0.76 0
3:41227305:G K345R missense_variant 0.76 0
3:41227305:T K345M missense_variant 0.76 0
3:41227331:C K354Q missense_variant 0.76 0
3:41227331:G K354E missense_variant 0.76 0
3:41227332:C K354T missense_variant 0.76 0
3:41227332:G K354R missense_variant 0.76 0
3:41227332:T K354M missense_variant 0.76 0
3:41224568:C K19T missense_variant 0.76 0
3:41224567:G K19E missense_variant 0.76 0
3:41233439:G K394E missense_variant 0.76 0
3:41233440:C K394T missense_variant 0.76 0
3:41233440:G K394R missense_variant 0.76 0
3:41233440:T K394I missense_variant 0.76 0
3:41233829:C K496Q missense_variant 0.76 0
3:41233829:G K496E missense_variant 0.76 0
3:41233865:C K508Q missense_variant 0.76 0
3:41233865:G K508E missense_variant 0.76 0
3:41233866:C K508T missense_variant 0.76 0
3:41233866:G K508R missense_variant 0.76 0
3:41233866:T K508M missense_variant 0.76 0
3:41236418:C K625Q missense_variant 0.76 0
3:41233646:G K435E missense_variant 0.73 0
3:41233647:T K435M missense_variant 0.73 0
3:41233647:C K435T missense_variant 0.73 0
3:41233646:C K435Q missense_variant 0.73 0
3:41233647:G K435R missense_variant 0.73 0
3:41225834:G I303M missense_variant 0.70 0
3:41233621:A N426K missense_variant 0.64 0
3:41233621:G N426K missense_variant 0.64 0
3:41233837:T L498F missense_variant 0.63 0
3:41233837:C L498F missense_variant 0.63 0
3:41233738:G I465M missense_variant 0.61 0
3:41225111:T K133N missense_variant 0.60 0
3:41225111:C K133N missense_variant 0.60 0
3:41233831:C K496N missense_variant 0.60 0
3:41233831:T K496N missense_variant 0.60 0
3:41236366:G I607M missense_variant 0.53 0
3:41233612:G I423M missense_variant 0.52 0
3:41225750:T L275F missense_variant 0.52 0
3:41225750:C L275F missense_variant 0.52 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(HC) Hepatic cancer HC 0.90 0.19