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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
CTNNB1 PRAD ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
3:41224633:G T41A missense_variant 1.00 11
3:41224646:T S45F missense_variant 1.00 7
3:41227275:T K335I missense_variant 0.60 4
3:41224646:G S45C missense_variant 1.00 3
3:41224645:C S45P missense_variant 1.00 3
3:41224606:T D32Y missense_variant 1.00 3
3:41224613:A G34E missense_variant 1.00 3
3:41224610:G S33C missense_variant 1.00 2
3:41224622:T S37F missense_variant 1.00 2
3:41224622:G S37C missense_variant 1.00 2
3:41224607:T D32V missense_variant 1.00 2
3:41224607:C D32A missense_variant 1.00 2
3:41224607:G D32G missense_variant 1.00 2
3:41224613:T G34V missense_variant 1.00 2
3:41227269:T Y333F missense_variant 0.94 2
3:41224610:A S33Y missense_variant 1.00 1
3:41224622:A S37Y missense_variant 1.00 1
3:41224634:T T41I missense_variant 1.00 1
3:41224621:G S37A missense_variant 1.00 1
3:41224609:G S33A missense_variant 1.00 1
3:41224609:C S33P missense_variant 1.00 1
3:41224606:C D32H missense_variant 1.00 1
3:41227275:C K335T missense_variant 0.60 1
3:41224610:T S33F missense_variant 1.00 0
3:41224646:A S45Y missense_variant 1.00 0
3:41224634:A T41N missense_variant 1.00 0
3:41224634:G T41S missense_variant 1.00 0
3:41224598:G S29C missense_variant 1.00 0
3:41224598:T S29F missense_variant 1.00 0
3:41224598:A S29Y missense_variant 1.00 0
3:41224633:C T41P missense_variant 1.00 0
3:41224633:T T41S missense_variant 1.00 0
3:41224609:A S33T missense_variant 1.00 0
3:41224621:C S37P missense_variant 1.00 0
3:41224621:A S37T missense_variant 1.00 0
3:41224601:C Y30S missense_variant 1.00 0
3:41224601:G Y30C missense_variant 1.00 0
3:41224601:T Y30F missense_variant 1.00 0
3:41224651:T S47C missense_variant 1.00 0
3:41224651:G S47G missense_variant 1.00 0
3:41224651:C S47R missense_variant 1.00 0
3:41224645:A S45T missense_variant 1.00 0
3:41224645:G S45A missense_variant 1.00 0
3:41224600:G Y30D missense_variant 1.00 0
3:41224600:C Y30H missense_variant 1.00 0
3:41224600:A Y30N missense_variant 1.00 0
3:41224652:T S47I missense_variant 1.00 0
3:41224652:C S47T missense_variant 1.00 0
3:41224652:A S47N missense_variant 1.00 0
3:41224630:C T40P missense_variant 1.00 0
3:41224630:T T40S missense_variant 1.00 0
3:41224619:C H36P missense_variant 1.00 0
3:41224619:G H36R missense_variant 1.00 0
3:41224619:T H36L missense_variant 1.00 0
3:41224615:C I35L missense_variant 1.00 0
3:41224615:G I35V missense_variant 1.00 0
3:41224615:T I35F missense_variant 1.00 0
3:41224630:G T40A missense_variant 1.00 0
3:41224653:G S47R missense_variant 1.00 0
3:41224653:A S47R missense_variant 1.00 0
3:41224631:G T40S missense_variant 1.00 0
3:41224631:A T40N missense_variant 1.00 0
3:41224631:T T40I missense_variant 1.00 0
3:41224624:A G38S missense_variant 1.00 0
3:41224624:C G38R missense_variant 1.00 0
3:41224624:T G38C missense_variant 1.00 0
3:41224625:A G38D missense_variant 1.00 0
3:41224625:C G38A missense_variant 1.00 0
3:41224625:T G38V missense_variant 1.00 0
3:41224606:A D32N missense_variant 1.00 0
3:41224627:A A39T missense_variant 1.00 0
3:41224627:C A39P missense_variant 1.00 0
3:41224627:T A39S missense_variant 1.00 0
3:41224612:C G34R missense_variant 1.00 0
3:41224613:C G34A missense_variant 1.00 0
3:41224612:A G34R missense_variant 1.00 0
3:41224658:T K49I missense_variant 1.00 0
3:41224657:C K49Q missense_variant 1.00 0
3:41224657:G K49E missense_variant 1.00 0
3:41224658:C K49T missense_variant 1.00 0
3:41224658:G K49R missense_variant 1.00 0
3:41224663:G N51D missense_variant 1.00 0
3:41224663:C N51H missense_variant 1.00 0
3:41224663:T N51Y missense_variant 1.00 0
3:41224664:C N51T missense_variant 1.00 0
3:41224664:G N51S missense_variant 1.00 0
3:41224664:T N51I missense_variant 1.00 0
3:41224636:G T42A missense_variant 1.00 0
3:41224636:C T42P missense_variant 1.00 0
3:41224636:T T42S missense_variant 1.00 0
3:41224618:T H36Y missense_variant 1.00 0
3:41224618:G H36D missense_variant 1.00 0
3:41224618:A H36N missense_variant 1.00 0
3:41224628:G A39G missense_variant 0.99 0
3:41224628:A A39D missense_variant 0.99 0
3:41224628:T A39V missense_variant 0.99 0
3:41224660:C G50R missense_variant 0.99 0
3:41224660:A G50S missense_variant 0.99 0
3:41224660:T G50C missense_variant 0.99 0
3:41224661:A G50D missense_variant 0.99 0
3:41224661:C G50A missense_variant 0.99 0
3:41224661:T G50V missense_variant 0.99 0
3:41224639:C A43P missense_variant 0.99 0
3:41224639:A A43T missense_variant 0.99 0
3:41224639:T A43S missense_variant 0.99 0
3:41224616:A I35N missense_variant 0.99 0
3:41224616:G I35S missense_variant 0.99 0
3:41224616:C I35T missense_variant 0.99 0
3:41224620:G H36Q missense_variant 0.99 0
3:41224620:A H36Q missense_variant 0.99 0
3:41224655:T G48V missense_variant 0.99 0
3:41224654:A G48S missense_variant 0.99 0
3:41224655:C G48A missense_variant 0.99 0
3:41224654:T G48C missense_variant 0.99 0
3:41224654:C G48R missense_variant 0.99 0
3:41224655:A G48D missense_variant 0.99 0
3:41224643:A P44H missense_variant 0.99 0
3:41224640:G A43G missense_variant 0.99 0
3:41224643:T P44L missense_variant 0.99 0
3:41224640:A A43D missense_variant 0.99 0
3:41224637:T T42I missense_variant 0.99 0
3:41224637:G T42R missense_variant 0.99 0
3:41224642:T P44S missense_variant 0.99 0
3:41224642:G P44A missense_variant 0.99 0
3:41224637:A T42K missense_variant 0.99 0
3:41224642:A P44T missense_variant 0.99 0
3:41224640:T A43V missense_variant 0.99 0
3:41224643:G P44R missense_variant 0.99 0
3:41224608:G D32E missense_variant 0.99 0
3:41224608:A D32E missense_variant 0.99 0
3:41224617:G I35M missense_variant 0.99 0
3:41224604:G L31R missense_variant 0.98 0
3:41224604:C L31P missense_variant 0.98 0
3:41224649:C L46P missense_variant 0.98 0
3:41224649:G L46R missense_variant 0.98 0
3:41224649:A L46Q missense_variant 0.98 0
3:41224604:A L31Q missense_variant 0.98 0
3:41224659:T K49N missense_variant 0.97 0
3:41224659:C K49N missense_variant 0.97 0
3:41224603:A L31M missense_variant 0.97 0
3:41224603:G L31V missense_variant 0.97 0
3:41224648:A L46M missense_variant 0.97 0
3:41224648:G L46V missense_variant 0.97 0
3:41224602:G Y30* stop_gained 0.97 0
3:41224602:A Y30* stop_gained 0.97 0
3:41224612:T G34* stop_gained 0.97 0
3:41224657:T K49* stop_gained 0.96 0
3:41227269:G Y333C missense_variant 0.94 0
3:41227269:C Y333S missense_variant 0.94 0
3:41236481:C S646P missense_variant 0.81 0
3:41236481:G S646A missense_variant 0.81 0
3:41236481:A S646T missense_variant 0.81 0
3:41227268:C Y333H missense_variant 0.80 0
3:41227268:G Y333D missense_variant 0.80 0
3:41227268:A Y333N missense_variant 0.80 0
3:41224969:G Y86C missense_variant 0.79 0
3:41224969:C Y86S missense_variant 0.79 0
3:41224969:T Y86F missense_variant 0.79 0
3:41225662:T S246L missense_variant 0.78 0
3:41225016:T T102S missense_variant 0.78 0
3:41225016:C T102P missense_variant 0.78 0
3:41225016:G T102A missense_variant 0.78 0
3:41225046:C T112P missense_variant 0.78 0
3:41225046:G T112A missense_variant 0.78 0
3:41225046:T T112S missense_variant 0.78 0
3:41225070:C T120P missense_variant 0.78 0
3:41225070:G T120A missense_variant 0.78 0
3:41225070:T T120S missense_variant 0.78 0
3:41225137:C Y142S missense_variant 0.78 0
3:41225137:G Y142C missense_variant 0.78 0
3:41225137:T Y142F missense_variant 0.78 0
3:41227265:C T332P missense_variant 0.78 0
3:41227265:G T332A missense_variant 0.78 0
3:41227265:T T332S missense_variant 0.78 0
3:41233436:C T393P missense_variant 0.78 0
3:41233436:G T393A missense_variant 0.78 0
3:41233436:T T393S missense_variant 0.78 0
3:41233809:C Y489S missense_variant 0.78 0
3:41233809:G Y489C missense_variant 0.78 0
3:41233809:T Y489F missense_variant 0.78 0
3:41236594:C Y654S missense_variant 0.78 0
3:41236594:G Y654C missense_variant 0.78 0
3:41236594:T Y654F missense_variant 0.78 0
3:41239139:C S715R missense_variant 0.78 0
3:41239139:G S715G missense_variant 0.78 0
3:41239139:T S715C missense_variant 0.78 0
3:41233757:C T472P missense_variant 0.78 0
3:41233757:G T472A missense_variant 0.78 0
3:41233757:T T472S missense_variant 0.78 0
3:41234281:T T556I missense_variant 0.75 0
3:41234281:A T556K missense_variant 0.75 0
3:41234281:G T556R missense_variant 0.75 0
3:41234266:T T551M missense_variant 0.75 0
3:41234266:G T551R missense_variant 0.75 0
3:41234266:A T551K missense_variant 0.75 0
3:41235760:G T574A missense_variant 0.74 0
3:41236668:C T679P missense_variant 0.74 0
3:41224579:C S23R missense_variant 0.74 0
3:41224703:T Y64F missense_variant 0.74 0
3:41224703:G Y64C missense_variant 0.74 0
3:41224703:C Y64S missense_variant 0.74 0
3:41224579:G S23G missense_variant 0.74 0
3:41224579:T S23C missense_variant 0.74 0
3:41235760:T T574S missense_variant 0.74 0
3:41235760:C T574P missense_variant 0.74 0
3:41236590:T T653S missense_variant 0.74 0
3:41236590:G T653A missense_variant 0.74 0
3:41236590:C T653P missense_variant 0.74 0
3:41236668:T T679S missense_variant 0.74 0
3:41227263:C Y331S missense_variant 0.74 0
3:41227263:G Y331C missense_variant 0.74 0
3:41227263:T Y331F missense_variant 0.74 0
3:41239167:C Y724S missense_variant 0.74 0
3:41239167:G Y724C missense_variant 0.74 0
3:41239167:T Y724F missense_variant 0.74 0
3:41236668:G T679A missense_variant 0.74 0
3:41233724:G T461A missense_variant 0.74 0
3:41233724:C T461P missense_variant 0.74 0
3:41233724:T T461S missense_variant 0.74 0
3:41234268:C S552P missense_variant 0.68 0
3:41234268:G S552A missense_variant 0.68 0
3:41234268:A S552T missense_variant 0.68 0
3:41227266:G T332S missense_variant 0.68 0
3:41227266:A T332N missense_variant 0.68 0
3:41227266:T T332I missense_variant 0.68 0
3:41236482:T S646F missense_variant 0.67 0
3:41236482:A S646Y missense_variant 0.67 0
3:41236482:G S646C missense_variant 0.67 0
3:41225410:A S191Y missense_variant 0.64 0
3:41225410:G S191C missense_variant 0.64 0
3:41225410:T S191F missense_variant 0.64 0
3:41225017:T T102I missense_variant 0.64 0
3:41225017:G T102R missense_variant 0.64 0
3:41225017:A T102K missense_variant 0.64 0
3:41233437:A T393N missense_variant 0.64 0
3:41233437:G T393S missense_variant 0.64 0
3:41233437:T T393I missense_variant 0.64 0
3:41236359:A S605Y missense_variant 0.64 0
3:41236359:G S605C missense_variant 0.64 0
3:41236359:T S605F missense_variant 0.64 0
3:41236657:T S675L missense_variant 0.64 0
3:41225047:A T112K missense_variant 0.64 0
3:41225047:G T112R missense_variant 0.64 0
3:41225047:T T112I missense_variant 0.64 0
3:41225071:A T120N missense_variant 0.64 0
3:41225071:G T120S missense_variant 0.64 0
3:41225071:T T120I missense_variant 0.64 0
3:41233758:A T472N missense_variant 0.64 0
3:41233758:G T472S missense_variant 0.64 0
3:41233758:T T472I missense_variant 0.64 0
3:41239148:C S718P missense_variant 0.63 0
3:41239148:A S718T missense_variant 0.63 0
3:41239148:G S718A missense_variant 0.63 0
3:41234143:G T510S missense_variant 0.63 0
3:41234143:T T510I missense_variant 0.63 0
3:41234143:A T510N missense_variant 0.63 0
3:41227274:G K335E missense_variant 0.60 0
3:41227274:C K335Q missense_variant 0.60 0
3:41227275:G K335R missense_variant 0.60 0
3:41225425:G S196C missense_variant 0.59 0
3:41235761:A T574N missense_variant 0.59 0
3:41235761:G T574S missense_variant 0.59 0
3:41235761:T T574I missense_variant 0.59 0
3:41236669:A T679N missense_variant 0.59 0
3:41236669:G T679S missense_variant 0.59 0
3:41225503:T S222F missense_variant 0.59 0
3:41225503:G S222C missense_variant 0.59 0
3:41225503:A S222Y missense_variant 0.59 0
3:41236591:A T653K missense_variant 0.59 0
3:41236591:G T653R missense_variant 0.59 0
3:41236591:T T653I missense_variant 0.59 0
3:41239158:A S721Y missense_variant 0.59 0
3:41239158:G S721C missense_variant 0.59 0
3:41239158:T S721F missense_variant 0.59 0
3:41236669:T T679I missense_variant 0.59 0
3:41225374:A S179Y missense_variant 0.59 0
3:41225374:G S179C missense_variant 0.59 0
3:41225374:T S179F missense_variant 0.59 0
3:41225425:T S196F missense_variant 0.59 0
3:41225425:A S196Y missense_variant 0.59 0
3:41239149:A S718Y missense_variant 0.59 0
3:41239149:G S718C missense_variant 0.59 0
3:41239149:T S718F missense_variant 0.59 0
3:41233725:A T461N missense_variant 0.59 0
3:41233725:G T461S missense_variant 0.59 0
3:41233725:T T461I missense_variant 0.59 0
3:41234269:G S552C missense_variant 0.53 0
3:41234269:A S552Y missense_variant 0.53 0
3:41234269:T S552F missense_variant 0.53 0
3:41236641:C Y670H missense_variant 0.51 0
3:41236641:G Y670D missense_variant 0.51 0
3:41236656:A S675T missense_variant 0.51 0
3:41236656:C S675P missense_variant 0.51 0
3:41224597:G S29A missense_variant 0.51 0
3:41236656:G S675A missense_variant 0.51 0
3:41233808:C Y489H missense_variant 0.51 0
3:41233808:G Y489D missense_variant 0.51 0
3:41236358:A S605T missense_variant 0.51 0
3:41236358:C S605P missense_variant 0.51 0
3:41236358:G S605A missense_variant 0.51 0
3:41225136:G Y142D missense_variant 0.51 0
3:41224597:A S29T missense_variant 0.51 0
3:41224597:C S29P missense_variant 0.51 0
3:41225661:G S246A missense_variant 0.51 0
3:41225661:C S246P missense_variant 0.51 0
3:41225661:A S246T missense_variant 0.51 0
3:41225409:A S191T missense_variant 0.51 0
3:41225409:C S191P missense_variant 0.51 0
3:41225409:G S191A missense_variant 0.51 0
3:41236593:C Y654H missense_variant 0.51 0
3:41236593:A Y654N missense_variant 0.51 0
3:41236593:G Y654D missense_variant 0.51 0
3:41225136:A Y142N missense_variant 0.51 0
3:41225136:C Y142H missense_variant 0.51 0
3:41233808:A Y489N missense_variant 0.51 0
3:41236641:A Y670N missense_variant 0.51 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(PRAD) Prostate adenocarcinoma PRAD 0.78 0.27