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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
FBXW7 UCS ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
4:152328233:A R465C missense_variant 0.99 4
4:152326214:T R479Q missense_variant 0.97 3
4:152328232:T R465H missense_variant 0.99 2
4:152326137:C R505G missense_variant 0.99 2
4:152328232:G R465P missense_variant 0.99 1
4:152326136:A R505L missense_variant 0.99 1
4:152328358:A G423V missense_variant 0.97 1
4:152329754:A T385I missense_variant 0.97 1
4:152326151:C H500R missense_variant 0.83 1
4:152329715:A S398F missense_variant 0.52 1
4:152324366:A S558F missense_variant 0.52 1
4:152329721:T S396N missense_variant 0.51 1
4:152328232:A R465L missense_variant 0.99 0
4:152328233:C R465G missense_variant 0.99 0
4:152328233:T R465S missense_variant 0.99 0
4:152326137:A R505C missense_variant 0.99 0
4:152326137:T R505S missense_variant 0.99 0
4:152326136:G R505P missense_variant 0.99 0
4:152326136:T R505H missense_variant 0.99 0
4:152326214:G R479P missense_variant 0.97 0
4:152326214:A R479L missense_variant 0.97 0
4:152328359:T G423R missense_variant 0.97 0
4:152328359:G G423R missense_variant 0.97 0
4:152328358:G G423A missense_variant 0.97 0
4:152328358:T G423E missense_variant 0.97 0
4:152329754:C T385R missense_variant 0.97 0
4:152329754:T T385K missense_variant 0.97 0
4:152326215:C R479G missense_variant 0.96 0
4:152329755:A T385S missense_variant 0.93 0
4:152329755:C T385A missense_variant 0.93 0
4:152329755:G T385P missense_variant 0.93 0
4:152328359:A G423* stop_gained 0.89 0
4:152326215:A R479* stop_gained 0.87 0
4:152328229:G C466S missense_variant 0.86 0
4:152328229:T C466Y missense_variant 0.86 0
4:152328229:A C466F missense_variant 0.86 0
4:152326152:T H500N missense_variant 0.85 0
4:152326152:A H500Y missense_variant 0.85 0
4:152326152:C H500D missense_variant 0.85 0
4:152326151:G H500P missense_variant 0.83 0
4:152326151:A H500L missense_variant 0.83 0
4:152328215:T E471K missense_variant 0.82 0
4:152328208:T R473K missense_variant 0.82 0
4:152328208:G R473T missense_variant 0.82 0
4:152328208:A R473I missense_variant 0.82 0
4:152326077:T V525M missense_variant 0.82 0
4:152326077:G V525L missense_variant 0.82 0
4:152326077:A V525L missense_variant 0.82 0
4:152326073:G W526S missense_variant 0.82 0
4:152326073:A W526L missense_variant 0.82 0
4:152326072:G W526C missense_variant 0.82 0
4:152326071:A D527Y missense_variant 0.82 0
4:152326071:G D527H missense_variant 0.82 0
4:152326071:T D527N missense_variant 0.82 0
4:152326072:A W526C missense_variant 0.82 0
4:152328251:T G459R missense_variant 0.82 0
4:152328251:G G459R missense_variant 0.82 0
4:152328251:A G459W missense_variant 0.82 0
4:152328250:T G459E missense_variant 0.82 0
4:152328250:G G459A missense_variant 0.82 0
4:152328250:A G459V missense_variant 0.82 0
4:152328274:T G451E missense_variant 0.82 0
4:152326178:A G491V missense_variant 0.82 0
4:152326178:G G491A missense_variant 0.82 0
4:152328236:T V464M missense_variant 0.82 0
4:152328236:G V464L missense_variant 0.82 0
4:152328274:G G451A missense_variant 0.82 0
4:152328274:A G451V missense_variant 0.82 0
4:152328236:A V464L missense_variant 0.82 0
4:152326178:T G491D missense_variant 0.82 0
4:152328268:T C453Y missense_variant 0.82 0
4:152328268:G C453S missense_variant 0.82 0
4:152328268:A C453F missense_variant 0.82 0
4:152326191:A D487Y missense_variant 0.82 0
4:152328225:T M467I missense_variant 0.82 0
4:152328225:G M467I missense_variant 0.82 0
4:152328225:A M467I missense_variant 0.82 0
4:152326191:G D487H missense_variant 0.82 0
4:152326191:T D487N missense_variant 0.82 0
4:152326192:A W486C missense_variant 0.82 0
4:152326192:G W486C missense_variant 0.82 0
4:152328215:G E471Q missense_variant 0.82 0
4:152328248:C H460D missense_variant 0.81 0
4:152328248:T H460N missense_variant 0.81 0
4:152328244:C T461S missense_variant 0.81 0
4:152328259:C T456S missense_variant 0.81 0
4:152328259:T T456N missense_variant 0.81 0
4:152328218:A H470Y missense_variant 0.81 0
4:152328241:T S462Y missense_variant 0.81 0
4:152328241:C S462C missense_variant 0.81 0
4:152328241:A S462F missense_variant 0.81 0
4:152328244:T T461N missense_variant 0.81 0
4:152328244:A T461I missense_variant 0.81 0
4:152328248:A H460Y missense_variant 0.81 0
4:152328218:T H470N missense_variant 0.81 0
4:152328218:C H470D missense_variant 0.81 0
4:152328224:T H468N missense_variant 0.81 0
4:152328238:T T463N missense_variant 0.81 0
4:152328238:C T463S missense_variant 0.81 0
4:152328238:A T463I missense_variant 0.81 0
4:152328224:C H468D missense_variant 0.81 0
4:152328259:A T456I missense_variant 0.81 0
4:152328224:A H468Y missense_variant 0.81 0
4:152326097:C A518G missense_variant 0.81 0
4:152326097:T A518E missense_variant 0.81 0
4:152326097:A A518V missense_variant 0.81 0
4:152326205:A T482I missense_variant 0.79 0
4:152326205:C T482S missense_variant 0.79 0
4:152326205:T T482N missense_variant 0.79 0
4:152326217:T S478Y missense_variant 0.79 0
4:152326217:C S478C missense_variant 0.79 0
4:152326217:A S478F missense_variant 0.79 0
4:152326104:C S516G missense_variant 0.78 0
4:152326079:A K524M missense_variant 0.78 0
4:152326079:C K524R missense_variant 0.78 0
4:152326079:G K524T missense_variant 0.78 0
4:152326080:C K524E missense_variant 0.78 0
4:152326080:G K524Q missense_variant 0.78 0
4:152326086:A M522L missense_variant 0.78 0
4:152326086:C M522V missense_variant 0.78 0
4:152326094:G Y519S missense_variant 0.78 0
4:152326121:G D510A missense_variant 0.78 0
4:152326121:C D510G missense_variant 0.78 0
4:152326121:A D510V missense_variant 0.78 0
4:152326094:C Y519C missense_variant 0.78 0
4:152326094:A Y519F missense_variant 0.78 0
4:152326091:G D520A missense_variant 0.78 0
4:152326104:G S516R missense_variant 0.78 0
4:152326086:G M522L missense_variant 0.78 0
4:152326104:A S516C missense_variant 0.78 0
4:152326091:C D520G missense_variant 0.78 0
4:152326091:A D520V missense_variant 0.78 0
4:152326142:T A503E missense_variant 0.72 0
4:152326128:C Q508E missense_variant 0.72 0
4:152326128:T Q508K missense_variant 0.72 0
4:152326142:A A503V missense_variant 0.72 0
4:152326145:T A502E missense_variant 0.72 0
4:152326145:C A502G missense_variant 0.72 0
4:152326142:C A503G missense_variant 0.72 0
4:152326145:A A502V missense_variant 0.72 0
4:152326211:A D480V missense_variant 0.71 0
4:152326211:G D480A missense_variant 0.71 0
4:152326206:C T482A missense_variant 0.71 0
4:152326206:A T482S missense_variant 0.71 0
4:152326206:G T482P missense_variant 0.71 0
4:152326224:A S476C missense_variant 0.71 0
4:152326224:C S476G missense_variant 0.71 0
4:152326224:G S476R missense_variant 0.71 0
4:152326211:C D480G missense_variant 0.71 0
4:152328230:C C466G missense_variant 0.71 0
4:152328230:G C466R missense_variant 0.71 0
4:152328230:T C466S missense_variant 0.71 0
4:152326130:G V507A missense_variant 0.68 0
4:152326139:T V504D missense_variant 0.68 0
4:152326130:T V507D missense_variant 0.68 0
4:152326139:C V504G missense_variant 0.68 0
4:152326134:C C506G missense_variant 0.68 0
4:152326134:T C506S missense_variant 0.68 0
4:152326134:G C506R missense_variant 0.68 0
4:152326139:G V504A missense_variant 0.68 0
4:152326130:C V507G missense_variant 0.68 0
4:152328211:G K472T missense_variant 0.65 0
4:152326190:A D487V missense_variant 0.65 0
4:152326190:C D487G missense_variant 0.65 0
4:152326190:G D487A missense_variant 0.65 0
4:152328253:G Y458S missense_variant 0.65 0
4:152328253:C Y458C missense_variant 0.65 0
4:152328253:A Y458F missense_variant 0.65 0
4:152328247:G H460P missense_variant 0.65 0
4:152328247:C H460R missense_variant 0.65 0
4:152328247:A H460L missense_variant 0.65 0
4:152328245:G T461P missense_variant 0.65 0
4:152328245:C T461A missense_variant 0.65 0
4:152328245:A T461S missense_variant 0.65 0
4:152328239:G T463P missense_variant 0.65 0
4:152328239:C T463A missense_variant 0.65 0
4:152328239:A T463S missense_variant 0.65 0
4:152328271:G E452A missense_variant 0.65 0
4:152328271:C E452G missense_variant 0.65 0
4:152328271:A E452V missense_variant 0.65 0
4:152328227:G M467L missense_variant 0.65 0
4:152328227:C M467V missense_variant 0.65 0
4:152328227:A M467L missense_variant 0.65 0
4:152328262:G H455P missense_variant 0.65 0
4:152328262:C H455R missense_variant 0.65 0
4:152328262:A H455L missense_variant 0.65 0
4:152328260:G T456P missense_variant 0.65 0
4:152328223:G H468P missense_variant 0.65 0
4:152328223:C H468R missense_variant 0.65 0
4:152328223:A H468L missense_variant 0.65 0
4:152328217:G H470P missense_variant 0.65 0
4:152328217:C H470R missense_variant 0.65 0
4:152328217:A H470L missense_variant 0.65 0
4:152328212:G K472Q missense_variant 0.65 0
4:152328260:C T456A missense_variant 0.65 0
4:152328260:A T456S missense_variant 0.65 0
4:152328212:C K472E missense_variant 0.65 0
4:152328211:C K472R missense_variant 0.65 0
4:152328211:A K472I missense_variant 0.65 0
4:152326070:A D527V missense_variant 0.65 0
4:152326070:C D527G missense_variant 0.65 0
4:152326070:G D527A missense_variant 0.65 0
4:152326208:T A481D missense_variant 0.65 0
4:152326208:C A481G missense_variant 0.65 0
4:152326208:A A481V missense_variant 0.65 0
4:152326176:C Q492E missense_variant 0.65 0
4:152326167:C H495D missense_variant 0.65 0
4:152326167:T H495N missense_variant 0.65 0
4:152328221:A L469F missense_variant 0.65 0
4:152328263:T H455N missense_variant 0.65 0
4:152328263:C H455D missense_variant 0.65 0
4:152328263:A H455Y missense_variant 0.65 0
4:152328221:T L469I missense_variant 0.65 0
4:152328221:C L469V missense_variant 0.65 0
4:152326176:T Q492K missense_variant 0.65 0
4:152326167:A H495Y missense_variant 0.65 0
4:152328235:G V464A missense_variant 0.63 0
4:152326173:T C493S missense_variant 0.63 0
4:152326173:G C493R missense_variant 0.63 0
4:152326173:C C493G missense_variant 0.63 0
4:152328220:T L469H missense_variant 0.63 0
4:152326074:C W526G missense_variant 0.63 0
4:152326074:G W526R missense_variant 0.63 0
4:152328226:C M467R missense_variant 0.63 0
4:152328226:G M467T missense_variant 0.63 0
4:152328226:T M467K missense_variant 0.63 0
4:152326074:T W526R missense_variant 0.63 0
4:152326076:C V525G missense_variant 0.63 0
4:152326076:G V525A missense_variant 0.63 0
4:152326076:T V525E missense_variant 0.63 0
4:152328254:C Y458D missense_variant 0.63 0
4:152328254:G Y458H missense_variant 0.63 0
4:152328254:T Y458N missense_variant 0.63 0
4:152328256:G L457S missense_variant 0.63 0
4:152328269:C C453G missense_variant 0.63 0
4:152328269:G C453R missense_variant 0.63 0
4:152328269:T C453S missense_variant 0.63 0
4:152328220:C L469R missense_variant 0.63 0
4:152328220:G L469P missense_variant 0.63 0
4:152328235:C V464G missense_variant 0.63 0
4:152328235:T V464E missense_variant 0.63 0
4:152328242:C S462A missense_variant 0.63 0
4:152328242:G S462P missense_variant 0.63 0
4:152328242:T S462T missense_variant 0.63 0
4:152326146:T A502T missense_variant 0.63 0
4:152326146:A A502S missense_variant 0.63 0
4:152326149:G V501L missense_variant 0.63 0
4:152326149:T V501I missense_variant 0.63 0
4:152326146:G A502P missense_variant 0.63 0
4:152326133:T C506Y missense_variant 0.63 0
4:152326154:T G499D missense_variant 0.63 0
4:152326154:G G499A missense_variant 0.63 0
4:152326154:A G499V missense_variant 0.63 0
4:152326140:T V504I missense_variant 0.63 0
4:152326140:G V504L missense_variant 0.63 0
4:152326133:G C506S missense_variant 0.63 0
4:152326133:A C506F missense_variant 0.63 0
4:152326140:A V504F missense_variant 0.63 0
4:152326149:A V501F missense_variant 0.63 0
4:152326155:G G499R missense_variant 0.62 0
4:152326155:T G499S missense_variant 0.62 0
4:152326155:A G499C missense_variant 0.62 0
4:152326163:G V496A missense_variant 0.60 0
4:152326106:C V515G missense_variant 0.60 0
4:152326106:G V515A missense_variant 0.60 0
4:152326106:T V515D missense_variant 0.60 0
4:152326082:C V523G missense_variant 0.60 0
4:152326082:G V523A missense_variant 0.60 0
4:152326109:C V514G missense_variant 0.60 0
4:152326109:G V514A missense_variant 0.60 0
4:152326109:T V514D missense_variant 0.60 0
4:152326082:T V523E missense_variant 0.60 0
4:152326160:G L497S missense_variant 0.60 0
4:152326125:C Y509D missense_variant 0.60 0
4:152326125:G Y509H missense_variant 0.60 0
4:152326125:T Y509N missense_variant 0.60 0
4:152326160:C L497W missense_variant 0.60 0
4:152326169:G L494S missense_variant 0.60 0
4:152326095:C Y519D missense_variant 0.60 0
4:152326095:G Y519H missense_variant 0.60 0
4:152326095:T Y519N missense_variant 0.60 0
4:152326163:C V496G missense_variant 0.60 0
4:152326163:T V496D missense_variant 0.60 0
4:152326196:T V485D missense_variant 0.59 0
4:152326229:T V474D missense_variant 0.59 0
4:152326229:G V474A missense_variant 0.59 0
4:152326218:T S478T missense_variant 0.59 0
4:152326194:C W486G missense_variant 0.59 0
4:152326229:C V474G missense_variant 0.59 0
4:152326226:T V475D missense_variant 0.59 0
4:152326226:G V475A missense_variant 0.59 0
4:152326202:C L483R missense_variant 0.59 0
4:152326202:G L483P missense_variant 0.59 0
4:152326218:C S478A missense_variant 0.59 0
4:152326202:T L483H missense_variant 0.59 0
4:152326194:G W486R missense_variant 0.59 0
4:152326194:T W486R missense_variant 0.59 0
4:152326226:C V475G missense_variant 0.59 0
4:152326218:G S478P missense_variant 0.59 0
4:152326196:C V485G missense_variant 0.59 0
4:152326196:G V485A missense_variant 0.59 0
4:152326164:A V496F missense_variant 0.55 0
4:152326164:G V496L missense_variant 0.55 0
4:152326092:A D520Y missense_variant 0.55 0
4:152326092:G D520H missense_variant 0.55 0
4:152326092:T D520N missense_variant 0.55 0
4:152326098:A A518S missense_variant 0.55 0
4:152326098:G A518P missense_variant 0.55 0
4:152326098:T A518T missense_variant 0.55 0
4:152326100:A G517V missense_variant 0.55 0
4:152326100:G G517A missense_variant 0.55 0
4:152326100:T G517E missense_variant 0.55 0
4:152326101:G G517R missense_variant 0.55 0
4:152326101:T G517R missense_variant 0.55 0
4:152326103:A S516I missense_variant 0.55 0
4:152326103:G S516T missense_variant 0.55 0
4:152326103:T S516N missense_variant 0.55 0
4:152326107:A V515F missense_variant 0.55 0
4:152326107:G V515L missense_variant 0.55 0
4:152326107:T V515I missense_variant 0.55 0
4:152326112:A R513M missense_variant 0.55 0
4:152326112:G R513T missense_variant 0.55 0
4:152326112:T R513K missense_variant 0.55 0
4:152326122:A D510Y missense_variant 0.55 0
4:152326122:G D510H missense_variant 0.55 0
4:152326122:T D510N missense_variant 0.55 0
4:152326172:T C493Y missense_variant 0.55 0
4:152326172:G C493S missense_variant 0.55 0
4:152326172:A C493F missense_variant 0.55 0
4:152326164:T V496I missense_variant 0.55 0
4:152326143:T A503T missense_variant 0.52 0
4:152326143:G A503P missense_variant 0.52 0
4:152326143:A A503S missense_variant 0.52 0
4:152332656:T R309S missense_variant 0.52 0
4:152332656:C R309G missense_variant 0.52 0
4:152332656:A R309C missense_variant 0.52 0
4:152324274:A L589F missense_variant 0.52 0
4:152324187:C Q618E missense_variant 0.52 0
4:152324187:T Q618K missense_variant 0.52 0
4:152324192:A T616I missense_variant 0.52 0
4:152324192:C T616R missense_variant 0.52 0
4:152324192:T T616K missense_variant 0.52 0
4:152324196:C Q615E missense_variant 0.52 0
4:152324196:T Q615K missense_variant 0.52 0
4:152324205:C Q612E missense_variant 0.52 0
4:152324205:T Q612K missense_variant 0.52 0
4:152324234:A T602I missense_variant 0.52 0
4:152324234:C T602R missense_variant 0.52 0
4:152324234:T T602K missense_variant 0.52 0
4:152324237:A S601F missense_variant 0.52 0
4:152324237:C S601C missense_variant 0.52 0
4:152324237:T S601Y missense_variant 0.52 0
4:152324252:A S596F missense_variant 0.52 0
4:152324252:C S596C missense_variant 0.52 0
4:152324252:T S596Y missense_variant 0.52 0
4:152324274:C L589V missense_variant 0.52 0
4:152324274:T L589I missense_variant 0.52 0
4:152324288:A T584I missense_variant 0.52 0
4:152324288:C T584R missense_variant 0.52 0
4:152324288:T T584K missense_variant 0.52 0
4:152324294:A S582L missense_variant 0.52 0
4:152324294:C S582W missense_variant 0.52 0
4:152324298:C Q581E missense_variant 0.52 0
4:152324298:T Q581K missense_variant 0.52 0
4:152324301:A H580Y missense_variant 0.52 0
4:152324301:C H580D missense_variant 0.52 0
4:152324301:T H580N missense_variant 0.52 0
4:152324312:A T576M missense_variant 0.52 0
4:152324312:C T576R missense_variant 0.52 0
4:152324312:T T576K missense_variant 0.52 0
4:152324316:A H575Y missense_variant 0.52 0
4:152324316:C H575D missense_variant 0.52 0
4:152324316:T H575N missense_variant 0.52 0
4:152324354:A S562L missense_variant 0.52 0
4:152324357:A T561I missense_variant 0.52 0
4:152324357:C T561R missense_variant 0.52 0
4:152324357:T T561K missense_variant 0.52 0
4:152324366:C S558C missense_variant 0.52 0
4:152324366:T S558Y missense_variant 0.52 0
4:152324382:A H553Y missense_variant 0.52 0
4:152324382:C H553D missense_variant 0.52 0
4:152324382:T H553N missense_variant 0.52 0
4:152328277:A T450I missense_variant 0.52 0
4:152328277:C T450S missense_variant 0.52 0
4:152328277:T T450N missense_variant 0.52 0
4:152328283:A A448V missense_variant 0.52 0
4:152328283:C A448G missense_variant 0.52 0
4:152328283:T A448E missense_variant 0.52 0
4:152328301:A T442I missense_variant 0.52 0
4:152328301:C T442R missense_variant 0.52 0
4:152328301:T T442K missense_variant 0.52 0
4:152328310:A T439I missense_variant 0.52 0
4:152328310:C T439R missense_variant 0.52 0
4:152328310:T T439K missense_variant 0.52 0
4:152328313:A S438F missense_variant 0.52 0
4:152328313:C S438C missense_variant 0.52 0
4:152328313:T S438Y missense_variant 0.52 0
4:152328344:C Q428E missense_variant 0.52 0
4:152328344:T Q428K missense_variant 0.52 0
4:152328346:A S427L missense_variant 0.52 0
4:152328349:A S426L missense_variant 0.52 0
4:152328364:A T421I missense_variant 0.52 0
4:152328364:C T421R missense_variant 0.52 0
4:152328364:T T421K missense_variant 0.52 0
4:152328368:A H420Y missense_variant 0.52 0
4:152328368:C H420D missense_variant 0.52 0
4:152328368:T H420N missense_variant 0.52 0
4:152328379:A T416I missense_variant 0.52 0
4:152328379:C T416R missense_variant 0.52 0
4:152328379:T T416K missense_variant 0.52 0
4:152329679:A T410I missense_variant 0.52 0
4:152329679:C T410R missense_variant 0.52 0
4:152329679:T T410K missense_variant 0.52 0
4:152329685:A A408V missense_variant 0.52 0
4:152329685:C A408G missense_variant 0.52 0
4:152329685:T A408E missense_variant 0.52 0
4:152329688:A S407L missense_variant 0.52 0
4:152329703:A T402I missense_variant 0.52 0
4:152329703:C T402S missense_variant 0.52 0
4:152329703:T T402N missense_variant 0.52 0
4:152329715:C S398C missense_variant 0.52 0
4:152329715:T S398Y missense_variant 0.52 0
4:152329764:A H382Y missense_variant 0.52 0
4:152329764:C H382D missense_variant 0.52 0
4:152329764:T H382N missense_variant 0.52 0
4:152329773:A H379Y missense_variant 0.52 0
4:152329773:C H379D missense_variant 0.52 0
4:152329773:T H379N missense_variant 0.52 0
4:152330736:A P373L missense_variant 0.52 0
4:152330736:C P373R missense_variant 0.52 0
4:152330736:T P373H missense_variant 0.52 0
4:152330737:A P373S missense_variant 0.52 0
4:152330737:C P373A missense_variant 0.52 0
4:152330737:T P373T missense_variant 0.52 0
4:152330739:A S372F missense_variant 0.52 0
4:152330739:C S372C missense_variant 0.52 0
4:152330739:T S372Y missense_variant 0.52 0
4:152330779:A H359Y missense_variant 0.52 0
4:152330779:C H359D missense_variant 0.52 0
4:152330779:T H359N missense_variant 0.52 0
4:152330782:C Q358E missense_variant 0.52 0
4:152330782:T Q358K missense_variant 0.52 0
4:152330793:A A354V missense_variant 0.52 0
4:152330793:C A354G missense_variant 0.52 0
4:152330793:T A354E missense_variant 0.52 0
4:152330805:A P350L missense_variant 0.52 0
4:152330805:C P350R missense_variant 0.52 0
4:152330805:T P350Q missense_variant 0.52 0
4:152330806:A P350S missense_variant 0.52 0
4:152330806:C P350A missense_variant 0.52 0
4:152330806:T P350T missense_variant 0.52 0
4:152330823:A P344L missense_variant 0.52 0
4:152330823:C P344R missense_variant 0.52 0
4:152330823:T P344Q missense_variant 0.52 0
4:152330856:A P333L missense_variant 0.52 0
4:152330856:C P333R missense_variant 0.52 0
4:152330856:T P333Q missense_variant 0.52 0
4:152330857:A P333S missense_variant 0.52 0
4:152330857:C P333A missense_variant 0.52 0
4:152330857:T P333T missense_variant 0.52 0
4:152324278:G M587I missense_variant 0.51 0
4:152324277:T E588K missense_variant 0.51 0
4:152324277:G E588Q missense_variant 0.51 0
4:152324372:T S556N missense_variant 0.51 0
4:152324372:G S556T missense_variant 0.51 0
4:152324372:A S556I missense_variant 0.51 0
4:152324370:T G557R missense_variant 0.51 0
4:152324370:G G557R missense_variant 0.51 0
4:152324369:T G557E missense_variant 0.51 0
4:152324369:G G557A missense_variant 0.51 0
4:152324369:A G557V missense_variant 0.51 0
4:152324361:T D560N missense_variant 0.51 0
4:152324361:G D560H missense_variant 0.51 0
4:152324361:A D560Y missense_variant 0.51 0
4:152324348:T R564H missense_variant 0.51 0
4:152324348:G R564P missense_variant 0.51 0
4:152324348:A R564L missense_variant 0.51 0
4:152324346:T V565I missense_variant 0.51 0
4:152324346:G V565L missense_variant 0.51 0
4:152324346:A V565F missense_variant 0.51 0
4:152324342:G W566S missense_variant 0.51 0
4:152324342:A W566L missense_variant 0.51 0
4:152324341:G W566C missense_variant 0.51 0
4:152324341:A W566C missense_variant 0.51 0
4:152324340:T D567N missense_variant 0.51 0
4:152324340:G D567H missense_variant 0.51 0
4:152324340:A D567Y missense_variant 0.51 0
4:152324337:T V568M missense_variant 0.51 0
4:152324337:G V568L missense_variant 0.51 0
4:152324337:A V568L missense_variant 0.51 0
4:152324334:T E569K missense_variant 0.51 0
4:152324334:G E569Q missense_variant 0.51 0
4:152324328:T G571R missense_variant 0.51 0
4:152324328:G G571R missense_variant 0.51 0
4:152324328:A G571W missense_variant 0.51 0
4:152324327:T G571E missense_variant 0.51 0
4:152324327:G G571A missense_variant 0.51 0
4:152324327:A G571V missense_variant 0.51 0
4:152324321:T C573Y missense_variant 0.51 0
4:152324321:G C573S missense_variant 0.51 0
4:152324321:A C573F missense_variant 0.51 0
4:152324304:T G579R missense_variant 0.51 0
4:152324304:G G579R missense_variant 0.51 0
4:152324304:A G579W missense_variant 0.51 0
4:152324303:T G579E missense_variant 0.51 0
4:152324303:G G579A missense_variant 0.51 0
4:152324303:A G579V missense_variant 0.51 0
4:152324285:T S585N missense_variant 0.51 0
4:152324285:G S585T missense_variant 0.51 0
4:152324285:A S585I missense_variant 0.51 0
4:152324283:T G586R missense_variant 0.51 0
4:152324283:G G586R missense_variant 0.51 0
4:152324282:T G586E missense_variant 0.51 0
4:152324282:G G586A missense_variant 0.51 0
4:152324282:A G586V missense_variant 0.51 0
4:152324278:T M587I missense_variant 0.51 0
4:152324278:A M587I missense_variant 0.51 0
4:152324268:T D591N missense_variant 0.51 0
4:152324268:G D591H missense_variant 0.51 0
4:152324268:A D591Y missense_variant 0.51 0
4:152324256:T V595I missense_variant 0.51 0
4:152324256:G V595L missense_variant 0.51 0
4:152324256:A V595F missense_variant 0.51 0
4:152324250:T G597R missense_variant 0.51 0
4:152324250:G G597R missense_variant 0.51 0
4:152324250:A G597W missense_variant 0.51 0
4:152324249:T G597E missense_variant 0.51 0
4:152324249:G G597A missense_variant 0.51 0
4:152324249:A G597V missense_variant 0.51 0
4:152324244:T A599T missense_variant 0.51 0
4:152324244:G A599P missense_variant 0.51 0
4:152324244:A A599S missense_variant 0.51 0
4:152324241:T D600N missense_variant 0.51 0
4:152324241:G D600H missense_variant 0.51 0
4:152324241:A D600Y missense_variant 0.51 0
4:152324222:G W606S missense_variant 0.51 0
4:152324222:A W606L missense_variant 0.51 0
4:152324221:G W606C missense_variant 0.51 0
4:152324221:A W606C missense_variant 0.51 0
4:152324220:T D607N missense_variant 0.51 0
4:152324220:G D607H missense_variant 0.51 0
4:152324220:A D607Y missense_variant 0.51 0
4:152324207:T G611E missense_variant 0.51 0
4:152324207:G G611A missense_variant 0.51 0
4:152324207:A G611V missense_variant 0.51 0
4:152324201:T C613Y missense_variant 0.51 0
4:152324201:G C613S missense_variant 0.51 0
4:152324201:A C613F missense_variant 0.51 0
4:152324184:T G619S missense_variant 0.51 0
4:152324184:G G619R missense_variant 0.51 0
4:152324184:A G619C missense_variant 0.51 0
4:152328275:G G451R missense_variant 0.51 0
4:152328275:T G451R missense_variant 0.51 0
4:152328281:G E449Q missense_variant 0.51 0
4:152328281:T E449K missense_variant 0.51 0
4:152330860:G E332Q missense_variant 0.51 0
4:152330860:T E332K missense_variant 0.51 0
4:152330749:G E369Q missense_variant 0.51 0
4:152328284:A A448S missense_variant 0.51 0
4:152328284:G A448P missense_variant 0.51 0
4:152328284:T A448T missense_variant 0.51 0
4:152328288:A W446C missense_variant 0.51 0
4:152328288:G W446C missense_variant 0.51 0
4:152328289:A W446L missense_variant 0.51 0
4:152328289:G W446S missense_variant 0.51 0
4:152328293:A V445L missense_variant 0.51 0
4:152328293:G V445L missense_variant 0.51 0
4:152328293:T V445M missense_variant 0.51 0
4:152330749:T E369K missense_variant 0.51 0
4:152330751:A G368V missense_variant 0.51 0
4:152330751:G G368A missense_variant 0.51 0
4:152328304:A R441L missense_variant 0.51 0
4:152328304:G R441P missense_variant 0.51 0
4:152328304:T R441Q missense_variant 0.51 0
4:152328308:A D440Y missense_variant 0.51 0
4:152328308:G D440H missense_variant 0.51 0
4:152328308:T D440N missense_variant 0.51 0
4:152330751:T G368E missense_variant 0.51 0
4:152330752:G G368R missense_variant 0.51 0
4:152330752:T G368R missense_variant 0.51 0
4:152330754:A R367L missense_variant 0.51 0
4:152330754:G R367P missense_variant 0.51 0
4:152330754:T R367Q missense_variant 0.51 0
4:152328316:A G437V missense_variant 0.51 0
4:152328316:G G437A missense_variant 0.51 0
4:152328316:T G437E missense_variant 0.51 0
4:152328317:G G437R missense_variant 0.51 0
4:152328317:T G437R missense_variant 0.51 0
4:152328319:A S436I missense_variant 0.51 0
4:152328319:G S436T missense_variant 0.51 0
4:152328319:T S436N missense_variant 0.51 0
4:152328335:A D431Y missense_variant 0.51 0
4:152328335:G D431H missense_variant 0.51 0
4:152328335:T D431N missense_variant 0.51 0
4:152328337:A R430I missense_variant 0.51 0
4:152328337:G R430T missense_variant 0.51 0
4:152328337:T R430K missense_variant 0.51 0
4:152328339:A M429I missense_variant 0.51 0
4:152328339:G M429I missense_variant 0.51 0
4:152328339:T M429I missense_variant 0.51 0
4:152330757:A R366M missense_variant 0.51 0
4:152330757:G R366T missense_variant 0.51 0
4:152330757:T R366K missense_variant 0.51 0
4:152330759:A W365C missense_variant 0.51 0
4:152328351:A W425C missense_variant 0.51 0
4:152328351:G W425C missense_variant 0.51 0
4:152328352:A W425L missense_variant 0.51 0
4:152328352:G W425S missense_variant 0.51 0
4:152328356:A V424L missense_variant 0.51 0
4:152328356:G V424L missense_variant 0.51 0
4:152328356:T V424I missense_variant 0.51 0
4:152328361:A G422V missense_variant 0.51 0
4:152328361:G G422A missense_variant 0.51 0
4:152328361:T G422D missense_variant 0.51 0
4:152328362:A G422C missense_variant 0.51 0
4:152328362:G G422R missense_variant 0.51 0
4:152328362:T G422S missense_variant 0.51 0
4:152330759:G W365C missense_variant 0.51 0
4:152330760:A W365L missense_variant 0.51 0
4:152330760:G W365S missense_variant 0.51 0
4:152330770:A D362Y missense_variant 0.51 0
4:152330770:G D362H missense_variant 0.51 0
4:152330770:T D362N missense_variant 0.51 0
4:152328370:A G419V missense_variant 0.51 0
4:152328370:G G419A missense_variant 0.51 0
4:152328370:T G419E missense_variant 0.51 0
4:152328371:G G419R missense_variant 0.51 0
4:152328371:T G419R missense_variant 0.51 0
4:152328374:A V418L missense_variant 0.51 0
4:152328374:G V418L missense_variant 0.51 0
4:152328374:T V418M missense_variant 0.51 0
4:152330775:A R360I missense_variant 0.51 0
4:152330775:G R360T missense_variant 0.51 0
4:152330775:T R360K missense_variant 0.51 0
4:152328382:A R415I missense_variant 0.51 0
4:152328382:G R415T missense_variant 0.51 0
4:152328382:T R415K missense_variant 0.51 0
4:152328388:A C413F missense_variant 0.51 0
4:152328388:G C413S missense_variant 0.51 0
4:152328388:T C413Y missense_variant 0.51 0
4:152329676:A G411V missense_variant 0.51 0
4:152329676:G G411A missense_variant 0.51 0
4:152329676:T G411D missense_variant 0.51 0
4:152329677:A G411C missense_variant 0.51 0
4:152329677:G G411R missense_variant 0.51 0
4:152329677:T G411S missense_variant 0.51 0
4:152330808:A S349I missense_variant 0.51 0
4:152330808:G S349T missense_variant 0.51 0
4:152330808:T S349N missense_variant 0.51 0
4:152330863:A D331Y missense_variant 0.51 0
4:152330863:G D331H missense_variant 0.51 0
4:152330784:A R357I missense_variant 0.51 0
4:152329686:A A408S missense_variant 0.51 0
4:152329686:G A408P missense_variant 0.51 0
4:152329686:T A408T missense_variant 0.51 0
4:152330784:G R357T missense_variant 0.51 0
4:152329690:A W406C missense_variant 0.51 0
4:152329690:G W406C missense_variant 0.51 0
4:152329691:A W406L missense_variant 0.51 0
4:152329691:G W406S missense_variant 0.51 0
4:152329695:A V405F missense_variant 0.51 0
4:152329695:G V405L missense_variant 0.51 0
4:152329695:T V405I missense_variant 0.51 0
4:152330784:T R357K missense_variant 0.51 0
4:152330863:T D331N missense_variant 0.51 0
4:152330868:A G329V missense_variant 0.51 0
4:152329710:A D400Y missense_variant 0.51 0
4:152329710:G D400H missense_variant 0.51 0
4:152329710:T D400N missense_variant 0.51 0
4:152329713:A D399Y missense_variant 0.51 0
4:152329713:G D399H missense_variant 0.51 0
4:152329713:T D399N missense_variant 0.51 0
4:152330868:G G329A missense_variant 0.51 0
4:152330794:A A354S missense_variant 0.51 0
4:152329718:A G397V missense_variant 0.51 0
4:152329718:G G397A missense_variant 0.51 0
4:152329718:T G397D missense_variant 0.51 0
4:152329719:A G397C missense_variant 0.51 0
4:152329719:G G397R missense_variant 0.51 0
4:152329719:T G397S missense_variant 0.51 0
4:152329721:A S396I missense_variant 0.51 0
4:152329721:G S396T missense_variant 0.51 0
4:152329751:A C386F missense_variant 0.51 0
4:152329751:G C386S missense_variant 0.51 0
4:152329751:T C386Y missense_variant 0.51 0
4:152329761:A V383L missense_variant 0.51 0
4:152329761:G V383L missense_variant 0.51 0
4:152329761:T V383M missense_variant 0.51 0
4:152330794:G A354P missense_variant 0.51 0
4:152330794:T A354T missense_variant 0.51 0
4:152330796:A S353I missense_variant 0.51 0
4:152329767:A D381Y missense_variant 0.51 0
4:152329767:G D381H missense_variant 0.51 0
4:152329767:T D381N missense_variant 0.51 0
4:152329770:A D380Y missense_variant 0.51 0
4:152329770:G D380H missense_variant 0.51 0
4:152329770:T D380N missense_variant 0.51 0
4:152330796:G S353T missense_variant 0.51 0
4:152330796:T S353N missense_variant 0.51 0
4:152330801:A W351C missense_variant 0.51 0
4:152329775:A G378V missense_variant 0.51 0
4:152329775:G G378A missense_variant 0.51 0
4:152329775:T G378E missense_variant 0.51 0
4:152329776:G G378R missense_variant 0.51 0
4:152329776:T G378R missense_variant 0.51 0
4:152329785:A V375L missense_variant 0.51 0
4:152329785:G V375L missense_variant 0.51 0
4:152329785:T V375M missense_variant 0.51 0
4:152330732:A K374N missense_variant 0.51 0
4:152330732:G K374N missense_variant 0.51 0
4:152330801:G W351C missense_variant 0.51 0
4:152330802:A W351L missense_variant 0.51 0
4:152330802:G W351S missense_variant 0.51 0
4:152330868:T G329E missense_variant 0.51 0
4:152326185:T E489K missense_variant 0.51 0
4:152326185:G E489Q missense_variant 0.51 0
4:152326179:T G491S missense_variant 0.51 0
4:152326179:G G491R missense_variant 0.51 0
4:152326179:A G491C missense_variant 0.51 0
4:152326059:T E531K missense_variant 0.51 0
4:152326059:G E531Q missense_variant 0.51 0
4:152324391:T D550N missense_variant 0.51 0
4:152324391:G D550H missense_variant 0.51 0
4:152324391:A D550Y missense_variant 0.51 0
4:152324387:T G551D missense_variant 0.51 0
4:152324387:G G551A missense_variant 0.51 0
4:152324387:A G551V missense_variant 0.51 0
4:152324376:T V555M missense_variant 0.51 0
4:152324376:G V555L missense_variant 0.51 0
4:152324376:A V555L missense_variant 0.51 0
4:152324232:A V603F missense_variant 0.51 0
4:152324232:G V603L missense_variant 0.51 0
4:152324232:T V603I missense_variant 0.51 0
4:152323114:C Q631E missense_variant 0.51 0
4:152323089:T T639N missense_variant 0.51 0
4:152323089:C T639S missense_variant 0.51 0
4:152323089:A T639I missense_variant 0.51 0
4:152323083:A S641L missense_variant 0.51 0
4:152323071:T T645N missense_variant 0.51 0
4:152323071:C T645S missense_variant 0.51 0
4:152322930:C T692S missense_variant 0.51 0
4:152322930:A T692I missense_variant 0.51 0
4:152322921:C T695S missense_variant 0.51 0
4:152322921:A T695I missense_variant 0.51 0
4:152322916:T L697M missense_variant 0.51 0
4:152322921:T T695N missense_variant 0.51 0
4:152323122:C T628S missense_variant 0.51 0
4:152323122:A T628I missense_variant 0.51 0
4:152323114:T Q631K missense_variant 0.51 0
4:152323138:A H623Y missense_variant 0.51 0
4:152323135:T Q624K missense_variant 0.51 0
4:152323135:C Q624E missense_variant 0.51 0
4:152323128:T A626D missense_variant 0.51 0
4:152323128:C A626G missense_variant 0.51 0
4:152323128:A A626V missense_variant 0.51 0
4:152323122:T T628N missense_variant 0.51 0
4:152322916:C L697V missense_variant 0.51 0
4:152322951:T A685E missense_variant 0.51 0
4:152322951:C A685G missense_variant 0.51 0
4:152322961:C L682V missense_variant 0.51 0
4:152322951:A A685V missense_variant 0.51 0
4:152322930:T T692N missense_variant 0.51 0
4:152323071:A T645I missense_variant 0.51 0
4:152322972:A S678L missense_variant 0.51 0
4:152322966:T T680K missense_variant 0.51 0
4:152322966:C T680R missense_variant 0.51 0
4:152322966:A T680I missense_variant 0.51 0
4:152322961:T L682M missense_variant 0.51 0
4:152323147:T P620T missense_variant 0.51 0
4:152323147:C P620A missense_variant 0.51 0
4:152323147:A P620S missense_variant 0.51 0
4:152323146:T P620H missense_variant 0.51 0
4:152323146:C P620R missense_variant 0.51 0
4:152323146:A P620L missense_variant 0.51 0
4:152323138:T H623N missense_variant 0.51 0
4:152323138:C H623D missense_variant 0.51 0
4:152326200:A R484W missense_variant 0.50 0
4:152326200:C R484G missense_variant 0.50 0
4:152326150:T H500Q missense_variant 0.50 0
4:152328228:C C466W missense_variant 0.50 0
4:152326132:C C506W missense_variant 0.50 0
4:152326150:C H500Q missense_variant 0.50 0
4:152326159:A L497F missense_variant 0.50 0
4:152326159:G L497F missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(UCS) Uterine carcinosarcoma UCS 0.59 0.11