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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
IRF4 MM ×
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Mutation AA change Consequence type BoostDM score IntOGen frequency
6:394972:G K123R missense_variant 1.00 15
6:394900:C C99S missense_variant 0.98 5
6:394920:T D106Y missense_variant 0.98 4
6:394954:T D117V missense_variant 0.99 1
6:394920:C D106H missense_variant 0.98 1
6:393328:G K59R missense_variant 0.96 1
6:394965:A P121T missense_variant 0.91 1
6:394951:G L116R missense_variant 0.81 1
6:401730:G E351G missense_variant 0.80 1
6:394971:C K123Q missense_variant 1.00 0
6:394972:T K123I missense_variant 1.00 0
6:394972:C K123T missense_variant 1.00 0
6:394971:G K123E missense_variant 1.00 0
6:394971:T K123* stop_gained 1.00 0
6:394969:C Y122S missense_variant 0.99 0
6:394969:G Y122C missense_variant 0.99 0
6:394969:T Y122F missense_variant 0.99 0
6:394954:G D117G missense_variant 0.99 0
6:394954:C D117A missense_variant 0.99 0
6:394912:G K103R missense_variant 0.99 0
6:394912:T K103M missense_variant 0.99 0
6:394911:G K103E missense_variant 0.99 0
6:394911:C K103Q missense_variant 0.99 0
6:394912:C K103T missense_variant 0.99 0
6:394911:T K103* stop_gained 0.99 0
6:394948:T Q115L missense_variant 0.99 0
6:394948:G Q115R missense_variant 0.99 0
6:394887:G T95A missense_variant 0.99 0
6:394887:T T95S missense_variant 0.99 0
6:394948:C Q115P missense_variant 0.99 0
6:394978:C Y125S missense_variant 0.99 0
6:394870:G D89G missense_variant 0.99 0
6:394878:C T92P missense_variant 0.99 0
6:394944:T S114C missense_variant 0.99 0
6:394944:G S114G missense_variant 0.99 0
6:394944:C S114R missense_variant 0.99 0
6:394878:G T92A missense_variant 0.99 0
6:394878:T T92S missense_variant 0.99 0
6:394870:T D89V missense_variant 0.99 0
6:394939:T E112V missense_variant 0.99 0
6:394939:G E112G missense_variant 0.99 0
6:394939:C E112A missense_variant 0.99 0
6:394983:G I127V missense_variant 0.99 0
6:394870:C D89A missense_variant 0.99 0
6:394927:C E108A missense_variant 0.99 0
6:394921:G D106G missense_variant 0.99 0
6:394921:C D106A missense_variant 0.99 0
6:394914:C S104R missense_variant 0.99 0
6:394914:G S104G missense_variant 0.99 0
6:394914:T S104C missense_variant 0.99 0
6:394917:T N105Y missense_variant 0.99 0
6:394917:G N105D missense_variant 0.99 0
6:394917:C N105H missense_variant 0.99 0
6:394884:C K94Q missense_variant 0.99 0
6:394983:T I127F missense_variant 0.99 0
6:394884:G K94E missense_variant 0.99 0
6:394885:C K94T missense_variant 0.99 0
6:394963:T D120V missense_variant 0.99 0
6:394963:G D120G missense_variant 0.99 0
6:394963:C D120A missense_variant 0.99 0
6:394983:C I127L missense_variant 0.99 0
6:394978:T Y125F missense_variant 0.99 0
6:394978:G Y125C missense_variant 0.99 0
6:394885:G K94R missense_variant 0.99 0
6:394885:T K94M missense_variant 0.99 0
6:394887:C T95P missense_variant 0.99 0
6:394956:T I118F missense_variant 0.99 0
6:394956:G I118V missense_variant 0.99 0
6:394956:C I118L missense_variant 0.99 0
6:394909:T N102I missense_variant 0.99 0
6:394927:T E108V missense_variant 0.99 0
6:394927:G E108G missense_variant 0.99 0
6:394921:T D106V missense_variant 0.99 0
6:394930:T E109V missense_variant 0.99 0
6:394930:G E109G missense_variant 0.99 0
6:394930:C E109A missense_variant 0.99 0
6:394908:C N102H missense_variant 0.99 0
6:394908:G N102D missense_variant 0.99 0
6:394908:T N102Y missense_variant 0.99 0
6:394909:C N102T missense_variant 0.99 0
6:394909:G N102S missense_variant 0.99 0
6:394953:A D117N missense_variant 0.99 0
6:394953:C D117H missense_variant 0.99 0
6:394953:T D117Y missense_variant 0.99 0
6:394884:T K94* stop_gained 0.98 0
6:394915:A S104N missense_variant 0.98 0
6:394974:T V124L missense_variant 0.98 0
6:394974:C V124L missense_variant 0.98 0
6:394974:A V124M missense_variant 0.98 0
6:394962:T D120Y missense_variant 0.98 0
6:394962:C D120H missense_variant 0.98 0
6:394962:A D120N missense_variant 0.98 0
6:394945:T S114I missense_variant 0.98 0
6:394945:C S114T missense_variant 0.98 0
6:394945:A S114N missense_variant 0.98 0
6:394942:T R113L missense_variant 0.98 0
6:394942:C R113P missense_variant 0.98 0
6:394942:A R113Q missense_variant 0.98 0
6:394938:C E112Q missense_variant 0.98 0
6:394938:A E112K missense_variant 0.98 0
6:394929:C E109Q missense_variant 0.98 0
6:394929:A E109K missense_variant 0.98 0
6:394920:A D106N missense_variant 0.98 0
6:394915:T S104I missense_variant 0.98 0
6:394915:C S104T missense_variant 0.98 0
6:394902:T A100S missense_variant 0.98 0
6:394902:C A100P missense_variant 0.98 0
6:394902:A A100T missense_variant 0.98 0
6:394900:T C99F missense_variant 0.98 0
6:394900:A C99Y missense_variant 0.98 0
6:394897:T R98L missense_variant 0.98 0
6:394897:C R98P missense_variant 0.98 0
6:394897:A R98Q missense_variant 0.98 0
6:394891:T R96L missense_variant 0.98 0
6:394891:C R96P missense_variant 0.98 0
6:394891:A R96H missense_variant 0.98 0
6:394869:A D89N missense_variant 0.98 0
6:394869:C D89H missense_variant 0.98 0
6:394869:T D89Y missense_variant 0.98 0
6:394883:T W93C missense_variant 0.98 0
6:394883:C W93C missense_variant 0.98 0
6:394882:T W93L missense_variant 0.98 0
6:394882:C W93S missense_variant 0.98 0
6:394861:T D86V missense_variant 0.98 0
6:394861:G D86G missense_variant 0.98 0
6:394861:C D86A missense_variant 0.98 0
6:394852:C E83A missense_variant 0.98 0
6:394852:T E83V missense_variant 0.98 0
6:394864:T K87M missense_variant 0.98 0
6:394852:G E83G missense_variant 0.98 0
6:394864:C K87T missense_variant 0.98 0
6:394863:G K87E missense_variant 0.98 0
6:394864:G K87R missense_variant 0.98 0
6:394863:C K87Q missense_variant 0.98 0
6:394855:C G84A missense_variant 0.98 0
6:394851:C E83Q missense_variant 0.98 0
6:394851:A E83K missense_variant 0.98 0
6:394860:T D86Y missense_variant 0.98 0
6:394860:C D86H missense_variant 0.98 0
6:394860:A D86N missense_variant 0.98 0
6:394855:T G84V missense_variant 0.98 0
6:394855:A G84D missense_variant 0.98 0
6:394854:T G84C missense_variant 0.98 0
6:394854:C G84R missense_variant 0.98 0
6:394854:A G84S missense_variant 0.98 0
6:394883:A W93* stop_gained 0.98 0
6:394882:A W93* stop_gained 0.98 0
6:394929:T E109* stop_gained 0.98 0
6:394938:T E112* stop_gained 0.98 0
6:394863:T K87* stop_gained 0.98 0
6:393232:C W27S missense_variant 0.98 0
6:393240:T D30Y missense_variant 0.98 0
6:393240:A D30N missense_variant 0.98 0
6:393233:T W27C missense_variant 0.98 0
6:393233:C W27C missense_variant 0.98 0
6:393226:T R25L missense_variant 0.98 0
6:393232:T W27L missense_variant 0.98 0
6:393226:C R25P missense_variant 0.98 0
6:393226:A R25H missense_variant 0.98 0
6:393240:C D30H missense_variant 0.98 0
6:393354:C A68P missense_variant 0.98 0
6:393351:C D67H missense_variant 0.98 0
6:393351:T D67Y missense_variant 0.98 0
6:393354:A A68T missense_variant 0.98 0
6:393351:A D67N missense_variant 0.98 0
6:393368:T K72N missense_variant 0.98 0
6:393368:C K72N missense_variant 0.98 0
6:393354:T A68S missense_variant 0.98 0
6:393345:A E65K missense_variant 0.98 0
6:393321:A A57T missense_variant 0.98 0
6:393321:C A57P missense_variant 0.98 0
6:393321:T A57S missense_variant 0.98 0
6:393324:A G58S missense_variant 0.98 0
6:393324:C G58R missense_variant 0.98 0
6:393324:T G58C missense_variant 0.98 0
6:393325:A G58D missense_variant 0.98 0
6:393325:C G58A missense_variant 0.98 0
6:393325:T G58V missense_variant 0.98 0
6:393333:A D61N missense_variant 0.98 0
6:393333:C D61H missense_variant 0.98 0
6:393333:T D61Y missense_variant 0.98 0
6:393345:C E65Q missense_variant 0.98 0
6:393348:A E66K missense_variant 0.98 0
6:393348:C E66Q missense_variant 0.98 0
6:394851:T E83* stop_gained 0.98 0
6:393313:T W54L missense_variant 0.98 0
6:393314:T W54C missense_variant 0.98 0
6:394821:T A73S missense_variant 0.98 0
6:393313:C W54S missense_variant 0.98 0
6:393314:C W54C missense_variant 0.98 0
6:394825:T W74L missense_variant 0.98 0
6:394825:C W74S missense_variant 0.98 0
6:394821:C A73P missense_variant 0.98 0
6:394821:A A73T missense_variant 0.98 0
6:393278:C W42C missense_variant 0.97 0
6:393277:T W42L missense_variant 0.97 0
6:393277:C W42S missense_variant 0.97 0
6:393268:T G39V missense_variant 0.97 0
6:393268:C G39A missense_variant 0.97 0
6:393268:A G39E missense_variant 0.97 0
6:393267:T G39W missense_variant 0.97 0
6:393279:A E43K missense_variant 0.97 0
6:393304:C R51P missense_variant 0.97 0
6:393304:A R51H missense_variant 0.97 0
6:393288:C E46Q missense_variant 0.97 0
6:393288:A E46K missense_variant 0.97 0
6:393285:C E45Q missense_variant 0.97 0
6:393285:A E45K missense_variant 0.97 0
6:393279:C E43Q missense_variant 0.97 0
6:393304:T R51L missense_variant 0.97 0
6:393278:T W42C missense_variant 0.97 0
6:393267:C G39R missense_variant 0.97 0
6:393267:A G39R missense_variant 0.97 0
6:393249:T D33Y missense_variant 0.97 0
6:393249:C D33H missense_variant 0.97 0
6:393249:A D33N missense_variant 0.97 0
6:394827:T A75S missense_variant 0.97 0
6:394826:C W74C missense_variant 0.97 0
6:394826:T W74C missense_variant 0.97 0
6:394827:A A75T missense_variant 0.97 0
6:394827:C A75P missense_variant 0.97 0
6:394840:T G79V missense_variant 0.97 0
6:394840:C G79A missense_variant 0.97 0
6:394840:A G79E missense_variant 0.97 0
6:394839:C G79R missense_variant 0.97 0
6:394839:A G79R missense_variant 0.97 0
6:393232:A W27* stop_gained 0.97 0
6:393233:A W27* stop_gained 0.97 0
6:393368:A K72K splice_region_variant 0.97 0
6:393348:T E66* stop_gained 0.97 0
6:393345:T E65* stop_gained 0.97 0
6:393314:A W54* stop_gained 0.97 0
6:393313:A W54* stop_gained 0.97 0
6:394825:A W74* stop_gained 0.97 0
6:393288:T E46* stop_gained 0.97 0
6:393277:A W42* stop_gained 0.97 0
6:393279:T E43* stop_gained 0.97 0
6:393285:T E45* stop_gained 0.97 0
6:393278:A W42* stop_gained 0.97 0
6:394826:A W74* stop_gained 0.97 0
6:394839:T G79* stop_gained 0.97 0
6:393327:C K59Q missense_variant 0.96 0
6:393327:G K59E missense_variant 0.96 0
6:393328:C K59T missense_variant 0.96 0
6:393328:T K59M missense_variant 0.96 0
6:393258:G K36E missense_variant 0.96 0
6:393258:C K36Q missense_variant 0.96 0
6:393327:T K59* stop_gained 0.95 0
6:393258:T K36* stop_gained 0.95 0
6:393334:C D61A missense_variant 0.94 0
6:393334:G D61G missense_variant 0.94 0
6:393334:T D61V missense_variant 0.94 0
6:393337:C Y62S missense_variant 0.94 0
6:393337:G Y62C missense_variant 0.94 0
6:393337:T Y62F missense_variant 0.94 0
6:393339:C N63H missense_variant 0.94 0
6:393339:G N63D missense_variant 0.94 0
6:393339:T N63Y missense_variant 0.94 0
6:393340:C N63T missense_variant 0.94 0
6:393340:G N63S missense_variant 0.94 0
6:393340:T N63I missense_variant 0.94 0
6:393346:C E65A missense_variant 0.94 0
6:393346:T E65V missense_variant 0.94 0
6:393346:G E65G missense_variant 0.94 0
6:393331:C Q60P missense_variant 0.94 0
6:393331:G Q60R missense_variant 0.94 0
6:393331:T Q60L missense_variant 0.94 0
6:393291:G K47E missense_variant 0.94 0
6:393250:C D33A missense_variant 0.94 0
6:393250:G D33G missense_variant 0.94 0
6:393250:T D33V missense_variant 0.94 0
6:393262:C Y37S missense_variant 0.94 0
6:393262:G Y37C missense_variant 0.94 0
6:393262:T Y37F missense_variant 0.94 0
6:393280:C E43A missense_variant 0.94 0
6:393306:T I52F missense_variant 0.94 0
6:393306:G I52V missense_variant 0.94 0
6:393306:C I52L missense_variant 0.94 0
6:393280:G E43G missense_variant 0.94 0
6:393280:T E43V missense_variant 0.94 0
6:393282:C N44H missense_variant 0.94 0
6:393282:G N44D missense_variant 0.94 0
6:393282:T N44Y missense_variant 0.94 0
6:393283:C N44T missense_variant 0.94 0
6:393283:G N44S missense_variant 0.94 0
6:393283:T N44I missense_variant 0.94 0
6:393289:C E46A missense_variant 0.94 0
6:393289:G E46G missense_variant 0.94 0
6:393289:T E46V missense_variant 0.94 0
6:393291:C K47Q missense_variant 0.94 0
6:394843:G K80R missense_variant 0.94 0
6:394837:T K78I missense_variant 0.94 0
6:394837:G K78R missense_variant 0.94 0
6:394837:C K78T missense_variant 0.94 0
6:394843:T K80M missense_variant 0.94 0
6:394836:G K78E missense_variant 0.94 0
6:394836:C K78Q missense_variant 0.94 0
6:394842:G K80E missense_variant 0.94 0
6:394842:C K80Q missense_variant 0.94 0
6:394843:C K80T missense_variant 0.94 0
6:393367:G K72R missense_variant 0.94 0
6:393366:G K72E missense_variant 0.94 0
6:393352:C D67A missense_variant 0.94 0
6:393352:G D67G missense_variant 0.94 0
6:393352:T D67V missense_variant 0.94 0
6:393366:C K72Q missense_variant 0.94 0
6:393367:T K72M missense_variant 0.94 0
6:393367:C K72T missense_variant 0.94 0
6:393319:T H56L missense_variant 0.94 0
6:393315:C K55Q missense_variant 0.94 0
6:393315:G K55E missense_variant 0.94 0
6:393316:C K55T missense_variant 0.94 0
6:393316:G K55R missense_variant 0.94 0
6:393316:T K55M missense_variant 0.94 0
6:393319:C H56P missense_variant 0.94 0
6:393319:G H56R missense_variant 0.94 0
6:393237:G I29V missense_variant 0.94 0
6:393244:C Q31P missense_variant 0.94 0
6:393241:T D30V missense_variant 0.94 0
6:393241:G D30G missense_variant 0.94 0
6:393237:T I29F missense_variant 0.94 0
6:393244:G Q31R missense_variant 0.94 0
6:393237:C I29L missense_variant 0.94 0
6:393241:C D30A missense_variant 0.94 0
6:393229:T Q26L missense_variant 0.94 0
6:393244:T Q31L missense_variant 0.94 0
6:393229:C Q26P missense_variant 0.94 0
6:393229:G Q26R missense_variant 0.94 0
6:393291:T K47* stop_gained 0.93 0
6:394842:T K80* stop_gained 0.92 0
6:394836:T K78* stop_gained 0.92 0
6:393366:T K72* stop_gained 0.92 0
6:393315:T K55* stop_gained 0.92 0
6:394966:G P121R missense_variant 0.91 0
6:394966:T P121L missense_variant 0.91 0
6:394966:A P121Q missense_variant 0.91 0
6:394965:T P121S missense_variant 0.91 0
6:394965:G P121A missense_variant 0.91 0
6:394968:C Y122H missense_variant 0.88 0
6:394968:G Y122D missense_variant 0.88 0
6:394968:A Y122N missense_variant 0.88 0
6:394857:T I85F missense_variant 0.86 0
6:394857:C I85L missense_variant 0.86 0
6:394857:G I85V missense_variant 0.86 0
6:393253:T S34I missense_variant 0.84 0
6:393253:A S34N missense_variant 0.84 0
6:393253:C S34T missense_variant 0.84 0
6:401724:G K349R missense_variant 0.84 0
6:401747:C K357Q missense_variant 0.84 0
6:401747:G K357E missense_variant 0.84 0
6:401724:C K349T missense_variant 0.84 0
6:401724:T K349I missense_variant 0.84 0
6:393322:A A57E missense_variant 0.82 0
6:393330:A Q60K missense_variant 0.82 0
6:393322:T A57V missense_variant 0.82 0
6:393322:G A57G missense_variant 0.82 0
6:393330:G Q60E missense_variant 0.82 0
6:394924:C F107S missense_variant 0.81 0
6:394924:A F107Y missense_variant 0.81 0
6:394923:G F107V missense_variant 0.81 0
6:394923:C F107L missense_variant 0.81 0
6:394923:A F107I missense_variant 0.81 0
6:394894:A L97Q missense_variant 0.81 0
6:394894:C L97P missense_variant 0.81 0
6:394894:G L97R missense_variant 0.81 0
6:394975:A V124E missense_variant 0.81 0
6:394987:G V128G missense_variant 0.81 0
6:394987:C V128A missense_variant 0.81 0
6:394987:A V128D missense_variant 0.81 0
6:394975:G V124G missense_variant 0.81 0
6:394975:C V124A missense_variant 0.81 0
6:394984:G I127S missense_variant 0.81 0
6:394984:C I127T missense_variant 0.81 0
6:394984:A I127N missense_variant 0.81 0
6:394977:G Y125D missense_variant 0.81 0
6:394977:C Y125H missense_variant 0.81 0
6:394977:A Y125N missense_variant 0.81 0
6:394957:A I118N missense_variant 0.81 0
6:394957:G I118S missense_variant 0.81 0
6:394959:A S119T missense_variant 0.81 0
6:394951:C L116P missense_variant 0.81 0
6:394951:A L116Q missense_variant 0.81 0
6:394959:C S119P missense_variant 0.81 0
6:394906:C L101S missense_variant 0.81 0
6:394906:G L101W missense_variant 0.81 0
6:394881:A W93R missense_variant 0.81 0
6:394881:C W93R missense_variant 0.81 0
6:394881:G W93G missense_variant 0.81 0
6:394959:G S119A missense_variant 0.81 0
6:394899:A C99S missense_variant 0.81 0
6:394933:G L110R missense_variant 0.81 0
6:394933:C L110P missense_variant 0.81 0
6:394933:A L110Q missense_variant 0.81 0
6:394899:C C99R missense_variant 0.81 0
6:394899:G C99G missense_variant 0.81 0
6:394924:G F107C missense_variant 0.81 0
6:394957:C I118T missense_variant 0.81 0
6:394849:C R82P missense_variant 0.81 0
6:394849:T R82L missense_variant 0.81 0
6:394849:A R82Q missense_variant 0.81 0
6:405129:T H404L missense_variant 0.80 0
6:401424:C D249A missense_variant 0.80 0
6:401424:G D249G missense_variant 0.80 0
6:401424:T D249V missense_variant 0.80 0
6:401436:C H253P missense_variant 0.80 0
6:401436:G H253R missense_variant 0.80 0
6:401436:T H253L missense_variant 0.80 0
6:401457:C E260A missense_variant 0.80 0
6:401457:G E260G missense_variant 0.80 0
6:401457:T E260V missense_variant 0.80 0
6:401472:C E265A missense_variant 0.80 0
6:401472:G E265G missense_variant 0.80 0
6:401472:T E265V missense_variant 0.80 0
6:401477:C T267P missense_variant 0.80 0
6:401477:G T267A missense_variant 0.80 0
6:401477:T T267S missense_variant 0.80 0
6:401486:C S270R missense_variant 0.80 0
6:401486:G S270G missense_variant 0.80 0
6:401486:T S270C missense_variant 0.80 0
6:401493:C E272A missense_variant 0.80 0
6:401493:G E272G missense_variant 0.80 0
6:401493:T E272V missense_variant 0.80 0
6:401643:C D322A missense_variant 0.80 0
6:401643:G D322G missense_variant 0.80 0
6:401643:T D322V missense_variant 0.80 0
6:401652:C Y325S missense_variant 0.80 0
6:401652:G Y325C missense_variant 0.80 0
6:401652:T Y325F missense_variant 0.80 0
6:401720:C N348H missense_variant 0.80 0
6:401720:G N348D missense_variant 0.80 0
6:401720:T N348Y missense_variant 0.80 0
6:401721:C N348T missense_variant 0.80 0
6:401721:G N348S missense_variant 0.80 0
6:401721:T N348I missense_variant 0.80 0
6:401730:C E351A missense_variant 0.80 0
6:401730:T E351V missense_variant 0.80 0
6:405018:C E367A missense_variant 0.80 0
6:405018:G E367G missense_variant 0.80 0
6:405018:T E367V missense_variant 0.80 0
6:405084:C E389A missense_variant 0.80 0
6:405084:G E389G missense_variant 0.80 0
6:405084:T E389V missense_variant 0.80 0
6:405087:C E390A missense_variant 0.80 0
6:405087:G E390G missense_variant 0.80 0
6:405087:T E390V missense_variant 0.80 0
6:405096:C D393A missense_variant 0.80 0
6:405096:G D393G missense_variant 0.80 0
6:405096:T D393V missense_variant 0.80 0
6:405102:C Q395P missense_variant 0.80 0
6:405102:G Q395R missense_variant 0.80 0
6:405102:T Q395L missense_variant 0.80 0
6:405129:C H404P missense_variant 0.80 0
6:405129:G H404R missense_variant 0.80 0
6:394903:T A100V missense_variant 0.79 0
6:394888:G T95R missense_variant 0.79 0
6:394903:A A100D missense_variant 0.79 0
6:394888:T T95M missense_variant 0.79 0
6:394879:A T92N missense_variant 0.79 0
6:394947:A Q115K missense_variant 0.79 0
6:394947:G Q115E missense_variant 0.79 0
6:394879:T T92I missense_variant 0.79 0
6:394876:T P91L missense_variant 0.79 0
6:394876:G P91R missense_variant 0.79 0
6:394876:A P91H missense_variant 0.79 0
6:394873:T P90L missense_variant 0.79 0
6:394873:G P90R missense_variant 0.79 0
6:394873:A P90H missense_variant 0.79 0
6:394879:G T92S missense_variant 0.79 0
6:394872:T P90S missense_variant 0.79 0
6:394872:G P90A missense_variant 0.79 0
6:394872:A P90T missense_variant 0.79 0
6:394960:T S119L missense_variant 0.79 0
6:394888:A T95K missense_variant 0.79 0
6:394903:G A100G missense_variant 0.79 0
6:401759:G T361A missense_variant 0.79 0
6:401759:T T361S missense_variant 0.79 0
6:395001:C K133Q missense_variant 0.79 0
6:395001:G K133E missense_variant 0.79 0
6:395002:T K133I missense_variant 0.79 0
6:395002:C K133T missense_variant 0.79 0
6:395002:G K133R missense_variant 0.79 0
6:394993:C E130A missense_variant 0.79 0
6:401757:T D360V missense_variant 0.79 0
6:401759:C T361P missense_variant 0.79 0
6:395004:C K134Q missense_variant 0.79 0
6:395004:G K134E missense_variant 0.79 0
6:394993:T E130V missense_variant 0.79 0
6:394993:G E130G missense_variant 0.79 0
6:401757:C D360A missense_variant 0.79 0
6:401757:G D360G missense_variant 0.79 0
6:401580:T R301M missense_variant 0.79 0
6:401580:A R301K missense_variant 0.79 0
6:401580:C R301T missense_variant 0.79 0
6:401747:T K357* stop_gained 0.79 0
6:393243:G Q31E missense_variant 0.77 0
6:393318:G H56D missense_variant 0.77 0
6:393318:T H56Y missense_variant 0.77 0
6:393243:A Q31K missense_variant 0.77 0
6:393228:G Q26E missense_variant 0.77 0
6:393228:A Q26K missense_variant 0.77 0
6:394822:A A73D missense_variant 0.77 0
6:394822:G A73G missense_variant 0.77 0
6:393318:A H56N missense_variant 0.77 0
6:394822:T A73V missense_variant 0.77 0
6:394926:A E108K missense_variant 0.77 0
6:394926:C E108Q missense_variant 0.77 0
6:393330:T Q60* stop_gained 0.77 0
6:393358:A A69E missense_variant 0.76 0
6:393355:G A68G missense_variant 0.76 0
6:393355:A A68D missense_variant 0.76 0
6:393355:T A68V missense_variant 0.76 0
6:393358:T A69V missense_variant 0.76 0
6:393358:G A69G missense_variant 0.76 0
6:394906:A L101* stop_gained 0.76 0
6:394867:G P88R missense_variant 0.76 0
6:394867:A P88Q missense_variant 0.76 0
6:394867:T P88L missense_variant 0.76 0
6:394833:G F77V missense_variant 0.75 0
6:394833:C F77L missense_variant 0.75 0
6:394833:A F77I missense_variant 0.75 0
6:394831:G L76R missense_variant 0.75 0
6:394831:C L76P missense_variant 0.75 0
6:394831:A L76Q missense_variant 0.75 0
6:395004:T K134* stop_gained 0.74 0
6:395001:T K133* stop_gained 0.74 0
6:394960:G S119* stop_gained 0.74 0
6:394960:A S119* stop_gained 0.74 0
6:394947:T Q115* stop_gained 0.74 0
6:393309:G P53A missense_variant 0.74 0
6:393310:T P53L missense_variant 0.74 0
6:393310:G P53R missense_variant 0.74 0
6:393265:G P38R missense_variant 0.74 0
6:393309:T P53S missense_variant 0.74 0
6:393310:A P53H missense_variant 0.74 0
6:393265:A P38H missense_variant 0.74 0
6:393309:A P53T missense_variant 0.74 0
6:393265:T P38L missense_variant 0.74 0
6:393336:G Y62D missense_variant 0.73 0
6:393336:A Y62N missense_variant 0.73 0
6:393336:C Y62H missense_variant 0.73 0
6:394828:G A75G missense_variant 0.73 0
6:394828:A A75E missense_variant 0.73 0
6:394828:T A75V missense_variant 0.73 0
6:401642:A D322N missense_variant 0.73 0
6:394992:A E130K missense_variant 0.73 0
6:394992:C E130Q missense_variant 0.73 0
6:394995:A G131R missense_variant 0.73 0
6:394995:C G131R missense_variant 0.73 0
6:394996:A G131E missense_variant 0.73 0
6:394996:C G131A missense_variant 0.73 0
6:394996:T G131V missense_variant 0.73 0
6:401456:A E260K missense_variant 0.73 0
6:401456:C E260Q missense_variant 0.73 0
6:401777:A E367K missense_variant 0.73 0
6:401777:C E367Q missense_variant 0.73 0
6:401465:A V263M missense_variant 0.73 0
6:401465:C V263L missense_variant 0.73 0
6:401465:T V263L missense_variant 0.73 0
6:401471:A E265K missense_variant 0.73 0
6:401471:C E265Q missense_variant 0.73 0
6:405095:C D393H missense_variant 0.73 0
6:405095:T D393Y missense_variant 0.73 0
6:405111:C R398T missense_variant 0.73 0
6:405045:A R376H missense_variant 0.73 0
6:405045:C R376P missense_variant 0.73 0
6:405045:T R376L missense_variant 0.73 0
6:405080:A G388R missense_variant 0.73 0
6:405080:C G388R missense_variant 0.73 0
6:405081:A G388E missense_variant 0.73 0
6:405081:C G388A missense_variant 0.73 0
6:401495:A G273S missense_variant 0.73 0
6:401495:C G273R missense_variant 0.73 0
6:401495:T G273C missense_variant 0.73 0
6:401496:A G273D missense_variant 0.73 0
6:401496:C G273A missense_variant 0.73 0
6:401496:T G273V missense_variant 0.73 0
6:401499:A C274Y missense_variant 0.73 0
6:401499:C C274S missense_variant 0.73 0
6:401499:T C274F missense_variant 0.73 0
6:401591:A E305K missense_variant 0.73 0
6:401591:C E305Q missense_variant 0.73 0
6:401618:A G314S missense_variant 0.73 0
6:401618:C G314R missense_variant 0.73 0
6:401618:T G314C missense_variant 0.73 0
6:401619:A G314D missense_variant 0.73 0
6:401619:C G314A missense_variant 0.73 0
6:401619:T G314V missense_variant 0.73 0
6:401631:C W318S missense_variant 0.73 0
6:401631:T W318L missense_variant 0.73 0
6:401632:C W318C missense_variant 0.73 0
6:401632:T W318C missense_variant 0.73 0
6:401635:A M319I missense_variant 0.73 0
6:401635:C M319I missense_variant 0.73 0
6:401635:T M319I missense_variant 0.73 0
6:401642:C D322H missense_variant 0.73 0
6:401642:T D322Y missense_variant 0.73 0
6:405081:T G388V missense_variant 0.73 0
6:405083:A E389K missense_variant 0.73 0
6:405083:C E389Q missense_variant 0.73 0
6:401645:A G323R missense_variant 0.73 0
6:401645:C G323R missense_variant 0.73 0
6:401645:T G323W missense_variant 0.73 0
6:401646:A G323E missense_variant 0.73 0
6:401646:C G323A missense_variant 0.73 0
6:401646:T G323V missense_variant 0.73 0
6:405111:T R398I missense_variant 0.73 0
6:405125:A A403T missense_variant 0.73 0
6:401654:A A326T missense_variant 0.73 0
6:401654:C A326P missense_variant 0.73 0
6:401654:T A326S missense_variant 0.73 0
6:401661:A R328K missense_variant 0.73 0
6:401661:C R328T missense_variant 0.73 0
6:401661:T R328I missense_variant 0.73 0
6:401667:A C330Y missense_variant 0.73 0
6:401667:C C330S missense_variant 0.73 0
6:401667:T C330F missense_variant 0.73 0
6:401676:A R333K missense_variant 0.73 0
6:401676:C R333T missense_variant 0.73 0
6:401676:T R333M missense_variant 0.73 0
6:401685:C W336S missense_variant 0.73 0
6:401685:T W336L missense_variant 0.73 0
6:405125:C A403P missense_variant 0.73 0
6:405086:A E390K missense_variant 0.73 0
6:405086:C E390Q missense_variant 0.73 0
6:405125:T A403S missense_variant 0.73 0
6:401729:A E351K missense_variant 0.73 0
6:401729:C E351Q missense_variant 0.73 0
6:405111:A R398K missense_variant 0.73 0
6:405095:A D393N missense_variant 0.73 0
6:401735:A D353N missense_variant 0.73 0
6:401735:C D353H missense_variant 0.73 0
6:401735:T D353Y missense_variant 0.73 0
6:393363:A F71I missense_variant 0.73 0
6:393364:C F71S missense_variant 0.73 0
6:393361:G L70R missense_variant 0.73 0
6:393361:C L70P missense_variant 0.73 0
6:393363:C F71L missense_variant 0.73 0
6:393361:A L70H missense_variant 0.73 0
6:393364:A F71Y missense_variant 0.73 0
6:393364:G F71C missense_variant 0.73 0
6:393363:G F71V missense_variant 0.73 0
6:394824:C W74R missense_variant 0.73 0
6:394824:G W74G missense_variant 0.73 0
6:394824:A W74R missense_variant 0.73 0
6:393298:A I49N missense_variant 0.73 0
6:393312:A W54R missense_variant 0.73 0
6:393312:C W54R missense_variant 0.73 0
6:393312:G W54G missense_variant 0.73 0
6:393307:A I52N missense_variant 0.73 0
6:393301:G F50C missense_variant 0.73 0
6:393301:C F50S missense_variant 0.73 0
6:393301:A F50Y missense_variant 0.73 0
6:393300:G F50V missense_variant 0.73 0
6:393300:C F50L missense_variant 0.73 0
6:393300:A F50I missense_variant 0.73 0
6:393298:G I49S missense_variant 0.73 0
6:393298:C I49T missense_variant 0.73 0
6:393307:C I52T missense_variant 0.73 0
6:393307:G I52S missense_variant 0.73 0
6:393271:A L40Q missense_variant 0.73 0
6:393261:A Y37N missense_variant 0.73 0
6:393274:C V41A missense_variant 0.73 0
6:393271:G L40R missense_variant 0.73 0
6:393271:C L40P missense_variant 0.73 0
6:393274:G V41G missense_variant 0.73 0
6:393276:C W42R missense_variant 0.73 0
6:393276:G W42G missense_variant 0.73 0
6:393261:C Y37H missense_variant 0.73 0
6:393261:G Y37D missense_variant 0.73 0
6:393274:A V41E missense_variant 0.73 0
6:393276:A W42R missense_variant 0.73 0
6:393256:C G35A missense_variant 0.73 0
6:393256:A G35D missense_variant 0.73 0
6:393256:T G35V missense_variant 0.73 0
6:393247:G I32S missense_variant 0.73 0
6:393235:A L28Q missense_variant 0.73 0
6:393235:C L28P missense_variant 0.73 0
6:393235:G L28R missense_variant 0.73 0
6:393238:A I29N missense_variant 0.73 0
6:393238:C I29T missense_variant 0.73 0
6:393238:G I29S missense_variant 0.73 0
6:393247:A I32N missense_variant 0.73 0
6:393247:C I32T missense_variant 0.73 0
6:393223:G L24R missense_variant 0.73 0
6:393223:A L24H missense_variant 0.73 0
6:393223:C L24P missense_variant 0.73 0
6:393231:A W27R missense_variant 0.73 0
6:393231:C W27R missense_variant 0.73 0
6:393231:G W27G missense_variant 0.73 0
6:393228:T Q26* stop_gained 0.72 0
6:393243:T Q31* stop_gained 0.72 0
6:394926:T E108* stop_gained 0.71 0
6:401612:A E312K missense_variant 0.68 0
6:401612:C E312Q missense_variant 0.68 0
6:405080:T G388* stop_gained 0.68 0
6:401591:T E305* stop_gained 0.68 0
6:405086:T E390* stop_gained 0.68 0
6:401777:T E367* stop_gained 0.68 0
6:401471:T E265* stop_gained 0.68 0
6:401631:A W318* stop_gained 0.68 0
6:394992:T E130* stop_gained 0.68 0
6:401632:A W318* stop_gained 0.68 0
6:394995:T G131* stop_gained 0.68 0
6:405083:T E389* stop_gained 0.68 0
6:401685:A W336* stop_gained 0.68 0
6:401456:T E260* stop_gained 0.68 0
6:401729:T E351* stop_gained 0.68 0
6:393211:A G20D missense_variant 0.65 0
6:393217:A G22E missense_variant 0.65 0
6:393211:T G20V missense_variant 0.65 0
6:393217:C G22A missense_variant 0.65 0
6:393217:T G22V missense_variant 0.65 0
6:393211:C G20A missense_variant 0.65 0
6:401612:T E312* stop_gained 0.62 0
6:394918:T N105I missense_variant 0.62 0
6:394918:C N105T missense_variant 0.62 0
6:394918:G N105S missense_variant 0.62 0
6:393292:C K47T missense_variant 0.62 0
6:393292:G K47R missense_variant 0.62 0
6:393292:T K47M missense_variant 0.62 0
6:401613:G E312G missense_variant 0.52 0
6:401613:T E312V missense_variant 0.52 0
6:401613:C E312A missense_variant 0.52 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(MM) Multiple myeloma MM 0.56 0.15