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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
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Mutation AA change Consequence type BoostDM score IntOGen frequency
4:54728092:C V654A missense_variant 1.00 5
4:54733175:G Y823D missense_variant 1.00 4
4:54733174:G N822K missense_variant 0.99 3
4:54727495:C L576P missense_variant 1.00 2
4:54727444:C V559A missense_variant 0.99 2
4:54727444:A V559D missense_variant 0.99 2
4:54729353:T T670I missense_variant 0.98 2
4:54728055:G K642E missense_variant 0.96 2
4:54733175:C Y823H missense_variant 1.00 1
4:54727437:G W557G missense_variant 1.00 1
4:54727437:C W557R missense_variant 1.00 1
4:54733167:G D820G missense_variant 1.00 1
4:54733167:C D820A missense_variant 1.00 1
4:54733172:T N822Y missense_variant 1.00 1
4:54733154:C D816H missense_variant 1.00 1
4:54733168:G D820E missense_variant 0.99 1
4:54733168:A D820E missense_variant 0.99 1
4:54733174:A N822K missense_variant 0.99 1
4:54727447:A V560D missense_variant 0.99 1
4:54727503:T D579Y missense_variant 0.96 1
4:54733133:G C809G missense_variant 0.95 1
4:54736498:C A829P missense_variant 0.91 1
4:54727422:C M552L missense_variant 0.87 1
4:54733175:A Y823N missense_variant 1.00 0
4:54727437:A W557R missense_variant 1.00 0
4:54733167:T D820V missense_variant 1.00 0
4:54733172:G N822D missense_variant 1.00 0
4:54733172:C N822H missense_variant 1.00 0
4:54733154:T D816Y missense_variant 1.00 0
4:54733155:T D816V missense_variant 1.00 0
4:54733155:G D816G missense_variant 1.00 0
4:54733154:A D816N missense_variant 1.00 0
4:54733155:C D816A missense_variant 1.00 0
4:54733173:C N822T missense_variant 1.00 0
4:54733173:T N822I missense_variant 1.00 0
4:54733173:G N822S missense_variant 1.00 0
4:54728092:A V654E missense_variant 1.00 0
4:54728092:G V654G missense_variant 1.00 0
4:54727495:G L576R missense_variant 1.00 0
4:54727495:A L576H missense_variant 1.00 0
4:54733176:G Y823C missense_variant 1.00 0
4:54733176:T Y823F missense_variant 1.00 0
4:54733176:C Y823S missense_variant 1.00 0
4:54728091:C V654L missense_variant 1.00 0
4:54733134:A C809Y missense_variant 1.00 0
4:54733134:C C809S missense_variant 1.00 0
4:54733134:T C809F missense_variant 1.00 0
4:54728091:A V654M missense_variant 1.00 0
4:54733166:A D820N missense_variant 1.00 0
4:54733166:C D820H missense_variant 1.00 0
4:54733166:T D820Y missense_variant 1.00 0
4:54728091:T V654L missense_variant 1.00 0
4:54727439:T W557C missense_variant 0.99 0
4:54727439:C W557C missense_variant 0.99 0
4:54727438:C W557S missense_variant 0.99 0
4:54727438:T W557L missense_variant 0.99 0
4:54727519:A F584Y missense_variant 0.99 0
4:54727519:C F584S missense_variant 0.99 0
4:54727519:G F584C missense_variant 0.99 0
4:54727480:C I571T missense_variant 0.99 0
4:54727480:A I571K missense_variant 0.99 0
4:54727512:G W582G missense_variant 0.99 0
4:54727512:C W582R missense_variant 0.99 0
4:54727512:A W582R missense_variant 0.99 0
4:54727447:G V560G missense_variant 0.99 0
4:54727444:G V559G missense_variant 0.99 0
4:54727518:A F584I missense_variant 0.99 0
4:54727447:C V560A missense_variant 0.99 0
4:54727518:C F584L missense_variant 0.99 0
4:54727518:G F584V missense_variant 0.99 0
4:54727480:G I571R missense_variant 0.99 0
4:54727470:C Y568H missense_variant 0.99 0
4:54727500:G Y578D missense_variant 0.99 0
4:54727500:C Y578H missense_variant 0.99 0
4:54727500:A Y578N missense_variant 0.99 0
4:54727470:G Y568D missense_variant 0.99 0
4:54727470:A Y568N missense_variant 0.99 0
4:54727534:A L589Q missense_variant 0.99 0
4:54727540:G F591C missense_variant 0.99 0
4:54727540:A F591Y missense_variant 0.99 0
4:54727534:G L589R missense_variant 0.99 0
4:54727534:C L589P missense_variant 0.99 0
4:54727540:C F591S missense_variant 0.99 0
4:54723685:A G445R missense_variant 0.99 0
4:54723685:C G445R missense_variant 0.99 0
4:54727486:A P573Q missense_variant 0.98 0
4:54727485:T P573S missense_variant 0.98 0
4:54727485:G P573A missense_variant 0.98 0
4:54727485:A P573T missense_variant 0.98 0
4:54727498:G P577R missense_variant 0.98 0
4:54727497:T P577S missense_variant 0.98 0
4:54727497:G P577A missense_variant 0.98 0
4:54727497:A P577T missense_variant 0.98 0
4:54727491:G Q575E missense_variant 0.98 0
4:54727491:A Q575K missense_variant 0.98 0
4:54727486:T P573L missense_variant 0.98 0
4:54727486:G P573R missense_variant 0.98 0
4:54727521:A P585T missense_variant 0.98 0
4:54727521:G P585A missense_variant 0.98 0
4:54727521:T P585S missense_variant 0.98 0
4:54727434:A Q556K missense_variant 0.98 0
4:54727434:G Q556E missense_variant 0.98 0
4:54727522:A P585H missense_variant 0.98 0
4:54727522:G P585R missense_variant 0.98 0
4:54727522:T P585L missense_variant 0.98 0
4:54727498:T P577L missense_variant 0.98 0
4:54727498:A P577H missense_variant 0.98 0
4:54729376:G L678V missense_variant 0.98 0
4:54729353:A T670K missense_variant 0.98 0
4:54729353:G T670R missense_variant 0.98 0
4:54729338:G P665R missense_variant 0.98 0
4:54729338:A P665H missense_variant 0.98 0
4:54729376:T L678F missense_variant 0.98 0
4:54729338:T P665L missense_variant 0.98 0
4:54729376:A L678I missense_variant 0.98 0
4:54731912:C D759H missense_variant 0.98 0
4:54731912:A D759N missense_variant 0.98 0
4:54731912:T D759Y missense_variant 0.98 0
4:54727419:A P551T missense_variant 0.98 0
4:54727419:G P551A missense_variant 0.98 0
4:54727419:T P551S missense_variant 0.98 0
4:54727420:A P551H missense_variant 0.98 0
4:54727420:G P551R missense_variant 0.98 0
4:54727420:T P551L missense_variant 0.98 0
4:54727439:A W557* stop_gained 0.98 0
4:54727438:A W557* stop_gained 0.98 0
4:54729365:A C674Y missense_variant 0.98 0
4:54729365:T C674F missense_variant 0.98 0
4:54729365:C C674S missense_variant 0.98 0
4:54737257:A Q927K missense_variant 0.97 0
4:54737257:G Q927E missense_variant 0.97 0
4:54727425:G Y553D missense_variant 0.97 0
4:54727425:A Y553N missense_variant 0.97 0
4:54727425:C Y553H missense_variant 0.97 0
4:54731925:A A763D missense_variant 0.97 0
4:54731967:A A777E missense_variant 0.97 0
4:54731967:G A777G missense_variant 0.97 0
4:54731967:T A777V missense_variant 0.97 0
4:54736574:T S854F missense_variant 0.97 0
4:54736525:T P838S missense_variant 0.97 0
4:54731988:T A784V missense_variant 0.97 0
4:54731988:G A784G missense_variant 0.97 0
4:54731955:G S773C missense_variant 0.97 0
4:54736604:T S864F missense_variant 0.97 0
4:54731955:T S773F missense_variant 0.97 0
4:54736508:T P832L missense_variant 0.97 0
4:54736508:G P832R missense_variant 0.97 0
4:54736508:A P832H missense_variant 0.97 0
4:54736507:T P832S missense_variant 0.97 0
4:54736604:G S864C missense_variant 0.97 0
4:54736553:A T847K missense_variant 0.97 0
4:54731960:A Q775K missense_variant 0.97 0
4:54731988:A A784D missense_variant 0.97 0
4:54731960:G Q775E missense_variant 0.97 0
4:54736604:A S864Y missense_variant 0.97 0
4:54736507:G P832A missense_variant 0.97 0
4:54736507:A P832T missense_variant 0.97 0
4:54736525:G P838A missense_variant 0.97 0
4:54736553:T T847M missense_variant 0.97 0
4:54736553:G T847R missense_variant 0.97 0
4:54731925:T A763V missense_variant 0.97 0
4:54736574:A S854Y missense_variant 0.97 0
4:54736574:G S854C missense_variant 0.97 0
4:54736525:A P838T missense_variant 0.97 0
4:54736523:T A837V missense_variant 0.97 0
4:54731925:G A763G missense_variant 0.97 0
4:54736523:G A837G missense_variant 0.97 0
4:54736523:A A837E missense_variant 0.97 0
4:54731955:A S773Y missense_variant 0.97 0
4:54728107:T A659V missense_variant 0.97 0
4:54728113:G T661S missense_variant 0.97 0
4:54728113:A T661N missense_variant 0.97 0
4:54727865:T A606V missense_variant 0.97 0
4:54727865:G A606G missense_variant 0.97 0
4:54727865:A A606E missense_variant 0.97 0
4:54728038:T A636V missense_variant 0.97 0
4:54728113:T T661I missense_variant 0.97 0
4:54728079:T H650Y missense_variant 0.97 0
4:54728017:G A629G missense_variant 0.97 0
4:54728017:A A629D missense_variant 0.97 0
4:54728079:G H650D missense_variant 0.97 0
4:54728017:T A629V missense_variant 0.97 0
4:54728019:A H630N missense_variant 0.97 0
4:54728011:T P627L missense_variant 0.97 0
4:54728011:G P627R missense_variant 0.97 0
4:54728079:A H650N missense_variant 0.97 0
4:54728011:A P627Q missense_variant 0.97 0
4:54728019:G H630D missense_variant 0.97 0
4:54728019:T H630Y missense_variant 0.97 0
4:54727844:T A599V missense_variant 0.97 0
4:54727844:G A599G missense_variant 0.97 0
4:54727844:A A599D missense_variant 0.97 0
4:54728107:A A659D missense_variant 0.97 0
4:54728107:G A659G missense_variant 0.97 0
4:54727838:T A597V missense_variant 0.97 0
4:54727838:G A597G missense_variant 0.97 0
4:54727838:A A597D missense_variant 0.97 0
4:54728038:G A636G missense_variant 0.97 0
4:54728038:A A636D missense_variant 0.97 0
4:54727910:T A621V missense_variant 0.97 0
4:54727910:G A621G missense_variant 0.97 0
4:54727910:A A621D missense_variant 0.97 0
4:54729347:A V668D missense_variant 0.97 0
4:54729385:G F681V missense_variant 0.97 0
4:54729385:C F681L missense_variant 0.97 0
4:54729380:G L679W missense_variant 0.97 0
4:54729377:A L678H missense_variant 0.97 0
4:54729385:A F681I missense_variant 0.97 0
4:54729350:A I669N missense_variant 0.97 0
4:54729361:A C673S missense_variant 0.97 0
4:54729350:G I669S missense_variant 0.97 0
4:54729344:C L667P missense_variant 0.97 0
4:54729344:A L667Q missense_variant 0.97 0
4:54729350:C I669T missense_variant 0.97 0
4:54729409:G F689V missense_variant 0.97 0
4:54729361:C C673R missense_variant 0.97 0
4:54729361:G C673G missense_variant 0.97 0
4:54729409:C F689L missense_variant 0.97 0
4:54729409:A F689I missense_variant 0.97 0
4:54729377:G L678R missense_variant 0.97 0
4:54729380:C L679S missense_variant 0.97 0
4:54729377:C L678P missense_variant 0.97 0
4:54729344:G L667R missense_variant 0.97 0
4:54729389:G L682W missense_variant 0.97 0
4:54729389:C L682S missense_variant 0.97 0
4:54729347:G V668G missense_variant 0.97 0
4:54729347:C V668A missense_variant 0.97 0
4:54736811:A P896H missense_variant 0.97 0
4:54736735:G P871A missense_variant 0.97 0
4:54736735:T P871S missense_variant 0.97 0
4:54736729:T P869S missense_variant 0.97 0
4:54736729:G P869A missense_variant 0.97 0
4:54736729:A P869T missense_variant 0.97 0
4:54736759:A F879I missense_variant 0.97 0
4:54736759:C F879L missense_variant 0.97 0
4:54736759:G F879V missense_variant 0.97 0
4:54736760:A F879Y missense_variant 0.97 0
4:54736760:C F879S missense_variant 0.97 0
4:54736760:G F879C missense_variant 0.97 0
4:54736799:A P892H missense_variant 0.97 0
4:54736799:G P892R missense_variant 0.97 0
4:54733149:T A814V missense_variant 0.97 0
4:54733149:G A814G missense_variant 0.97 0
4:54733149:A A814D missense_variant 0.97 0
4:54733092:T A795V missense_variant 0.97 0
4:54733092:G A795G missense_variant 0.97 0
4:54733092:A A795D missense_variant 0.97 0
4:54733089:T A794V missense_variant 0.97 0
4:54733089:G A794G missense_variant 0.97 0
4:54733089:A A794E missense_variant 0.97 0
4:54733076:T H790Y missense_variant 0.97 0
4:54733076:G H790D missense_variant 0.97 0
4:54733076:A H790N missense_variant 0.97 0
4:54736799:T P892L missense_variant 0.97 0
4:54736820:G M899R missense_variant 0.97 0
4:54736820:C M899T missense_variant 0.97 0
4:54736820:A M899K missense_variant 0.97 0
4:54736811:T P896L missense_variant 0.97 0
4:54736811:G P896R missense_variant 0.97 0
4:54736735:A P871T missense_variant 0.97 0
4:54733110:A T801N missense_variant 0.97 0
4:54733110:T T801I missense_variant 0.97 0
4:54733110:G T801S missense_variant 0.97 0
4:54731915:A D760N missense_variant 0.97 0
4:54731915:C D760H missense_variant 0.97 0
4:54731915:T D760Y missense_variant 0.97 0
4:54731332:C D716H missense_variant 0.96 0
4:54731332:A D716N missense_variant 0.96 0
4:54731352:T M722I missense_variant 0.96 0
4:54731352:C M722I missense_variant 0.96 0
4:54731352:A M722I missense_variant 0.96 0
4:54731344:C E720Q missense_variant 0.96 0
4:54731358:T M724I missense_variant 0.96 0
4:54731358:C M724I missense_variant 0.96 0
4:54731358:A M724I missense_variant 0.96 0
4:54731353:T D723Y missense_variant 0.96 0
4:54731353:C D723H missense_variant 0.96 0
4:54731353:A D723N missense_variant 0.96 0
4:54731344:A E720K missense_variant 0.96 0
4:54731332:T D716Y missense_variant 0.96 0
4:54738433:G Y936C missense_variant 0.96 0
4:54738433:C Y936S missense_variant 0.96 0
4:54738433:T Y936F missense_variant 0.96 0
4:54727503:A D579N missense_variant 0.96 0
4:54727503:C D579H missense_variant 0.96 0
4:54728055:C K642Q missense_variant 0.96 0
4:54731888:A D751N missense_variant 0.96 0
4:54731888:T D751Y missense_variant 0.96 0
4:54731888:C D751H missense_variant 0.96 0
4:54723685:T G445* stop_gained 0.95 0
4:54733133:C C809R missense_variant 0.95 0
4:54733133:A C809S missense_variant 0.95 0
4:54736600:A F863I missense_variant 0.95 0
4:54736607:C L865S missense_variant 0.95 0
4:54736603:G S864A missense_variant 0.95 0
4:54736603:C S864P missense_variant 0.95 0
4:54736603:A S864T missense_variant 0.95 0
4:54736601:G F863C missense_variant 0.95 0
4:54736601:C F863S missense_variant 0.95 0
4:54736601:A F863Y missense_variant 0.95 0
4:54736600:G F863V missense_variant 0.95 0
4:54736600:C F863L missense_variant 0.95 0
4:54736598:G L862R missense_variant 0.95 0
4:54736598:C L862P missense_variant 0.95 0
4:54736598:A L862Q missense_variant 0.95 0
4:54736591:G W860G missense_variant 0.95 0
4:54736591:C W860R missense_variant 0.95 0
4:54736591:A W860R missense_variant 0.95 0
4:54736589:G L859R missense_variant 0.95 0
4:54736589:C L859P missense_variant 0.95 0
4:54736589:A L859H missense_variant 0.95 0
4:54736586:G F858C missense_variant 0.95 0
4:54736586:C F858S missense_variant 0.95 0
4:54736586:A F858Y missense_variant 0.95 0
4:54736583:G I857S missense_variant 0.95 0
4:54736583:C I857T missense_variant 0.95 0
4:54736583:A I857N missense_variant 0.95 0
4:54736576:G Y855D missense_variant 0.95 0
4:54736576:C Y855H missense_variant 0.95 0
4:54736576:A Y855N missense_variant 0.95 0
4:54736573:G S854A missense_variant 0.95 0
4:54736573:C S854P missense_variant 0.95 0
4:54736573:A S854T missense_variant 0.95 0
4:54736570:G W853G missense_variant 0.95 0
4:54736570:C W853R missense_variant 0.95 0
4:54736570:A W853R missense_variant 0.95 0
4:54736568:G V852G missense_variant 0.95 0
4:54736568:C V852A missense_variant 0.95 0
4:54736568:A V852D missense_variant 0.95 0
4:54736549:G Y846D missense_variant 0.95 0
4:54736549:C Y846H missense_variant 0.95 0
4:54736549:A Y846N missense_variant 0.95 0
4:54736547:G V845G missense_variant 0.95 0
4:54736547:C V845A missense_variant 0.95 0
4:54736547:A V845E missense_variant 0.95 0
4:54736538:G F842C missense_variant 0.95 0
4:54736538:C F842S missense_variant 0.95 0
4:54736538:A F842Y missense_variant 0.95 0
4:54736537:G F842V missense_variant 0.95 0
4:54736537:C F842L missense_variant 0.95 0
4:54736537:A F842I missense_variant 0.95 0
4:54736535:G I841S missense_variant 0.95 0
4:54736535:C I841T missense_variant 0.95 0
4:54736535:A I841N missense_variant 0.95 0
4:54736520:G M836R missense_variant 0.95 0
4:54736520:C M836T missense_variant 0.95 0
4:54736520:A M836K missense_variant 0.95 0
4:54736516:G W835G missense_variant 0.95 0
4:54736516:C W835R missense_variant 0.95 0
4:54736516:A W835R missense_variant 0.95 0
4:54736511:G V833G missense_variant 0.95 0
4:54736511:C V833A missense_variant 0.95 0
4:54736511:A V833E missense_variant 0.95 0
4:54736505:G L831R missense_variant 0.95 0
4:54736505:C L831P missense_variant 0.95 0
4:54736505:A L831Q missense_variant 0.95 0
4:54733179:G V824G missense_variant 0.95 0
4:54733179:C V824A missense_variant 0.95 0
4:54733179:A V824E missense_variant 0.95 0
4:54731985:G L783R missense_variant 0.95 0
4:54731985:C L783P missense_variant 0.95 0
4:54731985:A L783H missense_variant 0.95 0
4:54731981:G F782V missense_variant 0.95 0
4:54731981:C F782L missense_variant 0.95 0
4:54731981:A F782I missense_variant 0.95 0
4:54731977:T M780I missense_variant 0.95 0
4:54731977:C M780I missense_variant 0.95 0
4:54731977:A M780I missense_variant 0.95 0
4:54731976:G M780R missense_variant 0.95 0
4:54731976:C M780T missense_variant 0.95 0
4:54731976:A M780K missense_variant 0.95 0
4:54731964:G V776G missense_variant 0.95 0
4:54731964:C V776A missense_variant 0.95 0
4:54731964:A V776E missense_variant 0.95 0
4:54731952:G F772C missense_variant 0.95 0
4:54731952:C F772S missense_variant 0.95 0
4:54731952:A F772Y missense_variant 0.95 0
4:54727876:A G610S missense_variant 0.95 0
4:54727876:C G610R missense_variant 0.95 0
4:54727876:T G610C missense_variant 0.95 0
4:54731951:G F772V missense_variant 0.95 0
4:54731951:C F772L missense_variant 0.95 0
4:54731951:A F772I missense_variant 0.95 0
4:54731943:G L769W missense_variant 0.95 0
4:54731943:C L769S missense_variant 0.95 0
4:54731928:G L764R missense_variant 0.95 0
4:54731928:C L764P missense_variant 0.95 0
4:54731928:A L764Q missense_variant 0.95 0
4:54729355:C E671Q missense_variant 0.94 0
4:54737210:T P911L missense_variant 0.94 0
4:54737221:A P915T missense_variant 0.94 0
4:54737221:G P915A missense_variant 0.94 0
4:54737221:T P915S missense_variant 0.94 0
4:54737225:A T916K missense_variant 0.94 0
4:54729355:A E671K missense_variant 0.94 0
4:54737209:A P911T missense_variant 0.94 0
4:54737209:G P911A missense_variant 0.94 0
4:54729395:C R684T missense_variant 0.94 0
4:54729395:T R684I missense_variant 0.94 0
4:54737209:T P911S missense_variant 0.94 0
4:54729395:A R684K missense_variant 0.94 0
4:54737225:T T916I missense_variant 0.94 0
4:54737225:G T916R missense_variant 0.94 0
4:54737210:A P911H missense_variant 0.94 0
4:54737210:G P911R missense_variant 0.94 0
4:54727491:T Q575* stop_gained 0.94 0
4:54727434:T Q556* stop_gained 0.94 0
4:54727482:A D572N missense_variant 0.93 0
4:54727482:T D572Y missense_variant 0.93 0
4:54727482:C D572H missense_variant 0.93 0
4:54728041:G L637R missense_variant 0.92 0
4:54727847:G F600C missense_variant 0.92 0
4:54728044:A M638K missense_variant 0.92 0
4:54728044:C M638T missense_variant 0.92 0
4:54728044:G M638R missense_variant 0.92 0
4:54727847:C F600S missense_variant 0.92 0
4:54727847:A F600Y missense_variant 0.92 0
4:54727846:G F600V missense_variant 0.92 0
4:54728046:A S639T missense_variant 0.92 0
4:54728046:C S639P missense_variant 0.92 0
4:54728046:G S639A missense_variant 0.92 0
4:54727846:C F600L missense_variant 0.92 0
4:54727846:A F600I missense_variant 0.92 0
4:54727832:G L595R missense_variant 0.92 0
4:54727832:C L595P missense_variant 0.92 0
4:54727832:A L595Q missense_variant 0.92 0
4:54728053:A L641H missense_variant 0.92 0
4:54728053:C L641P missense_variant 0.92 0
4:54728053:G L641R missense_variant 0.92 0
4:54728089:A I653N missense_variant 0.92 0
4:54736777:A E885K missense_variant 0.92 0
4:54728059:A V643D missense_variant 0.92 0
4:54728059:C V643A missense_variant 0.92 0
4:54728059:G V643G missense_variant 0.92 0
4:54728062:A L644Q missense_variant 0.92 0
4:54728062:C L644P missense_variant 0.92 0
4:54728062:G L644R missense_variant 0.92 0
4:54736777:C E885Q missense_variant 0.92 0
4:54728109:G C660G missense_variant 0.92 0
4:54728109:C C660R missense_variant 0.92 0
4:54728109:A C660S missense_variant 0.92 0
4:54728071:A L647H missense_variant 0.92 0
4:54728071:C L647P missense_variant 0.92 0
4:54728071:G L647R missense_variant 0.92 0
4:54728101:G L657R missense_variant 0.92 0
4:54728101:C L657P missense_variant 0.92 0
4:54728101:A L657H missense_variant 0.92 0
4:54728098:G L656R missense_variant 0.92 0
4:54728098:C L656P missense_variant 0.92 0
4:54728098:A L656Q missense_variant 0.92 0
4:54728089:C I653T missense_variant 0.92 0
4:54727922:G L625R missense_variant 0.92 0
4:54727922:C L625P missense_variant 0.92 0
4:54727922:A L625H missense_variant 0.92 0
4:54727919:G M624R missense_variant 0.92 0
4:54727919:C M624T missense_variant 0.92 0
4:54727919:A M624K missense_variant 0.92 0
4:54727913:G V622G missense_variant 0.92 0
4:54727913:C V622A missense_variant 0.92 0
4:54727913:A V622E missense_variant 0.92 0
4:54727907:G V620G missense_variant 0.92 0
4:54727907:C V620A missense_variant 0.92 0
4:54727907:A V620D missense_variant 0.92 0
4:54727880:C L611S missense_variant 0.92 0
4:54727859:G V604G missense_variant 0.92 0
4:54727859:C V604A missense_variant 0.92 0
4:54727859:A V604D missense_variant 0.92 0
4:54727856:G V603G missense_variant 0.92 0
4:54727856:C V603A missense_variant 0.92 0
4:54727856:A V603D missense_variant 0.92 0
4:54728041:A L637H missense_variant 0.92 0
4:54728041:C L637P missense_variant 0.92 0
4:54728089:G I653S missense_variant 0.92 0
4:54723698:C R449T missense_variant 0.92 0
4:54723698:T R449I missense_variant 0.92 0
4:54723698:A R449K missense_variant 0.92 0
4:54738529:T Q968L missense_variant 0.92 0
4:54737251:A E925K missense_variant 0.92 0
4:54737251:C E925Q missense_variant 0.92 0
4:54738498:C N958H missense_variant 0.92 0
4:54738498:G N958D missense_variant 0.92 0
4:54738498:T N958Y missense_variant 0.92 0
4:54738510:C S962R missense_variant 0.92 0
4:54738510:G S962G missense_variant 0.92 0
4:54738510:T S962C missense_variant 0.92 0
4:54738529:C Q968P missense_variant 0.92 0
4:54738529:G Q968R missense_variant 0.92 0
4:54723586:C K412Q missense_variant 0.92 0
4:54723586:G K412E missense_variant 0.92 0
4:54729346:A V668I missense_variant 0.92 0
4:54729346:T V668F missense_variant 0.92 0
4:54729346:C V668L missense_variant 0.92 0
4:54731930:T D765Y missense_variant 0.92 0
4:54731930:C D765H missense_variant 0.92 0
4:54731930:A D765N missense_variant 0.92 0
4:54736791:A M889I missense_variant 0.92 0
4:54736791:T M889I missense_variant 0.92 0
4:54736791:C M889I missense_variant 0.92 0
4:54728118:C G663R missense_variant 0.92 0
4:54728118:A G663R missense_variant 0.92 0
4:54737257:T Q927* stop_gained 0.91 0
4:54733135:G C809W missense_variant 0.91 0
4:54733140:G F811C missense_variant 0.91 0
4:54733158:C I817T missense_variant 0.91 0
4:54733074:C I789T missense_variant 0.91 0
4:54733140:C F811S missense_variant 0.91 0
4:54733140:A F811Y missense_variant 0.91 0
4:54733139:G F811V missense_variant 0.91 0
4:54733070:C C788R missense_variant 0.91 0
4:54733139:A F811I missense_variant 0.91 0
4:54736732:A Y870N missense_variant 0.91 0
4:54736732:C Y870H missense_variant 0.91 0
4:54736732:G Y870D missense_variant 0.91 0
4:54733086:C L793S missense_variant 0.91 0
4:54733086:G L793W missense_variant 0.91 0
4:54733101:A I798N missense_variant 0.91 0
4:54733101:C I798T missense_variant 0.91 0
4:54733101:G I798S missense_variant 0.91 0
4:54733074:G I789S missense_variant 0.91 0
4:54733139:C F811L missense_variant 0.91 0
4:54733158:G I817S missense_variant 0.91 0
4:54736783:A F887I missense_variant 0.91 0
4:54736783:C F887L missense_variant 0.91 0
4:54736783:G F887V missense_variant 0.91 0
4:54733107:G L800R missense_variant 0.91 0
4:54733107:C L800P missense_variant 0.91 0
4:54733131:G I808S missense_variant 0.91 0
4:54733107:A L800H missense_variant 0.91 0
4:54733104:G L799R missense_variant 0.91 0
4:54733104:C L799P missense_variant 0.91 0
4:54733104:A L799H missense_variant 0.91 0
4:54733070:A C788S missense_variant 0.91 0
4:54733146:C L813P missense_variant 0.91 0
4:54733146:A L813Q missense_variant 0.91 0
4:54733074:A I789N missense_variant 0.91 0
4:54733131:C I808T missense_variant 0.91 0
4:54733070:G C788G missense_variant 0.91 0
4:54733158:A I817N missense_variant 0.91 0
4:54733131:A I808N missense_variant 0.91 0
4:54733146:G L813R missense_variant 0.91 0
4:54728065:T S645I missense_variant 0.91 0
4:54728065:A S645N missense_variant 0.91 0
4:54728065:C S645T missense_variant 0.91 0
4:54727861:A E605K missense_variant 0.91 0
4:54733178:C V824L missense_variant 0.91 0
4:54733178:T V824L missense_variant 0.91 0
4:54736498:A A829T missense_variant 0.91 0
4:54736498:T A829S missense_variant 0.91 0
4:54731936:C E767Q missense_variant 0.91 0
4:54731936:A E767K missense_variant 0.91 0
4:54737197:G W907G missense_variant 0.91 0
4:54737197:C W907R missense_variant 0.91 0
4:54737197:A W907R missense_variant 0.91 0
4:54737194:G C906G missense_variant 0.91 0
4:54737194:C C906R missense_variant 0.91 0
4:54737194:A C906S missense_variant 0.91 0
4:54737186:G M903R missense_variant 0.91 0
4:54737186:C M903T missense_variant 0.91 0
4:54737186:A M903K missense_variant 0.91 0
4:54737183:G I902R missense_variant 0.91 0
4:54737183:C I902T missense_variant 0.91 0
4:54737183:A I902K missense_variant 0.91 0
4:54737228:C F917S missense_variant 0.91 0
4:54737228:A F917Y missense_variant 0.91 0
4:54737227:G F917V missense_variant 0.91 0
4:54737227:C F917L missense_variant 0.91 0
4:54737227:A F917I missense_variant 0.91 0
4:54727861:C E605Q missense_variant 0.91 0
4:54737237:G I920S missense_variant 0.91 0
4:54737237:C I920T missense_variant 0.91 0
4:54737237:A I920N missense_variant 0.91 0
4:54737228:G F917C missense_variant 0.91 0
4:54733178:A V824M missense_variant 0.91 0
4:54737176:G Y900D missense_variant 0.91 0
4:54737176:C Y900H missense_variant 0.91 0
4:54737176:A Y900N missense_variant 0.91 0
4:54736727:C S868T missense_variant 0.91 0
4:54736727:A S868N missense_variant 0.91 0
4:54736739:C G872A missense_variant 0.91 0
4:54736739:A G872E missense_variant 0.91 0
4:54736727:T S868I missense_variant 0.91 0
4:54737206:T D910Y missense_variant 0.91 0
4:54727870:T A608S missense_variant 0.91 0
4:54727870:C A608P missense_variant 0.91 0
4:54733119:T R804L missense_variant 0.91 0
4:54733119:C R804P missense_variant 0.91 0
4:54727870:A A608T missense_variant 0.91 0
4:54733119:A R804Q missense_variant 0.91 0
4:54737206:A D910N missense_variant 0.91 0
4:54737206:C D910H missense_variant 0.91 0
4:54736739:T G872V missense_variant 0.91 0
4:54731960:T Q775* stop_gained 0.90 0
4:54729380:A L679* stop_gained 0.90 0
4:54729389:A L682* stop_gained 0.90 0
4:54731344:T E720* stop_gained 0.89 0
4:54727492:G Q575R missense_variant 0.87 0
4:54727492:T Q575L missense_variant 0.87 0
4:54727464:G N566D missense_variant 0.87 0
4:54727504:G D579G missense_variant 0.87 0
4:54727504:C D579A missense_variant 0.87 0
4:54727492:C Q575P missense_variant 0.87 0
4:54727465:G N566S missense_variant 0.87 0
4:54727465:C N566T missense_variant 0.87 0
4:54727464:T N566Y missense_variant 0.87 0
4:54727510:C K581T missense_variant 0.87 0
4:54727483:T D572V missense_variant 0.87 0
4:54727504:T D579V missense_variant 0.87 0
4:54727464:C N566H missense_variant 0.87 0
4:54727528:T N587I missense_variant 0.87 0
4:54727528:G N587S missense_variant 0.87 0
4:54727479:G I571V missense_variant 0.87 0
4:54727479:C I571L missense_variant 0.87 0
4:54727440:G K558E missense_variant 0.87 0
4:54727528:C N587T missense_variant 0.87 0
4:54727516:T E583V missense_variant 0.87 0
4:54727516:G E583G missense_variant 0.87 0
4:54727516:C E583A missense_variant 0.87 0
4:54727429:G E554G missense_variant 0.87 0
4:54727510:T K581I missense_variant 0.87 0
4:54727429:C E554A missense_variant 0.87 0
4:54727440:C K558Q missense_variant 0.87 0
4:54727429:T E554V missense_variant 0.87 0
4:54727422:T M552L missense_variant 0.87 0
4:54727510:G K581R missense_variant 0.87 0
4:54727422:G M552V missense_variant 0.87 0
4:54727479:T I571L missense_variant 0.87 0
4:54727465:T N566I missense_variant 0.87 0
4:54727483:C D572A missense_variant 0.87 0
4:54727483:G D572G missense_variant 0.87 0
4:54727471:G Y568C missense_variant 0.87 0
4:54727501:G Y578C missense_variant 0.87 0
4:54727501:T Y578F missense_variant 0.87 0
4:54727501:C Y578S missense_variant 0.87 0
4:54727471:C Y568S missense_variant 0.87 0
4:54727471:T Y568F missense_variant 0.87 0
4:54728055:T K642* stop_gained 0.87 0
4:54723680:C C443S missense_variant 0.87 0
4:54723640:A A430T missense_variant 0.87 0
4:54723640:C A430P missense_variant 0.87 0
4:54723640:T A430S missense_variant 0.87 0
4:54723646:A G432R missense_variant 0.87 0
4:54723646:C G432R missense_variant 0.87 0
4:54723647:A G432E missense_variant 0.87 0
4:54723647:C G432A missense_variant 0.87 0
4:54723647:T G432V missense_variant 0.87 0
4:54723671:C W440S missense_variant 0.87 0
4:54723671:T W440L missense_variant 0.87 0
4:54723672:C W440C missense_variant 0.87 0
4:54723672:T W440C missense_variant 0.87 0
4:54723680:A C443Y missense_variant 0.87 0
4:54723680:T C443F missense_variant 0.87 0
4:54738508:C G961A missense_variant 0.87 0
4:54738508:A G961D missense_variant 0.87 0
4:54738511:A S962N missense_variant 0.87 0
4:54738511:T S962I missense_variant 0.87 0
4:54738493:T R956L missense_variant 0.87 0
4:54727233:C H519P missense_variant 0.87 0
4:54727233:G H519R missense_variant 0.87 0
4:54727233:T H519L missense_variant 0.87 0
4:54738493:C R956P missense_variant 0.87 0
4:54738493:A R956Q missense_variant 0.87 0
4:54727311:C Y545S missense_variant 0.87 0
4:54727311:G Y545C missense_variant 0.87 0
4:54727311:T Y545F missense_variant 0.87 0
4:54727313:C K546Q missense_variant 0.87 0
4:54727313:G K546E missense_variant 0.87 0
4:54727323:C Q549P missense_variant 0.87 0
4:54723635:A C428Y missense_variant 0.87 0
4:54723635:C C428S missense_variant 0.87 0
4:54723635:T C428F missense_variant 0.87 0
4:54727323:G Q549R missense_variant 0.87 0
4:54727323:T Q549L missense_variant 0.87 0
4:54738511:C S962T missense_variant 0.87 0
4:54738508:T G961V missense_variant 0.87 0
4:54727450:C E561A missense_variant 0.87 0
4:54727450:G E561G missense_variant 0.87 0
4:54727450:T E561V missense_variant 0.87 0
4:54727459:C N564T missense_variant 0.87 0
4:54727459:G N564S missense_variant 0.87 0
4:54727459:T N564I missense_variant 0.87 0
4:54727525:A R586K missense_variant 0.85 0
4:54727525:C R586T missense_variant 0.85 0
4:54727525:T R586I missense_variant 0.85 0
4:54727462:A G565E missense_variant 0.85 0
4:54727449:A E561K missense_variant 0.85 0
4:54727461:C G565R missense_variant 0.85 0
4:54727461:A G565R missense_variant 0.85 0
4:54727324:T Q549H missense_variant 0.85 0
4:54727324:C Q549H missense_variant 0.85 0
4:54737252:T E925V missense_variant 0.85 0
4:54737252:C E925A missense_variant 0.85 0
4:54727513:C W582S missense_variant 0.85 0
4:54727513:T W582L missense_variant 0.85 0
4:54737252:G E925G missense_variant 0.85 0
4:54727514:C W582C missense_variant 0.85 0
4:54727514:T W582C missense_variant 0.85 0
4:54727515:A E583K missense_variant 0.85 0
4:54727515:C E583Q missense_variant 0.85 0
4:54727259:T G528C missense_variant 0.85 0
4:54727259:C G528R missense_variant 0.85 0
4:54727259:A G528S missense_variant 0.85 0
4:54727449:C E561Q missense_variant 0.85 0
4:54727462:T G565V missense_variant 0.85 0
4:54727462:C G565A missense_variant 0.85 0
4:54736531:G S840G missense_variant 0.85 0
4:54736531:T S840C missense_variant 0.85 0
4:54731958:C Y774S missense_variant 0.85 0
4:54731958:G Y774C missense_variant 0.85 0
4:54731958:T Y774F missense_variant 0.85 0
4:54736550:C Y846S missense_variant 0.85 0
4:54736550:G Y846C missense_variant 0.85 0
4:54731961:C Q775P missense_variant 0.85 0
4:54731961:G Q775R missense_variant 0.85 0
4:54731961:T Q775L missense_variant 0.85 0
4:54736550:T Y846F missense_variant 0.85 0
4:54736552:C T847P missense_variant 0.85 0
4:54736552:G T847A missense_variant 0.85 0
4:54736552:T T847S missense_variant 0.85 0
4:54736559:C E849A missense_variant 0.85 0
4:54736559:G E849G missense_variant 0.85 0
4:54736559:T E849V missense_variant 0.85 0
4:54736561:C S850R missense_variant 0.85 0
4:54736561:G S850G missense_variant 0.85 0
4:54736561:T S850C missense_variant 0.85 0
4:54736565:C D851A missense_variant 0.85 0
4:54736565:G D851G missense_variant 0.85 0
4:54736565:T D851V missense_variant 0.85 0
4:54736577:C Y855S missense_variant 0.85 0
4:54736577:G Y855C missense_variant 0.85 0
4:54736577:T Y855F missense_variant 0.85 0
4:54736595:C E861A missense_variant 0.85 0
4:54736595:G E861G missense_variant 0.85 0
4:54736595:T E861V missense_variant 0.85 0
4:54731993:C K786Q missense_variant 0.85 0
4:54731993:G K786E missense_variant 0.85 0
4:54731997:T N787I missense_variant 0.85 0
4:54731997:C N787T missense_variant 0.85 0
4:54736513:C K834Q missense_variant 0.85 0
4:54731997:G N787S missense_variant 0.85 0
4:54736513:G K834E missense_variant 0.85 0
4:54736514:C K834T missense_variant 0.85 0
4:54736514:G K834R missense_variant 0.85 0
4:54736514:T K834M missense_variant 0.85 0
4:54731931:C D765A missense_variant 0.85 0
4:54731931:G D765G missense_variant 0.85 0
4:54731931:T D765V missense_variant 0.85 0
4:54736519:C M836L missense_variant 0.85 0
4:54736519:G M836V missense_variant 0.85 0
4:54736519:T M836L missense_variant 0.85 0
4:54733191:T N828I missense_variant 0.85 0
4:54733191:G N828S missense_variant 0.85 0
4:54733191:C N828T missense_variant 0.85 0
4:54733190:T N828Y missense_variant 0.85 0
4:54731948:C S771R missense_variant 0.85 0
4:54731948:G S771G missense_variant 0.85 0
4:54731948:T S771C missense_variant 0.85 0
4:54733190:G N828D missense_variant 0.85 0
4:54733190:C N828H missense_variant 0.85 0
4:54736529:C E839A missense_variant 0.85 0
4:54736529:G E839G missense_variant 0.85 0
4:54736529:T E839V missense_variant 0.85 0
4:54736531:C S840R missense_variant 0.85 0
4:54729374:G D677G missense_variant 0.85 0
4:54729352:C T670P missense_variant 0.85 0
4:54729352:G T670A missense_variant 0.85 0
4:54729352:T T670S missense_variant 0.85 0
4:54729356:C E671A missense_variant 0.85 0
4:54729356:G E671G missense_variant 0.85 0
4:54729356:T E671V missense_variant 0.85 0
4:54729374:C D677A missense_variant 0.85 0
4:54729374:T D677V missense_variant 0.85 0
4:54729382:C N680H missense_variant 0.85 0
4:54729382:G N680D missense_variant 0.85 0
4:54729382:T N680Y missense_variant 0.85 0
4:54729383:C N680T missense_variant 0.85 0
4:54729383:G N680S missense_variant 0.85 0
4:54729383:T N680I missense_variant 0.85 0
4:54729397:C K685Q missense_variant 0.85 0
4:54729397:G K685E missense_variant 0.85 0
4:54729398:C K685T missense_variant 0.85 0
4:54729398:G K685R missense_variant 0.85 0
4:54729398:T K685I missense_variant 0.85 0
4:54729404:C D687A missense_variant 0.85 0
4:54729404:G D687G missense_variant 0.85 0
4:54729404:T D687V missense_variant 0.85 0
4:54729457:G N705D missense_variant 0.85 0
4:54729430:T D696Y missense_variant 0.85 0
4:54729457:T N705Y missense_variant 0.85 0
4:54729457:C N705H missense_variant 0.85 0
4:54729430:C D696H missense_variant 0.85 0
4:54729458:T N705I missense_variant 0.85 0
4:54729458:G N705S missense_variant 0.85 0
4:54729458:C N705T missense_variant 0.85 0
4:54729430:A D696N missense_variant 0.85 0
4:54729452:T Y703F missense_variant 0.85 0
4:54729452:G Y703C missense_variant 0.85 0
4:54729452:C Y703S missense_variant 0.85 0
4:54736607:G L865* stop_gained 0.83 0
4:54736607:A L865* stop_gained 0.83 0
4:54731943:A L769* stop_gained 0.83 0
4:54727302:G I542S missense_variant 0.83 0
4:54727242:C F522S missense_variant 0.83 0
4:54727284:A M536K missense_variant 0.83 0
4:54727284:C M536T missense_variant 0.83 0
4:54727242:G F522C missense_variant 0.83 0
4:54727284:G M536R missense_variant 0.83 0
4:54727290:A I538N missense_variant 0.83 0
4:54727290:C I538T missense_variant 0.83 0
4:54727241:A F522I missense_variant 0.83 0
4:54727239:G L521R missense_variant 0.83 0
4:54727290:G I538S missense_variant 0.83 0
4:54727241:G F522V missense_variant 0.83 0
4:54727239:C L521P missense_variant 0.83 0
4:54727241:C F522L missense_variant 0.83 0
4:54727296:A V540E missense_variant 0.83 0
4:54727305:C L543P missense_variant 0.83 0
4:54727305:G L543R missense_variant 0.83 0
4:54727310:A Y545N missense_variant 0.83 0
4:54727296:C V540A missense_variant 0.83 0
4:54727310:C Y545H missense_variant 0.83 0
4:54727254:C L526P missense_variant 0.83 0
4:54727254:G L526R missense_variant 0.83 0
4:54727296:G V540G missense_variant 0.83 0
4:54727310:G Y545D missense_variant 0.83 0
4:54727239:A L521Q missense_variant 0.83 0
4:54727302:A I542N missense_variant 0.83 0
4:54727302:C I542T missense_variant 0.83 0
4:54727242:A F522Y missense_variant 0.83 0
4:54727305:A L543Q missense_variant 0.83 0
4:54727254:A L526Q missense_variant 0.83 0
4:54727316:C Y547H missense_variant 0.83 0
4:54727316:G Y547D missense_variant 0.83 0
4:54727316:A Y547N missense_variant 0.83 0
4:54737201:T D908V missense_variant 0.83 0
4:54737201:G D908G missense_variant 0.83 0
4:54737201:C D908A missense_variant 0.83 0
4:54727828:G T594A missense_variant 0.83 0
4:54727828:C T594P missense_variant 0.83 0
4:54733136:A D810N missense_variant 0.83 0
4:54733136:C D810H missense_variant 0.83 0
4:54733136:T D810Y missense_variant 0.83 0
4:54733137:C D810A missense_variant 0.83 0
4:54733137:G D810G missense_variant 0.83 0
4:54733137:T D810V missense_variant 0.83 0
4:54727843:C A599P missense_variant 0.83 0
4:54727843:T A599S missense_variant 0.83 0
4:54727849:A G601R missense_variant 0.83 0
4:54727849:C G601R missense_variant 0.83 0
4:54733142:A G812S missense_variant 0.83 0
4:54733142:C G812R missense_variant 0.83 0
4:54733142:T G812C missense_variant 0.83 0
4:54733143:A G812D missense_variant 0.83 0
4:54733143:C G812A missense_variant 0.83 0
4:54733143:T G812V missense_variant 0.83 0
4:54727849:T G601W missense_variant 0.83 0
4:54727850:A G601E missense_variant 0.83 0
4:54727850:C G601A missense_variant 0.83 0
4:54733148:A A814T missense_variant 0.83 0
4:54733148:C A814P missense_variant 0.83 0
4:54733148:T A814S missense_variant 0.83 0
4:54727823:T G592V missense_variant 0.83 0
4:54727823:C G592A missense_variant 0.83 0
4:54733152:A R815K missense_variant 0.83 0
4:54733152:C R815T missense_variant 0.83 0
4:54733152:T R815I missense_variant 0.83 0
4:54727823:A G592E missense_variant 0.83 0
4:54727542:T G592W missense_variant 0.83 0
4:54727542:C G592R missense_variant 0.83 0
4:54727542:A G592R missense_variant 0.83 0
4:54727850:T G601V missense_variant 0.83 0
4:54727853:C K602T missense_variant 0.83 0
4:54733157:C I817L missense_variant 0.83 0
4:54733157:G I817V missense_variant 0.83 0
4:54733157:T I817F missense_variant 0.83 0
4:54727853:G K602R missense_variant 0.83 0
4:54727853:T K602M missense_variant 0.83 0
4:54727855:A V603I missense_variant 0.83 0
4:54727855:C V603L missense_variant 0.83 0
4:54727855:T V603F missense_variant 0.83 0
4:54727858:A V604I missense_variant 0.83 0
4:54731973:T G779V missense_variant 0.83 0
4:54731973:C G779A missense_variant 0.83 0
4:54731973:A G779D missense_variant 0.83 0
4:54731972:T G779C missense_variant 0.83 0
4:54731972:C G779R missense_variant 0.83 0
4:54731972:A G779S missense_variant 0.83 0
4:54727858:C V604L missense_variant 0.83 0
4:54727858:T V604F missense_variant 0.83 0
4:54731966:T A777S missense_variant 0.83 0
4:54731966:C A777P missense_variant 0.83 0
4:54731966:A A777T missense_variant 0.83 0
4:54727864:A A606T missense_variant 0.83 0
4:54731963:T V776L missense_variant 0.83 0
4:54731963:C V776L missense_variant 0.83 0
4:54731963:A V776M missense_variant 0.83 0
4:54727864:C A606P missense_variant 0.83 0
4:54727864:T A606S missense_variant 0.83 0
4:54727877:A G610D missense_variant 0.83 0
4:54733187:A G827R missense_variant 0.83 0
4:54733187:C G827R missense_variant 0.83 0
4:54733188:A G827E missense_variant 0.83 0
4:54733188:C G827A missense_variant 0.83 0
4:54733188:T G827V missense_variant 0.83 0
4:54727877:C G610A missense_variant 0.83 0
4:54727877:T G610V missense_variant 0.83 0
4:54731939:T D768Y missense_variant 0.83 0
4:54731939:C D768H missense_variant 0.83 0
4:54731939:A D768N missense_variant 0.83 0
4:54736502:A R830Q missense_variant 0.83 0
4:54736502:C R830P missense_variant 0.83 0
4:54736502:T R830L missense_variant 0.83 0
4:54727891:A D615N missense_variant 0.83 0
4:54727891:C D615H missense_variant 0.83 0
4:54727891:T D615Y missense_variant 0.83 0
4:54727892:C D615A missense_variant 0.83 0
4:54727892:G D615G missense_variant 0.83 0
4:54727892:T D615V missense_variant 0.83 0
4:54736510:A V833M missense_variant 0.83 0
4:54736510:C V833L missense_variant 0.83 0
4:54736510:T V833L missense_variant 0.83 0
4:54727906:A V620I missense_variant 0.83 0
4:54727906:C V620L missense_variant 0.83 0
4:54727906:T V620F missense_variant 0.83 0
4:54727909:A A621T missense_variant 0.83 0
4:54727909:C A621P missense_variant 0.83 0
4:54727909:T A621S missense_variant 0.83 0
4:54727912:A V622I missense_variant 0.83 0
4:54727912:C V622L missense_variant 0.83 0
4:54727912:T V622L missense_variant 0.83 0
4:54736517:C W835S missense_variant 0.83 0
4:54736517:T W835L missense_variant 0.83 0
4:54736518:C W835C missense_variant 0.83 0
4:54736518:T W835C missense_variant 0.83 0
4:54727915:C K623Q missense_variant 0.83 0
4:54727915:G K623E missense_variant 0.83 0
4:54727916:C K623T missense_variant 0.83 0
4:54727916:G K623R missense_variant 0.83 0
4:54727916:T K623M missense_variant 0.83 0
4:54736521:A M836I missense_variant 0.83 0
4:54736521:C M836I missense_variant 0.83 0
4:54736521:T M836I missense_variant 0.83 0
4:54727918:C M624L missense_variant 0.83 0
4:54727918:G M624V missense_variant 0.83 0
4:54727918:T M624L missense_variant 0.83 0
4:54727920:A M624I missense_variant 0.83 0
4:54727920:C M624I missense_variant 0.83 0
4:54736528:A E839K missense_variant 0.83 0
4:54736528:C E839Q missense_variant 0.83 0
4:54727920:T M624I missense_variant 0.83 0
4:54727924:C K626Q missense_variant 0.83 0
4:54727924:G K626E missense_variant 0.83 0
4:54736532:A S840N missense_variant 0.83 0
4:54736532:C S840T missense_variant 0.83 0
4:54736532:T S840I missense_variant 0.83 0
4:54736544:A C844Y missense_variant 0.83 0
4:54736544:C C844S missense_variant 0.83 0
4:54736544:T C844F missense_variant 0.83 0
4:54733083:G D792G missense_variant 0.83 0
4:54733083:T D792V missense_variant 0.83 0
4:54733083:C D792A missense_variant 0.83 0
4:54733082:T D792Y missense_variant 0.83 0
4:54733088:A A794T missense_variant 0.83 0
4:54733088:C A794P missense_variant 0.83 0
4:54733088:T A794S missense_variant 0.83 0
4:54727841:A G598E missense_variant 0.83 0
4:54727840:C G598R missense_variant 0.83 0
4:54733091:A A795T missense_variant 0.83 0
4:54733091:C A795P missense_variant 0.83 0
4:54733091:T A795S missense_variant 0.83 0
4:54727840:A G598R missense_variant 0.83 0
4:54727835:T G596V missense_variant 0.83 0
4:54727835:C G596A missense_variant 0.83 0
4:54733095:A R796K missense_variant 0.83 0
4:54733095:C R796T missense_variant 0.83 0
4:54733095:T R796I missense_variant 0.83 0
4:54733097:C N797H missense_variant 0.83 0
4:54733097:G N797D missense_variant 0.83 0
4:54733097:T N797Y missense_variant 0.83 0
4:54733098:C N797T missense_variant 0.83 0
4:54733098:G N797S missense_variant 0.83 0
4:54733098:T N797I missense_variant 0.83 0
4:54733082:C D792H missense_variant 0.83 0
4:54733082:A D792N missense_variant 0.83 0
4:54733080:T R791I missense_variant 0.83 0
4:54733080:C R791T missense_variant 0.83 0
4:54733080:A R791K missense_variant 0.83 0
4:54733077:T H790L missense_variant 0.83 0
4:54733077:G H790R missense_variant 0.83 0
4:54733077:C H790P missense_variant 0.83 0
4:54727841:C G598A missense_variant 0.83 0
4:54727835:A G596D missense_variant 0.83 0
4:54727834:T G596C missense_variant 0.83 0
4:54727834:C G596R missense_variant 0.83 0
4:54727841:T G598V missense_variant 0.83 0
4:54727843:A A599T missense_variant 0.83 0
4:54733071:T C788F missense_variant 0.83 0
4:54733127:C K807Q missense_variant 0.83 0
4:54733127:G K807E missense_variant 0.83 0
4:54733128:C K807T missense_variant 0.83 0
4:54733128:G K807R missense_variant 0.83 0
4:54733128:T K807M missense_variant 0.83 0
4:54733130:C I808L missense_variant 0.83 0
4:54733130:G I808V missense_variant 0.83 0
4:54733130:T I808F missense_variant 0.83 0
4:54733071:C C788S missense_variant 0.83 0
4:54733071:A C788Y missense_variant 0.83 0
4:54727834:A G596S missense_variant 0.83 0
4:54727828:T T594S missense_variant 0.83 0
4:54729362:C C673S missense_variant 0.83 0
4:54729362:A C673Y missense_variant 0.83 0
4:54736747:A V875I missense_variant 0.83 0
4:54736747:C V875L missense_variant 0.83 0
4:54736747:T V875F missense_variant 0.83 0
4:54736750:A D876N missense_variant 0.83 0
4:54736750:C D876H missense_variant 0.83 0
4:54736750:T D876Y missense_variant 0.83 0
4:54736756:C K878Q missense_variant 0.83 0
4:54736756:G K878E missense_variant 0.83 0
4:54728037:A A636T missense_variant 0.83 0
4:54728037:C A636P missense_variant 0.83 0
4:54728037:T A636S missense_variant 0.83 0
4:54736780:A G886S missense_variant 0.83 0
4:54736780:C G886R missense_variant 0.83 0
4:54736780:T G886C missense_variant 0.83 0
4:54736781:A G886D missense_variant 0.83 0
4:54736781:C G886A missense_variant 0.83 0
4:54736781:T G886V missense_variant 0.83 0
4:54728045:A M638I missense_variant 0.83 0
4:54728045:C M638I missense_variant 0.83 0
4:54728045:T M638I missense_variant 0.83 0
4:54728049:A E640K missense_variant 0.83 0
4:54728049:C E640Q missense_variant 0.83 0
4:54736816:A E898K missense_variant 0.83 0
4:54736816:C E898Q missense_variant 0.83 0
4:54728050:C E640A missense_variant 0.83 0
4:54728050:G E640G missense_variant 0.83 0
4:54728050:T E640V missense_variant 0.83 0
4:54728056:C K642T missense_variant 0.83 0
4:54728056:G K642R missense_variant 0.83 0
4:54728056:T K642I missense_variant 0.83 0
4:54728064:C S645R missense_variant 0.83 0
4:54737185:C M903L missense_variant 0.83 0
4:54737185:G M903V missense_variant 0.83 0
4:54737185:T M903L missense_variant 0.83 0
4:54729335:T G664V missense_variant 0.83 0
4:54729335:C G664A missense_variant 0.83 0
4:54729335:A G664E missense_variant 0.83 0
4:54737187:A M903I missense_variant 0.83 0
4:54737187:C M903I missense_variant 0.83 0
4:54737187:T M903I missense_variant 0.83 0
4:54728121:T G664W missense_variant 0.83 0
4:54728121:C G664R missense_variant 0.83 0
4:54728121:A G664R missense_variant 0.83 0
4:54737195:A C906Y missense_variant 0.83 0
4:54737195:C C906S missense_variant 0.83 0
4:54737195:T C906F missense_variant 0.83 0
4:54737198:C W907S missense_variant 0.83 0
4:54737198:T W907L missense_variant 0.83 0
4:54737199:C W907C missense_variant 0.83 0
4:54737199:T W907C missense_variant 0.83 0
4:54728119:T G663V missense_variant 0.83 0
4:54728119:C G663A missense_variant 0.83 0
4:54728119:A G663E missense_variant 0.83 0
4:54737207:C D910A missense_variant 0.83 0
4:54737207:G D910G missense_variant 0.83 0
4:54737207:T D910V missense_variant 0.83 0
4:54728064:G S645G missense_variant 0.83 0
4:54728064:T S645C missense_variant 0.83 0
4:54728112:T T661S missense_variant 0.83 0
4:54728112:G T661A missense_variant 0.83 0
4:54737216:C K913T missense_variant 0.83 0
4:54737216:G K913R missense_variant 0.83 0
4:54737216:T K913I missense_variant 0.83 0
4:54737219:A R914K missense_variant 0.83 0
4:54737219:C R914T missense_variant 0.83 0
4:54737219:T R914I missense_variant 0.83 0
4:54728112:C T661P missense_variant 0.83 0
4:54728110:T C660F missense_variant 0.83 0
4:54728110:C C660S missense_variant 0.83 0
4:54728110:A C660Y missense_variant 0.83 0
4:54728068:C Y646S missense_variant 0.83 0
4:54728068:G Y646C missense_variant 0.83 0
4:54728068:T Y646F missense_variant 0.83 0
4:54728073:A G648S missense_variant 0.83 0
4:54728106:T A659S missense_variant 0.83 0
4:54728106:C A659P missense_variant 0.83 0
4:54728106:A A659T missense_variant 0.83 0
4:54728104:T G658V missense_variant 0.83 0
4:54728104:C G658A missense_variant 0.83 0
4:54728104:A G658E missense_variant 0.83 0
4:54737243:C Q922P missense_variant 0.83 0
4:54737243:G Q922R missense_variant 0.83 0
4:54737243:T Q922L missense_variant 0.83 0
4:54728103:C G658R missense_variant 0.83 0
4:54728103:A G658R missense_variant 0.83 0
4:54728073:C G648R missense_variant 0.83 0
4:54728073:T G648C missense_variant 0.83 0
4:54728074:A G648D missense_variant 0.83 0
4:54728074:C G648A missense_variant 0.83 0
4:54728074:T G648V missense_variant 0.83 0
4:54728077:C N649T missense_variant 0.83 0
4:54728095:T N655I missense_variant 0.83 0
4:54728095:G N655S missense_variant 0.83 0
4:54728095:C N655T missense_variant 0.83 0
4:54728094:T N655Y missense_variant 0.83 0
4:54728094:G N655D missense_variant 0.83 0
4:54728094:C N655H missense_variant 0.83 0
4:54728077:G N649S missense_variant 0.83 0
4:54728077:T N649I missense_variant 0.83 0
4:54728080:C H650P missense_variant 0.83 0
4:54728086:G N652S missense_variant 0.83 0
4:54728086:T N652I missense_variant 0.83 0
4:54728086:C N652T missense_variant 0.83 0
4:54728085:T N652Y missense_variant 0.83 0
4:54728085:G N652D missense_variant 0.83 0
4:54728085:C N652H missense_variant 0.83 0
4:54728080:T H650L missense_variant 0.83 0
4:54727925:C K626T missense_variant 0.83 0
4:54727925:G K626R missense_variant 0.83 0
4:54729403:T D687Y missense_variant 0.83 0
4:54729403:C D687H missense_variant 0.83 0
4:54729403:A D687N missense_variant 0.83 0
4:54729401:T R686L missense_variant 0.83 0
4:54729401:C R686P missense_variant 0.83 0
4:54729401:A R686H missense_variant 0.83 0
4:54727925:T K626M missense_variant 0.83 0
4:54728013:C S628R missense_variant 0.83 0
4:54728013:G S628G missense_variant 0.83 0
4:54729392:T R683I missense_variant 0.83 0
4:54729392:C R683T missense_variant 0.83 0
4:54729392:A R683K missense_variant 0.83 0
4:54736562:A S850N missense_variant 0.83 0
4:54736562:C S850T missense_variant 0.83 0
4:54736562:T S850I missense_variant 0.83 0
4:54736564:A D851N missense_variant 0.83 0
4:54736564:C D851H missense_variant 0.83 0
4:54736564:T D851Y missense_variant 0.83 0
4:54728013:T S628C missense_variant 0.83 0
4:54728016:A A629T missense_variant 0.83 0
4:54728016:C A629P missense_variant 0.83 0
4:54736567:A V852I missense_variant 0.83 0
4:54736567:C V852L missense_variant 0.83 0
4:54736567:T V852F missense_variant 0.83 0
4:54728016:T A629S missense_variant 0.83 0
4:54728028:A E633K missense_variant 0.83 0
4:54728028:C E633Q missense_variant 0.83 0
4:54736571:C W853S missense_variant 0.83 0
4:54736571:T W853L missense_variant 0.83 0
4:54736572:C W853C missense_variant 0.83 0
4:54736572:T W853C missense_variant 0.83 0
4:54728029:C E633A missense_variant 0.83 0
4:54728029:G E633G missense_variant 0.83 0
4:54728029:T E633V missense_variant 0.83 0
4:54728034:A E635K missense_variant 0.83 0
4:54728034:C E635Q missense_variant 0.83 0
4:54728080:G H650R missense_variant 0.83 0
4:54736579:A G856R missense_variant 0.83 0
4:54736579:C G856R missense_variant 0.83 0
4:54736579:T G856W missense_variant 0.83 0
4:54736580:A G856E missense_variant 0.83 0
4:54736580:C G856A missense_variant 0.83 0
4:54736580:T G856V missense_variant 0.83 0
4:54736592:C W860S missense_variant 0.83 0
4:54736592:T W860L missense_variant 0.83 0
4:54736593:C W860C missense_variant 0.83 0
4:54736593:T W860C missense_variant 0.83 0
4:54736594:A E861K missense_variant 0.83 0
4:54736594:C E861Q missense_variant 0.83 0
4:54729373:T D677Y missense_variant 0.83 0
4:54729373:C D677H missense_variant 0.83 0
4:54729373:A D677N missense_variant 0.83 0
4:54729371:T G676V missense_variant 0.83 0
4:54729371:C G676A missense_variant 0.83 0
4:54729371:A G676D missense_variant 0.83 0
4:54736609:A G866R missense_variant 0.83 0
4:54736609:C G866R missense_variant 0.83 0
4:54736721:A G866E missense_variant 0.83 0
4:54736721:C G866A missense_variant 0.83 0
4:54736721:T G866V missense_variant 0.83 0
4:54736726:C S868R missense_variant 0.83 0
4:54736726:G S868G missense_variant 0.83 0
4:54736726:T S868C missense_variant 0.83 0
4:54729370:T G676C missense_variant 0.83 0
4:54729370:C G676R missense_variant 0.83 0
4:54729370:A G676S missense_variant 0.83 0
4:54728035:C E635A missense_variant 0.83 0
4:54728035:G E635G missense_variant 0.83 0
4:54728035:T E635V missense_variant 0.83 0
4:54736733:C Y870S missense_variant 0.83 0
4:54736733:G Y870C missense_variant 0.83 0
4:54736733:T Y870F missense_variant 0.83 0
4:54729362:T C673F missense_variant 0.83 0
4:54727874:T Y609F missense_variant 0.83 0
4:54737177:G Y900C missense_variant 0.83 0
4:54727874:C Y609S missense_variant 0.83 0
4:54737177:T Y900F missense_variant 0.83 0
4:54737177:C Y900S missense_variant 0.83 0
4:54727874:G Y609C missense_variant 0.83 0
4:54729355:T E671* stop_gained 0.82 0
4:54728088:T I653F missense_variant 0.81 0
4:54728043:G M638V missense_variant 0.81 0
4:54727825:G K593E missense_variant 0.81 0
4:54728088:G I653V missense_variant 0.81 0
4:54728043:C M638L missense_variant 0.81 0
4:54727825:C K593Q missense_variant 0.81 0
4:54728088:C I653L missense_variant 0.81 0
4:54728043:T M638L missense_variant 0.81 0
4:54736775:G K884R missense_variant 0.81 0
4:54736775:T K884M missense_variant 0.81 0
4:54736775:C K884T missense_variant 0.81 0
4:54733177:A Y823* stop_gained 0.79 0
4:54733177:G Y823* stop_gained 0.79 0
4:54733135:A C809* stop_gained 0.77 0
4:54737251:T E925* stop_gained 0.76 0
4:54723586:T K412* stop_gained 0.76 0
4:54727880:A L611* stop_gained 0.76 0
4:54727880:G L611* stop_gained 0.76 0
4:54736777:T E885* stop_gained 0.76 0
4:54728118:T G663* stop_gained 0.75 0
4:54733156:G D816E missense_variant 0.73 0
4:54733156:A D816E missense_variant 0.73 0
4:54733086:A L793* stop_gained 0.73 0
4:54731937:C E767A missense_variant 0.73 0
4:54736582:T I857F missense_variant 0.73 0
4:54736582:G I857V missense_variant 0.73 0
4:54736582:C I857L missense_variant 0.73 0
4:54731994:G K786R missense_variant 0.73 0
4:54731994:C K786T missense_variant 0.73 0
4:54731994:T K786M missense_variant 0.73 0
4:54731937:G E767G missense_variant 0.73 0
4:54731937:T E767V missense_variant 0.73 0
4:54729451:A Y703N missense_variant 0.73 0
4:54729451:C Y703H missense_variant 0.73 0
4:54729451:G Y703D missense_variant 0.73 0
4:54731936:T E767* stop_gained 0.73 0
4:54727861:T E605* stop_gained 0.73 0
4:54736771:G I883V missense_variant 0.72 0
4:54736771:C I883L missense_variant 0.72 0
4:54736789:C M889L missense_variant 0.72 0
4:54736763:G Y880C missense_variant 0.72 0
4:54736763:C Y880S missense_variant 0.72 0
4:54736789:T M889L missense_variant 0.72 0
4:54736789:G M889V missense_variant 0.72 0
4:54736763:T Y880F missense_variant 0.72 0
4:54736771:T I883F missense_variant 0.72 0
4:54723691:C E447Q missense_variant 0.72 0
4:54723691:A E447K missense_variant 0.72 0
4:54727248:T P524L missense_variant 0.69 0
4:54727232:A H519N missense_variant 0.69 0
4:54727248:G P524R missense_variant 0.69 0
4:54727248:A P524H missense_variant 0.69 0
4:54727245:T T523I missense_variant 0.69 0
4:54727245:G T523S missense_variant 0.69 0
4:54727245:A T523N missense_variant 0.69 0
4:54727232:G H519D missense_variant 0.69 0
4:54727232:T H519Y missense_variant 0.69 0
4:54727440:T K558* stop_gained 0.65 0
4:54723672:A W440* stop_gained 0.65 0
4:54727313:T K546* stop_gained 0.65 0
4:54723646:T G432* stop_gained 0.65 0
4:54723671:A W440* stop_gained 0.65 0
4:54727324:A Q549Q splice_region_variant 0.62 0
4:54727513:A W582* stop_gained 0.62 0
4:54727449:T E561* stop_gained 0.62 0
4:54727461:T G565* stop_gained 0.62 0
4:54727515:T E583* stop_gained 0.62 0
4:54727514:A W582* stop_gained 0.62 0
4:54736513:T K834* stop_gained 0.61 0
4:54731993:T K786* stop_gained 0.61 0
4:54729397:T K685* stop_gained 0.61 0
4:54736802:T E893V missense_variant 0.57 0
4:54731882:C E749Q missense_variant 0.57 0
4:54731882:A E749K missense_variant 0.57 0
4:54736802:C E893A missense_variant 0.57 0
4:54736802:G E893G missense_variant 0.57 0
4:54728049:T E640* stop_gained 0.57 0
4:54736594:T E861* stop_gained 0.57 0
4:54733187:T G827* stop_gained 0.57 0
4:54737199:A W907* stop_gained 0.57 0
4:54728120:T G663G splice_region_variant 0.57 0
4:54736528:T E839* stop_gained 0.57 0
4:54728034:T E635* stop_gained 0.57 0
4:54736571:A W853* stop_gained 0.57 0
4:54728120:G G663G splice_region_variant 0.57 0
4:54728120:C G663G splice_region_variant 0.57 0
4:54737198:A W907* stop_gained 0.57 0
4:54736518:A W835* stop_gained 0.57 0
4:54727915:T K623* stop_gained 0.57 0
4:54728103:T G658* stop_gained 0.57 0
4:54736756:T K878* stop_gained 0.57 0
4:54728028:T E633* stop_gained 0.57 0
4:54736572:A W853* stop_gained 0.57 0
4:54733127:T K807* stop_gained 0.57 0
4:54736609:T G866* stop_gained 0.57 0
4:54727924:T K626* stop_gained 0.57 0
4:54727840:T G598* stop_gained 0.57 0
4:54736517:A W835* stop_gained 0.57 0
4:54736593:A W860* stop_gained 0.57 0
4:54736592:A W860* stop_gained 0.57 0
4:54736816:T E898* stop_gained 0.57 0
4:54727825:T K593* stop_gained 0.56 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(OS) Osteosarcoma OS 0.60 0.21