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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
KMT2D CESC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
12:49040632:A Q2380* stop_gained 1.00 2
12:49031861:A R4282* stop_gained 0.98 2
12:49054564:A E122* stop_gained 1.00 1
12:49027061:A E4969* stop_gained 1.00 1
12:49044257:A K1711* stop_gained 1.00 1
12:49048739:A E1351* stop_gained 1.00 1
12:49040473:A E2433* stop_gained 1.00 1
12:49026224:A Q5248* stop_gained 1.00 1
12:49022769:A Q5387* stop_gained 1.00 1
12:49034069:A Q3580* stop_gained 1.00 1
12:49034846:A Q3441* stop_gained 1.00 1
12:49047997:A Q1402* stop_gained 1.00 1
12:49046724:A Q1435* stop_gained 1.00 1
12:49032686:A Q4007* stop_gained 1.00 1
12:49033328:A Q3793* stop_gained 1.00 1
12:49040835:C S2312* stop_gained 0.99 1
12:49040844:T S2309* stop_gained 0.99 1
12:49039464:A R2734* stop_gained 0.98 1
12:49050503:A Q1029* stop_gained 0.98 1
12:49051048:A E879* stop_gained 0.98 1
12:49049918:A E1224* stop_gained 1.00 0
12:49043181:A E1847* stop_gained 1.00 0
12:49032986:A Q3907* stop_gained 1.00 0
12:49038916:A Q2814* stop_gained 1.00 0
12:49033172:A Q3845* stop_gained 1.00 0
12:49037725:A E3211* stop_gained 1.00 0
12:49037722:A K3212* stop_gained 1.00 0
12:49040704:A Q2356* stop_gained 1.00 0
12:49028024:A E4834* stop_gained 1.00 0
12:49028944:A K4756* stop_gained 1.00 0
12:49027256:A R4904* stop_gained 1.00 0
12:49032740:A Q3989* stop_gained 1.00 0
12:49029468:A E4670* stop_gained 1.00 0
12:49032011:A Q4232* stop_gained 1.00 0
12:49037158:A Q3400* stop_gained 1.00 0
12:49049987:A K1201* stop_gained 1.00 0
12:49050629:A E987* stop_gained 1.00 0
12:49028887:A E4775* stop_gained 1.00 0
12:49031456:A Q4417* stop_gained 1.00 0
12:49028888:T W4774* stop_gained 1.00 0
12:49033532:A Q3725* stop_gained 1.00 0
12:49037236:A Q3374* stop_gained 1.00 0
12:49033136:A Q3857* stop_gained 1.00 0
12:49038391:A E2989* stop_gained 1.00 0
12:49032725:A Q3994* stop_gained 1.00 0
12:49028889:T W4774* stop_gained 1.00 0
12:49034634:T S3463* stop_gained 1.00 0
12:49027838:A K4870* stop_gained 1.00 0
12:49032941:A Q3922* stop_gained 1.00 0
12:49054591:A E113* stop_gained 1.00 0
12:49028830:A K4794* stop_gained 1.00 0
12:49040722:A Q2350* stop_gained 1.00 0
12:49030331:A E4650* stop_gained 1.00 0
12:49039879:A G2631* stop_gained 1.00 0
12:49033139:A Q3856* stop_gained 1.00 0
12:49028063:A E4821* stop_gained 1.00 0
12:49043076:A E1882* stop_gained 1.00 0
12:49043079:A E1881* stop_gained 1.00 0
12:49026695:A K5091* stop_gained 1.00 0
12:49033472:A Q3745* stop_gained 1.00 0
12:49031317:T L4463* stop_gained 1.00 0
12:49029470:C S4669* stop_gained 1.00 0
12:49029470:T S4669* stop_gained 1.00 0
12:49043900:A K1763* stop_gained 1.00 0
12:49046140:A E1540* stop_gained 1.00 0
12:49046172:T W1529* stop_gained 1.00 0
12:49038895:A Q2821* stop_gained 1.00 0
12:49048676:A K1372* stop_gained 1.00 0
12:49030322:A K4653* stop_gained 1.00 0
12:49034269:T W3513* stop_gained 1.00 0
12:49040749:A Q2341* stop_gained 1.00 0
12:49053606:A E237* stop_gained 1.00 0
12:49053525:A K264* stop_gained 1.00 0
12:49043948:A E1747* stop_gained 1.00 0
12:49030985:A K4527* stop_gained 1.00 0
12:49037893:A K3155* stop_gained 1.00 0
12:49026867:T C5033* stop_gained 1.00 0
12:49031897:A Q4270* stop_gained 1.00 0
12:49053209:A K318* stop_gained 1.00 0
12:49029232:A E4694* stop_gained 1.00 0
12:49043939:A E1750* stop_gained 1.00 0
12:49039602:A E2688* stop_gained 1.00 0
12:49044830:T L1626* stop_gained 1.00 0
12:49049133:C S1331* stop_gained 1.00 0
12:49049133:T S1331* stop_gained 1.00 0
12:49055021:A G19* stop_gained 1.00 0
12:49038399:T L2986* stop_gained 1.00 0
12:49033895:A Q3604* stop_gained 1.00 0
12:49033484:A Q3741* stop_gained 1.00 0
12:49032053:A Q4218* stop_gained 1.00 0
12:49044233:A E1719* stop_gained 1.00 0
12:49028030:A K4832* stop_gained 1.00 0
12:49043665:A E1813* stop_gained 1.00 0
12:49041475:A R2099* stop_gained 1.00 0
12:49054099:T C184* stop_gained 1.00 0
12:49033664:A Q3681* stop_gained 1.00 0
12:49032734:A Q3991* stop_gained 1.00 0
12:49028884:A K4776* stop_gained 1.00 0
12:49041529:A E2081* stop_gained 1.00 0
12:49033076:A Q3877* stop_gained 1.00 0
12:49032953:A Q3918* stop_gained 1.00 0
12:49043933:A K1752* stop_gained 1.00 0
12:49027832:A Q4872* stop_gained 1.00 0
12:49049920:C S1223* stop_gained 1.00 0
12:49049920:T S1223* stop_gained 1.00 0
12:49044786:A K1641* stop_gained 1.00 0
12:49046294:A E1517* stop_gained 1.00 0
12:49039497:A E2723* stop_gained 1.00 0
12:49054579:A Q117* stop_gained 1.00 0
12:49026854:A E5038* stop_gained 1.00 0
12:49038172:A K3062* stop_gained 1.00 0
12:49034611:A Q3471* stop_gained 1.00 0
12:49038298:A K3020* stop_gained 1.00 0
12:49053272:A G297* stop_gained 1.00 0
12:49044812:T S1632* stop_gained 1.00 0
12:49049800:T S1263* stop_gained 1.00 0
12:49044812:C S1632* stop_gained 1.00 0
12:49049800:C S1263* stop_gained 1.00 0
12:49041006:T L2255* stop_gained 1.00 0
12:49042858:A K1889* stop_gained 1.00 0
12:49044864:A R1615* stop_gained 1.00 0
12:49031336:A E4457* stop_gained 1.00 0
12:49028096:A K4810* stop_gained 1.00 0
12:49039505:T W2720* stop_gained 1.00 0
12:49040307:T S2488* stop_gained 1.00 0
12:49044493:A K1665* stop_gained 1.00 0
12:49033490:A Q3739* stop_gained 1.00 0
12:49033457:A Q3750* stop_gained 1.00 0
12:49040457:T S2438* stop_gained 1.00 0
12:49031312:A K4465* stop_gained 1.00 0
12:49032194:A Q4171* stop_gained 1.00 0
12:49040457:C S2438* stop_gained 1.00 0
12:49041061:A Q2237* stop_gained 1.00 0
12:49041657:A K2078* stop_gained 1.00 0
12:49026857:A E5037* stop_gained 1.00 0
12:49027322:A E4882* stop_gained 1.00 0
12:49030988:A Q4526* stop_gained 1.00 0
12:49038337:A E3007* stop_gained 1.00 0
12:49037622:C L3245* stop_gained 1.00 0
12:49054072:C Y193* stop_gained 1.00 0
12:49042816:A R1903* stop_gained 1.00 0
12:49054072:T Y193* stop_gained 1.00 0
12:49037622:T L3245* stop_gained 1.00 0
12:49054687:A E81* stop_gained 1.00 0
12:49054711:A E73* stop_gained 1.00 0
12:49043641:A Q1821* stop_gained 1.00 0
12:49043118:A E1868* stop_gained 1.00 0
12:49040995:A E2259* stop_gained 1.00 0
12:49034629:A G3465* stop_gained 1.00 0
12:49033133:A Q3858* stop_gained 1.00 0
12:49038625:A E2911* stop_gained 1.00 0
12:49041262:A Q2170* stop_gained 1.00 0
12:49031405:A E4434* stop_gained 1.00 0
12:49040899:A E2291* stop_gained 1.00 0
12:49032101:A Q4202* stop_gained 1.00 0
12:49041274:A Q2166* stop_gained 1.00 0
12:49054005:A E216* stop_gained 1.00 0
12:49053033:A E332* stop_gained 1.00 0
12:49032485:A Q4074* stop_gained 1.00 0
12:49045929:A K1578* stop_gained 1.00 0
12:49046671:C Y1452* stop_gained 1.00 0
12:49046671:T Y1452* stop_gained 1.00 0
12:49040230:A Q2514* stop_gained 1.00 0
12:49055300:A E9* stop_gained 1.00 0
12:49037590:A E3256* stop_gained 1.00 0
12:49044451:A E1679* stop_gained 1.00 0
12:49037479:A Q3293* stop_gained 1.00 0
12:49041505:A K2089* stop_gained 1.00 0
12:49031393:A E4438* stop_gained 1.00 0
12:49037422:A Q3312* stop_gained 1.00 0
12:49040719:A E2351* stop_gained 1.00 0
12:49033109:A Q3866* stop_gained 1.00 0
12:49037653:A K3235* stop_gained 1.00 0
12:49042837:A K1896* stop_gained 1.00 0
12:49054668:T L87* stop_gained 1.00 0
12:49037566:A Q3264* stop_gained 1.00 0
12:49037647:A E3237* stop_gained 1.00 0
12:49037626:A E3244* stop_gained 1.00 0
12:49037587:A K3257* stop_gained 1.00 0
12:49034419:A G3500* stop_gained 1.00 0
12:49031255:A R4484* stop_gained 1.00 0
12:49043764:A E1780* stop_gained 1.00 0
12:49037256:T L3367* stop_gained 1.00 0
12:49037173:A Q3395* stop_gained 1.00 0
12:49053038:T S330* stop_gained 1.00 0
12:49054311:C S169* stop_gained 1.00 0
12:49053038:C S330* stop_gained 1.00 0
12:49054311:T S169* stop_gained 1.00 0
12:49037248:A Q3370* stop_gained 1.00 0
12:49031003:A K4521* stop_gained 1.00 0
12:49030955:A K4537* stop_gained 1.00 0
12:49029223:A E4697* stop_gained 1.00 0
12:49044254:A K1712* stop_gained 1.00 0
12:49041214:A E2186* stop_gained 1.00 0
12:49032833:A Q3958* stop_gained 1.00 0
12:49033667:A Q3680* stop_gained 1.00 0
12:49031018:A K4516* stop_gained 1.00 0
12:49040932:A E2280* stop_gained 1.00 0
12:49044747:A E1654* stop_gained 1.00 0
12:49042633:T L1932* stop_gained 1.00 0
12:49027052:A E4972* stop_gained 1.00 0
12:49029417:A Q4687* stop_gained 1.00 0
12:49031459:A K4416* stop_gained 1.00 0
12:49040755:A E2339* stop_gained 1.00 0
12:49032926:A Q3927* stop_gained 1.00 0
12:49044439:A E1683* stop_gained 1.00 0
12:49042158:A Q2014* stop_gained 1.00 0
12:49039872:T S2633* stop_gained 1.00 0
12:49039872:C S2633* stop_gained 1.00 0
12:49033127:A Q3860* stop_gained 1.00 0
12:49042810:A Q1905* stop_gained 1.00 0
12:49026597:T C5123* stop_gained 1.00 0
12:49033391:A K3772* stop_gained 1.00 0
12:49037584:A K3258* stop_gained 1.00 0
12:49032869:A Q3946* stop_gained 1.00 0
12:49033178:A Q3843* stop_gained 1.00 0
12:49049747:A G1281* stop_gained 1.00 0
12:49027278:T Y4896* stop_gained 1.00 0
12:49027278:C Y4896* stop_gained 1.00 0
12:49043363:A G1845* stop_gained 1.00 0
12:49032119:A Q4196* stop_gained 1.00 0
12:49037266:A Q3364* stop_gained 1.00 0
12:49049773:T L1272* stop_gained 1.00 0
12:49048736:A E1352* stop_gained 1.00 0
12:49026950:A E5006* stop_gained 1.00 0
12:49032983:A Q3908* stop_gained 1.00 0
12:49049863:T L1242* stop_gained 1.00 0
12:49037691:T L3222* stop_gained 1.00 0
12:49040908:A K2288* stop_gained 1.00 0
12:49031177:A E4510* stop_gained 1.00 0
12:49046784:A K1415* stop_gained 1.00 0
12:49034927:A K3414* stop_gained 1.00 0
12:49041696:A K2065* stop_gained 1.00 0
12:49038220:A E3046* stop_gained 1.00 0
12:49037608:A E3250* stop_gained 1.00 0
12:49042167:A E2011* stop_gained 1.00 0
12:49031249:A E4486* stop_gained 1.00 0
12:49030940:A E4542* stop_gained 1.00 0
12:49032731:A Q3992* stop_gained 1.00 0
12:49026335:A E5211* stop_gained 1.00 0
12:49037515:A Q3281* stop_gained 1.00 0
12:49046297:A E1516* stop_gained 1.00 0
12:49024926:A E5269* stop_gained 1.00 0
12:49037884:A Q3158* stop_gained 1.00 0
12:49055287:T S13* stop_gained 1.00 0
12:49053639:A E226* stop_gained 1.00 0
12:49033520:A Q3729* stop_gained 1.00 0
12:49030654:A G4596* stop_gained 1.00 0
12:49032023:A Q4228* stop_gained 1.00 0
12:49049137:A K1330* stop_gained 1.00 0
12:49055287:C S13* stop_gained 1.00 0
12:49048733:A E1353* stop_gained 1.00 0
12:49026452:A G5172* stop_gained 1.00 0
12:49024902:A E5277* stop_gained 1.00 0
12:49055315:A Q4* stop_gained 1.00 0
12:49027021:T W4982* stop_gained 1.00 0
12:49038154:A E3068* stop_gained 1.00 0
12:49044499:A E1663* stop_gained 1.00 0
12:49034297:A E3504* stop_gained 1.00 0
12:49040353:A Q2473* stop_gained 1.00 0
12:49034870:A K3433* stop_gained 1.00 0
12:49027025:A K4981* stop_gained 1.00 0
12:49024875:A E5286* stop_gained 1.00 0
12:49042104:A K2032* stop_gained 1.00 0
12:49033913:A K3598* stop_gained 1.00 0
12:49043930:A K1753* stop_gained 1.00 0
12:49024866:A K5289* stop_gained 1.00 0
12:49041961:A K2047* stop_gained 1.00 0
12:49026557:A K5137* stop_gained 1.00 0
12:49026551:A K5139* stop_gained 1.00 0
12:49024600:A K5344* stop_gained 1.00 0
12:49044284:A R1702* stop_gained 1.00 0
12:49033958:A K3583* stop_gained 1.00 0
12:49033949:A K3586* stop_gained 1.00 0
12:49033271:A Q3812* stop_gained 1.00 0
12:49045950:A E1571* stop_gained 1.00 0
12:49033493:A Q3738* stop_gained 1.00 0
12:49055285:A E14* stop_gained 1.00 0
12:49033118:A Q3863* stop_gained 1.00 0
12:49054094:C S186* stop_gained 1.00 0
12:49027925:A K4841* stop_gained 1.00 0
12:49041018:T S2251* stop_gained 1.00 0
12:49045926:A E1579* stop_gained 1.00 0
12:49054094:T S186* stop_gained 1.00 0
12:49045920:A E1581* stop_gained 1.00 0
12:49055294:A K11* stop_gained 1.00 0
12:49033706:A Q3667* stop_gained 1.00 0
12:49045935:A K1576* stop_gained 1.00 0
12:49055312:A K5* stop_gained 1.00 0
12:49032017:A Q4230* stop_gained 1.00 0
12:49027093:T S4958* stop_gained 1.00 0
12:49033487:A Q3740* stop_gained 1.00 0
12:49044212:A Q1726* stop_gained 1.00 0
12:49044203:A E1729* stop_gained 1.00 0
12:49027093:C S4958* stop_gained 1.00 0
12:49032431:A Q4092* stop_gained 1.00 0
12:49044505:A E1661* stop_gained 1.00 0
12:49042846:A Q1893* stop_gained 1.00 0
12:49054407:T W137* stop_gained 1.00 0
12:49042305:A E1965* stop_gained 1.00 0
12:49043096:C L1875* stop_gained 1.00 0
12:49043096:T L1875* stop_gained 1.00 0
12:49038913:A Q2815* stop_gained 1.00 0
12:49034584:A Q3480* stop_gained 1.00 0
12:49041986:T W2038* stop_gained 1.00 0
12:49038910:A Q2816* stop_gained 1.00 0
12:49033892:A Q3605* stop_gained 1.00 0
12:49044890:T S1606* stop_gained 1.00 0
12:49049867:A E1241* stop_gained 1.00 0
12:49053010:T W339* stop_gained 1.00 0
12:49040140:A E2544* stop_gained 1.00 0
12:49044890:C S1606* stop_gained 1.00 0
12:49031288:A Q4473* stop_gained 1.00 0
12:49033618:C S3696* stop_gained 1.00 0
12:49027246:T S4907* stop_gained 1.00 0
12:49032044:A Q4221* stop_gained 1.00 0
12:49032047:A Q4220* stop_gained 1.00 0
12:49033618:T S3696* stop_gained 1.00 0
12:49037221:A Q3379* stop_gained 1.00 0
12:49039584:A Q2694* stop_gained 1.00 0
12:49034665:A Q3453* stop_gained 1.00 0
12:49040437:A Q2445* stop_gained 1.00 0
12:49031198:A Q4503* stop_gained 1.00 0
12:49033436:A Q3757* stop_gained 1.00 0
12:49033130:A Q3859* stop_gained 1.00 0
12:49038286:A E3024* stop_gained 1.00 0
12:49033874:A Q3611* stop_gained 1.00 0
12:49042864:A E1887* stop_gained 1.00 0
12:49038271:A E3029* stop_gained 1.00 0
12:49043975:A E1738* stop_gained 1.00 0
12:49029411:A E4689* stop_gained 1.00 0
12:49034099:A Q3570* stop_gained 1.00 0
12:49037556:T S3267* stop_gained 1.00 0
12:49037556:C S3267* stop_gained 1.00 0
12:49030952:A K4538* stop_gained 1.00 0
12:49044442:A E1682* stop_gained 1.00 0
12:49044448:A E1680* stop_gained 1.00 0
12:49044463:A E1675* stop_gained 1.00 0
12:49037518:A Q3280* stop_gained 1.00 0
12:49029168:T L4715* stop_gained 1.00 0
12:49033558:T L3716* stop_gained 1.00 0
12:49031338:C S4456* stop_gained 1.00 0
12:49031338:T S4456* stop_gained 1.00 0
12:49033558:C L3716* stop_gained 1.00 0
12:49032743:A Q3988* stop_gained 1.00 0
12:49049891:A E1233* stop_gained 1.00 0
12:49044879:A K1610* stop_gained 1.00 0
12:49053978:A E225* stop_gained 1.00 0
12:49032158:A Q4183* stop_gained 1.00 0
12:49037662:A E3232* stop_gained 1.00 0
12:49049741:A K1283* stop_gained 1.00 0
12:49049726:A K1288* stop_gained 1.00 0
12:49049687:A K1301* stop_gained 1.00 0
12:49044927:A E1594* stop_gained 1.00 0
12:49044935:T W1591* stop_gained 1.00 0
12:49044945:A E1588* stop_gained 1.00 0
12:49042329:A E1957* stop_gained 1.00 0
12:49043782:A E1774* stop_gained 1.00 0
12:49046264:A E1527* stop_gained 1.00 0
12:49041306:T S2155* stop_gained 1.00 0
12:49034422:A Q3499* stop_gained 1.00 0
12:49034476:A E3481* stop_gained 1.00 0
12:49042296:A E1968* stop_gained 1.00 0
12:49043767:A K1779* stop_gained 1.00 0
12:49038346:A E3004* stop_gained 1.00 0
12:49042759:A Q1922* stop_gained 1.00 0
12:49037596:A E3254* stop_gained 1.00 0
12:49049969:A E1207* stop_gained 1.00 0
12:49027874:A K4858* stop_gained 1.00 0
12:49049792:A E1266* stop_gained 1.00 0
12:49033901:A Q3602* stop_gained 1.00 0
12:49049735:A E1285* stop_gained 1.00 0
12:49049729:A E1287* stop_gained 1.00 0
12:49037581:A E3259* stop_gained 1.00 0
12:49029462:A K4672* stop_gained 1.00 0
12:49040113:A Q2553* stop_gained 1.00 0
12:49040788:A K2328* stop_gained 1.00 0
12:49041445:A Q2109* stop_gained 1.00 0
12:49044487:A E1667* stop_gained 1.00 0
12:49054406:T W137* stop_gained 1.00 0
12:49054382:T W145* stop_gained 1.00 0
12:49044424:A K1688* stop_gained 1.00 0
12:49054395:T W141* stop_gained 1.00 0
12:49049179:A G1316* stop_gained 1.00 0
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12:49052920:T C369* stop_gained 0.98 0
12:49052655:C Y389* stop_gained 0.98 0
12:49050410:A K1060* stop_gained 0.98 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(CESC) Cervix squamous cancer CESC 0.06 0.00