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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
MYD88 DLBCL ×
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Mutation AA change Consequence type BoostDM score IntOGen frequency
3:38141150:C L273P missense_variant 1.00 35
3:38140801:A S251N missense_variant 0.98 12
3:38140541:G S219C missense_variant 1.00 4
3:38140534:T V217F missense_variant 0.89 2
3:38140768:C M240T missense_variant 0.88 2
3:38140846:T P266L missense_variant 0.94 1
3:38140792:C Y248S missense_variant 0.91 1
3:38141150:G L273R missense_variant 1.00 0
3:38141150:A L273Q missense_variant 1.00 0
3:38140541:T S219F missense_variant 1.00 0
3:38140541:A S219Y missense_variant 1.00 0
3:38140537:C W218R missense_variant 1.00 0
3:38140537:A W218R missense_variant 1.00 0
3:38140535:A V217D missense_variant 1.00 0
3:38140535:G V217G missense_variant 1.00 0
3:38140535:C V217A missense_variant 1.00 0
3:38140537:G W218G missense_variant 1.00 0
3:38140532:T C216F missense_variant 0.98 0
3:38140532:C C216S missense_variant 0.98 0
3:38140532:A C216Y missense_variant 0.98 0
3:38140526:T G214V missense_variant 0.98 0
3:38140526:C G214A missense_variant 0.98 0
3:38140526:A G214D missense_variant 0.98 0
3:38140525:T G214C missense_variant 0.98 0
3:38140525:C G214R missense_variant 0.98 0
3:38140525:A G214S missense_variant 0.98 0
3:38141132:A G267D missense_variant 0.98 0
3:38140848:T G267C missense_variant 0.98 0
3:38140848:C G267R missense_variant 0.98 0
3:38140848:A G267S missense_variant 0.98 0
3:38140568:A R228K missense_variant 0.98 0
3:38140773:A V242M missense_variant 0.98 0
3:38140516:T V211F missense_variant 0.98 0
3:38140770:A V241M missense_variant 0.98 0
3:38140770:C V241L missense_variant 0.98 0
3:38140516:C V211L missense_variant 0.98 0
3:38140516:A V211I missense_variant 0.98 0
3:38140770:T V241L missense_variant 0.98 0
3:38140801:T S251I missense_variant 0.98 0
3:38140801:C S251T missense_variant 0.98 0
3:38140773:T V242L missense_variant 0.98 0
3:38140773:C V242L missense_variant 0.98 0
3:38140568:C R228T missense_variant 0.98 0
3:38141132:T G267V missense_variant 0.98 0
3:38140568:T R228M missense_variant 0.98 0
3:38140561:C E226Q missense_variant 0.98 0
3:38140561:A E226K missense_variant 0.98 0
3:38140569:C R228S missense_variant 0.98 0
3:38140569:T R228S missense_variant 0.98 0
3:38141132:C G267A missense_variant 0.98 0
3:38140759:A C237Y missense_variant 0.98 0
3:38140759:C C237S missense_variant 0.98 0
3:38140759:T C237F missense_variant 0.98 0
3:38141147:A R272Q missense_variant 0.98 0
3:38141147:C R272P missense_variant 0.98 0
3:38141147:T R272L missense_variant 0.98 0
3:38140538:T W218L missense_variant 0.97 0
3:38140538:C W218S missense_variant 0.97 0
3:38141164:G Y278D missense_variant 0.96 0
3:38141164:A Y278N missense_variant 0.96 0
3:38141153:G I274S missense_variant 0.96 0
3:38141153:C I274T missense_variant 0.96 0
3:38141153:A I274N missense_variant 0.96 0
3:38141159:G I276S missense_variant 0.96 0
3:38141159:C I276T missense_variant 0.96 0
3:38141159:A I276N missense_variant 0.96 0
3:38141174:A M281K missense_variant 0.96 0
3:38141174:C M281T missense_variant 0.96 0
3:38141174:G M281R missense_variant 0.96 0
3:38141164:C Y278H missense_variant 0.96 0
3:38140539:C W218C missense_variant 0.96 0
3:38140539:T W218C missense_variant 0.96 0
3:38140511:C R209P missense_variant 0.96 0
3:38140511:A R209H missense_variant 0.96 0
3:38140511:T R209L missense_variant 0.96 0
3:38140475:C Q197P missense_variant 0.96 0
3:38140475:G Q197R missense_variant 0.96 0
3:38140475:T Q197L missense_variant 0.96 0
3:38140543:C I220L missense_variant 0.95 0
3:38140543:G I220V missense_variant 0.95 0
3:38140543:T I220F missense_variant 0.95 0
3:38140830:A A261T missense_variant 0.95 0
3:38140830:C A261P missense_variant 0.95 0
3:38140830:T A261S missense_variant 0.95 0
3:38140785:C D246H missense_variant 0.95 0
3:38140785:A D246N missense_variant 0.95 0
3:38140471:C E196Q missense_variant 0.95 0
3:38140837:A S263N missense_variant 0.95 0
3:38140837:C S263T missense_variant 0.95 0
3:38140837:T S263I missense_variant 0.95 0
3:38140447:A V188M missense_variant 0.95 0
3:38140471:A E196K missense_variant 0.95 0
3:38140499:C C205S missense_variant 0.95 0
3:38140499:A C205Y missense_variant 0.95 0
3:38140499:T C205F missense_variant 0.95 0
3:38140501:A V206M missense_variant 0.95 0
3:38140501:C V206L missense_variant 0.95 0
3:38140501:T V206L missense_variant 0.95 0
3:38140812:C D255H missense_variant 0.95 0
3:38140812:A D255N missense_variant 0.95 0
3:38140810:T C254F missense_variant 0.95 0
3:38140507:A D208N missense_variant 0.95 0
3:38140507:C D208H missense_variant 0.95 0
3:38140507:T D208Y missense_variant 0.95 0
3:38140810:C C254S missense_variant 0.95 0
3:38140810:A C254Y missense_variant 0.95 0
3:38140812:T D255Y missense_variant 0.95 0
3:38140458:T M191I missense_variant 0.95 0
3:38140458:C M191I missense_variant 0.95 0
3:38140788:T D247Y missense_variant 0.95 0
3:38140788:C D247H missense_variant 0.95 0
3:38140788:A D247N missense_variant 0.95 0
3:38140785:T D246Y missense_variant 0.95 0
3:38140447:C V188L missense_variant 0.95 0
3:38140447:T V188L missense_variant 0.95 0
3:38140458:A M191I missense_variant 0.95 0
3:38140555:A L224I missense_variant 0.94 0
3:38140845:T P266S missense_variant 0.94 0
3:38140846:A P266Q missense_variant 0.94 0
3:38140846:G P266R missense_variant 0.94 0
3:38140522:A P213T missense_variant 0.94 0
3:38140522:G P213A missense_variant 0.94 0
3:38140522:T P213S missense_variant 0.94 0
3:38140523:A P213H missense_variant 0.94 0
3:38140523:G P213R missense_variant 0.94 0
3:38140523:T P213L missense_variant 0.94 0
3:38140845:G P266A missense_variant 0.94 0
3:38140845:A P266T missense_variant 0.94 0
3:38140555:G L224V missense_variant 0.94 0
3:38140555:T L224F missense_variant 0.94 0
3:38140477:C T198P missense_variant 0.93 0
3:38140477:G T198A missense_variant 0.93 0
3:38140477:T T198S missense_variant 0.93 0
3:38141138:T H269L missense_variant 0.92 0
3:38141138:C H269P missense_variant 0.92 0
3:38141138:G H269R missense_variant 0.92 0
3:38140762:T R238L missense_variant 0.92 0
3:38140762:C R238P missense_variant 0.92 0
3:38140762:A R238H missense_variant 0.92 0
3:38141144:G K271R missense_variant 0.91 0
3:38141144:T K271M missense_variant 0.91 0
3:38141144:C K271T missense_variant 0.91 0
3:38141179:C K283Q missense_variant 0.91 0
3:38141179:G K283E missense_variant 0.91 0
3:38141143:C K271Q missense_variant 0.91 0
3:38141143:G K271E missense_variant 0.91 0
3:38140792:T Y248F missense_variant 0.91 0
3:38140792:G Y248C missense_variant 0.91 0
3:38140561:T E226* stop_gained 0.90 0
3:38140564:C K227Q missense_variant 0.89 0
3:38140564:G K227E missense_variant 0.89 0
3:38140534:C V217L missense_variant 0.89 0
3:38140534:A V217I missense_variant 0.89 0
3:38140768:G M240R missense_variant 0.88 0
3:38140768:A M240K missense_variant 0.88 0
3:38140795:C L249P missense_variant 0.87 0
3:38140559:G I225S missense_variant 0.87 0
3:38140559:C I225T missense_variant 0.87 0
3:38140758:A C237S missense_variant 0.87 0
3:38140758:C C237R missense_variant 0.87 0
3:38140758:G C237G missense_variant 0.87 0
3:38140559:A I225N missense_variant 0.87 0
3:38140840:A L264H missense_variant 0.87 0
3:38140556:G L224R missense_variant 0.87 0
3:38140556:C L224P missense_variant 0.87 0
3:38140795:G L249R missense_variant 0.87 0
3:38140840:C L264P missense_variant 0.87 0
3:38140840:G L264R missense_variant 0.87 0
3:38140795:A L249Q missense_variant 0.87 0
3:38140556:A L224H missense_variant 0.87 0
3:38140771:A V241E missense_variant 0.87 0
3:38140771:C V241A missense_variant 0.87 0
3:38140771:G V241G missense_variant 0.87 0
3:38140544:G I220S missense_variant 0.87 0
3:38140544:C I220T missense_variant 0.87 0
3:38140544:A I220N missense_variant 0.87 0
3:38140774:A V242E missense_variant 0.87 0
3:38140774:C V242A missense_variant 0.87 0
3:38140774:G V242G missense_variant 0.87 0
3:38140531:G C216G missense_variant 0.87 0
3:38140531:C C216R missense_variant 0.87 0
3:38140531:A C216S missense_variant 0.87 0
3:38140520:G L212R missense_variant 0.87 0
3:38140520:C L212P missense_variant 0.87 0
3:38140520:A L212Q missense_variant 0.87 0
3:38140517:G V211G missense_variant 0.87 0
3:38140791:A Y248N missense_variant 0.87 0
3:38140791:C Y248H missense_variant 0.87 0
3:38140791:G Y248D missense_variant 0.87 0
3:38140517:C V211A missense_variant 0.87 0
3:38140517:A V211D missense_variant 0.87 0
3:38140453:C E190Q missense_variant 0.86 0
3:38140453:A E190K missense_variant 0.86 0
3:38140833:G L262V missense_variant 0.86 0
3:38140818:A Q257K missense_variant 0.86 0
3:38140833:T L262F missense_variant 0.86 0
3:38140822:T T258I missense_variant 0.86 0
3:38140833:A L262I missense_variant 0.86 0
3:38140831:A A261E missense_variant 0.86 0
3:38140822:G T258S missense_variant 0.86 0
3:38140783:A S245Y missense_variant 0.86 0
3:38140783:G S245C missense_variant 0.86 0
3:38140783:T S245F missense_variant 0.86 0
3:38140822:A T258N missense_variant 0.86 0
3:38140818:G Q257E missense_variant 0.86 0
3:38140831:T A261V missense_variant 0.86 0
3:38140831:G A261G missense_variant 0.86 0
3:38140538:A W218* stop_gained 0.85 0
3:38140456:C M191L missense_variant 0.84 0
3:38140456:T M191L missense_variant 0.84 0
3:38140456:G M191V missense_variant 0.84 0
3:38140769:A M240I missense_variant 0.83 0
3:38140769:C M240I missense_variant 0.83 0
3:38140769:T M240I missense_variant 0.83 0
3:38140767:T M240L missense_variant 0.82 0
3:38140767:C M240L missense_variant 0.82 0
3:38140767:G M240V missense_variant 0.82 0
3:38140539:A W218* stop_gained 0.81 0
3:38141167:C K279Q missense_variant 0.80 0
3:38141173:T M281L missense_variant 0.80 0
3:38141167:G K279E missense_variant 0.80 0
3:38141168:C K279T missense_variant 0.80 0
3:38141168:G K279R missense_variant 0.80 0
3:38141152:T I274F missense_variant 0.80 0
3:38141152:G I274V missense_variant 0.80 0
3:38141152:C I274L missense_variant 0.80 0
3:38141168:T K279M missense_variant 0.80 0
3:38141173:G M281V missense_variant 0.80 0
3:38141173:C M281L missense_variant 0.80 0
3:38140514:C D210A missense_variant 0.80 0
3:38140558:T I225F missense_variant 0.80 0
3:38140800:C S251R missense_variant 0.80 0
3:38140562:C E226A missense_variant 0.80 0
3:38140800:G S251G missense_variant 0.80 0
3:38140514:T D210V missense_variant 0.80 0
3:38140553:C E223A missense_variant 0.80 0
3:38140553:G E223G missense_variant 0.80 0
3:38140553:T E223V missense_variant 0.80 0
3:38140562:T E226V missense_variant 0.80 0
3:38140558:C I225L missense_variant 0.80 0
3:38140558:G I225V missense_variant 0.80 0
3:38140800:T S251C missense_variant 0.80 0
3:38140514:G D210G missense_variant 0.80 0
3:38140562:G E226G missense_variant 0.80 0
3:38140824:C K259Q missense_variant 0.75 0
3:38140824:G K259E missense_variant 0.75 0
3:38140825:C K259T missense_variant 0.75 0
3:38140825:G K259R missense_variant 0.75 0
3:38140492:C K203Q missense_variant 0.75 0
3:38140492:G K203E missense_variant 0.75 0
3:38140493:C K203T missense_variant 0.75 0
3:38140836:C S263R missense_variant 0.75 0
3:38140836:G S263G missense_variant 0.75 0
3:38140836:T S263C missense_variant 0.75 0
3:38140825:T K259I missense_variant 0.75 0
3:38140508:T D208V missense_variant 0.75 0
3:38140472:C E196A missense_variant 0.75 0
3:38140472:G E196G missense_variant 0.75 0
3:38140472:T E196V missense_variant 0.75 0
3:38140508:G D208G missense_variant 0.75 0
3:38140508:C D208A missense_variant 0.75 0
3:38140789:T D247V missense_variant 0.75 0
3:38140789:G D247G missense_variant 0.75 0
3:38140789:C D247A missense_variant 0.75 0
3:38140459:T I192F missense_variant 0.75 0
3:38140813:C D255A missense_variant 0.75 0
3:38140813:G D255G missense_variant 0.75 0
3:38140813:T D255V missense_variant 0.75 0
3:38140459:G I192V missense_variant 0.75 0
3:38140459:C I192L missense_variant 0.75 0
3:38140493:T K203M missense_variant 0.75 0
3:38140493:G K203R missense_variant 0.75 0
3:38140786:T D246V missense_variant 0.75 0
3:38140786:G D246G missense_variant 0.75 0
3:38140819:C Q257P missense_variant 0.75 0
3:38140819:G Q257R missense_variant 0.75 0
3:38140819:T Q257L missense_variant 0.75 0
3:38140821:C T258P missense_variant 0.75 0
3:38140821:G T258A missense_variant 0.75 0
3:38140821:T T258S missense_variant 0.75 0
3:38140786:C D246A missense_variant 0.75 0
3:38140471:T E196* stop_gained 0.75 0
3:38140834:A L262H missense_variant 0.73 0
3:38140444:C F187L missense_variant 0.73 0
3:38140444:G F187V missense_variant 0.73 0
3:38140445:A F187Y missense_variant 0.73 0
3:38140445:C F187S missense_variant 0.73 0
3:38140445:G F187C missense_variant 0.73 0
3:38140448:A V188E missense_variant 0.73 0
3:38140448:C V188A missense_variant 0.73 0
3:38140448:G V188G missense_variant 0.73 0
3:38140457:A M191K missense_variant 0.73 0
3:38140457:C M191T missense_variant 0.73 0
3:38140457:G M191R missense_variant 0.73 0
3:38140460:A I192N missense_variant 0.73 0
3:38140460:C I192T missense_variant 0.73 0
3:38140460:G I192S missense_variant 0.73 0
3:38140469:A L195Q missense_variant 0.73 0
3:38140469:C L195P missense_variant 0.73 0
3:38140469:G L195R missense_variant 0.73 0
3:38140490:A L202Q missense_variant 0.73 0
3:38140490:C L202P missense_variant 0.73 0
3:38140490:G L202R missense_variant 0.73 0
3:38140496:C L204S missense_variant 0.73 0
3:38140496:G L204W missense_variant 0.73 0
3:38140498:A C205S missense_variant 0.73 0
3:38140498:C C205R missense_variant 0.73 0
3:38140498:G C205G missense_variant 0.73 0
3:38140502:A V206E missense_variant 0.73 0
3:38140502:C V206A missense_variant 0.73 0
3:38140502:G V206G missense_variant 0.73 0
3:38140777:A V243D missense_variant 0.73 0
3:38140777:C V243A missense_variant 0.73 0
3:38140777:G V243G missense_variant 0.73 0
3:38140780:A V244D missense_variant 0.73 0
3:38140780:C V244A missense_variant 0.73 0
3:38140780:G V244G missense_variant 0.73 0
3:38140809:A C254S missense_variant 0.73 0
3:38140809:C C254R missense_variant 0.73 0
3:38140809:G C254G missense_variant 0.73 0
3:38140815:A F256I missense_variant 0.73 0
3:38140815:C F256L missense_variant 0.73 0
3:38140815:G F256V missense_variant 0.73 0
3:38140816:A F256Y missense_variant 0.73 0
3:38140816:C F256S missense_variant 0.73 0
3:38140816:G F256C missense_variant 0.73 0
3:38140828:A F260Y missense_variant 0.73 0
3:38140828:C F260S missense_variant 0.73 0
3:38140828:G F260C missense_variant 0.73 0
3:38140444:A F187I missense_variant 0.73 0
3:38140834:C L262P missense_variant 0.73 0
3:38140834:G L262R missense_variant 0.73 0
3:38141156:T P275L missense_variant 0.73 0
3:38141137:T H269Y missense_variant 0.73 0
3:38141137:G H269D missense_variant 0.73 0
3:38141137:A H269N missense_variant 0.73 0
3:38141155:T P275S missense_variant 0.73 0
3:38141155:G P275A missense_variant 0.73 0
3:38141155:A P275T missense_variant 0.73 0
3:38141156:G P275R missense_variant 0.73 0
3:38141156:A P275H missense_variant 0.73 0
3:38141179:T K283* stop_gained 0.59 0
3:38141143:T K271* stop_gained 0.58 0
3:38140564:T K227* stop_gained 0.54 0
3:38141258:A R309H missense_variant 0.54 0
3:38141258:C R309P missense_variant 0.54 0
3:38141258:T R309L missense_variant 0.54 0
3:38141263:A A311T missense_variant 0.54 0
3:38141263:C A311P missense_variant 0.54 0
3:38141263:T A311S missense_variant 0.54 0
3:38141201:A R290K missense_variant 0.54 0
3:38141201:C R290T missense_variant 0.54 0
3:38141201:T R290M missense_variant 0.54 0
3:38141246:C W305S missense_variant 0.54 0
3:38141246:T W305L missense_variant 0.54 0
3:38141247:C W305C missense_variant 0.54 0
3:38141247:T W305C missense_variant 0.54 0
3:38141252:C W307S missense_variant 0.54 0
3:38141252:T W307L missense_variant 0.54 0
3:38141253:C W307C missense_variant 0.54 0
3:38141253:T W307C missense_variant 0.54 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(DLBCL) Diffuse large B-cell lymphoma DLBCL 0.92 0.18