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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
NFE2L2 ESCA ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
2:177234225:G G31A missense_variant 1.00 3
2:177234082:G E79Q missense_variant 1.00 2
2:177234216:G R34P missense_variant 1.00 1
2:177234232:G D29H missense_variant 1.00 1
2:177234076:T G81S missense_variant 1.00 1
2:177234075:A G81V missense_variant 1.00 1
2:177234076:G G81R missense_variant 1.00 1
2:177234082:T E79K missense_variant 1.00 1
2:177234240:C Q26R missense_variant 1.00 1
2:177234072:C E82G missense_variant 1.00 1
2:177234072:G E82A missense_variant 1.00 1
2:177234081:C E79G missense_variant 1.00 1
2:177234225:A G31V missense_variant 1.00 1
2:177234225:T G31E missense_variant 1.00 1
2:177234229:A L30F missense_variant 1.00 1
2:177234241:T Q26K missense_variant 1.00 1
2:177234245:T W24* stop_gained 1.00 1
2:177234247:G W24R missense_variant 1.00 1
2:177234247:T W24R missense_variant 1.00 1
2:177234078:C T80R missense_variant 1.00 1
2:177234217:C R34G missense_variant 0.99 1
2:177234205:G D38H missense_variant 0.60 1
2:177231474:T E377K missense_variant 0.53 1
2:177234226:G G31R missense_variant 1.00 0
2:177234238:T D27N missense_variant 1.00 0
2:177234238:G D27H missense_variant 1.00 0
2:177234238:A D27Y missense_variant 1.00 0
2:177234219:G S33T missense_variant 1.00 0
2:177234232:A D29Y missense_variant 1.00 0
2:177234226:T G31R missense_variant 1.00 0
2:177234216:T R34Q missense_variant 1.00 0
2:177234232:T D29N missense_variant 1.00 0
2:177234245:A W24C missense_variant 1.00 0
2:177234219:T S33N missense_variant 1.00 0
2:177234245:G W24C missense_variant 1.00 0
2:177234223:T V32I missense_variant 1.00 0
2:177234223:G V32L missense_variant 1.00 0
2:177234219:A S33I missense_variant 1.00 0
2:177234223:A V32L missense_variant 1.00 0
2:177234216:A R34L missense_variant 1.00 0
2:177234246:A W24L missense_variant 1.00 0
2:177234246:G W24S missense_variant 1.00 0
2:177234073:G E82Q missense_variant 1.00 0
2:177234076:A G81C missense_variant 1.00 0
2:177234075:T G81D missense_variant 1.00 0
2:177234075:G G81A missense_variant 1.00 0
2:177234073:T E82K missense_variant 1.00 0
2:177234237:G D27A missense_variant 1.00 0
2:177234240:A Q26L missense_variant 1.00 0
2:177234240:G Q26P missense_variant 1.00 0
2:177234237:A D27V missense_variant 1.00 0
2:177234237:C D27G missense_variant 1.00 0
2:177234231:G D29A missense_variant 1.00 0
2:177234231:C D29G missense_variant 1.00 0
2:177234231:A D29V missense_variant 1.00 0
2:177234079:A T80S missense_variant 1.00 0
2:177234079:C T80A missense_variant 1.00 0
2:177234079:G T80P missense_variant 1.00 0
2:177234081:A E79V missense_variant 1.00 0
2:177234072:A E82V missense_variant 1.00 0
2:177234081:G E79A missense_variant 1.00 0
2:177234228:T L30H missense_variant 1.00 0
2:177234234:C I28R missense_variant 1.00 0
2:177234234:G I28T missense_variant 1.00 0
2:177234234:T I28K missense_variant 1.00 0
2:177234228:C L30R missense_variant 1.00 0
2:177234228:G L30P missense_variant 1.00 0
2:177234241:C Q26E missense_variant 1.00 0
2:177234229:C L30V missense_variant 1.00 0
2:177234229:T L30I missense_variant 1.00 0
2:177234226:A G31* stop_gained 1.00 0
2:177234247:C W24G missense_variant 1.00 0
2:177234246:T W24* stop_gained 1.00 0
2:177234078:A T80I missense_variant 1.00 0
2:177234078:T T80K missense_variant 1.00 0
2:177234244:C R25G missense_variant 1.00 0
2:177234244:A R25W missense_variant 1.00 0
2:177234073:A E82* stop_gained 1.00 0
2:177234082:A E79* stop_gained 1.00 0
2:177234241:A Q26* stop_gained 0.99 0
2:177234217:A R34* stop_gained 0.98 0
2:177234222:T V32E missense_variant 0.97 0
2:177234222:C V32G missense_variant 0.97 0
2:177234222:G V32A missense_variant 0.97 0
2:177234235:G I28L missense_variant 0.92 0
2:177234235:C I28V missense_variant 0.92 0
2:177234235:A I28L missense_variant 0.92 0
2:177234243:A R25M missense_variant 0.92 0
2:177234243:T R25K missense_variant 0.92 0
2:177234243:G R25T missense_variant 0.92 0
2:177234239:A Q26H missense_variant 0.91 0
2:177234239:G Q26H missense_variant 0.91 0
2:177234236:C D27E missense_variant 0.85 0
2:177234236:T D27E missense_variant 0.85 0
2:177234242:G R25S missense_variant 0.83 0
2:177234242:A R25S missense_variant 0.83 0
2:177234220:A S33C missense_variant 0.83 0
2:177234230:C D29E missense_variant 0.83 0
2:177234220:C S33G missense_variant 0.83 0
2:177234230:T D29E missense_variant 0.83 0
2:177234220:G S33R missense_variant 0.83 0
2:177234233:C I28M missense_variant 0.83 0
2:177234218:C S33R missense_variant 0.83 0
2:177234218:T S33R missense_variant 0.83 0
2:177234080:A E79D missense_variant 0.82 0
2:177234080:G E79D missense_variant 0.82 0
2:177234211:A V36L missense_variant 0.60 0
2:177234205:A D38Y missense_variant 0.60 0
2:177234271:T D16N missense_variant 0.60 0
2:177234271:G D16H missense_variant 0.60 0
2:177234192:T R42Q missense_variant 0.60 0
2:177234192:G R42P missense_variant 0.60 0
2:177234192:A R42L missense_variant 0.60 0
2:177234124:T E65K missense_variant 0.60 0
2:177234124:G E65Q missense_variant 0.60 0
2:177234088:T D77N missense_variant 0.60 0
2:177234088:G D77H missense_variant 0.60 0
2:177234211:T V36I missense_variant 0.60 0
2:177234211:G V36L missense_variant 0.60 0
2:177234205:T D38N missense_variant 0.60 0
2:177234088:A D77Y missense_variant 0.60 0
2:177234085:T E78K missense_variant 0.60 0
2:177234085:G E78Q missense_variant 0.60 0
2:177234214:T E35K missense_variant 0.60 0
2:177230922:C Y561D missense_variant 0.60 0
2:177233296:T C119Y missense_variant 0.60 0
2:177233296:G C119S missense_variant 0.60 0
2:177233296:A C119F missense_variant 0.60 0
2:177231273:T D444N missense_variant 0.60 0
2:177233292:T M120I missense_variant 0.60 0
2:177233292:G M120I missense_variant 0.60 0
2:177233292:A M120I missense_variant 0.60 0
2:177234271:A D16Y missense_variant 0.60 0
2:177234256:T D21N missense_variant 0.60 0
2:177234256:G D21H missense_variant 0.60 0
2:177234256:A D21Y missense_variant 0.60 0
2:177230922:G Y561H missense_variant 0.60 0
2:177230922:T Y561N missense_variant 0.60 0
2:177231273:A D444Y missense_variant 0.60 0
2:177231273:G D444H missense_variant 0.60 0
2:177234214:G E35Q missense_variant 0.60 0
2:177231476:T S376Y missense_variant 0.58 0
2:177231476:C S376C missense_variant 0.58 0
2:177231476:A S376F missense_variant 0.58 0
2:177231465:T E380K missense_variant 0.53 0
2:177231582:T D341N missense_variant 0.53 0
2:177231582:G D341H missense_variant 0.53 0
2:177231582:A D341Y missense_variant 0.53 0
2:177231576:T D343N missense_variant 0.53 0
2:177231576:G D343H missense_variant 0.53 0
2:177231576:A D343Y missense_variant 0.53 0
2:177231570:T G345S missense_variant 0.53 0
2:177231570:G G345R missense_variant 0.53 0
2:177231570:A G345C missense_variant 0.53 0
2:177231482:T S374N missense_variant 0.53 0
2:177231482:G S374T missense_variant 0.53 0
2:177231482:A S374I missense_variant 0.53 0
2:177231480:T D375N missense_variant 0.53 0
2:177231480:G D375H missense_variant 0.53 0
2:177231480:A D375Y missense_variant 0.53 0
2:177231474:G E377Q missense_variant 0.53 0
2:177231468:T E379K missense_variant 0.53 0
2:177231468:G E379Q missense_variant 0.53 0
2:177231465:G E380Q missense_variant 0.53 0
2:177231459:T D382N missense_variant 0.53 0
2:177231459:G D382H missense_variant 0.53 0
2:177231459:A D382Y missense_variant 0.53 0
2:177232519:C F156C missense_variant 0.52 0
2:177232519:G F156S missense_variant 0.52 0
2:177232519:T F156Y missense_variant 0.52 0
2:177231591:T E338K missense_variant 0.52 0
2:177231591:G E338Q missense_variant 0.52 0
2:177231746:C Y286C missense_variant 0.52 0
2:177231746:G Y286S missense_variant 0.52 0
2:177234196:C Q41E missense_variant 0.52 0
2:177234196:T Q41K missense_variant 0.52 0
2:177231182:T I474N missense_variant 0.52 0
2:177231182:G I474T missense_variant 0.52 0
2:177231182:C I474S missense_variant 0.52 0
2:177231746:A Y286F missense_variant 0.52 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(ESCA) Esophageal cancer ESCA 0.20 0.10