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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
NFE2L2 HNSC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
2:177234082:G E79Q missense_variant 1.00 4
2:177234232:G D29H missense_variant 1.00 4
2:177234082:T E79K missense_variant 1.00 3
2:177234245:G W24C missense_variant 1.00 1
2:177234076:A G81C missense_variant 1.00 1
2:177234237:A D27V missense_variant 1.00 1
2:177234237:C D27G missense_variant 1.00 1
2:177234079:C T80A missense_variant 1.00 1
2:177234072:A E82V missense_variant 1.00 1
2:177234247:G W24R missense_variant 1.00 1
2:177234228:T L30H missense_variant 1.00 1
2:177234234:G I28T missense_variant 1.00 1
2:177234228:G L30P missense_variant 1.00 1
2:177234229:A L30F missense_variant 1.00 1
2:177234232:A D29Y missense_variant 1.00 1
2:177234232:T D29N missense_variant 1.00 1
2:177234217:C R34G missense_variant 0.98 1
2:177234222:C V32G missense_variant 0.91 1
2:177231999:A I202F missense_variant 0.69 1
2:177230895:T D570N missense_variant 0.67 1
2:177231236:G R456T missense_variant 0.67 1
2:177231233:C D457G missense_variant 0.61 1
2:177234246:G W24S missense_variant 1.00 0
2:177234246:A W24L missense_variant 1.00 0
2:177234216:G R34P missense_variant 1.00 0
2:177234226:G G31R missense_variant 1.00 0
2:177234245:A W24C missense_variant 1.00 0
2:177234216:A R34L missense_variant 1.00 0
2:177234223:T V32I missense_variant 1.00 0
2:177234219:G S33T missense_variant 1.00 0
2:177234219:A S33I missense_variant 1.00 0
2:177234238:A D27Y missense_variant 1.00 0
2:177234238:G D27H missense_variant 1.00 0
2:177234238:T D27N missense_variant 1.00 0
2:177234226:T G31R missense_variant 1.00 0
2:177234223:A V32L missense_variant 1.00 0
2:177234219:T S33N missense_variant 1.00 0
2:177234223:G V32L missense_variant 1.00 0
2:177234216:T R34Q missense_variant 1.00 0
2:177234073:G E82Q missense_variant 1.00 0
2:177234076:G G81R missense_variant 1.00 0
2:177234075:T G81D missense_variant 1.00 0
2:177234075:G G81A missense_variant 1.00 0
2:177234075:A G81V missense_variant 1.00 0
2:177234073:T E82K missense_variant 1.00 0
2:177234076:T G81S missense_variant 1.00 0
2:177234240:G Q26P missense_variant 1.00 0
2:177234231:G D29A missense_variant 1.00 0
2:177234231:C D29G missense_variant 1.00 0
2:177234237:G D27A missense_variant 1.00 0
2:177234231:A D29V missense_variant 1.00 0
2:177234240:A Q26L missense_variant 1.00 0
2:177234240:C Q26R missense_variant 1.00 0
2:177234081:G E79A missense_variant 1.00 0
2:177234072:G E82A missense_variant 1.00 0
2:177234081:C E79G missense_variant 1.00 0
2:177234072:C E82G missense_variant 1.00 0
2:177234081:A E79V missense_variant 1.00 0
2:177234079:G T80P missense_variant 1.00 0
2:177234079:A T80S missense_variant 1.00 0
2:177234246:T W24* stop_gained 1.00 0
2:177234226:A G31* stop_gained 1.00 0
2:177234245:T W24* stop_gained 1.00 0
2:177234073:A E82* stop_gained 1.00 0
2:177234082:A E79* stop_gained 1.00 0
2:177234247:C W24G missense_variant 1.00 0
2:177234247:T W24R missense_variant 1.00 0
2:177234229:C L30V missense_variant 1.00 0
2:177234241:C Q26E missense_variant 1.00 0
2:177234241:T Q26K missense_variant 1.00 0
2:177234234:C I28R missense_variant 1.00 0
2:177234229:T L30I missense_variant 1.00 0
2:177234234:T I28K missense_variant 1.00 0
2:177234228:C L30R missense_variant 1.00 0
2:177234078:A T80I missense_variant 1.00 0
2:177234078:C T80R missense_variant 1.00 0
2:177234078:T T80K missense_variant 1.00 0
2:177234241:A Q26* stop_gained 0.99 0
2:177234225:A G31V missense_variant 0.98 0
2:177234225:T G31E missense_variant 0.98 0
2:177234225:G G31A missense_variant 0.98 0
2:177234244:A R25W missense_variant 0.98 0
2:177234244:C R25G missense_variant 0.98 0
2:177234217:A R34* stop_gained 0.94 0
2:177234222:G V32A missense_variant 0.91 0
2:177234222:T V32E missense_variant 0.91 0
2:177234230:C D29E missense_variant 0.81 0
2:177234230:T D29E missense_variant 0.81 0
2:177234218:C S33R missense_variant 0.80 0
2:177234218:T S33R missense_variant 0.80 0
2:177234233:C I28M missense_variant 0.80 0
2:177234080:A E79D missense_variant 0.80 0
2:177234080:G E79D missense_variant 0.80 0
2:177234088:G D77H missense_variant 0.79 0
2:177234271:T D16N missense_variant 0.79 0
2:177234271:G D16H missense_variant 0.79 0
2:177234271:A D16Y missense_variant 0.79 0
2:177234256:T D21N missense_variant 0.79 0
2:177234256:G D21H missense_variant 0.79 0
2:177234256:A D21Y missense_variant 0.79 0
2:177230922:C Y561D missense_variant 0.79 0
2:177230922:G Y561H missense_variant 0.79 0
2:177230922:T Y561N missense_variant 0.79 0
2:177234214:T E35K missense_variant 0.79 0
2:177234214:G E35Q missense_variant 0.79 0
2:177234211:T V36I missense_variant 0.79 0
2:177234211:G V36L missense_variant 0.79 0
2:177234211:A V36L missense_variant 0.79 0
2:177234205:T D38N missense_variant 0.79 0
2:177234205:G D38H missense_variant 0.79 0
2:177234205:A D38Y missense_variant 0.79 0
2:177234192:T R42Q missense_variant 0.79 0
2:177234192:G R42P missense_variant 0.79 0
2:177234192:A R42L missense_variant 0.79 0
2:177234124:T E65K missense_variant 0.79 0
2:177234124:G E65Q missense_variant 0.79 0
2:177234088:T D77N missense_variant 0.79 0
2:177234088:A D77Y missense_variant 0.79 0
2:177234085:T E78K missense_variant 0.79 0
2:177234085:G E78Q missense_variant 0.79 0
2:177233296:T C119Y missense_variant 0.79 0
2:177233296:G C119S missense_variant 0.79 0
2:177233296:A C119F missense_variant 0.79 0
2:177233292:T M120I missense_variant 0.79 0
2:177233292:G M120I missense_variant 0.79 0
2:177233292:A M120I missense_variant 0.79 0
2:177231273:T D444N missense_variant 0.79 0
2:177231273:G D444H missense_variant 0.79 0
2:177231273:A D444Y missense_variant 0.79 0
2:177234220:A S33C missense_variant 0.78 0
2:177234220:G S33R missense_variant 0.78 0
2:177234220:C S33G missense_variant 0.78 0
2:177231476:T S376Y missense_variant 0.77 0
2:177231476:C S376C missense_variant 0.77 0
2:177231476:A S376F missense_variant 0.77 0
2:177231465:G E380Q missense_variant 0.73 0
2:177231465:T E380K missense_variant 0.73 0
2:177231468:G E379Q missense_variant 0.73 0
2:177231468:T E379K missense_variant 0.73 0
2:177231474:G E377Q missense_variant 0.73 0
2:177231474:T E377K missense_variant 0.73 0
2:177231480:A D375Y missense_variant 0.73 0
2:177231582:T D341N missense_variant 0.73 0
2:177231582:G D341H missense_variant 0.73 0
2:177231582:A D341Y missense_variant 0.73 0
2:177231576:T D343N missense_variant 0.73 0
2:177231576:G D343H missense_variant 0.73 0
2:177231576:A D343Y missense_variant 0.73 0
2:177231570:T G345S missense_variant 0.73 0
2:177231570:G G345R missense_variant 0.73 0
2:177231570:A G345C missense_variant 0.73 0
2:177231480:G D375H missense_variant 0.73 0
2:177231480:T D375N missense_variant 0.73 0
2:177231482:A S374I missense_variant 0.73 0
2:177231482:T S374N missense_variant 0.73 0
2:177231482:G S374T missense_variant 0.73 0
2:177231459:A D382Y missense_variant 0.73 0
2:177231459:G D382H missense_variant 0.73 0
2:177231459:T D382N missense_variant 0.73 0
2:177234235:G I28L missense_variant 0.73 0
2:177234235:A I28L missense_variant 0.73 0
2:177234235:C I28V missense_variant 0.73 0
2:177234242:G R25S missense_variant 0.73 0
2:177234242:A R25S missense_variant 0.73 0
2:177231591:G E338Q missense_variant 0.72 0
2:177232519:G F156S missense_variant 0.72 0
2:177232519:T F156Y missense_variant 0.72 0
2:177232519:C F156C missense_variant 0.72 0
2:177231591:T E338K missense_variant 0.72 0
2:177231182:C I474S missense_variant 0.72 0
2:177231182:G I474T missense_variant 0.72 0
2:177231182:T I474N missense_variant 0.72 0
2:177231746:G Y286S missense_variant 0.72 0
2:177231746:C Y286C missense_variant 0.72 0
2:177231746:A Y286F missense_variant 0.72 0
2:177234196:C Q41E missense_variant 0.72 0
2:177234196:T Q41K missense_variant 0.72 0
2:177234243:A R25M missense_variant 0.71 0
2:177234243:G R25T missense_variant 0.71 0
2:177234243:T R25K missense_variant 0.71 0
2:177230984:T L540H missense_variant 0.70 0
2:177230984:C L540R missense_variant 0.70 0
2:177230984:G L540P missense_variant 0.70 0
2:177232002:C N201D missense_variant 0.69 0
2:177231999:G I202L missense_variant 0.69 0
2:177232002:G N201H missense_variant 0.69 0
2:177232002:A N201Y missense_variant 0.69 0
2:177231999:C I202V missense_variant 0.69 0
2:177234236:T D27E missense_variant 0.68 0
2:177234236:C D27E missense_variant 0.68 0
2:177234135:A Q61L missense_variant 0.68 0
2:177234270:C D16G missense_variant 0.68 0
2:177234270:G D16A missense_variant 0.68 0
2:177230904:C M567V missense_variant 0.68 0
2:177230904:A M567L missense_variant 0.68 0
2:177234135:C Q61R missense_variant 0.68 0
2:177234213:C E35G missense_variant 0.68 0
2:177234204:A D38V missense_variant 0.68 0
2:177234270:A D16V missense_variant 0.68 0
2:177234213:G E35A missense_variant 0.68 0
2:177234204:C D38G missense_variant 0.68 0
2:177234213:A E35V missense_variant 0.68 0
2:177234264:G D18A missense_variant 0.68 0
2:177234264:C D18G missense_variant 0.68 0
2:177234084:G E78A missense_variant 0.68 0
2:177234153:C E55G missense_variant 0.68 0
2:177234153:A E55V missense_variant 0.68 0
2:177234147:G E57A missense_variant 0.68 0
2:177234259:C I20V missense_variant 0.68 0
2:177234153:G E55A missense_variant 0.68 0
2:177233299:G D118A missense_variant 0.68 0
2:177234135:G Q61P missense_variant 0.68 0
2:177230904:G M567L missense_variant 0.68 0
2:177234253:A I22L missense_variant 0.68 0
2:177234253:C I22V missense_variant 0.68 0
2:177234253:G I22L missense_variant 0.68 0
2:177234255:A D21V missense_variant 0.68 0
2:177234255:C D21G missense_variant 0.68 0
2:177234255:G D21A missense_variant 0.68 0
2:177234259:A I20F missense_variant 0.68 0
2:177234114:A K68I missense_variant 0.68 0
2:177234147:A E57V missense_variant 0.68 0
2:177234147:C E57G missense_variant 0.68 0
2:177234114:C K68R missense_variant 0.68 0
2:177234114:G K68T missense_variant 0.68 0
2:177234264:A D18V missense_variant 0.68 0
2:177233299:C D118G missense_variant 0.68 0
2:177233299:A D118V missense_variant 0.68 0
2:177234087:G D77A missense_variant 0.68 0
2:177234087:C D77G missense_variant 0.68 0
2:177234087:A D77V missense_variant 0.68 0
2:177234084:A E78V missense_variant 0.68 0
2:177234259:G I20L missense_variant 0.68 0
2:177234084:C E78G missense_variant 0.68 0
2:177234204:G D38A missense_variant 0.68 0
2:177234239:G Q26H missense_variant 0.67 0
2:177234239:A Q26H missense_variant 0.67 0
2:177230804:T P600Q missense_variant 0.67 0
2:177230804:C P600R missense_variant 0.67 0
2:177230804:A P600L missense_variant 0.67 0
2:177231105:T D500N missense_variant 0.67 0
2:177231168:A V479F missense_variant 0.67 0
2:177231168:G V479L missense_variant 0.67 0
2:177231168:T V479I missense_variant 0.67 0
2:177230979:G E542Q missense_variant 0.67 0
2:177230979:T E542K missense_variant 0.67 0
2:177230994:G E537Q missense_variant 0.67 0
2:177230994:T E537K missense_variant 0.67 0
2:177231000:G E535Q missense_variant 0.67 0
2:177231000:T E535K missense_variant 0.67 0
2:177231236:T R456K missense_variant 0.67 0
2:177231236:A R456I missense_variant 0.67 0
2:177231234:T D457N missense_variant 0.67 0
2:177231045:G E520Q missense_variant 0.67 0
2:177231045:T E520K missense_variant 0.67 0
2:177231234:G D457H missense_variant 0.67 0
2:177231234:A D457Y missense_variant 0.67 0
2:177231053:A R517I missense_variant 0.67 0
2:177231053:G R517T missense_variant 0.67 0
2:177231053:T R517K missense_variant 0.67 0
2:177231231:T E458K missense_variant 0.67 0
2:177231059:A R515I missense_variant 0.67 0
2:177231059:G R515T missense_variant 0.67 0
2:177231059:T R515K missense_variant 0.67 0
2:177231062:A C514F missense_variant 0.67 0
2:177231062:G C514S missense_variant 0.67 0
2:177231062:T C514Y missense_variant 0.67 0
2:177230838:T G589S missense_variant 0.67 0
2:177230838:G G589R missense_variant 0.67 0
2:177230838:A G589C missense_variant 0.67 0
2:177230837:T G589D missense_variant 0.67 0
2:177230837:G G589A missense_variant 0.67 0
2:177230837:A G589V missense_variant 0.67 0
2:177231072:A A511S missense_variant 0.67 0
2:177231072:G A511P missense_variant 0.67 0
2:177231072:T A511T missense_variant 0.67 0
2:177231075:A A510S missense_variant 0.67 0
2:177231075:G A510P missense_variant 0.67 0
2:177231075:T A510T missense_variant 0.67 0
2:177231078:A V509L missense_variant 0.67 0
2:177231078:G V509L missense_variant 0.67 0
2:177231078:T V509M missense_variant 0.67 0
2:177231231:G E458Q missense_variant 0.67 0
2:177231222:T A461T missense_variant 0.67 0
2:177231222:G A461P missense_variant 0.67 0
2:177231222:A A461S missense_variant 0.67 0
2:177231089:A G505V missense_variant 0.67 0
2:177231089:G G505A missense_variant 0.67 0
2:177231089:T G505D missense_variant 0.67 0
2:177231090:A G505C missense_variant 0.67 0
2:177231090:G G505R missense_variant 0.67 0
2:177231090:T G505S missense_variant 0.67 0
2:177231092:A R504M missense_variant 0.67 0
2:177231092:G R504T missense_variant 0.67 0
2:177231092:T R504K missense_variant 0.67 0
2:177231095:A R503M missense_variant 0.67 0
2:177231095:G R503T missense_variant 0.67 0
2:177231095:T R503K missense_variant 0.67 0
2:177231098:A R502L missense_variant 0.67 0
2:177231098:G R502P missense_variant 0.67 0
2:177231098:T R502H missense_variant 0.67 0
2:177231195:T V470I missense_variant 0.67 0
2:177231195:G V470L missense_variant 0.67 0
2:177231105:A D500Y missense_variant 0.67 0
2:177231105:G D500H missense_variant 0.67 0
2:177231129:G E492Q missense_variant 0.67 0
2:177231129:T E492K missense_variant 0.67 0
2:177231148:A M485I missense_variant 0.67 0
2:177231148:G M485I missense_variant 0.67 0
2:177231148:T M485I missense_variant 0.67 0
2:177231195:A V470L missense_variant 0.67 0
2:177230902:T M567I missense_variant 0.67 0
2:177230902:G M567I missense_variant 0.67 0
2:177230902:A M567I missense_variant 0.67 0
2:177230895:G D570H missense_variant 0.67 0
2:177230895:A D570Y missense_variant 0.67 0
2:177230886:T G573R missense_variant 0.67 0
2:177230886:G G573R missense_variant 0.67 0
2:177230885:T G573E missense_variant 0.67 0
2:177230885:G G573A missense_variant 0.67 0
2:177230885:A G573V missense_variant 0.67 0
2:177230913:A V564F missense_variant 0.67 0
2:177230913:G V564L missense_variant 0.67 0
2:177230913:T V564I missense_variant 0.67 0
2:177234051:C A89G missense_variant 0.66 0
2:177234051:A A89V missense_variant 0.66 0
2:177234051:T A89D missense_variant 0.66 0
2:177231278:T T442K missense_variant 0.66 0
2:177231278:C T442R missense_variant 0.66 0
2:177231278:A T442I missense_variant 0.66 0
2:177234250:T L23I missense_variant 0.66 0
2:177234250:C L23V missense_variant 0.66 0
2:177234250:A L23F missense_variant 0.66 0
2:177234111:T A69D missense_variant 0.66 0
2:177234111:A A69V missense_variant 0.66 0
2:177234111:C A69G missense_variant 0.66 0
2:177233306:T F116I missense_variant 0.65 0
2:177233306:C F116V missense_variant 0.65 0
2:177233306:G F116L missense_variant 0.65 0
2:177233284:G L123S missense_variant 0.65 0
2:177233284:C L123W missense_variant 0.65 0
2:177232579:T S136Y missense_variant 0.65 0
2:177232579:C S136C missense_variant 0.65 0
2:177232579:A S136F missense_variant 0.65 0
2:177231272:C D444G missense_variant 0.65 0
2:177231276:C K443E missense_variant 0.65 0
2:177231276:G K443Q missense_variant 0.65 0
2:177231251:A E451V missense_variant 0.65 0
2:177231251:C E451G missense_variant 0.65 0
2:177231272:G D444A missense_variant 0.65 0
2:177230811:C K598E missense_variant 0.65 0
2:177231251:G E451A missense_variant 0.65 0
2:177231270:C K445E missense_variant 0.65 0
2:177231270:G K445Q missense_variant 0.65 0
2:177230811:G K598Q missense_variant 0.65 0
2:177231272:A D444V missense_variant 0.65 0
2:177231977:G E209A missense_variant 0.65 0
2:177231977:C E209G missense_variant 0.65 0
2:177231977:A E209V missense_variant 0.65 0
2:177231513:C S364A missense_variant 0.64 0
2:177231513:T S364T missense_variant 0.64 0
2:177231513:G S364P missense_variant 0.64 0
2:177231590:G E338A missense_variant 0.64 0
2:177231449:A P385L missense_variant 0.64 0
2:177231449:C P385R missense_variant 0.64 0
2:177231449:T P385H missense_variant 0.64 0
2:177231458:A D382V missense_variant 0.64 0
2:177231458:C D382G missense_variant 0.64 0
2:177231458:G D382A missense_variant 0.64 0
2:177231464:A E380V missense_variant 0.64 0
2:177231464:C E380G missense_variant 0.64 0
2:177231464:G E380A missense_variant 0.64 0
2:177231467:A E379V missense_variant 0.64 0
2:177231467:C E379G missense_variant 0.64 0
2:177231467:G E379A missense_variant 0.64 0
2:177231473:A E377V missense_variant 0.64 0
2:177231473:C E377G missense_variant 0.64 0
2:177231473:G E377A missense_variant 0.64 0
2:177231479:A D375V missense_variant 0.64 0
2:177231479:C D375G missense_variant 0.64 0
2:177231479:G D375A missense_variant 0.64 0
2:177231483:A S374C missense_variant 0.64 0
2:177231483:C S374G missense_variant 0.64 0
2:177231483:G S374R missense_variant 0.64 0
2:177231575:A D343V missense_variant 0.64 0
2:177231575:C D343G missense_variant 0.64 0
2:177231575:G D343A missense_variant 0.64 0
2:177231581:A D341V missense_variant 0.64 0
2:177231581:C D341G missense_variant 0.64 0
2:177231581:G D341A missense_variant 0.64 0
2:177231590:A E338V missense_variant 0.64 0
2:177231590:C E338G missense_variant 0.64 0
2:177234102:A A72V missense_variant 0.64 0
2:177234102:C A72G missense_variant 0.64 0
2:177234102:T A72D missense_variant 0.64 0
2:177234136:T Q61K missense_variant 0.64 0
2:177234136:C Q61E missense_variant 0.64 0
2:177231810:C Q265E missense_variant 0.64 0
2:177231810:T Q265K missense_variant 0.64 0
2:177230853:C Q584E missense_variant 0.61 0
2:177230853:T Q584K missense_variant 0.61 0
2:177230969:C E545G missense_variant 0.61 0
2:177231179:G N475T missense_variant 0.61 0
2:177231179:C N475S missense_variant 0.61 0
2:177231179:A N475I missense_variant 0.61 0
2:177231230:A E458V missense_variant 0.61 0
2:177231230:C E458G missense_variant 0.61 0
2:177231230:G E458A missense_variant 0.61 0
2:177231233:A D457V missense_variant 0.61 0
2:177231233:G D457A missense_variant 0.61 0
2:177231164:G D480A missense_variant 0.61 0
2:177231164:C D480G missense_variant 0.61 0
2:177231164:A D480V missense_variant 0.61 0
2:177231140:G E488A missense_variant 0.61 0
2:177231140:C E488G missense_variant 0.61 0
2:177231140:A E488V missense_variant 0.61 0
2:177231137:G Q489P missense_variant 0.61 0
2:177231137:C Q489R missense_variant 0.61 0
2:177231137:A Q489L missense_variant 0.61 0
2:177231132:G N491H missense_variant 0.61 0
2:177231132:C N491D missense_variant 0.61 0
2:177231132:A N491Y missense_variant 0.61 0
2:177231128:G E492A missense_variant 0.61 0
2:177231128:C E492G missense_variant 0.61 0
2:177231128:A E492V missense_variant 0.61 0
2:177231122:G Q494P missense_variant 0.61 0
2:177231122:C Q494R missense_variant 0.61 0
2:177231122:A Q494L missense_variant 0.61 0
2:177232405:C I194S missense_variant 0.61 0
2:177232405:G I194T missense_variant 0.61 0
2:177232405:T I194N missense_variant 0.61 0
2:177232411:G L192S missense_variant 0.61 0
2:177232414:C L191R missense_variant 0.61 0
2:177232414:G L191P missense_variant 0.61 0
2:177232414:T L191Q missense_variant 0.61 0
2:177231104:G D500A missense_variant 0.61 0
2:177231104:C D500G missense_variant 0.61 0
2:177231104:A D500V missense_variant 0.61 0
2:177231102:G I501L missense_variant 0.61 0
2:177231102:C I501V missense_variant 0.61 0
2:177231102:A I501L missense_variant 0.61 0
2:177231087:G K506Q missense_variant 0.61 0
2:177231087:C K506E missense_variant 0.61 0
2:177231086:G K506T missense_variant 0.61 0
2:177231086:C K506R missense_variant 0.61 0
2:177231086:A K506M missense_variant 0.61 0
2:177231084:G N507H missense_variant 0.61 0
2:177231084:C N507D missense_variant 0.61 0
2:177231084:A N507Y missense_variant 0.61 0
2:177231083:G N507T missense_variant 0.61 0
2:177231083:C N507S missense_variant 0.61 0
2:177231083:A N507I missense_variant 0.61 0
2:177231081:G K508Q missense_variant 0.61 0
2:177231081:C K508E missense_variant 0.61 0
2:177231080:G K508T missense_variant 0.61 0
2:177231080:C K508R missense_variant 0.61 0
2:177231080:A K508I missense_variant 0.61 0
2:177231068:G Q512P missense_variant 0.61 0
2:177231068:C Q512R missense_variant 0.61 0
2:177231068:A Q512L missense_variant 0.61 0
2:177231066:G N513H missense_variant 0.61 0
2:177231066:C N513D missense_variant 0.61 0
2:177231066:A N513Y missense_variant 0.61 0
2:177231065:G N513T missense_variant 0.61 0
2:177231065:C N513S missense_variant 0.61 0
2:177231065:A N513I missense_variant 0.61 0
2:177231057:G K516Q missense_variant 0.61 0
2:177231057:C K516E missense_variant 0.61 0
2:177231056:G K516T missense_variant 0.61 0
2:177231056:C K516R missense_variant 0.61 0
2:177231056:A K516I missense_variant 0.61 0
2:177231051:G K518Q missense_variant 0.61 0
2:177231051:C K518E missense_variant 0.61 0
2:177231050:G K518T missense_variant 0.61 0
2:177231050:C K518R missense_variant 0.61 0
2:177231050:A K518I missense_variant 0.61 0
2:177231044:G E520A missense_variant 0.61 0
2:177231044:C E520G missense_variant 0.61 0
2:177231044:A E520V missense_variant 0.61 0
2:177231026:G E526A missense_variant 0.61 0
2:177231026:C E526G missense_variant 0.61 0
2:177231026:A E526V missense_variant 0.61 0
2:177231020:G D528A missense_variant 0.61 0
2:177231020:C D528G missense_variant 0.61 0
2:177231020:A D528V missense_variant 0.61 0
2:177230999:G E535A missense_variant 0.61 0
2:177230999:C E535G missense_variant 0.61 0
2:177230999:A E535V missense_variant 0.61 0
2:177230993:G E537A missense_variant 0.61 0
2:177230993:C E537G missense_variant 0.61 0
2:177230993:A E537V missense_variant 0.61 0
2:177230978:G E542A missense_variant 0.61 0
2:177230978:C E542G missense_variant 0.61 0
2:177230978:A E542V missense_variant 0.61 0
2:177230969:G E545A missense_variant 0.61 0
2:177231207:G I466L missense_variant 0.61 0
2:177230969:A E545V missense_variant 0.61 0
2:177230921:G Y561S missense_variant 0.61 0
2:177230921:C Y561C missense_variant 0.61 0
2:177230921:A Y561F missense_variant 0.61 0
2:177230915:G E563A missense_variant 0.61 0
2:177230915:C E563G missense_variant 0.61 0
2:177230915:A E563V missense_variant 0.61 0
2:177230894:G D570A missense_variant 0.61 0
2:177230894:C D570G missense_variant 0.61 0
2:177230894:A D570V missense_variant 0.61 0
2:177230891:G E571A missense_variant 0.61 0
2:177230891:C E571G missense_variant 0.61 0
2:177230891:A E571V missense_variant 0.61 0
2:177230864:G E580A missense_variant 0.61 0
2:177230864:C E580G missense_variant 0.61 0
2:177230864:A E580V missense_variant 0.61 0
2:177230852:G Q584P missense_variant 0.61 0
2:177230852:C Q584R missense_variant 0.61 0
2:177230852:A Q584L missense_variant 0.61 0
2:177230849:G Q585P missense_variant 0.61 0
2:177230849:C Q585R missense_variant 0.61 0
2:177230849:A Q585L missense_variant 0.61 0
2:177230840:G D588A missense_variant 0.61 0
2:177230840:C D588G missense_variant 0.61 0
2:177230840:A D588V missense_variant 0.61 0
2:177231186:A I473F missense_variant 0.61 0
2:177231186:C I473V missense_variant 0.61 0
2:177231186:G I473L missense_variant 0.61 0
2:177231180:G N475H missense_variant 0.61 0
2:177231180:C N475D missense_variant 0.61 0
2:177231180:A N475Y missense_variant 0.61 0
2:177231197:A P469L missense_variant 0.61 0
2:177231197:C P469R missense_variant 0.61 0
2:177231197:T P469H missense_variant 0.61 0
2:177231207:A I466F missense_variant 0.61 0
2:177231207:C I466V missense_variant 0.61 0
2:177232435:T I184N missense_variant 0.61 0
2:177232435:C I184S missense_variant 0.61 0
2:177231138:C Q489E missense_variant 0.61 0
2:177231138:T Q489K missense_variant 0.61 0
2:177232435:G I184T missense_variant 0.61 0
2:177231173:T P477H missense_variant 0.59 0
2:177231213:C L464V missense_variant 0.59 0
2:177231213:T L464I missense_variant 0.59 0
2:177231173:C P477R missense_variant 0.59 0
2:177231213:A L464F missense_variant 0.59 0
2:177231173:A P477L missense_variant 0.59 0
2:177230870:C P578R missense_variant 0.59 0
2:177231239:T T455K missense_variant 0.59 0
2:177231239:C T455R missense_variant 0.59 0
2:177231239:A T455I missense_variant 0.59 0
2:177230820:T P595T missense_variant 0.59 0
2:177230820:A P595S missense_variant 0.59 0
2:177230820:C P595A missense_variant 0.59 0
2:177230870:T P578H missense_variant 0.59 0
2:177230870:A P578L missense_variant 0.59 0
2:177230850:T Q585K missense_variant 0.59 0
2:177230850:C Q585E missense_variant 0.59 0
2:177230858:T S582Y missense_variant 0.59 0
2:177231215:A A463V missense_variant 0.59 0
2:177230858:A S582F missense_variant 0.59 0
2:177230858:C S582C missense_variant 0.59 0
2:177231215:T A463D missense_variant 0.59 0
2:177231215:C A463G missense_variant 0.59 0
2:177231747:C Y286D missense_variant 0.59 0
2:177231747:T Y286N missense_variant 0.59 0
2:177231747:G Y286H missense_variant 0.59 0
2:177231638:C L322R missense_variant 0.58 0
2:177231638:G L322P missense_variant 0.58 0
2:177231638:T L322Q missense_variant 0.58 0
2:177232004:T L200H missense_variant 0.58 0
2:177232004:C L200R missense_variant 0.58 0
2:177232004:G L200P missense_variant 0.58 0
2:177231749:T F285Y missense_variant 0.57 0
2:177231749:G F285S missense_variant 0.57 0
2:177231749:C F285C missense_variant 0.57 0
2:177231579:C S342A missense_variant 0.57 0
2:177231579:T S342T missense_variant 0.57 0
2:177231579:G S342P missense_variant 0.57 0
2:177234105:C F71C missense_variant 0.57 0
2:177234105:G F71S missense_variant 0.57 0
2:177234105:T F71Y missense_variant 0.57 0
2:177232432:G E185A missense_variant 0.57 0
2:177232432:C E185G missense_variant 0.57 0
2:177232432:A E185V missense_variant 0.57 0
2:177232408:C S193C missense_variant 0.57 0
2:177232408:T S193Y missense_variant 0.57 0
2:177231750:C F285V missense_variant 0.57 0
2:177231620:C F328C missense_variant 0.57 0
2:177231620:T F328Y missense_variant 0.57 0
2:177231620:G F328S missense_variant 0.57 0
2:177231537:T S356T missense_variant 0.57 0
2:177231537:G S356P missense_variant 0.57 0
2:177231762:T F281I missense_variant 0.57 0
2:177231537:C S356A missense_variant 0.57 0
2:177231762:G F281L missense_variant 0.57 0
2:177231762:C F281V missense_variant 0.57 0
2:177231761:T F281Y missense_variant 0.57 0
2:177231761:G F281S missense_variant 0.57 0
2:177232394:C Q198E missense_variant 0.57 0
2:177232394:T Q198K missense_variant 0.57 0
2:177231761:C F281C missense_variant 0.57 0
2:177231750:T F285I missense_variant 0.57 0
2:177231750:G F285L missense_variant 0.57 0
2:177232408:A S193F missense_variant 0.57 0
2:177233297:T C119S missense_variant 0.57 0
2:177231194:C V470G missense_variant 0.57 0
2:177231194:G V470A missense_variant 0.57 0
2:177231194:T V470E missense_variant 0.57 0
2:177233305:C F116C missense_variant 0.57 0
2:177233305:G F116S missense_variant 0.57 0
2:177233305:T F116Y missense_variant 0.57 0
2:177230879:T P575H missense_variant 0.57 0
2:177230879:C P575R missense_variant 0.57 0
2:177230879:A P575L missense_variant 0.57 0
2:177230877:T Y576N missense_variant 0.57 0
2:177230877:G Y576H missense_variant 0.57 0
2:177230877:C Y576D missense_variant 0.57 0
2:177230874:T S577T missense_variant 0.57 0
2:177230874:G S577P missense_variant 0.57 0
2:177230874:C S577A missense_variant 0.57 0
2:177231077:T V509E missense_variant 0.57 0
2:177231077:G V509A missense_variant 0.57 0
2:177231077:C V509G missense_variant 0.57 0
2:177231074:T A510D missense_variant 0.57 0
2:177231074:C A510G missense_variant 0.57 0
2:177231074:A A510V missense_variant 0.57 0
2:177231071:T A511D missense_variant 0.57 0
2:177231071:C A511G missense_variant 0.57 0
2:177231071:A A511V missense_variant 0.57 0
2:177231069:T Q512K missense_variant 0.57 0
2:177231069:C Q512E missense_variant 0.57 0
2:177230873:T S577Y missense_variant 0.57 0
2:177230873:C S577C missense_variant 0.57 0
2:177230873:A S577F missense_variant 0.57 0
2:177231204:A P467S missense_variant 0.57 0
2:177231204:C P467A missense_variant 0.57 0
2:177231204:T P467T missense_variant 0.57 0
2:177231063:T C514S missense_variant 0.57 0
2:177231063:G C514R missense_variant 0.57 0
2:177231063:C C514G missense_variant 0.57 0
2:177230862:T Y581N missense_variant 0.57 0
2:177230862:G Y581H missense_variant 0.57 0
2:177230862:C Y581D missense_variant 0.57 0
2:177230859:T S582T missense_variant 0.57 0
2:177230859:G S582P missense_variant 0.57 0
2:177230859:C S582A missense_variant 0.57 0
2:177230855:T L583Q missense_variant 0.57 0
2:177231047:T L519Q missense_variant 0.57 0
2:177234090:C L76R missense_variant 0.57 0
2:177234090:G L76P missense_variant 0.57 0
2:177234090:T L76Q missense_variant 0.57 0
2:177234096:G L74S missense_variant 0.57 0
2:177234100:C Q73E missense_variant 0.57 0
2:177234100:T Q73K missense_variant 0.57 0
2:177230819:T P595H missense_variant 0.57 0
2:177230819:C P595R missense_variant 0.57 0
2:177230819:A P595L missense_variant 0.57 0
2:177234108:C F70C missense_variant 0.57 0
2:177234108:G F70S missense_variant 0.57 0
2:177234108:T F70Y missense_variant 0.57 0
2:177231047:G L519P missense_variant 0.57 0
2:177231047:C L519R missense_variant 0.57 0
2:177230855:G L583P missense_variant 0.57 0
2:177230855:C L583R missense_variant 0.57 0
2:177231212:G L464P missense_variant 0.57 0
2:177231038:T I522K missense_variant 0.57 0
2:177231038:G I522T missense_variant 0.57 0
2:177231038:C I522R missense_variant 0.57 0
2:177231029:T L525Q missense_variant 0.57 0
2:177231029:G L525P missense_variant 0.57 0
2:177231029:C L525R missense_variant 0.57 0
2:177231212:T L464H missense_variant 0.57 0
2:177231212:C L464R missense_variant 0.57 0
2:177231206:C I466S missense_variant 0.57 0
2:177231206:G I466T missense_variant 0.57 0
2:177231206:T I466N missense_variant 0.57 0
2:177231017:G L529S missense_variant 0.57 0
2:177231008:G L532S missense_variant 0.57 0
2:177231008:C L532W missense_variant 0.57 0
2:177231200:C F468C missense_variant 0.57 0
2:177231200:G F468S missense_variant 0.57 0
2:177231200:T F468Y missense_variant 0.57 0
2:177230846:T T586K missense_variant 0.57 0
2:177230846:C T586R missense_variant 0.57 0
2:177230846:A T586I missense_variant 0.57 0
2:177230987:G L539S missense_variant 0.57 0
2:177230987:C L539W missense_variant 0.57 0
2:177234207:C F37C missense_variant 0.57 0
2:177234207:G F37S missense_variant 0.57 0
2:177234207:T F37Y missense_variant 0.57 0
2:177234208:C F37V missense_variant 0.57 0
2:177231221:A A461V missense_variant 0.57 0
2:177231221:C A461G missense_variant 0.57 0
2:177231221:T A461E missense_variant 0.57 0
2:177234208:G F37L missense_variant 0.57 0
2:177234208:T F37I missense_variant 0.57 0
2:177234210:C V36G missense_variant 0.57 0
2:177234210:G V36A missense_variant 0.57 0
2:177234210:T V36E missense_variant 0.57 0
2:177231201:C F468V missense_variant 0.57 0
2:177231177:T L476I missense_variant 0.57 0
2:177231177:C L476V missense_variant 0.57 0
2:177231201:G F468L missense_variant 0.57 0
2:177231177:A L476F missense_variant 0.57 0
2:177231201:T F468I missense_variant 0.57 0
2:177231176:T L476H missense_variant 0.57 0
2:177231176:G L476P missense_variant 0.57 0
2:177231176:C L476R missense_variant 0.57 0
2:177231174:T P477T missense_variant 0.57 0
2:177231174:C P477A missense_variant 0.57 0
2:177231174:A P477S missense_variant 0.57 0
2:177231242:C L454R missense_variant 0.57 0
2:177231242:G L454P missense_variant 0.57 0
2:177231242:T L454H missense_variant 0.57 0
2:177231246:A H453Y missense_variant 0.57 0
2:177231246:C H453D missense_variant 0.57 0
2:177231246:T H453N missense_variant 0.57 0
2:177230822:C V594G missense_variant 0.57 0
2:177230933:G L557P missense_variant 0.57 0
2:177230933:C L557R missense_variant 0.57 0
2:177230924:G L560S missense_variant 0.57 0
2:177231578:A S342F missense_variant 0.57 0
2:177231578:C S342C missense_variant 0.57 0
2:177231578:T S342Y missense_variant 0.57 0
2:177234267:G M17T missense_variant 0.57 0
2:177234267:T M17K missense_variant 0.57 0
2:177230831:T V591D missense_variant 0.57 0
2:177231125:T A493D missense_variant 0.57 0
2:177231125:C A493G missense_variant 0.57 0
2:177231125:A A493V missense_variant 0.57 0
2:177231123:T Q494K missense_variant 0.57 0
2:177231123:C Q494E missense_variant 0.57 0
2:177231635:A S323L missense_variant 0.57 0
2:177230831:G V591A missense_variant 0.57 0
2:177230831:C V591G missense_variant 0.57 0
2:177231185:C I473S missense_variant 0.57 0
2:177231824:A T260I missense_variant 0.57 0
2:177231824:C T260R missense_variant 0.57 0
2:177231824:T T260K missense_variant 0.57 0
2:177231119:T L495H missense_variant 0.57 0
2:177231119:G L495P missense_variant 0.57 0
2:177231119:C L495R missense_variant 0.57 0
2:177231116:T A496E missense_variant 0.57 0
2:177231116:C A496G missense_variant 0.57 0
2:177231116:A A496V missense_variant 0.57 0
2:177231113:G L497S missense_variant 0.57 0
2:177231110:T I498N missense_variant 0.57 0
2:177231110:G I498T missense_variant 0.57 0
2:177231185:G I473T missense_variant 0.57 0
2:177231185:T I473N missense_variant 0.57 0
2:177230912:T V564D missense_variant 0.57 0
2:177230912:G V564A missense_variant 0.57 0
2:177230912:C V564G missense_variant 0.57 0
2:177230910:T F565I missense_variant 0.57 0
2:177230910:G F565L missense_variant 0.57 0
2:177231110:C I498S missense_variant 0.57 0
2:177230910:C F565V missense_variant 0.57 0
2:177230909:T F565Y missense_variant 0.57 0
2:177230909:G F565S missense_variant 0.57 0
2:177230909:C F565C missense_variant 0.57 0
2:177230900:T L568Q missense_variant 0.57 0
2:177233272:C F127C missense_variant 0.57 0
2:177233272:G F127S missense_variant 0.57 0
2:177233272:T F127Y missense_variant 0.57 0
2:177233273:C F127V missense_variant 0.57 0
2:177233273:G F127L missense_variant 0.57 0
2:177233273:T F127I missense_variant 0.57 0
2:177233275:A T126I missense_variant 0.57 0
2:177233275:C T126R missense_variant 0.57 0
2:177233275:T T126K missense_variant 0.57 0
2:177230900:G L568P missense_variant 0.57 0
2:177231101:T I501K missense_variant 0.57 0
2:177233287:C L122R missense_variant 0.57 0
2:177233287:G L122P missense_variant 0.57 0
2:177233287:T L122H missense_variant 0.57 0
2:177231101:G I501T missense_variant 0.57 0
2:177231101:C I501R missense_variant 0.57 0
2:177230900:C L568R missense_variant 0.57 0
2:177233293:C M120R missense_variant 0.57 0
2:177233293:G M120T missense_variant 0.57 0
2:177233293:T M120K missense_variant 0.57 0
2:177231203:A P467L missense_variant 0.57 0
2:177231203:C P467R missense_variant 0.57 0
2:177231203:T P467Q missense_variant 0.57 0
2:177233297:C C119G missense_variant 0.57 0
2:177233297:G C119R missense_variant 0.57 0
2:177231566:T I346N missense_variant 0.57 0
2:177231134:C F490C missense_variant 0.57 0
2:177230945:C L553R missense_variant 0.57 0
2:177230933:T L557H missense_variant 0.57 0
2:177231572:A S344F missense_variant 0.57 0
2:177231572:C S344C missense_variant 0.57 0
2:177231572:T S344Y missense_variant 0.57 0
2:177231573:C S344A missense_variant 0.57 0
2:177231573:G S344P missense_variant 0.57 0
2:177231573:T S344T missense_variant 0.57 0
2:177230822:G V594A missense_variant 0.57 0
2:177234267:C M17R missense_variant 0.57 0
2:177231170:T V478D missense_variant 0.57 0
2:177231170:G V478A missense_variant 0.57 0
2:177231170:C V478G missense_variant 0.57 0
2:177234249:C L23R missense_variant 0.57 0
2:177234249:G L23P missense_variant 0.57 0
2:177234249:T L23H missense_variant 0.57 0
2:177231162:T F481I missense_variant 0.57 0
2:177231162:G F481L missense_variant 0.57 0
2:177231162:C F481V missense_variant 0.57 0
2:177231161:T F481Y missense_variant 0.57 0
2:177231161:G F481S missense_variant 0.57 0
2:177231161:C F481C missense_variant 0.57 0
2:177231152:T M484K missense_variant 0.57 0
2:177231284:A P440L missense_variant 0.57 0
2:177231284:C P440R missense_variant 0.57 0
2:177231284:T P440Q missense_variant 0.57 0
2:177234252:C I22R missense_variant 0.57 0
2:177234252:G I22T missense_variant 0.57 0
2:177234252:T I22K missense_variant 0.57 0
2:177230829:T F592I missense_variant 0.57 0
2:177230829:G F592L missense_variant 0.57 0
2:177230829:C F592V missense_variant 0.57 0
2:177231152:G M484T missense_variant 0.57 0
2:177231152:C M484R missense_variant 0.57 0
2:177231149:T M485K missense_variant 0.57 0
2:177230828:T F592Y missense_variant 0.57 0
2:177230828:G F592S missense_variant 0.57 0
2:177230828:C F592C missense_variant 0.57 0
2:177231149:G M485T missense_variant 0.57 0
2:177231149:C M485R missense_variant 0.57 0
2:177230826:T L593I missense_variant 0.57 0
2:177230826:C L593V missense_variant 0.57 0
2:177230826:A L593F missense_variant 0.57 0
2:177231147:T S486T missense_variant 0.57 0
2:177231147:G S486P missense_variant 0.57 0
2:177234258:C I20S missense_variant 0.57 0
2:177234258:G I20T missense_variant 0.57 0
2:177234258:T I20N missense_variant 0.57 0
2:177231147:C S486A missense_variant 0.57 0
2:177231146:T S486Y missense_variant 0.57 0
2:177231146:C S486C missense_variant 0.57 0
2:177231146:A S486F missense_variant 0.57 0
2:177230825:T L593H missense_variant 0.57 0
2:177230825:G L593P missense_variant 0.57 0
2:177230825:C L593R missense_variant 0.57 0
2:177230954:T L550H missense_variant 0.57 0
2:177230954:G L550P missense_variant 0.57 0
2:177230954:C L550R missense_variant 0.57 0
2:177230945:T L553Q missense_variant 0.57 0
2:177234261:C L19W missense_variant 0.57 0
2:177234261:G L19S missense_variant 0.57 0
2:177230822:T V594D missense_variant 0.57 0
2:177231512:A S364F missense_variant 0.57 0
2:177231512:C S364C missense_variant 0.57 0
2:177231512:T S364Y missense_variant 0.57 0
2:177230945:G L553P missense_variant 0.57 0
2:177231134:T F490Y missense_variant 0.57 0
2:177231134:G F490S missense_variant 0.57 0
2:177231533:A P357L missense_variant 0.57 0
2:177231533:C P357R missense_variant 0.57 0
2:177231533:T P357Q missense_variant 0.57 0
2:177231534:A P357S missense_variant 0.57 0
2:177231534:C P357A missense_variant 0.57 0
2:177231534:T P357T missense_variant 0.57 0
2:177231536:A S356L missense_variant 0.57 0
2:177231548:A P352L missense_variant 0.57 0
2:177231548:C P352R missense_variant 0.57 0
2:177231548:T P352H missense_variant 0.57 0
2:177231563:A S347L missense_variant 0.57 0
2:177231564:C S347A missense_variant 0.57 0
2:177231564:G S347P missense_variant 0.57 0
2:177231564:T S347T missense_variant 0.57 0
2:177231566:C I346S missense_variant 0.57 0
2:177231566:G I346T missense_variant 0.57 0
2:177234063:A P85L missense_variant 0.57 0
2:177234063:C P85R missense_variant 0.57 0
2:177234063:T P85Q missense_variant 0.57 0
2:177234124:A E65* stop_gained 0.54 0
2:177234085:A E78* stop_gained 0.54 0
2:177234214:A E35* stop_gained 0.54 0
2:177231539:C A355G missense_variant 0.51 0
2:177231539:A A355V missense_variant 0.51 0
2:177231621:T F328I missense_variant 0.51 0
2:177231621:C F328V missense_variant 0.51 0
2:177231621:G F328L missense_variant 0.51 0
2:177231539:T A355E missense_variant 0.51 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(HNSC) Head and neck squamous cell carcinoma HNSC 0.33 0.10