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Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
PIK3CA LGG ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
3:179234297:G H1047R missense_variant 1.00 4
3:179199690:A G118D missense_variant 0.98 4
3:179234284:G M1043V missense_variant 1.00 3
3:179210291:A E453K missense_variant 0.94 3
3:179218294:A E542K missense_variant 1.00 2
3:179234297:T H1047L missense_variant 1.00 1
3:179218307:C Q546P missense_variant 1.00 1
3:179218307:G Q546R missense_variant 1.00 1
3:179218304:C E545A missense_variant 1.00 1
3:179218306:G Q546E missense_variant 1.00 1
3:179218303:A E545K missense_variant 1.00 1
3:179199088:A R88Q missense_variant 1.00 1
3:179234296:T H1047Y missense_variant 1.00 1
3:179204576:A C378Y missense_variant 0.99 1
3:179234285:C M1043T missense_variant 0.99 1
3:179203763:T N345Y missense_variant 0.93 1
3:179210192:C C420R missense_variant 0.92 1
3:179199141:A G106S missense_variant 0.76 1
3:179230039:T C901F missense_variant 0.61 1
3:179230077:A G914R missense_variant 0.61 1
3:179210438:T P471L missense_variant 0.50 1
3:179234290:A D1045N missense_variant 1.00 0
3:179234290:C D1045H missense_variant 1.00 0
3:179234290:T D1045Y missense_variant 1.00 0
3:179234286:C M1043I missense_variant 1.00 0
3:179234286:T M1043I missense_variant 1.00 0
3:179234286:A M1043I missense_variant 1.00 0
3:179234302:T G1049C missense_variant 1.00 0
3:179234302:C G1049R missense_variant 1.00 0
3:179234302:A G1049S missense_variant 1.00 0
3:179234303:T G1049V missense_variant 1.00 0
3:179234303:A G1049D missense_variant 1.00 0
3:179234303:C G1049A missense_variant 1.00 0
3:179234297:C H1047P missense_variant 1.00 0
3:179234284:C M1043L missense_variant 1.00 0
3:179234284:T M1043L missense_variant 1.00 0
3:179234311:T T1052S missense_variant 1.00 0
3:179234311:C T1052P missense_variant 1.00 0
3:179234311:G T1052A missense_variant 1.00 0
3:179234287:G N1044D missense_variant 1.00 0
3:179234288:C N1044T missense_variant 1.00 0
3:179234287:T N1044Y missense_variant 1.00 0
3:179234287:C N1044H missense_variant 1.00 0
3:179234291:T D1045V missense_variant 1.00 0
3:179234291:G D1045G missense_variant 1.00 0
3:179234291:C D1045A missense_variant 1.00 0
3:179234288:T N1044I missense_variant 1.00 0
3:179234288:G N1044S missense_variant 1.00 0
3:179234300:G H1048R missense_variant 1.00 0
3:179234300:C H1048P missense_variant 1.00 0
3:179234300:T H1048L missense_variant 1.00 0
3:179218295:G E542G missense_variant 1.00 0
3:179218295:T E542V missense_variant 1.00 0
3:179218295:C E542A missense_variant 1.00 0
3:179218307:T Q546L missense_variant 1.00 0
3:179218312:C K548Q missense_variant 1.00 0
3:179218310:G E547G missense_variant 1.00 0
3:179218310:T E547V missense_variant 1.00 0
3:179218310:C E547A missense_variant 1.00 0
3:179218313:C K548T missense_variant 1.00 0
3:179218312:G K548E missense_variant 1.00 0
3:179218313:T K548I missense_variant 1.00 0
3:179218313:G K548R missense_variant 1.00 0
3:179218304:G E545G missense_variant 1.00 0
3:179218304:T E545V missense_variant 1.00 0
3:179218306:A Q546K missense_variant 1.00 0
3:179218286:A P539H missense_variant 1.00 0
3:179218286:G P539R missense_variant 1.00 0
3:179218286:T P539L missense_variant 1.00 0
3:179218285:T P539S missense_variant 1.00 0
3:179218285:A P539T missense_variant 1.00 0
3:179218285:G P539A missense_variant 1.00 0
3:179218309:A E547K missense_variant 1.00 0
3:179218309:C E547Q missense_variant 1.00 0
3:179218294:C E542Q missense_variant 1.00 0
3:179218303:C E545Q missense_variant 1.00 0
3:179199088:C R88P missense_variant 1.00 0
3:179199088:T R88L missense_variant 1.00 0
3:179198942:C E39D missense_variant 1.00 0
3:179198942:T E39D missense_variant 1.00 0
3:179234312:G T1052R missense_variant 1.00 0
3:179234312:A T1052K missense_variant 1.00 0
3:179234312:T T1052I missense_variant 1.00 0
3:179234296:A H1047N missense_variant 1.00 0
3:179234296:G H1047D missense_variant 1.00 0
3:179234299:G H1048D missense_variant 1.00 0
3:179234299:A H1048N missense_variant 1.00 0
3:179234299:T H1048Y missense_variant 1.00 0
3:179198938:C R38P missense_variant 1.00 0
3:179198940:C E39Q missense_variant 1.00 0
3:179198940:A E39K missense_variant 1.00 0
3:179198938:T R38L missense_variant 1.00 0
3:179198938:A R38H missense_variant 1.00 0
3:179198941:T E39V missense_variant 1.00 0
3:179198941:C E39A missense_variant 1.00 0
3:179198941:G E39G missense_variant 1.00 0
3:179234242:A D1029N missense_variant 1.00 0
3:179234242:T D1029Y missense_variant 1.00 0
3:179234242:C D1029H missense_variant 1.00 0
3:179198937:A R38S missense_variant 1.00 0
3:179198937:T R38C missense_variant 1.00 0
3:179198937:G R38G missense_variant 1.00 0
3:179204576:T C378F missense_variant 0.99 0
3:179204576:C C378S missense_variant 0.99 0
3:179234285:A M1043K missense_variant 0.99 0
3:179234285:G M1043R missense_variant 0.99 0
3:179199093:A C90S missense_variant 0.99 0
3:179199093:G C90G missense_variant 0.99 0
3:179199093:C C90R missense_variant 0.99 0
3:179199094:A C90Y missense_variant 0.99 0
3:179199094:T C90F missense_variant 0.99 0
3:179199094:C C90S missense_variant 0.99 0
3:179203760:C V344L missense_variant 0.99 0
3:179203760:A V344M missense_variant 0.99 0
3:179203760:T V344L missense_variant 0.99 0
3:179204575:A C378S missense_variant 0.99 0
3:179204575:C C378R missense_variant 0.99 0
3:179204575:G C378G missense_variant 0.99 0
3:179230313:G Q958R missense_variant 0.99 0
3:179234243:G D1029G missense_variant 0.99 0
3:179230313:T Q958L missense_variant 0.99 0
3:179230313:C Q958P missense_variant 0.99 0
3:179234243:T D1029V missense_variant 0.99 0
3:179234243:C D1029A missense_variant 0.99 0
3:179234293:A A1046T missense_variant 0.99 0
3:179234293:T A1046S missense_variant 0.99 0
3:179234293:C A1046P missense_variant 0.99 0
3:179234309:C W1051S missense_variant 0.99 0
3:179234306:T G1050V missense_variant 0.99 0
3:179234305:A G1050S missense_variant 0.99 0
3:179234305:C G1050R missense_variant 0.99 0
3:179234306:C G1050A missense_variant 0.99 0
3:179234305:T G1050C missense_variant 0.99 0
3:179234310:T W1051C missense_variant 0.99 0
3:179234310:C W1051C missense_variant 0.99 0
3:179234306:A G1050D missense_variant 0.99 0
3:179234309:T W1051L missense_variant 0.99 0
3:179199177:C G118R missense_variant 0.98 0
3:179199177:A G118S missense_variant 0.98 0
3:179199177:T G118C missense_variant 0.98 0
3:179218296:T E542D missense_variant 0.98 0
3:179218296:C E542D missense_variant 0.98 0
3:179218311:T E547D missense_variant 0.98 0
3:179218311:C E547D missense_variant 0.98 0
3:179218305:T E545D missense_variant 0.98 0
3:179218305:C E545D missense_variant 0.98 0
3:179199714:A C126Y missense_variant 0.98 0
3:179199690:C G118A missense_variant 0.98 0
3:179199690:T G118V missense_variant 0.98 0
3:179199695:A A120T missense_variant 0.98 0
3:179199695:C A120P missense_variant 0.98 0
3:179199695:T A120S missense_variant 0.98 0
3:179199701:A G122S missense_variant 0.98 0
3:179199701:C G122R missense_variant 0.98 0
3:179199701:T G122C missense_variant 0.98 0
3:179199702:A G122D missense_variant 0.98 0
3:179199702:C G122A missense_variant 0.98 0
3:179199702:T G122V missense_variant 0.98 0
3:179199706:A M123I missense_variant 0.98 0
3:179199706:C M123I missense_variant 0.98 0
3:179199706:T M123I missense_variant 0.98 0
3:179199714:C C126S missense_variant 0.98 0
3:179199714:T C126F missense_variant 0.98 0
3:179199716:A E127K missense_variant 0.98 0
3:179199716:C E127Q missense_variant 0.98 0
3:179199169:C R115P missense_variant 0.98 0
3:179199169:A R115Q missense_variant 0.98 0
3:179199169:T R115L missense_variant 0.98 0
3:179234204:A F1016Y missense_variant 0.97 0
3:179234204:C F1016S missense_variant 0.97 0
3:179234203:A F1016I missense_variant 0.97 0
3:179234203:C F1016L missense_variant 0.97 0
3:179234203:G F1016V missense_variant 0.97 0
3:179234204:G F1016C missense_variant 0.97 0
3:179218282:A D538N missense_variant 0.97 0
3:179218282:T D538Y missense_variant 0.97 0
3:179218280:T R537L missense_variant 0.97 0
3:179218280:C R537P missense_variant 0.97 0
3:179218282:C D538H missense_variant 0.97 0
3:179218280:A R537Q missense_variant 0.97 0
3:179234292:G D1045E missense_variant 0.97 0
3:179234292:A D1045E missense_variant 0.97 0
3:179234289:A N1044K missense_variant 0.97 0
3:179234289:G N1044K missense_variant 0.97 0
3:179210193:C C420S missense_variant 0.97 0
3:179210193:A C420Y missense_variant 0.97 0
3:179210193:T C420F missense_variant 0.97 0
3:179218308:T Q546H missense_variant 0.96 0
3:179218308:C Q546H missense_variant 0.96 0
3:179234298:A H1047Q missense_variant 0.96 0
3:179234298:G H1047Q missense_variant 0.96 0
3:179234301:G H1048Q missense_variant 0.96 0
3:179234301:A H1048Q missense_variant 0.96 0
3:179218300:C T544P missense_variant 0.96 0
3:179218300:T T544S missense_variant 0.96 0
3:179218297:C I543L missense_variant 0.96 0
3:179218297:G I543V missense_variant 0.96 0
3:179218297:T I543F missense_variant 0.96 0
3:179218300:G T544A missense_variant 0.96 0
3:179234277:A M1040I missense_variant 0.96 0
3:179234277:T M1040I missense_variant 0.96 0
3:179234277:C M1040I missense_variant 0.96 0
3:179218283:T D538V missense_variant 0.96 0
3:179218283:G D538G missense_variant 0.96 0
3:179218283:C D538A missense_variant 0.96 0
3:179234279:T K1041I missense_variant 0.96 0
3:179234279:G K1041R missense_variant 0.96 0
3:179234275:G M1040V missense_variant 0.96 0
3:179234282:C Q1042P missense_variant 0.96 0
3:179234278:C K1041Q missense_variant 0.96 0
3:179234275:T M1040L missense_variant 0.96 0
3:179234275:C M1040L missense_variant 0.96 0
3:179234279:C K1041T missense_variant 0.96 0
3:179234278:G K1041E missense_variant 0.96 0
3:179234282:G Q1042R missense_variant 0.96 0
3:179234282:T Q1042L missense_variant 0.96 0
3:179218312:T K548* stop_gained 0.95 0
3:179203761:G V344G missense_variant 0.95 0
3:179203761:A V344E missense_variant 0.95 0
3:179203761:C V344A missense_variant 0.95 0
3:179230307:G L956W missense_variant 0.94 0
3:179230307:C L956S missense_variant 0.94 0
3:179218301:A T544N missense_variant 0.94 0
3:179218292:T S541F missense_variant 0.94 0
3:179218301:G T544S missense_variant 0.94 0
3:179218292:G S541C missense_variant 0.94 0
3:179218301:T T544I missense_variant 0.94 0
3:179218292:A S541Y missense_variant 0.94 0
3:179210315:A V461I missense_variant 0.94 0
3:179210452:C E476Q missense_variant 0.94 0
3:179210452:A E476K missense_variant 0.94 0
3:179210441:T C472F missense_variant 0.94 0
3:179210441:C C472S missense_variant 0.94 0
3:179210441:A C472Y missense_variant 0.94 0
3:179210431:C E469Q missense_variant 0.94 0
3:179210431:A E469K missense_variant 0.94 0
3:179210322:T G463V missense_variant 0.94 0
3:179210286:A G451E missense_variant 0.94 0
3:179210286:C G451A missense_variant 0.94 0
3:179210286:T G451V missense_variant 0.94 0
3:179210291:C E453Q missense_variant 0.94 0
3:179210294:A D454N missense_variant 0.94 0
3:179210294:C D454H missense_variant 0.94 0
3:179210294:T D454Y missense_variant 0.94 0
3:179210312:A G460S missense_variant 0.94 0
3:179210312:C G460R missense_variant 0.94 0
3:179210312:T G460C missense_variant 0.94 0
3:179210313:A G460D missense_variant 0.94 0
3:179210313:C G460A missense_variant 0.94 0
3:179210313:T G460V missense_variant 0.94 0
3:179210315:C V461L missense_variant 0.94 0
3:179210315:T V461F missense_variant 0.94 0
3:179210321:A G463R missense_variant 0.94 0
3:179210321:C G463R missense_variant 0.94 0
3:179210322:A G463E missense_variant 0.94 0
3:179210322:C G463A missense_variant 0.94 0
3:179203763:G N345D missense_variant 0.93 0
3:179203763:C N345H missense_variant 0.93 0
3:179203764:T N345I missense_variant 0.93 0
3:179203764:G N345S missense_variant 0.93 0
3:179203764:C N345T missense_variant 0.93 0
3:179234294:T A1046V missense_variant 0.93 0
3:179234294:A A1046E missense_variant 0.93 0
3:179234294:G A1046G missense_variant 0.93 0
3:179234281:A Q1042K missense_variant 0.92 0
3:179234281:G Q1042E missense_variant 0.92 0
3:179210192:G C420G missense_variant 0.92 0
3:179210192:A C420S missense_variant 0.92 0
3:179218303:T E545* stop_gained 0.91 0
3:179218294:T E542* stop_gained 0.91 0
3:179218309:T E547* stop_gained 0.91 0
3:179199095:G C90W missense_variant 0.91 0
3:179230312:A Q958K missense_variant 0.90 0
3:179230312:G Q958E missense_variant 0.90 0
3:179218289:C L540P missense_variant 0.90 0
3:179218289:A L540H missense_variant 0.90 0
3:179218291:G S541A missense_variant 0.90 0
3:179218289:G L540R missense_variant 0.90 0
3:179218298:G I543S missense_variant 0.90 0
3:179218298:C I543T missense_variant 0.90 0
3:179218298:A I543N missense_variant 0.90 0
3:179218291:A S541T missense_variant 0.90 0
3:179218291:C S541P missense_variant 0.90 0
3:179218314:C K548N missense_variant 0.90 0
3:179218314:T K548N missense_variant 0.90 0
3:179199087:G R88G missense_variant 0.89 0
3:179198915:C M30I missense_variant 0.87 0
3:179198915:T M30I missense_variant 0.87 0
3:179198915:A M30I missense_variant 0.87 0
3:179218306:T Q546* stop_gained 0.86 0
3:179218279:G R537G missense_variant 0.84 0
3:179210512:C A496P missense_variant 0.84 0
3:179221119:T D717Y missense_variant 0.84 0
3:179221134:A E722K missense_variant 0.84 0
3:179221134:C E722Q missense_variant 0.84 0
3:179221143:A D725N missense_variant 0.84 0
3:179221143:C D725H missense_variant 0.84 0
3:179221143:T D725Y missense_variant 0.84 0
3:179221146:A E726K missense_variant 0.84 0
3:179221146:C E726Q missense_variant 0.84 0
3:179221157:C K729N missense_variant 0.84 0
3:179221157:T K729N missense_variant 0.84 0
3:179221119:A D717N missense_variant 0.84 0
3:179221098:C E710Q missense_variant 0.84 0
3:179221098:A E710K missense_variant 0.84 0
3:179221097:T M709I missense_variant 0.84 0
3:179221097:C M709I missense_variant 0.84 0
3:179221097:A M709I missense_variant 0.84 0
3:179221092:T A708S missense_variant 0.84 0
3:179221092:C A708P missense_variant 0.84 0
3:179221092:A A708T missense_variant 0.84 0
3:179221089:C E707Q missense_variant 0.84 0
3:179221089:A E707K missense_variant 0.84 0
3:179221086:T V706F missense_variant 0.84 0
3:179221086:C V706L missense_variant 0.84 0
3:179221086:A V706I missense_variant 0.84 0
3:179199899:T G188W missense_variant 0.84 0
3:179199899:C G188R missense_variant 0.84 0
3:179199899:A G188R missense_variant 0.84 0
3:179199893:T D186Y missense_variant 0.84 0
3:179199893:C D186H missense_variant 0.84 0
3:179199893:A D186N missense_variant 0.84 0
3:179199863:C E176Q missense_variant 0.84 0
3:179199863:A E176K missense_variant 0.84 0
3:179199851:C E172Q missense_variant 0.84 0
3:179199851:A E172K missense_variant 0.84 0
3:179199833:T V166F missense_variant 0.84 0
3:179199833:C V166L missense_variant 0.84 0
3:179199833:A V166I missense_variant 0.84 0
3:179199824:T A163S missense_variant 0.84 0
3:179199824:C A163P missense_variant 0.84 0
3:179199824:A A163T missense_variant 0.84 0
3:179199819:T S161I missense_variant 0.84 0
3:179199819:C S161T missense_variant 0.84 0
3:179199819:A S161N missense_variant 0.84 0
3:179199798:T R154M missense_variant 0.84 0
3:179199798:C R154T missense_variant 0.84 0
3:179199798:A R154K missense_variant 0.84 0
3:179199791:T D152Y missense_variant 0.84 0
3:179199791:C D152H missense_variant 0.84 0
3:179199791:A D152N missense_variant 0.84 0
3:179199788:T V151L missense_variant 0.84 0
3:179199788:C V151L missense_variant 0.84 0
3:179199788:A V151M missense_variant 0.84 0
3:179199782:C E149Q missense_variant 0.84 0
3:179199782:A E149K missense_variant 0.84 0
3:179199777:T C147F missense_variant 0.84 0
3:179199777:C C147S missense_variant 0.84 0
3:179199777:A C147Y missense_variant 0.84 0
3:179199773:T V146F missense_variant 0.84 0
3:179199773:C V146L missense_variant 0.84 0
3:179199773:A V146I missense_variant 0.84 0
3:179199756:T R140L missense_variant 0.84 0
3:179199756:C R140P missense_variant 0.84 0
3:179199756:A R140Q missense_variant 0.84 0
3:179199749:T D138Y missense_variant 0.84 0
3:179199749:C D138H missense_variant 0.84 0
3:179199749:A D138N missense_variant 0.84 0
3:179199743:T V136L missense_variant 0.84 0
3:179199743:C V136L missense_variant 0.84 0
3:179199743:A V136I missense_variant 0.84 0
3:179199740:C E135Q missense_variant 0.84 0
3:179210476:A V484I missense_variant 0.84 0
3:179210476:C V484L missense_variant 0.84 0
3:179210476:T V484L missense_variant 0.84 0
3:179210488:A D488N missense_variant 0.84 0
3:179210488:C D488H missense_variant 0.84 0
3:179210488:T D488Y missense_variant 0.84 0
3:179210503:A E493K missense_variant 0.84 0
3:179210503:C E493Q missense_variant 0.84 0
3:179210506:A E494K missense_variant 0.84 0
3:179210506:C E494Q missense_variant 0.84 0
3:179210512:A A496T missense_variant 0.84 0
3:179221119:C D717H missense_variant 0.84 0
3:179210512:T A496S missense_variant 0.84 0
3:179210531:A R502Q missense_variant 0.84 0
3:179210531:C R502P missense_variant 0.84 0
3:179210531:T R502L missense_variant 0.84 0
3:179210533:A E503K missense_variant 0.84 0
3:179210533:C E503Q missense_variant 0.84 0
3:179210539:A G505R missense_variant 0.84 0
3:179210539:C G505R missense_variant 0.84 0
3:179210540:A G505E missense_variant 0.84 0
3:179210540:C G505A missense_variant 0.84 0
3:179210540:T G505V missense_variant 0.84 0
3:179218217:A R516K missense_variant 0.84 0
3:179218217:C R516T missense_variant 0.84 0
3:179218217:T R516I missense_variant 0.84 0
3:179218222:A A518T missense_variant 0.84 0
3:179218222:C A518P missense_variant 0.84 0
3:179218222:T A518S missense_variant 0.84 0
3:179218226:A R519K missense_variant 0.84 0
3:179218226:C R519T missense_variant 0.84 0
3:179218226:T R519I missense_variant 0.84 0
3:179218228:A D520N missense_variant 0.84 0
3:179218228:C D520H missense_variant 0.84 0
3:179218228:T D520Y missense_variant 0.84 0
3:179199740:A E135K missense_variant 0.84 0
3:179199734:T D133Y missense_variant 0.84 0
3:179199734:C D133H missense_variant 0.84 0
3:179199734:A D133N missense_variant 0.84 0
3:179199728:T V131F missense_variant 0.84 0
3:179199728:C V131L missense_variant 0.84 0
3:179199728:A V131I missense_variant 0.84 0
3:179199722:T D129Y missense_variant 0.84 0
3:179199722:C D129H missense_variant 0.84 0
3:179199722:A D129N missense_variant 0.84 0
3:179204577:G C378W missense_variant 0.83 0
3:179230314:T Q958H missense_variant 0.82 0
3:179230314:C Q958H missense_variant 0.82 0
3:179198940:T E39* stop_gained 0.81 0
3:179230308:C L956F missense_variant 0.80 0
3:179230308:T L956F missense_variant 0.80 0
3:179234244:A D1029E missense_variant 0.80 0
3:179234244:G D1029E missense_variant 0.80 0
3:179230306:G L956V missense_variant 0.80 0
3:179230306:A L956M missense_variant 0.80 0
3:179234205:A F1016L missense_variant 0.80 0
3:179234205:G F1016L missense_variant 0.80 0
3:179199168:G R115G missense_variant 0.80 0
3:179199066:C E81Q missense_variant 0.76 0
3:179199066:A E81K missense_variant 0.76 0
3:179199142:T G106V missense_variant 0.76 0
3:179199142:C G106A missense_variant 0.76 0
3:179199142:A G106D missense_variant 0.76 0
3:179199141:T G106C missense_variant 0.76 0
3:179199141:C G106R missense_variant 0.76 0
3:179199126:T V101L missense_variant 0.76 0
3:179199126:A V101I missense_variant 0.76 0
3:179199126:C V101L missense_variant 0.76 0
3:179209644:C A399P missense_variant 0.76 0
3:179209644:A A399T missense_variant 0.76 0
3:179209644:T A399S missense_variant 0.76 0
3:179234308:A W1051R missense_variant 0.74 0
3:179234308:G W1051G missense_variant 0.74 0
3:179234308:C W1051R missense_variant 0.74 0
3:179209684:T R412L missense_variant 0.74 0
3:179209684:C R412P missense_variant 0.74 0
3:179209684:A R412Q missense_variant 0.74 0
3:179209680:T G411C missense_variant 0.74 0
3:179209674:T V409F missense_variant 0.74 0
3:179209681:A G411D missense_variant 0.74 0
3:179209681:C G411A missense_variant 0.74 0
3:179209669:C C407S missense_variant 0.74 0
3:179209698:C E417Q missense_variant 0.74 0
3:179209698:A E417K missense_variant 0.74 0
3:179209690:T G414V missense_variant 0.74 0
3:179209680:A G411S missense_variant 0.74 0
3:179209674:C V409L missense_variant 0.74 0
3:179209690:C G414A missense_variant 0.74 0
3:179209674:A V409I missense_variant 0.74 0
3:179209680:C G411R missense_variant 0.74 0
3:179209669:A C407Y missense_variant 0.74 0
3:179209681:T G411V missense_variant 0.74 0
3:179209690:A G414D missense_variant 0.74 0
3:179209689:T G414C missense_variant 0.74 0
3:179209689:C G414R missense_variant 0.74 0
3:179209689:A G414S missense_variant 0.74 0
3:179209669:T C407F missense_variant 0.74 0
3:179219670:T V616F missense_variant 0.73 0
3:179219670:C V616L missense_variant 0.73 0
3:179219714:T Q630H missense_variant 0.73 0
3:179219714:C Q630H missense_variant 0.73 0
3:179219670:A V616I missense_variant 0.73 0
3:179198859:C G12R missense_variant 0.71 0
3:179198859:A G12S missense_variant 0.71 0
3:179198859:T G12C missense_variant 0.71 0
3:179234310:A W1051* stop_gained 0.70 0
3:179234309:A W1051* stop_gained 0.70 0
3:179218284:G D538E missense_variant 0.69 0
3:179218284:A D538E missense_variant 0.69 0
3:179234276:G M1040R missense_variant 0.69 0
3:179234276:C M1040T missense_variant 0.69 0
3:179234276:A M1040K missense_variant 0.69 0
3:179218288:A L540I missense_variant 0.68 0
3:179218288:G L540V missense_variant 0.68 0
3:179218288:T L540F missense_variant 0.68 0
3:179199057:C E78Q missense_variant 0.68 0
3:179199036:T V71L missense_variant 0.68 0
3:179199036:C V71L missense_variant 0.68 0
3:179199036:A V71I missense_variant 0.68 0
3:179199018:C E65Q missense_variant 0.68 0
3:179199061:A R79K missense_variant 0.68 0
3:179198928:A E35K missense_variant 0.68 0
3:179199040:A S72N missense_variant 0.68 0
3:179199040:C S72T missense_variant 0.68 0
3:179199040:T S72I missense_variant 0.68 0
3:179199057:A E78K missense_variant 0.68 0
3:179199042:A V73I missense_variant 0.68 0
3:179199042:C V73L missense_variant 0.68 0
3:179199042:T V73F missense_variant 0.68 0
3:179198943:C A40P missense_variant 0.68 0
3:179198943:T A40S missense_variant 0.68 0
3:179198967:A E48K missense_variant 0.68 0
3:179198967:C E48Q missense_variant 0.68 0
3:179198979:A E52K missense_variant 0.68 0
3:179198943:A A40T missense_variant 0.68 0
3:179198979:C E52Q missense_variant 0.68 0
3:179198982:A A53T missense_variant 0.68 0
3:179198982:C A53P missense_variant 0.68 0
3:179198982:T A53S missense_variant 0.68 0
3:179198986:A R54K missense_variant 0.68 0
3:179198986:C R54T missense_variant 0.68 0
3:179198986:T R54I missense_variant 0.68 0
3:179199015:A D64N missense_variant 0.68 0
3:179199015:C D64H missense_variant 0.68 0
3:179199015:T D64Y missense_variant 0.68 0
3:179199018:A E65K missense_variant 0.68 0
3:179199063:C E80Q missense_variant 0.68 0
3:179199063:A E80K missense_variant 0.68 0
3:179198932:T C36F missense_variant 0.68 0
3:179198932:C C36S missense_variant 0.68 0
3:179198932:A C36Y missense_variant 0.68 0
3:179199061:T R79M missense_variant 0.68 0
3:179199061:C R79T missense_variant 0.68 0
3:179198928:C E35Q missense_variant 0.68 0
3:179210462:C W479S missense_variant 0.66 0
3:179210462:T W479L missense_variant 0.66 0
3:179218299:G I543M missense_variant 0.63 0
3:179221048:C R693P missense_variant 0.62 0
3:179209597:C W383S missense_variant 0.62 0
3:179209597:T W383L missense_variant 0.62 0
3:179209598:C W383C missense_variant 0.62 0
3:179209598:T W383C missense_variant 0.62 0
3:179209602:A E385K missense_variant 0.62 0
3:179209602:C E385Q missense_variant 0.62 0
3:179209606:C W386S missense_variant 0.62 0
3:179209606:T W386L missense_variant 0.62 0
3:179209607:C W386C missense_variant 0.62 0
3:179209607:T W386C missense_variant 0.62 0
3:179209617:A D390N missense_variant 0.62 0
3:179209617:C D390H missense_variant 0.62 0
3:179209617:T D390Y missense_variant 0.62 0
3:179209632:A D395N missense_variant 0.62 0
3:179209632:C D395H missense_variant 0.62 0
3:179209632:T D395Y missense_variant 0.62 0
3:179209642:A R398H missense_variant 0.62 0
3:179209642:C R398P missense_variant 0.62 0
3:179209642:T R398L missense_variant 0.62 0
3:179209647:A A400T missense_variant 0.62 0
3:179209647:C A400P missense_variant 0.62 0
3:179209647:T A400S missense_variant 0.62 0
3:179209657:A C403Y missense_variant 0.62 0
3:179209657:C C403S missense_variant 0.62 0
3:179209657:T C403F missense_variant 0.62 0
3:179210186:A E418K missense_variant 0.62 0
3:179210186:C E418Q missense_variant 0.62 0
3:179210201:A A423T missense_variant 0.62 0
3:179210201:C A423P missense_variant 0.62 0
3:179210201:T A423S missense_variant 0.62 0
3:179210205:C W424S missense_variant 0.62 0
3:179210205:T W424L missense_variant 0.62 0
3:179210206:C W424C missense_variant 0.62 0
3:179210206:T W424C missense_variant 0.62 0
3:179210207:A G425R missense_variant 0.62 0
3:179210207:C G425R missense_variant 0.62 0
3:179210208:A G425E missense_variant 0.62 0
3:179210208:C G425A missense_variant 0.62 0
3:179210208:T G425V missense_variant 0.62 0
3:179210225:A D431N missense_variant 0.62 0
3:179210225:C D431H missense_variant 0.62 0
3:179210225:T D431Y missense_variant 0.62 0
3:179210243:A V437I missense_variant 0.62 0
3:179210243:C V437L missense_variant 0.62 0
3:179210243:T V437L missense_variant 0.62 0
3:179210258:A A442T missense_variant 0.62 0
3:179210258:C A442P missense_variant 0.62 0
3:179210258:T A442S missense_variant 0.62 0
3:179210271:C W446S missense_variant 0.62 0
3:179210271:T W446L missense_variant 0.62 0
3:179210272:C W446C missense_variant 0.62 0
3:179210272:T W446C missense_variant 0.62 0
3:179210276:A V448I missense_variant 0.62 0
3:179210276:C V448L missense_variant 0.62 0
3:179210276:T V448L missense_variant 0.62 0
3:179210285:A G451R missense_variant 0.62 0
3:179210285:C G451R missense_variant 0.62 0
3:179210468:A S481N missense_variant 0.62 0
3:179210468:C S481T missense_variant 0.62 0
3:179210468:T S481I missense_variant 0.62 0
3:179218243:A E525K missense_variant 0.62 0
3:179218243:C E525Q missense_variant 0.62 0
3:179218249:A D527N missense_variant 0.62 0
3:179218249:C D527H missense_variant 0.62 0
3:179218249:T D527Y missense_variant 0.62 0
3:179218255:A E529K missense_variant 0.62 0
3:179218255:C E529Q missense_variant 0.62 0
3:179218315:A D549N missense_variant 0.62 0
3:179218315:C D549H missense_variant 0.62 0
3:179218315:T D549Y missense_variant 0.62 0
3:179218325:C W552S missense_variant 0.62 0
3:179218325:T W552L missense_variant 0.62 0
3:179218326:C W552C missense_variant 0.62 0
3:179218326:T W552C missense_variant 0.62 0
3:179218328:A S553N missense_variant 0.62 0
3:179218328:C S553T missense_variant 0.62 0
3:179218328:T S553I missense_variant 0.62 0
3:179218334:A R555K missense_variant 0.62 0
3:179218334:C R555T missense_variant 0.62 0
3:179218334:T R555I missense_variant 0.62 0
3:179219573:A M583I missense_variant 0.62 0
3:179219573:C M583I missense_variant 0.62 0
3:179219573:T M583I missense_variant 0.62 0
3:179219578:A C585Y missense_variant 0.62 0
3:179219578:C C585S missense_variant 0.62 0
3:179219578:T C585F missense_variant 0.62 0
3:179219589:A D589N missense_variant 0.62 0
3:179219589:C D589H missense_variant 0.62 0
3:179219589:T D589Y missense_variant 0.62 0
3:179219593:C W590S missense_variant 0.62 0
3:179219593:T W590L missense_variant 0.62 0
3:179219594:C W590C missense_variant 0.62 0
3:179219594:T W590C missense_variant 0.62 0
3:179219610:A E596K missense_variant 0.62 0
3:179219610:C E596Q missense_variant 0.62 0
3:179219616:A A598T missense_variant 0.62 0
3:179219616:C A598P missense_variant 0.62 0
3:179219616:T A598S missense_variant 0.62 0
3:179219621:A M599I missense_variant 0.62 0
3:179219621:C M599I missense_variant 0.62 0
3:179219621:T M599I missense_variant 0.62 0
3:179219622:A E600K missense_variant 0.62 0
3:179219622:C E600Q missense_variant 0.62 0
3:179219631:A D603N missense_variant 0.62 0
3:179219631:C D603H missense_variant 0.62 0
3:179219631:T D603Y missense_variant 0.62 0
3:179219646:A D608N missense_variant 0.62 0
3:179219646:C D608H missense_variant 0.62 0
3:179219646:T D608Y missense_variant 0.62 0
3:179219659:A R612Q missense_variant 0.62 0
3:179219659:C R612P missense_variant 0.62 0
3:179219659:T R612L missense_variant 0.62 0
3:179219667:A A615T missense_variant 0.62 0
3:179219667:C A615P missense_variant 0.62 0
3:179219667:T A615S missense_variant 0.62 0
3:179219677:A C618Y missense_variant 0.62 0
3:179219677:C C618S missense_variant 0.62 0
3:179219677:T C618F missense_variant 0.62 0
3:179219682:A E620K missense_variant 0.62 0
3:179219682:C E620Q missense_variant 0.62 0
3:179219697:A D625N missense_variant 0.62 0
3:179219697:C D625H missense_variant 0.62 0
3:179219697:T D625Y missense_variant 0.62 0
3:179219700:A D626N missense_variant 0.62 0
3:179219700:C D626H missense_variant 0.62 0
3:179219700:T D626Y missense_variant 0.62 0
3:179219730:A V636I missense_variant 0.62 0
3:179219730:C V636L missense_variant 0.62 0
3:179219730:T V636L missense_variant 0.62 0
3:179219735:C Q637H missense_variant 0.62 0
3:179219735:T Q637H missense_variant 0.62 0
3:179219949:A V638I missense_variant 0.62 0
3:179219949:C V638L missense_variant 0.62 0
3:179219949:T V638F missense_variant 0.62 0
3:179219961:A E642K missense_variant 0.62 0
3:179219961:C E642Q missense_variant 0.62 0
3:179219973:A D646N missense_variant 0.62 0
3:179219973:C D646H missense_variant 0.62 0
3:179219973:T D646Y missense_variant 0.62 0
3:179219985:A V650M missense_variant 0.62 0
3:179219985:C V650L missense_variant 0.62 0
3:179219985:T V650L missense_variant 0.62 0
3:179219989:A R651K missense_variant 0.62 0
3:179219989:C R651T missense_variant 0.62 0
3:179219989:T R651I missense_variant 0.62 0
3:179220006:A A657T missense_variant 0.62 0
3:179220006:C A657P missense_variant 0.62 0
3:179220006:T A657S missense_variant 0.62 0
3:179220022:A R662K missense_variant 0.62 0
3:179220022:C R662T missense_variant 0.62 0
3:179220022:T R662M missense_variant 0.62 0
3:179220027:A G664R missense_variant 0.62 0
3:179220027:C G664R missense_variant 0.62 0
3:179220027:T G664W missense_variant 0.62 0
3:179220028:A G664E missense_variant 0.62 0
3:179220028:C G664A missense_variant 0.62 0
3:179220028:T G664V missense_variant 0.62 0
3:179220043:C W669S missense_variant 0.62 0
3:179220043:T W669L missense_variant 0.62 0
3:179220044:C W669C missense_variant 0.62 0
3:179220044:T W669C missense_variant 0.62 0
3:179220990:A E674K missense_variant 0.62 0
3:179220990:C E674Q missense_variant 0.62 0
3:179220995:A M675I missense_variant 0.62 0
3:179220995:C M675I missense_variant 0.62 0
3:179220995:T M675I missense_variant 0.62 0
3:179221008:A V680I missense_variant 0.62 0
3:179221008:C V680L missense_variant 0.62 0
3:179221008:T V680F missense_variant 0.62 0
3:179221018:A R683K missense_variant 0.62 0
3:179221018:C R683T missense_variant 0.62 0
3:179221018:T R683M missense_variant 0.62 0
3:179221023:A G685S missense_variant 0.62 0
3:179221023:C G685R missense_variant 0.62 0
3:179221023:T G685C missense_variant 0.62 0
3:179221024:A G685D missense_variant 0.62 0
3:179221024:C G685A missense_variant 0.62 0
3:179221024:T G685V missense_variant 0.62 0
3:179221035:A E689K missense_variant 0.62 0
3:179221035:C E689Q missense_variant 0.62 0
3:179221045:A C692Y missense_variant 0.62 0
3:179221045:C C692S missense_variant 0.62 0
3:179221045:T C692F missense_variant 0.62 0
3:179221048:A R693H missense_variant 0.62 0
3:179221048:T R693L missense_variant 0.62 0
3:179221050:A A694T missense_variant 0.62 0
3:179221050:C A694P missense_variant 0.62 0
3:179221050:T A694S missense_variant 0.62 0
3:179221054:A C695Y missense_variant 0.62 0
3:179221054:C C695S missense_variant 0.62 0
3:179221054:T C695F missense_variant 0.62 0
3:179221056:A G696R missense_variant 0.62 0
3:179221056:C G696R missense_variant 0.62 0
3:179221056:T G696W missense_variant 0.62 0
3:179221057:A G696E missense_variant 0.62 0
3:179221057:C G696A missense_variant 0.62 0
3:179221057:T G696V missense_variant 0.62 0
3:179221061:A M697I missense_variant 0.62 0
3:179221061:C M697I missense_variant 0.62 0
3:179221061:T M697I missense_variant 0.62 0
3:179230077:C G914R missense_variant 0.61 0
3:179224165:A A758T missense_variant 0.61 0
3:179224165:C A758P missense_variant 0.61 0
3:179224165:T A758S missense_variant 0.61 0
3:179224177:A G762R missense_variant 0.61 0
3:179224177:C G762R missense_variant 0.61 0
3:179224178:A G762E missense_variant 0.61 0
3:179224178:C G762A missense_variant 0.61 0
3:179224178:T G762V missense_variant 0.61 0
3:179224187:A R765K missense_variant 0.61 0
3:179224187:C R765T missense_variant 0.61 0
3:179224187:T R765M missense_variant 0.61 0
3:179225968:A R808Q missense_variant 0.61 0
3:179225968:C R808P missense_variant 0.61 0
3:179225968:T R808L missense_variant 0.61 0
3:179225973:A D810N missense_variant 0.61 0
3:179225973:C D810H missense_variant 0.61 0
3:179225973:T D810Y missense_variant 0.61 0
3:179225978:A M811I missense_variant 0.61 0
3:179225978:C M811I missense_variant 0.61 0
3:179225978:T M811I missense_variant 0.61 0
3:179226005:A M820I missense_variant 0.61 0
3:179226005:C M820I missense_variant 0.61 0
3:179226005:T M820I missense_variant 0.61 0
3:179226006:A E821K missense_variant 0.61 0
3:179226006:C E821Q missense_variant 0.61 0
3:179226016:C W824S missense_variant 0.61 0
3:179226016:T W824L missense_variant 0.61 0
3:179226017:C W824C missense_variant 0.61 0
3:179226017:T W824C missense_variant 0.61 0
3:179226027:A G828S missense_variant 0.61 0
3:179226027:C G828R missense_variant 0.61 0
3:179226027:T G828C missense_variant 0.61 0
3:179226028:A G828D missense_variant 0.61 0
3:179226028:C G828A missense_variant 0.61 0
3:179226028:T G828V missense_variant 0.61 0
3:179226033:A D830N missense_variant 0.61 0
3:179226033:C D830H missense_variant 0.61 0
3:179226033:T D830Y missense_variant 0.61 0
3:179226040:A R832Q missense_variant 0.61 0
3:179226040:C R832P missense_variant 0.61 0
3:179226040:T R832L missense_variant 0.61 0
3:179230008:A D891N missense_variant 0.61 0
3:179230008:C D891H missense_variant 0.61 0
3:179230008:T D891Y missense_variant 0.61 0
3:179230014:A A893T missense_variant 0.61 0
3:179230014:C A893P missense_variant 0.61 0
3:179230014:T A893S missense_variant 0.61 0
3:179230020:A D895N missense_variant 0.61 0
3:179230020:C D895H missense_variant 0.61 0
3:179230020:T D895Y missense_variant 0.61 0
3:179230033:A R899H missense_variant 0.61 0
3:179230033:C R899P missense_variant 0.61 0
3:179230033:T R899L missense_variant 0.61 0
3:179230039:A C901Y missense_variant 0.61 0
3:179230039:C C901S missense_variant 0.61 0
3:179224132:C A747P missense_variant 0.61 0
3:179230041:A A902T missense_variant 0.61 0
3:179230041:C A902P missense_variant 0.61 0
3:179230041:T A902S missense_variant 0.61 0
3:179230044:A G903R missense_variant 0.61 0
3:179230044:C G903R missense_variant 0.61 0
3:179230045:A G903E missense_variant 0.61 0
3:179230045:C G903A missense_variant 0.61 0
3:179230045:T G903V missense_variant 0.61 0
3:179230051:A C905Y missense_variant 0.61 0
3:179230051:C C905S missense_variant 0.61 0
3:179230051:T C905F missense_variant 0.61 0
3:179230053:A V906I missense_variant 0.61 0
3:179230053:C V906L missense_variant 0.61 0
3:179230053:T V906L missense_variant 0.61 0
3:179230056:A A907T missense_variant 0.61 0
3:179230056:C A907P missense_variant 0.61 0
3:179230056:T A907S missense_variant 0.61 0
3:179230071:A G912R missense_variant 0.61 0
3:179230071:C G912R missense_variant 0.61 0
3:179230072:A G912E missense_variant 0.61 0
3:179230072:C G912A missense_variant 0.61 0
3:179230072:T G912V missense_variant 0.61 0
3:179224132:A A747T missense_variant 0.61 0
3:179224132:T A747S missense_variant 0.61 0
3:179230078:A G914E missense_variant 0.61 0
3:179230078:C G914A missense_variant 0.61 0
3:179230078:T G914V missense_variant 0.61 0
3:179230080:A D915N missense_variant 0.61 0
3:179230080:C D915H missense_variant 0.61 0
3:179230080:T D915Y missense_variant 0.61 0
3:179230084:A R916H missense_variant 0.61 0
3:179230084:C R916P missense_variant 0.61 0
3:179230084:T R916L missense_variant 0.61 0
3:179230093:A S919N missense_variant 0.61 0
3:179230093:C S919T missense_variant 0.61 0
3:179230093:T S919I missense_variant 0.61 0
3:179230103:A M922I missense_variant 0.61 0
3:179230103:C M922I missense_variant 0.61 0
3:179230103:T M922I missense_variant 0.61 0
3:179230104:A V923M missense_variant 0.61 0
3:179230104:C V923L missense_variant 0.61 0
3:179230104:T V923L missense_variant 0.61 0
3:179230110:A D925N missense_variant 0.61 0
3:179230110:C D925H missense_variant 0.61 0
3:179230110:T D925Y missense_variant 0.61 0
3:179230116:A G927R missense_variant 0.61 0
3:179230116:C G927R missense_variant 0.61 0
3:179230117:A G927E missense_variant 0.61 0
3:179230117:C G927A missense_variant 0.61 0
3:179230117:T G927V missense_variant 0.61 0
3:179230237:A D933N missense_variant 0.61 0
3:179230237:C D933H missense_variant 0.61 0
3:179230237:T D933Y missense_variant 0.61 0
3:179230243:A G935R missense_variant 0.61 0
3:179230243:C G935R missense_variant 0.61 0
3:179230244:A G935E missense_variant 0.61 0
3:179230244:C G935A missense_variant 0.61 0
3:179230244:T G935V missense_variant 0.61 0
3:179230255:A D939N missense_variant 0.61 0
3:179230255:C D939H missense_variant 0.61 0
3:179230255:T D939Y missense_variant 0.61 0
3:179230276:A G946S missense_variant 0.61 0
3:179230276:C G946R missense_variant 0.61 0
3:179230276:T G946C missense_variant 0.61 0
3:179230277:A G946D missense_variant 0.61 0
3:179230277:C G946A missense_variant 0.61 0
3:179230277:T G946V missense_variant 0.61 0
3:179230286:A R949Q missense_variant 0.61 0
3:179230286:C R949P missense_variant 0.61 0
3:179230286:T R949L missense_variant 0.61 0
3:179230288:A E950K missense_variant 0.61 0
3:179230288:C E950Q missense_variant 0.61 0
3:179230292:A R951H missense_variant 0.61 0
3:179230292:C R951P missense_variant 0.61 0
3:179230292:T R951L missense_variant 0.61 0
3:179230294:A V952M missense_variant 0.61 0
3:179230294:C V952L missense_variant 0.61 0
3:179230294:T V952L missense_variant 0.61 0
3:179224129:T D746Y missense_variant 0.61 0
3:179224129:C D746H missense_variant 0.61 0
3:179224129:A D746N missense_variant 0.61 0
3:179224128:T M745I missense_variant 0.61 0
3:179224128:C M745I missense_variant 0.61 0
3:179224128:A M745I missense_variant 0.61 0
3:179224120:T D743Y missense_variant 0.61 0
3:179224120:C D743H missense_variant 0.61 0
3:179224120:A D743N missense_variant 0.61 0
3:179224110:T M739I missense_variant 0.61 0
3:179224110:C M739I missense_variant 0.61 0
3:179224110:A M739I missense_variant 0.61 0
3:179224102:C E737Q missense_variant 0.61 0
3:179230315:A D959N missense_variant 0.61 0
3:179230315:C D959H missense_variant 0.61 0
3:179230315:T D959Y missense_variant 0.61 0
3:179230327:A V963M missense_variant 0.61 0
3:179230327:C V963L missense_variant 0.61 0
3:179230327:T V963L missense_variant 0.61 0
3:179230339:A G967R missense_variant 0.61 0
3:179230339:C G967R missense_variant 0.61 0
3:179230340:A G967E missense_variant 0.61 0
3:179230340:C G967A missense_variant 0.61 0
3:179230340:T G967V missense_variant 0.61 0
3:179230372:A E978K missense_variant 0.61 0
3:179230372:C E978Q missense_variant 0.61 0
3:179230376:A R979K missense_variant 0.61 0
3:179230376:C R979T missense_variant 0.61 0
3:179230376:T R979M missense_variant 0.61 0
3:179234101:A E982K missense_variant 0.61 0
3:179234101:C E982Q missense_variant 0.61 0
3:179234106:A M983I missense_variant 0.61 0
3:179234106:C M983I missense_variant 0.61 0
3:179234106:T M983I missense_variant 0.61 0
3:179234108:A C984Y missense_variant 0.61 0
3:179234108:C C984S missense_variant 0.61 0
3:179234108:T C984F missense_variant 0.61 0
3:179234116:A A987T missense_variant 0.61 0
3:179234116:C A987P missense_variant 0.61 0
3:179234116:T A987S missense_variant 0.61 0
3:179234125:A A990T missense_variant 0.61 0
3:179234125:C A990P missense_variant 0.61 0
3:179234125:T A990S missense_variant 0.61 0
3:179234132:A R992Q missense_variant 0.61 0
3:179234132:C R992P missense_variant 0.61 0
3:179234132:T R992L missense_variant 0.61 0
3:179224102:A E737K missense_variant 0.61 0
3:179224099:T V736F missense_variant 0.61 0
3:179224099:C V736L missense_variant 0.61 0
3:179224099:A V736I missense_variant 0.61 0
3:179224089:T M732I missense_variant 0.61 0
3:179224089:C M732I missense_variant 0.61 0
3:179224089:A M732I missense_variant 0.61 0
3:179224081:T V730L missense_variant 0.61 0
3:179234225:A R1023Q missense_variant 0.61 0
3:179234225:C R1023P missense_variant 0.61 0
3:179234225:T R1023L missense_variant 0.61 0
3:179234236:A A1027T missense_variant 0.61 0
3:179234236:C A1027P missense_variant 0.61 0
3:179234236:T A1027S missense_variant 0.61 0
3:179224081:C V730L missense_variant 0.61 0
3:179224081:A V730I missense_variant 0.61 0
3:179234251:A E1032K missense_variant 0.61 0
3:179234251:C E1032Q missense_variant 0.61 0
3:179234257:A E1034K missense_variant 0.61 0
3:179234257:C E1034Q missense_variant 0.61 0
3:179234260:A A1035T missense_variant 0.61 0
3:179234260:C A1035P missense_variant 0.61 0
3:179234260:T A1035S missense_variant 0.61 0
3:179234266:A E1037K missense_variant 0.61 0
3:179234266:C E1037Q missense_variant 0.61 0
3:179234322:A M1055I missense_variant 0.61 0
3:179234322:C M1055I missense_variant 0.61 0
3:179234322:T M1055I missense_variant 0.61 0
3:179234323:A D1056N missense_variant 0.61 0
3:179234323:C D1056H missense_variant 0.61 0
3:179234323:T D1056Y missense_variant 0.61 0
3:179234327:C W1057S missense_variant 0.61 0
3:179234327:T W1057L missense_variant 0.61 0
3:179234328:C W1057C missense_variant 0.61 0
3:179234328:T W1057C missense_variant 0.61 0
3:179219228:T P566L missense_variant 0.60 0
3:179219228:G P566R missense_variant 0.60 0
3:179219228:A P566H missense_variant 0.60 0
3:179219227:T P566S missense_variant 0.60 0
3:179219227:G P566A missense_variant 0.60 0
3:179219227:A P566T missense_variant 0.60 0
3:179219216:T P562L missense_variant 0.60 0
3:179219216:G P562R missense_variant 0.60 0
3:179219216:A P562H missense_variant 0.60 0
3:179219215:T P562S missense_variant 0.60 0
3:179219215:G P562A missense_variant 0.60 0
3:179219215:A P562T missense_variant 0.60 0
3:179219273:T A581V missense_variant 0.60 0
3:179219273:G A581G missense_variant 0.60 0
3:179219273:A A581D missense_variant 0.60 0
3:179199048:G Q75E missense_variant 0.60 0
3:179199048:A Q75K missense_variant 0.60 0
3:179219243:T S571F missense_variant 0.60 0
3:179219243:G S571C missense_variant 0.60 0
3:179219243:A S571Y missense_variant 0.60 0
3:179199097:T D91V missense_variant 0.58 0
3:179199052:T E76V missense_variant 0.58 0
3:179199052:C E76A missense_variant 0.58 0
3:179199052:G E76G missense_variant 0.58 0
3:179199097:C D91A missense_variant 0.58 0
3:179199097:G D91G missense_variant 0.58 0
3:179219201:G Y557C missense_variant 0.57 0
3:179219201:T Y557F missense_variant 0.57 0
3:179219201:C Y557S missense_variant 0.57 0
3:179219212:G I561V missense_variant 0.57 0
3:179219212:T I561F missense_variant 0.57 0
3:179219212:C I561L missense_variant 0.57 0
3:179199054:C A77P missense_variant 0.56 0
3:179199054:A A77T missense_variant 0.56 0
3:179199054:T A77S missense_variant 0.56 0
3:179234278:T K1041* stop_gained 0.55 0
3:179219198:T H556L missense_variant 0.55 0
3:179219198:G H556R missense_variant 0.55 0
3:179219198:C H556P missense_variant 0.55 0
3:179219260:G R577G missense_variant 0.55 0
3:179234280:T K1041N missense_variant 0.55 0
3:179234280:C K1041N missense_variant 0.55 0
3:179204527:G H362D missense_variant 0.53 0
3:179204527:A H362N missense_variant 0.53 0
3:179204516:A T358K missense_variant 0.53 0
3:179204516:G T358R missense_variant 0.53 0
3:179204516:T T358I missense_variant 0.53 0
3:179204585:T P381L missense_variant 0.53 0
3:179204585:G P381R missense_variant 0.53 0
3:179204585:A P381H missense_variant 0.53 0
3:179204584:T P381S missense_variant 0.53 0
3:179204584:G P381A missense_variant 0.53 0
3:179204584:A P381T missense_variant 0.53 0
3:179204579:T S379F missense_variant 0.53 0
3:179204579:G S379C missense_variant 0.53 0
3:179204579:A S379Y missense_variant 0.53 0
3:179204573:T P377L missense_variant 0.53 0
3:179204573:G P377R missense_variant 0.53 0
3:179204573:A P377H missense_variant 0.53 0
3:179204572:T P377S missense_variant 0.53 0
3:179204572:G P377A missense_variant 0.53 0
3:179204572:A P377T missense_variant 0.53 0
3:179204563:G Q374E missense_variant 0.53 0
3:179204563:A Q374K missense_variant 0.53 0
3:179204561:T T373I missense_variant 0.53 0
3:179204561:G T373S missense_variant 0.53 0
3:179204561:A T373N missense_variant 0.53 0
3:179204539:T P366S missense_variant 0.53 0
3:179204539:G P366A missense_variant 0.53 0
3:179204539:A P366T missense_variant 0.53 0
3:179204527:T H362Y missense_variant 0.53 0
3:179199716:T E127* stop_gained 0.52 0
3:179234283:T Q1042H missense_variant 0.52 0
3:179234283:C Q1042H missense_variant 0.52 0
3:179199085:C R87T missense_variant 0.52 0
3:179199085:T R87I missense_variant 0.52 0
3:179199085:A R87K missense_variant 0.52 0
3:179221078:C N703T missense_variant 0.52 0
3:179221078:G N703S missense_variant 0.52 0
3:179221078:T N703I missense_variant 0.52 0
3:179209692:C A415P missense_variant 0.52 0
3:179209692:T A415S missense_variant 0.52 0
3:179209692:A A415T missense_variant 0.52 0
3:179199103:C R93P missense_variant 0.51 0
3:179199103:T R93L missense_variant 0.51 0
3:179199103:A R93Q missense_variant 0.51 0
3:179210330:G P466A missense_variant 0.50 0
3:179210330:T P466S missense_variant 0.50 0
3:179210331:A P466Q missense_variant 0.50 0
3:179210307:A P458H missense_variant 0.50 0
3:179210331:G P466R missense_variant 0.50 0
3:179210331:T P466L missense_variant 0.50 0
3:179210435:A T470N missense_variant 0.50 0
3:179210435:G T470S missense_variant 0.50 0
3:179210435:T T470I missense_variant 0.50 0
3:179210437:A P471T missense_variant 0.50 0
3:179210437:G P471A missense_variant 0.50 0
3:179210437:T P471S missense_variant 0.50 0
3:179210438:A P471Q missense_variant 0.50 0
3:179210438:G P471R missense_variant 0.50 0
3:179210307:T P458L missense_variant 0.50 0
3:179210325:T S464L missense_variant 0.50 0
3:179210307:G P458R missense_variant 0.50 0
3:179210330:A P466T missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(LGG) Lower grade glioma G 0.53 0.21