Top
Note: You're navigating the results of models obtained with IntOGen (2020). A new boostDM version is available here.
PPP6C CM ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
9:125149801:A R301C missense_variant 1.00 22
9:125149782:A S307L missense_variant 0.98 4
9:125153646:A P223S missense_variant 1.00 3
9:125171093:A H92Y missense_variant 0.85 3
9:125149816:A P296S missense_variant 1.00 2
9:125153700:A P205S missense_variant 0.98 2
9:125149704:A P333L missense_variant 0.93 2
9:125149800:T R301H missense_variant 0.73 2
9:125153673:A R214* stop_gained 0.52 2
9:125149815:A P296L missense_variant 1.00 1
9:125153606:A P236L missense_variant 0.98 1
9:125153655:A Q220* stop_gained 0.97 1
9:125158280:A H151Y missense_variant 0.94 1
9:125158370:T D121N missense_variant 0.66 1
9:125149801:C R301G missense_variant 1.00 0
9:125149801:T R301S missense_variant 1.00 0
9:125149816:T P296T missense_variant 1.00 0
9:125149815:T P296H missense_variant 1.00 0
9:125149816:C P296A missense_variant 1.00 0
9:125149815:C P296R missense_variant 1.00 0
9:125153646:T P223T missense_variant 1.00 0
9:125153646:C P223A missense_variant 1.00 0
9:125149726:A P326S missense_variant 0.98 0
9:125149726:C P326A missense_variant 0.98 0
9:125149726:T P326T missense_variant 0.98 0
9:125149731:A A324V missense_variant 0.98 0
9:125149731:C A324G missense_variant 0.98 0
9:125149731:T A324E missense_variant 0.98 0
9:125149746:A P319L missense_variant 0.98 0
9:125149746:C P319R missense_variant 0.98 0
9:125149746:T P319Q missense_variant 0.98 0
9:125149747:A P319S missense_variant 0.98 0
9:125149747:C P319A missense_variant 0.98 0
9:125149747:T P319T missense_variant 0.98 0
9:125149870:C H278D missense_variant 0.98 0
9:125149870:A H278Y missense_variant 0.98 0
9:125149830:T T291K missense_variant 0.98 0
9:125149830:C T291R missense_variant 0.98 0
9:125149830:A T291I missense_variant 0.98 0
9:125149821:T S294Y missense_variant 0.98 0
9:125149821:C S294C missense_variant 0.98 0
9:125149821:A S294F missense_variant 0.98 0
9:125149818:T A295D missense_variant 0.98 0
9:125149782:C S307W missense_variant 0.98 0
9:125149785:A A306V missense_variant 0.98 0
9:125149785:C A306G missense_variant 0.98 0
9:125149785:T A306D missense_variant 0.98 0
9:125149818:C A295G missense_variant 0.98 0
9:125149818:A A295V missense_variant 0.98 0
9:125149915:T H263N missense_variant 0.98 0
9:125149915:C H263D missense_variant 0.98 0
9:125149915:A H263Y missense_variant 0.98 0
9:125149907:T N265K missense_variant 0.98 0
9:125149907:C N265K missense_variant 0.98 0
9:125149897:T L269I missense_variant 0.98 0
9:125149897:C L269V missense_variant 0.98 0
9:125149897:A L269F missense_variant 0.98 0
9:125149884:T A273E missense_variant 0.98 0
9:125149884:C A273G missense_variant 0.98 0
9:125149884:A A273V missense_variant 0.98 0
9:125149882:T H274N missense_variant 0.98 0
9:125149882:C H274D missense_variant 0.98 0
9:125149882:A H274Y missense_variant 0.98 0
9:125149879:T Q275K missense_variant 0.98 0
9:125149879:C Q275E missense_variant 0.98 0
9:125149870:T H278N missense_variant 0.98 0
9:125149719:A S328L missense_variant 0.98 0
9:125149725:A P326L missense_variant 0.98 0
9:125149725:C P326R missense_variant 0.98 0
9:125149725:T P326Q missense_variant 0.98 0
9:125149782:T S307* stop_gained 0.98 0
9:125149719:T S328* stop_gained 0.98 0
9:125149719:C S328* stop_gained 0.98 0
9:125149879:A Q275* stop_gained 0.98 0
9:125153576:A P246L missense_variant 0.98 0
9:125153540:A T258I missense_variant 0.98 0
9:125153540:C T258R missense_variant 0.98 0
9:125153540:T T258K missense_variant 0.98 0
9:125153549:A A255V missense_variant 0.98 0
9:125153549:C A255G missense_variant 0.98 0
9:125153549:T A255E missense_variant 0.98 0
9:125153567:A A249V missense_variant 0.98 0
9:125153567:C A249G missense_variant 0.98 0
9:125153567:T A249E missense_variant 0.98 0
9:125153576:C P246R missense_variant 0.98 0
9:125153576:T P246H missense_variant 0.98 0
9:125153577:A P246S missense_variant 0.98 0
9:125153577:C P246A missense_variant 0.98 0
9:125153577:T P246T missense_variant 0.98 0
9:125153585:A A243V missense_variant 0.98 0
9:125153585:C A243G missense_variant 0.98 0
9:125153585:T A243D missense_variant 0.98 0
9:125153591:A T241I missense_variant 0.98 0
9:125153591:C T241S missense_variant 0.98 0
9:125153591:T T241N missense_variant 0.98 0
9:125153606:C P236R missense_variant 0.98 0
9:125153606:T P236H missense_variant 0.98 0
9:125153607:A P236S missense_variant 0.98 0
9:125153607:C P236A missense_variant 0.98 0
9:125153607:T P236T missense_variant 0.98 0
9:125153612:A S234L missense_variant 0.98 0
9:125153633:A A227V missense_variant 0.98 0
9:125153633:C A227G missense_variant 0.98 0
9:125153633:T A227E missense_variant 0.98 0
9:125153643:A H224Y missense_variant 0.98 0
9:125153643:C H224D missense_variant 0.98 0
9:125153643:T H224N missense_variant 0.98 0
9:125153655:C Q220E missense_variant 0.98 0
9:125153655:T Q220K missense_variant 0.98 0
9:125153669:A T215I missense_variant 0.98 0
9:125153669:C T215S missense_variant 0.98 0
9:125153669:T T215N missense_variant 0.98 0
9:125153679:C Q212E missense_variant 0.98 0
9:125153679:T Q212K missense_variant 0.98 0
9:125153687:A T209I missense_variant 0.98 0
9:125153687:C T209R missense_variant 0.98 0
9:125153687:T T209K missense_variant 0.98 0
9:125153699:A P205L missense_variant 0.98 0
9:125153699:C P205R missense_variant 0.98 0
9:125153699:T P205H missense_variant 0.98 0
9:125153700:C P205A missense_variant 0.98 0
9:125153700:T P205T missense_variant 0.98 0
9:125153702:A S204F missense_variant 0.98 0
9:125153702:C S204C missense_variant 0.98 0
9:125153702:T S204Y missense_variant 0.98 0
9:125153715:A H200Y missense_variant 0.98 0
9:125153715:C H200D missense_variant 0.98 0
9:125153715:T H200N missense_variant 0.98 0
9:125153730:C Q195E missense_variant 0.98 0
9:125153730:T Q195K missense_variant 0.98 0
9:125153910:A A189V missense_variant 0.98 0
9:125153910:C A189G missense_variant 0.98 0
9:125153910:T A189E missense_variant 0.98 0
9:125153916:A T187I missense_variant 0.98 0
9:125153916:C T187R missense_variant 0.98 0
9:125153916:T T187K missense_variant 0.98 0
9:125153937:A T180I missense_variant 0.98 0
9:125153937:C T180S missense_variant 0.98 0
9:125153937:T T180N missense_variant 0.98 0
9:125153952:A A175V missense_variant 0.98 0
9:125153952:C A175G missense_variant 0.98 0
9:125153952:T A175D missense_variant 0.98 0
9:125153958:A A173V missense_variant 0.98 0
9:125153958:C A173G missense_variant 0.98 0
9:125153958:T A173D missense_variant 0.98 0
9:125153973:A T168I missense_variant 0.98 0
9:125153973:C T168S missense_variant 0.98 0
9:125153973:T T168N missense_variant 0.98 0
9:125153977:C Q167E missense_variant 0.98 0
9:125153977:T Q167K missense_variant 0.98 0
9:125153612:T S234* stop_gained 0.97 0
9:125153612:C S234* stop_gained 0.97 0
9:125153977:A Q167* stop_gained 0.97 0
9:125153730:A Q195* stop_gained 0.97 0
9:125153679:A Q212* stop_gained 0.97 0
9:125158259:C Q158E missense_variant 0.94 0
9:125158280:T H151N missense_variant 0.94 0
9:125158280:C H151D missense_variant 0.94 0
9:125158259:T Q158K missense_variant 0.94 0
9:125158339:C T131S missense_variant 0.94 0
9:125158345:T T129N missense_variant 0.94 0
9:125158345:C T129S missense_variant 0.94 0
9:125158345:A T129I missense_variant 0.94 0
9:125158339:T T131N missense_variant 0.94 0
9:125158339:A T131I missense_variant 0.94 0
9:125158259:A Q158* stop_gained 0.94 0
9:125149687:C P339A missense_variant 0.93 0
9:125149687:A P339S missense_variant 0.93 0
9:125149686:T P339Q missense_variant 0.93 0
9:125149686:C P339R missense_variant 0.93 0
9:125149678:C L342V missense_variant 0.93 0
9:125158261:A T157I missense_variant 0.93 0
9:125158261:C T157R missense_variant 0.93 0
9:125158261:T T157K missense_variant 0.93 0
9:125158268:C Q155E missense_variant 0.93 0
9:125158268:T Q155K missense_variant 0.93 0
9:125149686:A P339L missense_variant 0.93 0
9:125149705:T P333T missense_variant 0.93 0
9:125149705:C P333A missense_variant 0.93 0
9:125149705:A P333S missense_variant 0.93 0
9:125149704:T P333H missense_variant 0.93 0
9:125149704:C P333R missense_variant 0.93 0
9:125149702:T P334T missense_variant 0.93 0
9:125149702:C P334A missense_variant 0.93 0
9:125149702:A P334S missense_variant 0.93 0
9:125149701:T P334H missense_variant 0.93 0
9:125149701:C P334R missense_variant 0.93 0
9:125149701:A P334L missense_variant 0.93 0
9:125149695:T T336K missense_variant 0.93 0
9:125149695:C T336R missense_variant 0.93 0
9:125149695:A T336M missense_variant 0.93 0
9:125149692:T T337K missense_variant 0.93 0
9:125149692:C T337R missense_variant 0.93 0
9:125149692:A T337I missense_variant 0.93 0
9:125149689:T T338K missense_variant 0.93 0
9:125149678:A L342F missense_variant 0.93 0
9:125149689:C T338R missense_variant 0.93 0
9:125149678:T L342I missense_variant 0.93 0
9:125149689:A T338M missense_variant 0.93 0
9:125149687:T P339T missense_variant 0.93 0
9:125158268:A Q155* stop_gained 0.93 0
9:125171122:C S82* stop_gained 0.86 0
9:125171087:A Q94* stop_gained 0.86 0
9:125171122:T S82* stop_gained 0.86 0
9:125171140:T S76* stop_gained 0.86 0
9:125171132:A Q79* stop_gained 0.86 0
9:125171140:C S76* stop_gained 0.86 0
9:125171132:T Q79K missense_variant 0.85 0
9:125171129:C P80A missense_variant 0.85 0
9:125171129:T P80T missense_variant 0.85 0
9:125171132:C Q79E missense_variant 0.85 0
9:125171140:A S76L missense_variant 0.85 0
9:125171128:A P80L missense_variant 0.85 0
9:125171128:C P80R missense_variant 0.85 0
9:125171128:T P80Q missense_variant 0.85 0
9:125171129:A P80S missense_variant 0.85 0
9:125171122:A S82L missense_variant 0.85 0
9:125171119:T T83K missense_variant 0.85 0
9:125171119:C T83R missense_variant 0.85 0
9:125171119:A T83I missense_variant 0.85 0
9:125171117:T P84T missense_variant 0.85 0
9:125171117:C P84A missense_variant 0.85 0
9:125171117:A P84S missense_variant 0.85 0
9:125171116:T P84Q missense_variant 0.85 0
9:125171087:C Q94E missense_variant 0.85 0
9:125171116:C P84R missense_variant 0.85 0
9:125171116:A P84L missense_variant 0.85 0
9:125171110:T T86K missense_variant 0.85 0
9:125171110:C T86R missense_variant 0.85 0
9:125171110:A T86I missense_variant 0.85 0
9:125171093:T H92N missense_variant 0.85 0
9:125171093:C H92D missense_variant 0.85 0
9:125171087:T Q94K missense_variant 0.85 0
9:125160870:A Q107* stop_gained 0.81 0
9:125160878:A T104I missense_variant 0.79 0
9:125160878:C T104S missense_variant 0.79 0
9:125160857:C T111R missense_variant 0.79 0
9:125160864:C P109A missense_variant 0.79 0
9:125160864:T P109T missense_variant 0.79 0
9:125160857:A T111I missense_variant 0.79 0
9:125160864:A P109S missense_variant 0.79 0
9:125160878:T T104N missense_variant 0.79 0
9:125160863:C P109R missense_variant 0.79 0
9:125160870:C Q107E missense_variant 0.79 0
9:125160870:T Q107K missense_variant 0.79 0
9:125160863:A P109L missense_variant 0.79 0
9:125160857:T T111K missense_variant 0.79 0
9:125160863:T P109H missense_variant 0.79 0
9:125149800:A R301L missense_variant 0.73 0
9:125149800:G R301P missense_variant 0.73 0
9:125149867:G E279Q missense_variant 0.72 0
9:125149867:T E279K missense_variant 0.72 0
9:125153914:A V188L missense_variant 0.72 0
9:125149759:A N315Y missense_variant 0.72 0
9:125149759:C N315D missense_variant 0.72 0
9:125149759:G N315H missense_variant 0.72 0
9:125153914:T V188I missense_variant 0.72 0
9:125153914:G V188L missense_variant 0.72 0
9:125158243:A Y163F missense_variant 0.71 0
9:125158243:C Y163C missense_variant 0.71 0
9:125158243:G Y163S missense_variant 0.71 0
9:125149839:A K288M missense_variant 0.71 0
9:125149899:C K268R missense_variant 0.71 0
9:125149899:G K268T missense_variant 0.71 0
9:125149756:G T316P missense_variant 0.71 0
9:125158369:A D121V missense_variant 0.71 0
9:125149839:C K288R missense_variant 0.71 0
9:125149899:A K268I missense_variant 0.71 0
9:125149839:G K288T missense_variant 0.71 0
9:125149756:C T316A missense_variant 0.71 0
9:125158369:C D121G missense_variant 0.71 0
9:125158369:G D121A missense_variant 0.71 0
9:125149756:A T316S missense_variant 0.71 0
9:125153663:G E217A missense_variant 0.66 0
9:125153663:C E217G missense_variant 0.66 0
9:125153663:A E217V missense_variant 0.66 0
9:125158340:C T131A missense_variant 0.66 0
9:125158340:G T131P missense_variant 0.66 0
9:125158298:C T145A missense_variant 0.66 0
9:125158298:A T145S missense_variant 0.66 0
9:125153938:G T180P missense_variant 0.66 0
9:125153938:C T180A missense_variant 0.66 0
9:125153938:A T180S missense_variant 0.66 0
9:125153727:A I196F missense_variant 0.66 0
9:125153727:C I196V missense_variant 0.66 0
9:125153727:G I196L missense_variant 0.66 0
9:125149758:A N315I missense_variant 0.66 0
9:125149758:C N315S missense_variant 0.66 0
9:125149758:G N315T missense_variant 0.66 0
9:125158340:A T131S missense_variant 0.66 0
9:125158298:G T145P missense_variant 0.66 0
9:125158307:G D142H missense_variant 0.66 0
9:125158354:G S126T missense_variant 0.66 0
9:125158354:T S126N missense_variant 0.66 0
9:125158364:A G123C missense_variant 0.66 0
9:125158364:G G123R missense_variant 0.66 0
9:125158364:T G123S missense_variant 0.66 0
9:125158370:A D121Y missense_variant 0.66 0
9:125158370:G D121H missense_variant 0.66 0
9:125158307:A D142Y missense_variant 0.66 0
9:125158307:T D142N missense_variant 0.66 0
9:125158303:T R143H missense_variant 0.66 0
9:125158303:G R143P missense_variant 0.66 0
9:125158303:A R143L missense_variant 0.66 0
9:125158354:A S126I missense_variant 0.66 0
9:125158349:T E128K missense_variant 0.66 0
9:125158349:G E128Q missense_variant 0.66 0
9:125160888:C L101V missense_variant 0.64 0
9:125160888:T L101M missense_variant 0.64 0
9:125158250:A G161* stop_gained 0.52 0
9:125158277:A E152* stop_gained 0.52 0
9:125158286:G G149R missense_variant 0.52 0
9:125158286:T G149R missense_variant 0.52 0
9:125158241:T D164N missense_variant 0.52 0
9:125158241:G D164H missense_variant 0.52 0
9:125158241:A D164Y missense_variant 0.52 0
9:125158288:A R148L missense_variant 0.52 0
9:125158273:G S153T missense_variant 0.52 0
9:125158273:T S153N missense_variant 0.52 0
9:125158273:A S153I missense_variant 0.52 0
9:125158288:G R148P missense_variant 0.52 0
9:125158288:T R148Q missense_variant 0.52 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(CM) Cutaneous melanoma of the skin SOLID 0.72 0.12