BoostDM

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PIK3CA 3:179218314:T (K548N) × ESCA ×

Driver potential information

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Model	BoostDM class	BoostDM score
(ESCA) Esophageal Adenocarcinoma	Driver	0.93

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Feature importance

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Place the mouse pointer over a mutational feature for additional information. See the FAQs for more details about the feature importance.

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Feature	Feature value	SHAP value
3D Clustering in Cancer Type (3CT)	1.00	0.91 Medium positive
Linear Clustering Score (LCS)	1.00	0.28 Medium positive
Recurrent in PFAM Domain (DOM)	2.00	0.15 Medium positive
Consequence Type: Missense (MISSENSE)	1.00	0.05 Non-significant
Consequence Type: Splice-affecting (SPLICE)	0.00	0.00 Non-significant
Consequence Type: Nonsense (NONSENSE)	0.00	0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB)	0.00	0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG)	0.00	0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS)	0.00	0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION)	0.00	0.00 Non-significant

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