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PTPN11 12:112472960:G (E258G) × CANCER ×
Driver potential information
Model BoostDM class BoostDM score
(CANCER) Any Cancer Type Driver 1.00
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.23 Medium negative
3D Clustering in Cancer Type (3CT) 2.00 2.95 High positive
Recurrent in PFAM Domain (DOM) 0.00 -0.13 Medium negative
PhyloP 100-way Score (PHYLOP) 8.95 0.99 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 0.11 Medium positive
Consequence Type: Nonsense (NONSENSE) 0.00 0.00 Non-significant
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant