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SMAD4 18:51065537:A (S357Y) × EGC ×
Driver potential information
Model BoostDM class BoostDM score
(EGC) Esophagogastric Adenocarcinoma Passenger 0.31
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 2.00 0.34 Medium positive
3D Clustering in Cancer Type (3CT) 0.00 -0.70 Medium negative
Recurrent in PFAM Domain (DOM) 2.00 0.73 Medium positive
PhyloP 100-way Score (PHYLOP) 7.76 -0.40 Medium negative
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 0.01 Non-significant
Consequence Type: Nonsense (NONSENSE) 0.00 -0.30 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant