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SMAD4 18:51065539:C (G358R) × BOWEL ×
Driver potential information
Model BoostDM class BoostDM score
(BOWEL) Bowel Driver 0.62
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 2.00 -0.17 Medium negative
3D Clustering in Cancer Type (3CT) 0.00 -0.64 Medium negative
Recurrent in PFAM Domain (DOM) 2.00 0.34 Medium positive
PhyloP 100-way Score (PHYLOP) 9.80 0.77 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 -0.01 Non-significant
Consequence Type: Nonsense (NONSENSE) 0.00 -0.11 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant