Top
SMAD4 18:51078366:T (E520*) × BOWEL ×
Driver potential information
Model BoostDM class BoostDM score
(BOWEL) Bowel Driver 0.68
Feature importance

Place the mouse pointer over a mutational feature for additional information. See the FAQs for more details about the feature importance.

Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 0.00 Non-significant
3D Clustering in Cancer Type (3CT) 0.00 -0.65 Medium negative
Recurrent in PFAM Domain (DOM) 2.00 0.13 Medium positive
PhyloP 100-way Score (PHYLOP) 5.59 -0.73 Medium negative
Stop Codon in Last Exon (NMD) 1.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 0.00 0.06 Non-significant
Consequence Type: Nonsense (NONSENSE) 1.00 1.49 High positive
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant