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TP53 17:7674217:G (R249T) × HGGNOS ×
Driver potential information
Model BoostDM class BoostDM score
(HGGNOS) High-Grade Glioma Driver 0.99
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 1.00 0.26 Medium positive
3D Clustering in Cancer Type (3CT) 2.00 1.70 High positive
Recurrent in PFAM Domain (DOM) 2.00 0.31 Medium positive
PhyloP 100-way Score (PHYLOP) 7.91 0.19 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 1.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 1.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 -0.03 Non-significant
Consequence Type: Nonsense (NONSENSE) 0.00 -0.13 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant