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TP53 17:7674223:A (N247I) × BREAST ×
Driver potential information
Model BoostDM class BoostDM score
(BREAST) Breast Driver 0.97
Feature importance

Place the mouse pointer over a mutational feature for additional information. See the FAQs for more details about the feature importance.

Feature Feature value SHAP value
Linear Clustering Score (LCS) 1.00 -0.10 Non-significant
3D Clustering in Cancer Type (3CT) 2.00 1.18 High positive
Recurrent in PFAM Domain (DOM) 2.00 0.51 Medium positive
PhyloP 100-way Score (PHYLOP) 8.02 0.23 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 -0.01 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 -0.16 Medium negative
Consequence Type: Nonsense (NONSENSE) 0.00 -0.12 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 -0.06 Non-significant