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TP53 17:7674869:C (E221G) × SKIN ×
Driver potential information
Model BoostDM class BoostDM score
(SKIN) Skin Passenger 0.19
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.43 Medium negative
3D Clustering in Cancer Type (3CT) 1.00 0.57 Medium positive
Recurrent in PFAM Domain (DOM) 2.00 0.02 Non-significant
PhyloP 100-way Score (PHYLOP) 4.23 -0.39 Medium negative
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.01 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 -0.01 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.01 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 -0.28 Medium negative
Consequence Type: Nonsense (NONSENSE) 0.00 -0.18 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 -0.06 Non-significant